The Journal of Infectious Diseases最新文献_第10页

Female genital tract host factors and tenofovir and lamivudine active metabolites 女性生殖道宿主因素与替诺福韦和拉米夫定活性代谢物

The Journal of Infectious Diseases Pub Date : 2024-07-22 DOI: 10.1093/infdis/jiae372

Alyssa Lantz, Flavia Kiweewa Matovu, Reilly Johnson, Esther Isingel, Rita Nakalega, Samuel Kabwigu, Mags E Beksinska, Melanie R Nicol

{"title":"Female genital tract host factors and tenofovir and lamivudine active metabolites","authors":"Alyssa Lantz, Flavia Kiweewa Matovu, Reilly Johnson, Esther Isingel, Rita Nakalega, Samuel Kabwigu, Mags E Beksinska, Melanie R Nicol","doi":"10.1093/infdis/jiae372","DOIUrl":"https://doi.org/10.1093/infdis/jiae372","url":null,"abstract":"Background We previously reported the effect of contraception on cervical tenofovir concentrations in Ugandan women living with HIV. Here we explored the role of cervicovaginal cytokines and drug metabolizing enzymes and transporters (DMETs) to elucidate FGT drug disposition in a Ugandan cohort. Methods Cervicovaginal fluid and cervical biopsies were collected from Ugandan women living with HIV receiving tenofovir/lamivudine-based therapy and intramuscular depot medroxyprogesterone acetate (DMPA-IM; n=25), copper IUD (cuIUD; n=12), or condoms (n=13) as contraception. Cytokines were measured in cervicovaginal fluid (CVF). Ectocervical tenofovir diphosphate (TFVdp) and lamivudine triphosphate (3TCtp), dATP/dCTP concentrations, and immune marker/DMETs gene expression were measured in cervical biopsies. Results Cervical 3TCtp was not correlated with any CVF cytokines. Cervical TFVdp was correlated with IL-10, IL-7, and IL-17 in CVF. CCR5 mRNA expression in cervical biopsies was higher in cuIUD-users versus condoms-users. Using multivariable linear regression, CVF IL-17, tissue dATP, plasma estradiol, and plasma tenofovir were all significant predictors of cervical TFVdp. Tissue dCTP and plasma lamivudine were significant predictors of cervical 3TCtp. Conclusions TFVdp concentrations in cervix appear to be influenced by local inflammation. In contrast, 3TCtp FGT exposure was not affected by genital inflammation or DMETS. CuIUD users have more immune cells present, which may in turn influence local TFVdp disposition.","PeriodicalId":501010,"journal":{"name":"The Journal of Infectious Diseases","volume":"103 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141755363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Results of a nationally representative seroprevalence survey of chikungunya virus in Bangladesh 孟加拉国具有全国代表性的基孔肯雅病毒血清流行率调查结果

The Journal of Infectious Diseases Pub Date : 2024-06-28 DOI: 10.1093/infdis/jiae335

Sam W Allen, Gabriel Ribeiro Dos Santos, Kishor K Paul, Repon Paul, Mohammad Ziaur Rahman, Mohammad Shafiul Alam, Mahmudur Rahman, Hasan Mohammad Al-Amin, Jessica Vanhomwegen, Scott C Weaver, Taylor Smull, Kyu Han Lee, Emily S Gurley, Henrik Salje

{"title":"Results of a nationally representative seroprevalence survey of chikungunya virus in Bangladesh","authors":"Sam W Allen, Gabriel Ribeiro Dos Santos, Kishor K Paul, Repon Paul, Mohammad Ziaur Rahman, Mohammad Shafiul Alam, Mahmudur Rahman, Hasan Mohammad Al-Amin, Jessica Vanhomwegen, Scott C Weaver, Taylor Smull, Kyu Han Lee, Emily S Gurley, Henrik Salje","doi":"10.1093/infdis/jiae335","DOIUrl":"https://doi.org/10.1093/infdis/jiae335","url":null,"abstract":"There is an increasing global burden from chikungunya virus (CHIKV). Bangladesh reported a major epidemic in 2017, however, it was unclear if there had been prior widespread transmission. We conducted a nationally representative seroprevalence survey in 70 randomly selected communities immediately prior to the epidemic. We found 69/2,938 (2.4%) of sampled individuals were seropositive to CHIKV. Being seropositive to dengue virus (aOR 3.13 [95% CIs: 1.86-5.27]), male sex (aOR 0.59 [95% CIs: 0.36-0.99]), and community presence of Aedes aegypti mosquitoes (aOR: 1.80, 95% CI: 1.05–3.07) were significantly associated with CHIKV seropositivity. Using a spatial prediction model, we estimated that across the country, 4.99 (95% CI: 4.89 - 5.08) million people had been previously infected. These findings highlight high population susceptibility prior to the major outbreak and that previous outbreaks must have been spatially isolated.","PeriodicalId":501010,"journal":{"name":"The Journal of Infectious Diseases","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141462727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risk factors for recurrent urinary tract infections among women in a large integrated health care organization in the United States 美国一家大型综合医疗机构中妇女反复尿路感染的风险因素

The Journal of Infectious Diseases Pub Date : 2024-06-28 DOI: 10.1093/infdis/jiae331

Bradley K Ackerson, Sara Y Tartof, Lie H Chen, Richard Contreras, Iris Anne C Reyes, Jennifer H Ku, Michele Pellegrini, Johannes E Schmidt, Katia J Bruxvoort

{"title":"Risk factors for recurrent urinary tract infections among women in a large integrated health care organization in the United States","authors":"Bradley K Ackerson, Sara Y Tartof, Lie H Chen, Richard Contreras, Iris Anne C Reyes, Jennifer H Ku, Michele Pellegrini, Johannes E Schmidt, Katia J Bruxvoort","doi":"10.1093/infdis/jiae331","DOIUrl":"https://doi.org/10.1093/infdis/jiae331","url":null,"abstract":"Background Urinary tract infections (UTIs) occur commonly and often recur. However, recent data on the epidemiology of recurrent UTI (rUTI) are scarce. Methods Between 01/01/2016-31/12/2020, index uncomplicated UTIs (uUTI) from office, emergency department (ED), hospital, and virtual care settings were identified from electronic health records of women at Kaiser Permanente Southern California. We defined rUTI as ≥3 UTI within 365 days or ≥2 UTI within 180 days. We determined the proportion of women with cystitis index uUTI who had rUTI and examined factors associated with rUTIs using modified multivariable Poisson regression. Results Among 374,171 women with cystitis index uUTI, 54,318 (14.5%) had rUTI. A higher proportion of women with rUTI compared to those without rUTI were age 18-27 or ≥78 years at index uUTI (19.7% vs 18.7% and 9.0% vs 6.0%, respectively), were immunocompromised, or had a positive urine culture at index uUTI. In multivariable analyses, characteristics associated with rUTI included younger or older age (48-57 vs 18-27 years aRR=0.83 [95% CI: 0.80-0.85]; ≥78 vs 18-27 years aRR=1.07 [95%CI=1.03-1.11]), Charlson Comorbidity Index (≥3 vs 0, aRR=1.12 [95%CI:1.08-1.17]), and diabetes mellitus (aRR=1.07 [95%CI:1.04-1.10]). More frequent prior year outpatient and ED encounters, oral antibiotic prescriptions, oral contraceptive prescriptions, positive culture at index uUTI, and antibiotic resistant organisms were also associated with increased risk of rUTI. Conclusions The high risk of rUTI among women with cystitis is concerning, especially given previous reports of increasing UTI incidence. Current assessment of the epidemiology of rUTI may guide the development of preventive interventions against UTI.","PeriodicalId":501010,"journal":{"name":"The Journal of Infectious Diseases","volume":"336 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141462841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relative contributions of the novel diarylquinoline TBAJ-876 and its active metabolite to the bactericidal activity in a murine model of tuberculosis 新型二芳基喹啉 TBAJ-876 及其活性代谢物对小鼠结核病模型杀菌活性的相对贡献

The Journal of Infectious Diseases Pub Date : 2024-06-28 DOI: 10.1093/infdis/jiae332

Saskia E Mudde, Nicole C Ammerman, Marian T ten Kate, Nader Fotouhi, Manisha U Lotlikar, Hannelore I Bax, Jurriaan E M de Steenwinkel

{"title":"Relative contributions of the novel diarylquinoline TBAJ-876 and its active metabolite to the bactericidal activity in a murine model of tuberculosis","authors":"Saskia E Mudde, Nicole C Ammerman, Marian T ten Kate, Nader Fotouhi, Manisha U Lotlikar, Hannelore I Bax, Jurriaan E M de Steenwinkel","doi":"10.1093/infdis/jiae332","DOIUrl":"https://doi.org/10.1093/infdis/jiae332","url":null,"abstract":"Background TBAJ-876 is a next-generation diarylquinoline. In vivo, diarylquinoline metabolites are formed with activity against Mycobacterium tuberculosis. Species-specific differences in parent drug-to-metabolite ratios might impact the translational value of animal model-based predictions. This study investigates the contribution of TBAJ-876 and its major active metabolite, TBAJ-876-M3 (M3), to the total bactericidal activity in a mouse tuberculosis model. Methods In vitro activity of TBAJ-876 and M3 was investigated and compared to bedaquiline. Subsequently, a dose-response study was conducted in M. tuberculosis-infected BALB/c mice treated with TBAJ-876 (1.6/6.3/25 mg/kg) or M3 (3.1/12.5/50 mg/kg). Colony-forming units in the lungs and TBAJ-876 and M3 plasma concentrations were determined. M3’s contribution to TBAJ-876’s bactericidal activity was estimated based on M3-exposure following TBAJ-876 treatment and corresponding M3-activity observed in M3-treated animals. Results TBAJ-876 and M3 demonstrated profound bactericidal activity. Lungs of mice treated for 4 weeks with 50 mg/kg M3 were culture-negative. Following TBAJ-876 treatment, M3-exposures were 2.2-3.6x higher than for TBAJ-876. TBAJ-876 activity was substantially attributable to M3, given its high exposure and potent activity. Conclusion These findings emphasize the need to consider metabolites and their potentially distinct exposure and activity profiles compared to parent drugs to enhance the translational value of mouse model-driven predictions.","PeriodicalId":501010,"journal":{"name":"The Journal of Infectious Diseases","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141462729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antibodies to Helminth Defense Molecule-1 are associated with inflammation, organomegaly, and decreased nutritional status in schistosomiasis japonica 血吸虫防御分子-1抗体与日本血吸虫病的炎症、器官肿大和营养状况下降有关

The Journal of Infectious Diseases Pub Date : 2024-06-27 DOI: 10.1093/infdis/jiae330

Amanda E Ruiz, Sunthorn Pond-Tor, Ronald Stuart, Luz P Acosta, Hannah M Coutinho, Tjalling Leenstra, Sydney Fisher, Owen Fahey, Emily A McDonald, Mario A Jiz, Remigio M Olveda, Stephen T McGarvey, Jennifer F Friedman, Hannah Wei Wu, Jonathan D Kurtis

{"title":"Antibodies to Helminth Defense Molecule-1 are associated with inflammation, organomegaly, and decreased nutritional status in schistosomiasis japonica","authors":"Amanda E Ruiz, Sunthorn Pond-Tor, Ronald Stuart, Luz P Acosta, Hannah M Coutinho, Tjalling Leenstra, Sydney Fisher, Owen Fahey, Emily A McDonald, Mario A Jiz, Remigio M Olveda, Stephen T McGarvey, Jennifer F Friedman, Hannah Wei Wu, Jonathan D Kurtis","doi":"10.1093/infdis/jiae330","DOIUrl":"https://doi.org/10.1093/infdis/jiae330","url":null,"abstract":"Immunomodulation enhances parasite fitness by reducing inflammation-induced morbidity in the mammalian host, as well as by attenuating parasite-targeting immune responses. Using a whole proteome differential screening method, we identified Schistosoma japonicum Helminth Defense Molecule (SjHDM-1) as a target of antibodies expressed by S. japonicum resistant, but not susceptible, individuals. In a longitudinal cohort study (N=644) conducted in a S. japonicum endemic region of the Philippines, antibody levels to SjHDM-1 did not predict resistance to reinfection but were associated with increased measures of inflammation. Individuals with high levels of anti-SjHDM-1 IgG had higher levels of C-reactive protein compared to individuals with low anti-SjHDM-1. High anti-SjHDM-1 IgG responses were also associated with reduced biomarkers of nutritional status (albumin), as well as decreased anthropometric measures of nutritional status (WAZ and HAZ) and increased measures of hepatomegaly. Our results suggest that anti-SjHDM-1 responses inhibit the immunomodulatory function of SjHDM-1, resulting in increased morbidity.","PeriodicalId":501010,"journal":{"name":"The Journal of Infectious Diseases","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141462711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Maternal BCG scars and mortality risk for male and female newborns: observational study from Guinea-Bissau 孕产妇卡介苗疤痕与男女新生儿的死亡风险：几内亚比绍的观察性研究

The Journal of Infectious Diseases Pub Date : 2024-05-16 DOI: 10.1093/infdis/jiae262

Frederik Schaltz-Buchholzer, Sebastian Nielsen, Marcus Kjær Sørensen, Gabriel Marciano Gomes, Simon Hoff, Anna Memborg Toft, Elise Brenno Stjernholm, Ivan Monteiro, Peter Aaby, Christine Stabell Benn

{"title":"Maternal BCG scars and mortality risk for male and female newborns: observational study from Guinea-Bissau","authors":"Frederik Schaltz-Buchholzer, Sebastian Nielsen, Marcus Kjær Sørensen, Gabriel Marciano Gomes, Simon Hoff, Anna Memborg Toft, Elise Brenno Stjernholm, Ivan Monteiro, Peter Aaby, Christine Stabell Benn","doi":"10.1093/infdis/jiae262","DOIUrl":"https://doi.org/10.1093/infdis/jiae262","url":null,"abstract":"Background Maternal priming with Bacille Calmette-Guérin (BCG) has been associated with reduced mortality in male offspring. We investigated this association in a cohort of healthy BCG-vaccinated neonates. Methods Observational study within a randomized controlled trial comparing different BCG strains conducted in Guinea-Bissau from 2017-2020. As part of trial inclusion procedures, on the day of discharge from the maternity ward, maternal BCG scar status was evaluated by visual inspection, followed by offspring BCG and polio vaccination. Through mortality data collected at telephone interviews at six weeks and six months of age, we assessed all-cause mortality risk in Cox Proportional Hazards models adjusted for maternal schooling and BCG strain, providing adjusted Mortality Rate Ratios (aMRRs). Results 64% (11,070/17,275) of mothers had a BCG scar, which for females and overall was not associated with neither admission risk, admission severity nor all-cause mortality. By six months of age, the mortality rate (MR) was 4.1 (200 deaths/4,919 person-years) for the maternal BCG scar cohort and 5.2 (139 deaths/2,661 person-years) for no maternal scar, aMRR=0.86 (0.69-1.06). In males, six-month MRs were 4.3 (109/2,531) for maternal BCG scar vs 6.3 (87/1,376) for no scar, the maternal scar/no scar aMRR being 0.74 (0.56-0.99). In females, six-month MRs were 3.8 (91/2,388) vs 4.0 (52(1,286), the aMRR being 1.04 (0.74-1.47), p for interaction with sex=0.16. Conclusion While we cannot rule out an association in females, being born to a mother with a BCG scar reduced the risk of death during early infancy for BCG-vaccinated males, reproducing findings from previous studies.","PeriodicalId":501010,"journal":{"name":"The Journal of Infectious Diseases","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140954230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Review of the current TB human infection studies for use in accelerating TB vaccine development: A meeting report 回顾当前用于加速结核病疫苗开发的结核病人类感染研究：会议报告

The Journal of Infectious Diseases Pub Date : 2024-05-06 DOI: 10.1093/infdis/jiae238

Shobana Balasingam, Keertan Dheda, Sarah Fortune, Stephen B Gordon, Daniel Hoft, James G Kublin, Colleen N Loynachan, Helen McShane, Ben Morton, Sujatha Nambiar, Nimisha Raj Sharma, Brian Robertson, Lewis K Schrager, Charlotte L Weller

{"title":"Review of the current TB human infection studies for use in accelerating TB vaccine development: A meeting report","authors":"Shobana Balasingam, Keertan Dheda, Sarah Fortune, Stephen B Gordon, Daniel Hoft, James G Kublin, Colleen N Loynachan, Helen McShane, Ben Morton, Sujatha Nambiar, Nimisha Raj Sharma, Brian Robertson, Lewis K Schrager, Charlotte L Weller","doi":"10.1093/infdis/jiae238","DOIUrl":"https://doi.org/10.1093/infdis/jiae238","url":null,"abstract":"Tools to evaluate and accelerate tuberculosis (TB) vaccine development are needed to advance global TB control strategies. Validated human infection studies for TB have the potential to facilitate breakthroughs in understanding disease pathogenesis, identify correlates of protection, develop diagnostic tools, and accelerate and de-risk vaccine and drug development. However, key challenges remain for realizing the clinical utility of these models, which require further discussion and alignment amongst key stakeholders. In March 2023, the Wellcome Trust and the International AIDS Vaccine Initiative (IAVI) convened international experts involved in developing both TB and Bacillus Calmette-Guerin (BCG) human infection studies (including mucosal and intradermal challenge routes) to discuss the status of each of the models and the key enablers to move the field forward. This report provides a summary of the presentations and discussion from the meeting. Discussions identified key issues, including demonstrating model validity, to provide confidence for vaccine developers, which may be addressed through demonstration of known vaccine effects, e.g. BCG vaccination in specific populations, and by comparing results from field efficacy and human infection studies. The workshop underscored the importance of establishing safe and acceptable studies in high-burden settings, and the need to validate more than one model to allow for different scientific questions to be addressed as well as to provide confidence to vaccine developers and regulators around use of human infection study data in vaccine development and licensure pathways.","PeriodicalId":501010,"journal":{"name":"The Journal of Infectious Diseases","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140845048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Validation of an automated, end-to-end metagenomic sequencing assay for agnostic detection of respiratory viruses 验证用于呼吸道病毒检测的端到端自动元基因组测序法

The Journal of Infectious Diseases Pub Date : 2024-05-02 DOI: 10.1093/infdis/jiae226

Nick P G Gauthier, Wilson Chan, Kerstin Locher, Duane Smailus, Robin Coope, Marthe Charles, Agatha Jassem, Jennifer Kopetzky, Samuel D Chorlton, Amee R Manges

{"title":"Validation of an automated, end-to-end metagenomic sequencing assay for agnostic detection of respiratory viruses","authors":"Nick P G Gauthier, Wilson Chan, Kerstin Locher, Duane Smailus, Robin Coope, Marthe Charles, Agatha Jassem, Jennifer Kopetzky, Samuel D Chorlton, Amee R Manges","doi":"10.1093/infdis/jiae226","DOIUrl":"https://doi.org/10.1093/infdis/jiae226","url":null,"abstract":"Background Current molecular diagnostics are limited in the number and type of detectable pathogens. Metagenomic next generation sequencing (mNGS) is an emerging, and increasingly feasible, pathogen-agnostic diagnostic approach. Translational barriers prohibit the widespread adoption of this technology in clinical laboratories. We validate an end-to-end mNGS assay for detection of respiratory viruses. Our assay is optimized to reduce turnaround time, lower cost-per-sample, increase throughput, and deploy secure and actionable bioinformatic results. Methods We validated our assay using residual nasopharyngeal swab specimens from Vancouver General Hospital (n = 359), RT-PCR-positive, or negative for Influenza, SARS-CoV-2, and RSV. We quantified sample stability, assay precision, the effect of background nucleic acid levels, and analytical limits of detection. Diagnostic performance metrics were estimated. Results We report that our mNGS assay is highly precise, semi-quantitative, with analytical limits of detection ranging from 103-104 copies/mL. Our assay is highly specific (100%) and sensitive (61.9% Overall: 86.8%; RT-PCR Ct &lt; 30). Multiplexing capabilities enable processing of up to 55-specimens simultaneously on an Oxford Nanopore GridION device, with results reported within 12-hours. Conclusions This study outlines the diagnostic performance and feasibility of mNGS for respiratory viral diagnostics, infection control, and public health surveillance. We addressed translational barriers to widespread mNGS adoption.","PeriodicalId":501010,"journal":{"name":"The Journal of Infectious Diseases","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140820884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rhabdomyolysis, acute kidney injury, and mortality in Ebola virus disease: retrospective analysis of cases from Eastern Democratic Republic of the Congo, 2019 埃博拉病毒病中的横纹肌溶解症、急性肾损伤和死亡率：2019年对刚果民主共和国东部病例的回顾性分析

The Journal of Infectious Diseases Pub Date : 2024-05-02 DOI: 10.1093/infdis/jiae224

Kasereka Masumbuko Claude, Daniel Mukadi-Bamuleka, Richard Kitenge-Omasumbu, François Edidi-Atani, Meris Matondo Kuamfumu, Sabue Mulangu, Olivier Tshiani-Mbaya, Kambale Malengera Vicky, Placide Mbala-Kingebeni, Steve Ahuka-Mundeke, Jean-Jacques Muyembe-Tamfum, Bonita E Lee, Stan Houston, Zubia Mumtaz, Michael T Hawkes

{"title":"Rhabdomyolysis, acute kidney injury, and mortality in Ebola virus disease: retrospective analysis of cases from Eastern Democratic Republic of the Congo, 2019","authors":"Kasereka Masumbuko Claude, Daniel Mukadi-Bamuleka, Richard Kitenge-Omasumbu, François Edidi-Atani, Meris Matondo Kuamfumu, Sabue Mulangu, Olivier Tshiani-Mbaya, Kambale Malengera Vicky, Placide Mbala-Kingebeni, Steve Ahuka-Mundeke, Jean-Jacques Muyembe-Tamfum, Bonita E Lee, Stan Houston, Zubia Mumtaz, Michael T Hawkes","doi":"10.1093/infdis/jiae224","DOIUrl":"https://doi.org/10.1093/infdis/jiae224","url":null,"abstract":"Background Skeletal muscle injury in Ebola virus disease (EVD) has been reported, but its association with morbidity and mortality remains poorly defined. Methods Retrospective study of patients admitted to two EVD Treatment Units, over an eight-month period in 2019, during a large EVD epidemic in the Democratic Republic of the Congo. Results 333 patients (median age 30 years, 58% female) had at least one creatine kinase (CK) measurement (total 2,229 CK measurements, median 5 (IQR 1-11) per patient). 271 patients (81%) had an elevated CK (&gt;380U/L), 202 (61%) had rhabdomyolysis (CK&gt;1,000 IU/L), and 45 (14%) had severe rhabdomyolysis (≥5,000U/L). Among survivors, the maximum CK level was median 1,600 (IQR 550 to 3,400), peaking 3.4 days after admission (IQR 2.3 to 5.5) and decreasing thereafter. Among fatal cases, the CK rose monotonically until death, with maximum CK level of median 2,900 U/L (IQR 1,500 to 4,900). Rhabdomyolysis at admission was an independent predictor of AKI (aOR 2.2 [95%CI 1.2-3.8], p=0.0065) and mortality (aHR 1.7 [95%CI 1.03-2.9], p=0.037). Conclusions Rhabdomyolysis is associated with AKI and mortality in EVD patients. These findings may inform clinical practice by identifying lab monitoring priorities and highlighting the importance of fluid management.","PeriodicalId":501010,"journal":{"name":"The Journal of Infectious Diseases","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140821021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Food is Medicine for HIV: Improved health and hospitalizations in the Changing Health through Food Support (CHEFS-HIV) pragmatic randomized trial 食物是治疗艾滋病毒的药物：通过食物支持改变健康状况（CHEFS-HIV）实用随机试验改善健康状况和住院情况

The Journal of Infectious Diseases Pub Date : 2024-05-02 DOI: 10.1093/infdis/jiae195

Kartika Palar, Lila A Sheira, Edward A Frongillo, Asher A O’Donnell, Tessa M Nápoles, Mark Ryle, Simon Pitchford, Kim Madsen, Beth Phillips, Elise D Riley, Sheri D Weiser

{"title":"Food is Medicine for HIV: Improved health and hospitalizations in the Changing Health through Food Support (CHEFS-HIV) pragmatic randomized trial","authors":"Kartika Palar, Lila A Sheira, Edward A Frongillo, Asher A O’Donnell, Tessa M Nápoles, Mark Ryle, Simon Pitchford, Kim Madsen, Beth Phillips, Elise D Riley, Sheri D Weiser","doi":"10.1093/infdis/jiae195","DOIUrl":"https://doi.org/10.1093/infdis/jiae195","url":null,"abstract":"Background Policy support for “Food is Medicine”—medically tailored meals or groceries to improve health—is rapidly growing. No randomized trials have heretofore investigated the benefits of medically tailored food programs for people living with HIV (PLHIV). Methods The CHEFS-HIV pragmatic randomized trial included PLHIV who were clients of Project Open Hand (POH), a San Francisco-based nonprofit food organization. The intervention arm (n = 93) received comprehensive medically tailored meals, groceries, and nutritional education. Control participants (n = 98) received less intensive (POH “standard of care”) food services. Health, nutrition, and behavioral outcomes were assessed at baseline and 6 months later. Primary outcomes measured were viral non-suppression and health related quality of life. Mixed models estimated treatment effects as differences-in-differences between arms. Results The intervention arm had lower odds of hospitalization (odds ratio [OR] = 0.11), food insecurity (OR = 0.23), depressive symptoms (OR = 0.32), antiretroviral therapy adherence &lt;90% (OR = 0.18), and unprotected sex (OR = 0.18), and less fatty food consumption (β= –0.170 servings/day) over 6 months, compared to the control arm. There was no difference between study arms in viral non-suppression and health-related quality of life over 6 months. Conclusions A “Food-is-Medicine” intervention reduced hospitalizations and improved mental and physical health among PLHIV, despite no impact on viral suppression. Clinical Trials Registration NCT03191253","PeriodicalId":501010,"journal":{"name":"The Journal of Infectious Diseases","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140820891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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