Jack McHugh,Supavit Chesdachai,Murray Dunsirn,Nancy Wengenack,Paschalis Vergidis
{"title":"准假丝酵母对氟康唑的耐药性增加：美国参考实验室10年血培养分离株分析（2015-2024）","authors":"Jack McHugh,Supavit Chesdachai,Murray Dunsirn,Nancy Wengenack,Paschalis Vergidis","doi":"10.1093/infdis/jiaf249","DOIUrl":null,"url":null,"abstract":"Antifungal susceptibility testing among 1,740 Candida parapsilosis blood isolates submitted to a U.S. reference laboratory (2015-2024) revealed a significant increase in fluconazole resistance from 8.2% to 20.3% (odds ratio [OR] per year: 1.13; 95% confidence interval [CI]: 1.06-1.20; p<0.001), with notable acceleration since 2021. Voriconazole resistance remained stable over this period. Micafungin resistance was rare, but intermediate susceptibility significantly increased, especially after 2021 (OR per year: 1.42; 95% CI: 1.25-1.63; p<0.001). These findings highlight important recent shifts in antifungal susceptibility among C. parapsilosis isolates, emphasizing the need for ongoing surveillance and stewardship.","PeriodicalId":501010,"journal":{"name":"The Journal of Infectious Diseases","volume":"74 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Increasing Fluconazole Resistance in Candida parapsilosis: A 10-Year Analysis of Blood Culture Isolates at a US Reference Laboratory (2015-2024).\",\"authors\":\"Jack McHugh,Supavit Chesdachai,Murray Dunsirn,Nancy Wengenack,Paschalis Vergidis\",\"doi\":\"10.1093/infdis/jiaf249\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Antifungal susceptibility testing among 1,740 Candida parapsilosis blood isolates submitted to a U.S. reference laboratory (2015-2024) revealed a significant increase in fluconazole resistance from 8.2% to 20.3% (odds ratio [OR] per year: 1.13; 95% confidence interval [CI]: 1.06-1.20; p<0.001), with notable acceleration since 2021. Voriconazole resistance remained stable over this period. Micafungin resistance was rare, but intermediate susceptibility significantly increased, especially after 2021 (OR per year: 1.42; 95% CI: 1.25-1.63; p<0.001). These findings highlight important recent shifts in antifungal susceptibility among C. parapsilosis isolates, emphasizing the need for ongoing surveillance and stewardship.\",\"PeriodicalId\":501010,\"journal\":{\"name\":\"The Journal of Infectious Diseases\",\"volume\":\"74 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-05-13\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The Journal of Infectious Diseases\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1093/infdis/jiaf249\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Journal of Infectious Diseases","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1093/infdis/jiaf249","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Increasing Fluconazole Resistance in Candida parapsilosis: A 10-Year Analysis of Blood Culture Isolates at a US Reference Laboratory (2015-2024).
Antifungal susceptibility testing among 1,740 Candida parapsilosis blood isolates submitted to a U.S. reference laboratory (2015-2024) revealed a significant increase in fluconazole resistance from 8.2% to 20.3% (odds ratio [OR] per year: 1.13; 95% confidence interval [CI]: 1.06-1.20; p<0.001), with notable acceleration since 2021. Voriconazole resistance remained stable over this period. Micafungin resistance was rare, but intermediate susceptibility significantly increased, especially after 2021 (OR per year: 1.42; 95% CI: 1.25-1.63; p<0.001). These findings highlight important recent shifts in antifungal susceptibility among C. parapsilosis isolates, emphasizing the need for ongoing surveillance and stewardship.
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