The Journal of Infectious Diseases最新文献_第3页

An ideal Point-of-Care Test for Screening TB Infection. 一种理想的筛查结核感染的即时检测方法。

The Journal of Infectious Diseases Pub Date : 2025-05-19 DOI: 10.1093/infdis/jiaf259

Sarman Singh

引用次数: 0

The Madras trial and TB sanatoria. 马德拉斯试验和结核病疗养院。

The Journal of Infectious Diseases Pub Date : 2025-05-17 DOI: 10.1093/infdis/jiaf254

Zarir F Udwadia

引用次数: 0

End of the Pandemic or End of Progress? 大流行的终结还是进步的终结？

The Journal of Infectious Diseases Pub Date : 2025-05-16 DOI: 10.1093/infdis/jiaf257

Matifadza Hlatshwayo Davis,Kathleen R Page

引用次数: 0

A Pivotal Trial in the Decline of TB Sanatoria. 结核病疗养院衰落的关键试验。

The Journal of Infectious Diseases Pub Date : 2025-05-15 DOI: 10.1093/infdis/jiaf255

Petros C Karakousis,Graham Mooney

引用次数: 0

Probiotic Lactobacillus species modulate immune responses during vaginal epithelial cell colonization. 益生菌乳酸菌在阴道上皮细胞定植过程中调节免疫反应。

The Journal of Infectious Diseases Pub Date : 2025-05-15 DOI: 10.1093/infdis/jiaf221

Marisa Valentine,Diletta Rosati,Axel Dietschmann,Tim B Schille,Mihai G Netea,Bernhard Hube,Mark S Gresnigt

{"title":"Probiotic Lactobacillus species modulate immune responses during vaginal epithelial cell colonization.","authors":"Marisa Valentine,Diletta Rosati,Axel Dietschmann,Tim B Schille,Mihai G Netea,Bernhard Hube,Mark S Gresnigt","doi":"10.1093/infdis/jiaf221","DOIUrl":"https://doi.org/10.1093/infdis/jiaf221","url":null,"abstract":"BACKGROUNDVulvovaginal candidiasis (VVC), mainly caused by Candida albicans, affects approximately 75% of women at least once during their lifetime. VVC is characterized by fungal colonization, which leads to inappropriate local hyperinflammation and symptoms. Although the trigger of C. albicans pathogenicity is often unknown, antibiotic use and vaginal dysbiosis are associated with increased susceptibility to VVC. A healthy vaginal microbiota is normally dominated by Lactobacillus species, which are believed to keep C. albicans infections at bay. Probiotic lactobacilli are, therefore, explored to treat symptomatic VVC episodes. However, the influence of probiotic lactobacilli on immune responses in the context of VVC remains underexplored.METHODSWe investigated how probiotic lactobacilli influence vaginal epithelial and downstream inflammatory responses during C. albicans infection, using in vitro vaginal epithelial infection models and stimulating primary human immune cells with supernatants from these vaginal epithelial cells.RESULTSOur study shows that although most of the tested probiotic lactobacilli reduced C. albicans-induced vaginal epithelial cell damage, some species, particularly Limosilactobacillus fermentum and Lacticaseibacillus paracasei, elicited proinflammatory responses even in the absence of C. albicans. Probiotic lactobacilli also differentially modulated the C. albicans killing efficiency and production of reactive oxygen species by neutrophils.CONCLUSIONSOverall, vaginal epithelial and downstream immune responses during co-cultivation with C. albicans and probiotic lactobacilli were mostly driven by specific bacterial species and their interactions with the vaginal epithelium. Therefore, the induction of \"controlled\" inflammation by probiotic lactobacilli may be beneficial to improve neutrophil function, however, whether this alleviates immunopathology warrants further investigation.","PeriodicalId":501010,"journal":{"name":"The Journal of Infectious Diseases","volume":"128 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144065703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of protective immunity against diarrheal disease in early years of life. 在生命早期对腹泻疾病的保护性免疫的发展。

The Journal of Infectious Diseases Pub Date : 2025-05-15 DOI: 10.1093/infdis/jiaf256

Kurt Hanevik

引用次数: 0

Multiple approaches to genetic sequencing to identify hepatitis C virus reinfection among people who inject drugs 多种方法的基因测序，以确定丙型肝炎病毒再感染的注射吸毒者

The Journal of Infectious Diseases Pub Date : 2025-05-15 DOI: 10.1093/infdis/jiaf235

Kyra H Grantz, Raghavendran Anantharam, Abraham J Kandathil, Jeffrey Quinn, Jacqueline Astemborski, Gregory D Kirk, Oluwaseun Falade-Nwulia, Javier Cepeda, David L Thomas, Shruti H Mehta, Amy Wesolowski

{"title":"Multiple approaches to genetic sequencing to identify hepatitis C virus reinfection among people who inject drugs","authors":"Kyra H Grantz, Raghavendran Anantharam, Abraham J Kandathil, Jeffrey Quinn, Jacqueline Astemborski, Gregory D Kirk, Oluwaseun Falade-Nwulia, Javier Cepeda, David L Thomas, Shruti H Mehta, Amy Wesolowski","doi":"10.1093/infdis/jiaf235","DOIUrl":"https://doi.org/10.1093/infdis/jiaf235","url":null,"abstract":"The burden of hepatitis C virus (HCV) among persons who inject drugs is determined by dynamics of infection, spontaneous clearance, treatment clearance, treatment failure, and reinfection. Although analysis of HCV sequences is often used to infer the net contribution of these factors, those inferences are complicated by the quasispecies distribution and continued evolution of infection within each host. We used deep sequencing by Nanopore to study sequences of persons with and without self-reported HCV treatment. Even after years of evolution, sequences from the same person were always more similar than sequences from different persons and a Hamming distance threshold of 0.064 reliably differentiated (AUC 0.999) the groups. By comparison to sequences before treatment, identification of unique sequences (distance &gt; 0.064) after treatment reliably identified 8 of 28 instances of post-treatment reinfection. There were multiple causes for finding the same (distance &lt; 0.064) sequence after intended treatment including not commencing or abbreviating treatment, pharmacological treatment failure, or possibly reinfection from same source. These data underscore the value of HCV sequence analysis in understanding viral dynamics among PWID.","PeriodicalId":501010,"journal":{"name":"The Journal of Infectious Diseases","volume":"114 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143979767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reevaluating the clinical relevance of bacterial vaginosis-associated immune responses in HIV infection. 重新评估HIV感染中细菌性阴道病相关免疫反应的临床相关性

The Journal of Infectious Diseases Pub Date : 2025-05-14 DOI: 10.1093/infdis/jiaf227

Fangli Yu,Pan Ma,Jie Duan

引用次数: 0

Human Papillomavirus Persistence, Recurrence, and Incidence in Early Childhood. 人乳头瘤病毒在幼儿期的持续性、复发和发病率。

The Journal of Infectious Diseases Pub Date : 2025-05-14 DOI: 10.1093/infdis/jiaf213

Eméra Alice Bénard,Ana Maria Carceller,Marie-Hélène Mayrand,Jacques Lacroix,Joseph Niyibizi,Louise Laporte,François Audibert,François Coutlée,Helen Trottier,

{"title":"Human Papillomavirus Persistence, Recurrence, and Incidence in Early Childhood.","authors":"Eméra Alice Bénard,Ana Maria Carceller,Marie-Hélène Mayrand,Jacques Lacroix,Joseph Niyibizi,Louise Laporte,François Audibert,François Coutlée,Helen Trottier,","doi":"10.1093/infdis/jiaf213","DOIUrl":"https://doi.org/10.1093/infdis/jiaf213","url":null,"abstract":"BACKGROUNDLittle is known on the vertical transmission of human papillomavirus (HPV) and on the dynamics of HPV among children. Our objective was to determine the risk of HPV recurrence, persistence, and incidence over 2 years of age among children born to HPV-positive mothers.METHODSWe conducted the HERITAGE study among pregnant women recruited between 2010 and 2016 in Canada. HPV DNA testing was done on vaginal samples collected during the first and third trimesters of pregnancy, and on conjunctival, oral, pharyngeal, and genital samples collected in children from birth and at every 3-6 months up to 2 years. We estimated the probability of HPV vertical transmission, and of HPV recurrence, persistence, and incidence among children during follow-up. Time to clear HPV among children was estimated using Kaplan-Meier technique.RESULTSAmong the 422 women with HPV during pregnancy, 390 carried pregnancy to term, and 395 children were born alive including twins/triplets. HPV vertical transmission was estimated at 7.3% (95% confidence interval [CI], 5.0%-10.4%) with a genotype concordance of 85.2%. During the entire follow-up, we observed 91 HPV detections (among 51 children) including 2 recurrent and 1 persistent. Incident genotypes occurred in 26 of the 270 (9.6%) children with valid HPV testing during follow-up. Most HPV infections detected in children cleared with a mean time of 3.9 months (95% CI, 3.6-4.2 months).CONCLUSIONSHPV vertical transmission and incident HPV occasionally occur during infancy, but the risk of persistence or recurrence is overall very low.","PeriodicalId":501010,"journal":{"name":"The Journal of Infectious Diseases","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143945307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Placental Malaria Induces Oxidative Stress in Human Syncytiotrophoblast. 胎盘疟疾诱导人合胞滋养细胞氧化应激。

The Journal of Infectious Diseases Pub Date : 2025-05-14 DOI: 10.1093/infdis/jiaf243

Demba Sarr,Alicer K Andrew,Ashish K Shukla,Stephen Mwalimu,Julie M Moore

{"title":"Placental Malaria Induces Oxidative Stress in Human Syncytiotrophoblast.","authors":"Demba Sarr,Alicer K Andrew,Ashish K Shukla,Stephen Mwalimu,Julie M Moore","doi":"10.1093/infdis/jiaf243","DOIUrl":"https://doi.org/10.1093/infdis/jiaf243","url":null,"abstract":"BACKGROUNDPlacental malaria is characterized by the accumulation of Plasmodium falciparum-infected erythrocytes and maternal inflammation in the intervillous spaces of the placenta. These features are associated with placental damage and fetal compromise. However, understanding of the mechanisms that lead to poor pregnancy outcome and interventions targeting excessive host responses to placental malaria are still lacking. The syncytiotrophoblast, a cell of fetal origin, is known to be responsive to malaria-infected erythrocytes as well as the malaria toxin, hemozoin, but its susceptibility to oxidative stress and how this might contribute to placental damage and dysfunction has not yet been directly investigated.METHODSThe characteristics and key drivers of the syncytiotrophoblast response to oxidative stress were investigated using ex vivo human placental tissues and primary trophoblasts isolated from healthy pregnant women. Primary syncytiotrophoblast was exposed to hemozoin and tumor necrosis factor, a critical inflammatory cytokine, to model conditions found in human placental malaria.RESULTSThe data show remarkable lipid peroxidation in human placental samples from a malaria endemic setting and evidence of a modulated antioxidant response at the transcriptional level. Likewise, primary human syncytiotrophoblast exposed to hemozoin, tumor necrosis factor, and tumor necrosis factor combined with hemozoin in vitro exhibited increased markers of an anti-oxidative response, and, with hemozoin alone, oxidation of lipids and DNA.CONCLUSIONSThese results suggest that oxidative stress in syncytiotrophoblast is promoted by both hemozoin exposure and maternal inflammatory responses to placental malaria and contribute to an increased understanding of placental dysfunction and compromise in this infection.","PeriodicalId":501010,"journal":{"name":"The Journal of Infectious Diseases","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143945422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0