The Journal of Infectious Diseases最新文献_第4页

Maternal Inflammation Likely Drives Impaired Immune Responses to Respiratory Syncytial Virus in HIV-Exposed Uninfected Infants. 母体炎症可能导致暴露于hiv的未感染婴儿对呼吸道合胞病毒的免疫反应受损。

The Journal of Infectious Diseases Pub Date : 2025-09-24 DOI: 10.1093/infdis/jiaf493

Christiana Smith,Kaili Curtis,Adrianne Bonham,Shea Boyer,Kacey Navarro,Joyce Fu,Nicole Larrea,Judith C Shlay,Laurel L Lenz,Adriana Weinberg

{"title":"Maternal Inflammation Likely Drives Impaired Immune Responses to Respiratory Syncytial Virus in HIV-Exposed Uninfected Infants.","authors":"Christiana Smith,Kaili Curtis,Adrianne Bonham,Shea Boyer,Kacey Navarro,Joyce Fu,Nicole Larrea,Judith C Shlay,Laurel L Lenz,Adriana Weinberg","doi":"10.1093/infdis/jiaf493","DOIUrl":"https://doi.org/10.1093/infdis/jiaf493","url":null,"abstract":"BACKGROUNDRespiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infection and a major contributor to morbidity and mortality in HIV-exposed, uninfected (HEU) infants. The mechanisms underlying HEU infants' increased susceptibility to RSV are unclear.METHODSWe recruited pregnant women with and without HIV, plus HEU and HIV-unexposed (HUU) children at 12-18 months of age and collected peripheral and cord blood. We measured innate immune responses of infants to RSV using an in vitro model of human respiratory infection. These responses were correlated with markers of inflammation in maternal and cord blood. We also incubated HUU cord blood cells in plasma from women living with HIV (WLHIV) to recapitulate the RSV-specific responses in HEU cord blood cells.RESULTSWe enrolled 30 WLHIV, 61 HIV-negative women, 19 HEU and 20 HUU children. At birth, HEU infants demonstrated lower expression of IL-12 by dendritic cells (p<0.0001) and IFNγ by natural killer (NK) cells (p=0.007); the difference in IL-12 expression persisted to 12-18 months of age (p=0.015). WLHIV had high concentrations of multiple inflammatory molecules in peripheral blood; these correlated inversely with infant RSV-specific immune responses. Incubation of cord blood cells from HUU infants in maternal plasma from WLHIV significantly lowered RSV-specific NK cytotoxicity and antigen-presenting cell activation compared to incubation in HIV-negative maternal plasma.DISCUSSIONMaternal inflammation is a likely driver of innate immune dysregulation in HEU infants and predisposes to an increased susceptibility to RSV infection.","PeriodicalId":501010,"journal":{"name":"The Journal of Infectious Diseases","volume":"40 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145127042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

"Fostemsavir: More Than Meets the Eye". “ fostemsaviver：不只是表面现象”

The Journal of Infectious Diseases Pub Date : 2025-09-24 DOI: 10.1093/infdis/jiaf462

Siddharth Kogilwaimath,Netanya S Utay

引用次数: 0

Diagonal Investments in Health Systems: PEPFAR's Approach to Sustaining the HIV Response and Enhancing Global Health Security. 对卫生系统的对角线投资：总统防治艾滋病紧急救援计划维持艾滋病毒应对和加强全球卫生安全的方法。

The Journal of Infectious Diseases Pub Date : 2025-09-22 DOI: 10.1093/infdis/jiaf335

Maureen Bartee,Lindsey Yessick,James Maloney,Hank Tomlinson,Michael J A Reid

{"title":"Diagonal Investments in Health Systems: PEPFAR's Approach to Sustaining the HIV Response and Enhancing Global Health Security.","authors":"Maureen Bartee,Lindsey Yessick,James Maloney,Hank Tomlinson,Michael J A Reid","doi":"10.1093/infdis/jiaf335","DOIUrl":"https://doi.org/10.1093/infdis/jiaf335","url":null,"abstract":"As more countries reach the UNAIDS 95-95-95 goals, the world gets closer to achieving the Sustainable Development Goal of eliminating HIV as a public health threat by 2030. Strong health systems are essential for sustaining progress and preventing other health threats from disrupting and potentially reversing the gains that have been made in the fight against HIV. The US President's Emergency Plan for AIDS Relief has a strong track record of building capabilities in laboratories, the supply chain, disease surveillance, data analytics, and the health workforce; however, the impact on national health systems has been uneven. A diagonal approach should therefore be used going forward, blending disease-specific funding with system-strengthening investments. If this strategy is more intentional on integrating the HIV response into national health systems, including national public health institutions, while increasing resilience to other health threats, it should yield results not only for the HIV response but also for other priority diseases and broader health security.","PeriodicalId":501010,"journal":{"name":"The Journal of Infectious Diseases","volume":"39 1","pages":"S121-S124"},"PeriodicalIF":0.0,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145103320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Case for Strengthening Infection Prevention and Control in Primary Care. 加强初级保健感染预防和控制的案例。

The Journal of Infectious Diseases Pub Date : 2025-09-22 DOI: 10.1093/infdis/jiaf371

Miranda Deeves,Elizabeth Bancroft,Fernanda C Lessa,Catherine Godfrey,Benedetta Allegranzi

引用次数: 0

Mesenteric ischemia and bacterial translocation precipitate the intoxication phase of yellow fever 肠系膜缺血和细菌易位使黄热病的中毒期提前

The Journal of Infectious Diseases Pub Date : 2025-09-22 DOI: 10.1093/infdis/jiaf483

Mateus V Thomazella, Xueer Qiu, Cássia Gisele Terrassani Silveira, Carolina A Correia, Mariana P Marmorato, Erik Sanson, Andrew Norton, Mark Sharobim, Yeh-Li Ho, Marisa Dolhnikoff, Eduard Matkovic, Esper G Kallas, Amaro Nunes Duarte-Neto, Adam L Bailey

{"title":"Mesenteric ischemia and bacterial translocation precipitate the intoxication phase of yellow fever","authors":"Mateus V Thomazella, Xueer Qiu, Cássia Gisele Terrassani Silveira, Carolina A Correia, Mariana P Marmorato, Erik Sanson, Andrew Norton, Mark Sharobim, Yeh-Li Ho, Marisa Dolhnikoff, Eduard Matkovic, Esper G Kallas, Amaro Nunes Duarte-Neto, Adam L Bailey","doi":"10.1093/infdis/jiaf483","DOIUrl":"https://doi.org/10.1093/infdis/jiaf483","url":null,"abstract":"A lethality-defining feature of yellow fever (YF) is the development of “intoxication,” a poorly understood late complication of YF that develops in ∼30% of cases characterized by return of fever, lack of viremia, and hemorrhage. Using a hamster model of YF, we worked backwards from observations in humans to examine early events that precipitate the intoxication phase of YF. Severe gastrointestinal damage was a surprising feature of HA-YFV pathology. This was defined by early signs of ischemia followed by ischemia-induced erosion of the gut epithelial barrier, which served as an entry point for luminal bacteria that opportunistically spread via the portal system. Thus, the intoxication phase of YF is a sepsis-like syndrome caused by translocation of bacteria from a damaged intestinal tract. Evaluation of human YF cases for these previously disconnected disease features confirmed this overarching mechanism: bacteria were identified in the portal vein and liver parenchyma of fatal YF cases along with elevations in plasma markers of intestinal damage and bacteremia. These findings tie together several recent and historically unexplained observations surrounding the highly-lethal intoxication phase of YF in humans: a high AST/ALT ratio, “black vomit,” pancreatitis, and paradoxical neutrophilia, with implications for treating and prevent YF intoxication.","PeriodicalId":501010,"journal":{"name":"The Journal of Infectious Diseases","volume":"82 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145116534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advancing Infection Prevention and Control in the United States PEPFAR Programs. 推进美国总统防治艾滋病紧急救援计划的感染预防和控制。

The Journal of Infectious Diseases Pub Date : 2025-09-22 DOI: 10.1093/infdis/jiaf380

Danica J Gomes,Elizabeth A Bancroft,Ismail Lawal,Nicole Zender,Maria Insua,Deborah Goldstein,Benjamin Park,Todd Lucas,Diana Forno Rodriguez,Peter Kerndt,Meaghan O'Keefe Douglas,Fernanda C Lessa,Anand Date,Catherine Godfrey

{"title":"Advancing Infection Prevention and Control in the United States PEPFAR Programs.","authors":"Danica J Gomes,Elizabeth A Bancroft,Ismail Lawal,Nicole Zender,Maria Insua,Deborah Goldstein,Benjamin Park,Todd Lucas,Diana Forno Rodriguez,Peter Kerndt,Meaghan O'Keefe Douglas,Fernanda C Lessa,Anand Date,Catherine Godfrey","doi":"10.1093/infdis/jiaf380","DOIUrl":"https://doi.org/10.1093/infdis/jiaf380","url":null,"abstract":"Infection prevention and control (IPC) systems and practices are essential to ensuring safe healthcare delivery. The United States President's Emergency Plan for AIDS Relief (PEPFAR) prioritized IPC in healthcare settings and made significant progress in strengthening IPC across its programs and supported facilities, highlighted in this report. A short-term task team expanded PEPFAR's existing IPC requirements and policies and advanced systems to support adherence to normative guidance. Key IPC advances included the incorporation of IPC into PEPFAR's core program standards; the expansion of IPC standards, in line with global standards; the development of tailored IPC guidance and tools to specifically address PEPFAR-supported medical services; the addition of new indicators to PEPFAR's quality assurance tool to enhance IPC monitoring; and the establishment of an approach to IPC monitoring and evaluation to guide improvement interventions. These system advances were intended to identify challenges and drive improvements to IPC standards.","PeriodicalId":501010,"journal":{"name":"The Journal of Infectious Diseases","volume":"1 1","pages":"S145-S149"},"PeriodicalIF":0.0,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145103495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unpacking the Role, Nature, and Need to Sustain Robust Community Responses in Global Systems. 揭示在全球系统中维持强有力的社区反应的角色、性质和必要性。

The Journal of Infectious Diseases Pub Date : 2025-09-22 DOI: 10.1093/infdis/jiae586

Solange L Baptiste,Elizabeth Barr,Michael J A Reid,Danielle M Campbell

{"title":"Unpacking the Role, Nature, and Need to Sustain Robust Community Responses in Global Systems.","authors":"Solange L Baptiste,Elizabeth Barr,Michael J A Reid,Danielle M Campbell","doi":"10.1093/infdis/jiae586","DOIUrl":"https://doi.org/10.1093/infdis/jiae586","url":null,"abstract":"This commentary highlights the critical importance of community engagement within global public health programs, particularly concerning the human immunodeficiency virus (HIV) pandemic. Despite concerted efforts, progress toward HIV-related health targets remains stagnant, as marginalized communities continue to be disproportionately impacted. This commentary stresses the imperative of providing sustained support for community partnerships to bolster program efficiency and ensure long-term sustainability. By examining examples from both research and program implementation, we delineate the multifaceted roles that affected communities play in shaping health outcomes. Furthermore, this article outlines essential enabling conditions for effective community engagement. A case study illustrating successful community involvement is presented, showcasing the tangible benefits of community-led initiatives. Overall, this commentary provides valuable insights into the pivotal role of community engagement in global health initiatives and advocates for the integration of community perspectives into policy and practice to foster enduring progress and equitable health outcomes worldwide.","PeriodicalId":501010,"journal":{"name":"The Journal of Infectious Diseases","volume":"39 1","pages":"S130-S134"},"PeriodicalIF":0.0,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145103497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PEPFAR Laboratory Implementation Strategy as a Component of PEPFAR's 5-Year Strategy. PEPFAR实验室实施战略是PEPFAR五年战略的组成部分。

The Journal of Infectious Diseases Pub Date : 2025-09-22 DOI: 10.1093/infdis/jiaf337

George Alemnji,Ann Sangthong,Nicole Espy,Maureen Bartee

{"title":"PEPFAR Laboratory Implementation Strategy as a Component of PEPFAR's 5-Year Strategy.","authors":"George Alemnji,Ann Sangthong,Nicole Espy,Maureen Bartee","doi":"10.1093/infdis/jiaf337","DOIUrl":"https://doi.org/10.1093/infdis/jiaf337","url":null,"abstract":"Past United States President's Emergency Plan for AIDS Relief (PEPFAR) laboratory investments for human immunodeficiency virus (HIV) epidemic response, in collaboration with partner governments and other stakeholders, have had a fundamental and substantial impact on overall clinical and public health laboratory capacity in countries. These innovations have been and continue to be leveraged to improve the functioning of entire health systems, including providing essential high-quality clinical diagnostics for multiple diseases and responding to outbreaks and pandemics. This was recently demonstrated in the coronavirus disease 2019 pandemic and mpox outbreaks, during which existing PEPFAR-supported laboratory systems were leveraged to support diagnostic development and implementation, while remaining focused on sustaining past HIV and tuberculosis gains. Building on these gains, the PEPFAR Laboratory Implementation Strategy shares guidance on how PEPFAR's 5 × 3 strategic approaches could be used to continue working closely with national governments and other global health stakeholders to support countries' national public health systems in an integrated manner to sustain current HIV/AIDS gains and strengthen local capacity in anticipation of future pandemic preparedness and response.","PeriodicalId":501010,"journal":{"name":"The Journal of Infectious Diseases","volume":"18 1","pages":"S160-S164"},"PeriodicalIF":0.0,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145103500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Leveraging Laboratory Information Management Systems to Support HIV and Other Infectious Diseases Testing in PEPFAR-Supported Countries. 利用实验室信息管理系统支持在总统防治艾滋病紧急救援计划支持的国家进行艾滋病毒和其他传染病检测。

The Journal of Infectious Diseases Pub Date : 2025-09-22 DOI: 10.1093/infdis/jiaf338

Prisca Chikwanda,Thomas Stevens,Christina Mwangi,Clement Phiri,Jonathan Ntale,Thomas Nsibambi,Nshimba Mwansa,Nicole Espy,Raiva Simbi,Amy Peterson

引用次数: 0

PEPFAR Investments in Country Data Systems Support HIV Treatment Continuity: An Example From Haiti. 总统防治艾滋病紧急救援计划对国家数据系统的投资支持艾滋病毒治疗的连续性：以海地为例。

The Journal of Infectious Diseases Pub Date : 2025-09-22 DOI: 10.1093/infdis/jiaf340

Linda Mattocks,Nicasky Celestin,Kesner Francois,Patrice Joseph,Jean Solon Valles,Stephane Morisseau,Dan Rosen,Tiana Jaramillo,Ermane Robin,Irum Zaidi

引用次数: 0