Kareem B Elessawy, Marooj Mohamed Mahmoud Ibrahim, Rehab R Kassem, Heba M Fouad
{"title":"Palpebral Fissure Changes After Bilateral Recession Versus Unilateral Recession-Plication of Horizontal Rectus Muscles for Correction of Intermittent Exotropia.","authors":"Kareem B Elessawy, Marooj Mohamed Mahmoud Ibrahim, Rehab R Kassem, Heba M Fouad","doi":"10.3928/01913913-20241121-01","DOIUrl":"10.3928/01913913-20241121-01","url":null,"abstract":"<p><strong>Purpose: </strong>To compare changes of vertical palpebral fissure height after bilateral lateral rectus (BLR) recessions versus unilateral lateral rectus (LR) recession and medial rectus (MR) muscle scleral plication, for treatment of intermittent exotropia.</p><p><strong>Methods: </strong>This prospective, comparative, randomized study included 40 patients with intermittent exotropia who were divided into two groups: 20 patients who underwent BLR recessions (BLR recession group) and 20 patients who underwent unilateral LR recession and MR muscle scleral plication (recession-plication group). Eyelid evaluation included measurement of margin reflex distance 1 (MRD1) and margin reflex distance 2 (MRD2) at 1 week, 6 weeks, and 3 months postoperatively. Angle of deviation and any incomitance were also recorded at each visit.</p><p><strong>Results: </strong>There was no significant statistical difference in eyelid measurements after the surgery between both groups (<i>P</i> = 1.00). There was no significant statistical difference in ocular alignment after the surgery between both groups (<i>P</i> = 1.00). Also, there was no significant statistical difference in lateral incomitance after the surgery between both groups (<i>P</i> = 1.00).</p><p><strong>Conclusions: </strong>Both the unilateral recession and plication of horizontal rectus muscles technique and bilateral recession provide comparable surgical results for correction of exotropia without significant palpebral fissures changes or lateral incomitance. <b>[<i>J Pediatr Ophthalmol Strabismus</i>. 2025;62(3):182-189.]</b>.</p>","PeriodicalId":50095,"journal":{"name":"Journal of Pediatric Ophthalmology & Strabismus","volume":" ","pages":"182-189"},"PeriodicalIF":1.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142923807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Changes in PAX7 Positive Satellite Cells in Extraocular Muscle After Strabismus Surgery.","authors":"Eunseok Kang, Suk-Gyu Ha","doi":"10.3928/01913913-20241210-02","DOIUrl":"10.3928/01913913-20241210-02","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the effects of recession or re-section surgery on PAX 7 positive satellite cells of the extraocular muscle (EOM) in rabbits.</p><p><strong>Methods: </strong>A total of 20 rabbits (40 eyes) were included in this study. The superior rectus muscle of the right eye was either recessed or resected. Recession surgeries were performed at a distance of 5 mm (5 rabbits) and 10 mm (5 rabbits) from the original insertion, whereas resection surgeries were performed at a distance of 4 mm (5 rabbits) and 8 mm (5 rabbits). The superior rectus (operated muscle), inferior rectus (antagonist muscle), and superior rectus of the contralateral eye (control) were extracted 4 weeks after surgery. The number of PAX7 positive satellite cells was analyzed using immunohistochemistry.</p><p><strong>Results: </strong>The number of PAX7 positive satellite cells in the operated and antagonist muscles was higher than that in the control muscle after all surgeries (<i>P</i> < .05, all). The number of PAX7 positive satellite cells in the operated and antagonist muscles after resection surgery was higher than that after recession surgery (<i>P</i> < .05, all). Howerver, there were no significant differences of PAX7 positive satellite cells in the operated and antagonist muscles in recession and resection surgery according to the surgical amount (<i>P</i> > .05, all).</p><p><strong>Conclusions: </strong>PAX7 positive satellite cells in the operated and antagonist muscles showed an increase after resection surgery compared to recession surgery. This suggests that the extent of EOM regeneration may vary depending on the surgical method used for strabismus surgery. <b>[<i>J Pediatr Ophthalmol Strabismus</i>. 2025;62(3):190-195.]</b>.</p>","PeriodicalId":50095,"journal":{"name":"Journal of Pediatric Ophthalmology & Strabismus","volume":" ","pages":"190-195"},"PeriodicalIF":1.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143015248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pelin Akçay, Pelin Kiyat, Timur Köse, Ozlem Barut Selver
{"title":"Establishing Normative Data for Pediatric Corneal Sensitivity","authors":"Pelin Akçay, Pelin Kiyat, Timur Köse, Ozlem Barut Selver","doi":"10.3928/01913913-20250312-02","DOIUrl":"10.3928/01913913-20250312-02","url":null,"abstract":"<p><strong>Purpose: </strong>To define the normative data of corneal sensitivity in the pediatric age group, which currently lacks existing literature.</p><p><strong>Methods: </strong>The study included 122 children aged 5 to 18 years who had applied for a routine ophthalmological examination at the Ege University Department of Ophthalmology. A total of 122 right eyes were included in the study. The study excluded children with any ocular pathologies, any previous ocular surgery, a history of contact lens use, and systemic diseases such as diabetes mellitus. Corneal sensitivity values were determined by means of a Cochet-Bonnet esthesiometer, applied to five distinct regions of the cornea (central, superior, inferior, nasal, and temporal).</p><p><strong>Results: </strong>The mean age was 11.29 ± 4.6 years (range: 2 to 18 years), and the female/male ratio was 63/59. The mean corneal sensitivity values of the central cornea and four corneal regions (superior, inferior, temporal, and nasal) were 5.16 ± 0.47, 5.16 ± 0.48, 5.19 ± 0.47, 5.18 ± 0.46, and 5.18 ± 0.45 cm, respectively. A negative correlation was identified between age and corneal sensitivity. No statistically significant difference was observed in corneal sensitivity when comparing quadrants or genders (P > .05).</p><p><strong>Conclusions: </strong>Data delineating the typical values have been identified in adults and have been demonstrated to serve as a valuable diagnostic instrument, particularly in the context of neuropathy in diabetes. Nevertheless, to date, no normative data have been published for the pediatric age group. Therefore, this study makes a significant contribution to the field by pioneering the establishment of normative data for the pediatric age group regarding corneal sensitivity, as detected with the Cochet-Bonnet esthesiometer.</p>","PeriodicalId":50095,"journal":{"name":"Journal of Pediatric Ophthalmology & Strabismus","volume":" ","pages":"1-6"},"PeriodicalIF":0.9,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144029826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Taimur Siddiqui, Jay Jaber, Ryan Sorensen, Patrick J Hunt, Richard C Allen, Katherine J Williams
{"title":"Out-of-Pocket Expense for Surgical Chalazion Removal.","authors":"Taimur Siddiqui, Jay Jaber, Ryan Sorensen, Patrick J Hunt, Richard C Allen, Katherine J Williams","doi":"10.3928/01913913-20250227-04","DOIUrl":"https://doi.org/10.3928/01913913-20250227-04","url":null,"abstract":"<p><strong>Purpose: </strong>To provide an improved accounting of the economic burden of chalazion removal for patients.</p><p><strong>Methods: </strong>A retrospective study approved by the institutional review board of patients who underwent surgical incision and drainage of a chalazion at a tertiary academic center from January 2011 to December 2020 was conducted. Patients were younger than 18 years with a diagnosis of chalazion requiring excision. Out-of-pocket expenses were defined as sum of procedure cost, facility fees, and anesthesia. Center for Medicare and Medicaid Services (CMS) physician fee schedule data and the study hospital's cost estimator were used. Out-of-pocket expenses were calculated and adjusted to 2020 dollars. The cumulative cost was calculated by factoring in the average rate of surgical re-intervention for a chalazion recurrence. Cost trends were tabulated and visualized.</p><p><strong>Results: </strong>The unadjusted, average total incision and drainage cost for chalazion from 2011 to 2020 was $543.42, increasing from $513.89 to $563.48 (+9.7%). Using costs adjusted to 2020 dollars, cost declines from $591.27 (2011) to $563.48 (2020, -4.93%) were uncovered. Using an averaged recurrence rate of 24.3%, the cumulative adjusted total cost of incision and drainage decreased from $734.95 (2011) to $700.41 (2020, -4.70%).</p><p><strong>Conclusions: </strong>Chalazion treatment costs declined from 2011 to 2020, suggesting potentially greater affordability for families. However, families should be counseled up front on potential future expenses with surgical intervention for a recurring chalazion. Understanding total costs for recurring chalazion by accounting for potential surgical re-intervention will help pediatric ophthalmologists provide more informed counseling regarding the total cost of treatment with an appreciation for potential future costs if surgical re-intervention is required. <b>[<i>J Pediatr Ophthalmol Strabismus</i>. 20XX;XX(X):XXX-XXX.]</b>.</p>","PeriodicalId":50095,"journal":{"name":"Journal of Pediatric Ophthalmology & Strabismus","volume":" ","pages":"1-5"},"PeriodicalIF":1.0,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143711948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Surgical Treatment of Strabismus in Children With Developmental Delay: A Review of the Literature and Results of Personal Experience.","authors":"Aldo Vagge, Andrea Lembo, Paolo Nucci","doi":"10.3928/01913913-20241001-01","DOIUrl":"10.3928/01913913-20241001-01","url":null,"abstract":"<p><strong>Purpose: </strong>To review the current literature, to provide a foundation of knowledge on strabismus surgery in patients with developmental delay, and to present results from the authors' personal experience.</p><p><strong>Methods: </strong>The following terms were searched on PubMed: strabismus surgery, mental delay, developmental delay, Down syndrome, Angelman syndrome, cerebral palsy, hydrocephalus, Williams syndrome, fragile X syndrome, and fetal alcohol syndrome. Surgical outcomes were analyzed and discussed; only English articles were included. Medical records of 183 patients with developmental delay who underwent strabismus correction surgery from 2001 to 2020 were examined and discussed.</p><p><strong>Results: </strong>Articles were reviewed and analyzed, categorized based on the disease. The authors' experience included 183 patients with various diseases or syndromes: 44 Down syndrome, 40 fetal alcohol syndrome, 36 Williams syndrome, 9 fragile X syndrome, 12 Angelman syndrome, 11 Cohen syndrome, and 31 cerebral palsy. Surgical results at 3 and 18 months of follow-up were analyzed. Regarding esotropia surgery, 83.9% had a deviation of less than 8 prism diopters at 3 months and 53.8% at 18 months of follow-up. Hypocorrection was seen in 7.7% and 3.5% and hypercorrection was observed in 8.4% and 52.7% at 3 and 18 months, respectively. For exotropia, 60% had a deviation of less than 8 prism diopters at 3 months and 22.5% at 18 months. Hypocorrection occurred in 35% and 75%, whereas hypercorrection was found in 5% and 2.5%, respectively.</p><p><strong>Conclusions: </strong>A higher prevalence of strabismus was found in these patients and the surgical outcomes were more difficult to predict. Patients with esotropia were more hypercorrected, whereas those with exotropia were more hyporcorrected. <b>[<i>J Pediatr Ophthalmol Strabismus</i>. 2025;62(2):96-104.]</b>.</p>","PeriodicalId":50095,"journal":{"name":"Journal of Pediatric Ophthalmology & Strabismus","volume":" ","pages":"96-104"},"PeriodicalIF":1.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142774127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Camden Nelson, Bailee J Deshler, Brittany Bernstein, Stephen Aronoff
{"title":"Variability in the Evaluation and Treatment of Healthy Neonates With Uncomplicated Conjunctivitis.","authors":"Camden Nelson, Bailee J Deshler, Brittany Bernstein, Stephen Aronoff","doi":"10.3928/01913913-20241121-04","DOIUrl":"10.3928/01913913-20241121-04","url":null,"abstract":"<p><strong>Purpose: </strong>To explore the current state of diagnosis and management of neonatal conjunctivitis.</p><p><strong>Methods: </strong>Cosmos, an EHR-based, de-identified data set including more than 200 million patients, was used for this study. Neonates born between January 1, 2016 and December 31, 2022, discharged from the hospital by day 3 of life, and with an ambulatory visit within the first 4 weeks of life associated with a new diagnosis of neonatal conjunctivitis (SNOMED) or conjunctivitis (ICD-10 H10.*) were included. Cosmos slicer/dicer software was used to extract demographic, diagnostic, etiologic, and therapeutic data.</p><p><strong>Results: </strong>A total of 1,870 of 7,325,276 (0.0255%) neonates with a hospital stay of 3 days or less met criteria for inclusion: 96.5% were from the United States, 16.2% were admitted to the hospital, and bacterial cultures were obtained from 21.3%. Congenital lacrimal duct stenosis was causative in 2.7% of patients. Important infectious agents included staphylococcal, streptococcal, or enterococcal species (2.5%), <i>Neisseria gonorrhoeae</i> (1.6%), and <i>Chlamydia trachomatis</i> (0.6%). No herpesviral or <i>Pseudomonas</i> infections were identified. Antimicrobial agents were prescribed to 93.7% of patients and given ophthalmically (79.5%), orally (11.4%), and parenterally (7.7%).</p><p><strong>Conclusions: </strong>The evaluation and management of neonatal conjunctivitis within United States ambulatory settings are highly variable. Diagnostic studies are underused, resulting in limited etiologic data and a lack of susceptibility-guided treatment. <b>[<i>J Pediatr Ophthalmol Strabismus</i>. 2025;62(2):143-149.]</b>.</p>","PeriodicalId":50095,"journal":{"name":"Journal of Pediatric Ophthalmology & Strabismus","volume":" ","pages":"143-149"},"PeriodicalIF":1.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142923847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Darron Bacal, Alina Dumitrescu, Daniel Weaver, Rudolph S Wagner
{"title":"Surgical Options for Intermittent Exotropia.","authors":"Darron Bacal, Alina Dumitrescu, Daniel Weaver, Rudolph S Wagner","doi":"10.3928/01913913-20241210-01","DOIUrl":"https://doi.org/10.3928/01913913-20241210-01","url":null,"abstract":"","PeriodicalId":50095,"journal":{"name":"Journal of Pediatric Ophthalmology & Strabismus","volume":"62 2","pages":"81-83"},"PeriodicalIF":1.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Intravitreal Methotrexate and CAR-T Therapy for Anterior Segment B-Cell Acute Lymphoblastic Leukemia Relapse.","authors":"Chathuranka De Silva, Alan Connor, Wing Roberts","doi":"10.3928/01913913-20250117-01","DOIUrl":"10.3928/01913913-20250117-01","url":null,"abstract":"<p><p>The authors present a child with a rare case of unilateral pseudo-hypopyon and raised intraocular pressure as the only manifestation of acute lymphoblastic leukemia recurrence. This was treated with intravitreal methotrexate and chimeric antigen receptor T-cell therapy (CAR-T) with subsequent remission. This case demonstrates intravitreal methotrexate is a safe and effective adjunct to use with CAR-T therapy for relapsing acute lymphoblastic leukemia with ocular involvement. Further research should be sought on both CAR-T therapy and intravitreal methotrexate for acute lymphoblastic leukemia with ocular involvement. <b>[<i>J Pediatr Ophthalmol Strabismus</i>. 2025;62(2):e18-e21.]</b>.</p>","PeriodicalId":50095,"journal":{"name":"Journal of Pediatric Ophthalmology & Strabismus","volume":"62 2","pages":"e18-e21"},"PeriodicalIF":1.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Karthika R Chandran, Shailja Tibrewal, Soveeta Rath, Suma Ganesh
{"title":"Mini Lens for Mini Eyes: Management of Congenital Cataract With Microcornea.","authors":"Karthika R Chandran, Shailja Tibrewal, Soveeta Rath, Suma Ganesh","doi":"10.3928/01913913-20250227-01","DOIUrl":"10.3928/01913913-20250227-01","url":null,"abstract":"<p><p>Management of congenital cataract associated with microcornea is challenging, often due to limited options for intraocular lens implantation. This case report describes the use of a small posterior-fixated iris claw lens for optical rehabilitation of cataract with microcornea, which resulted in significant improvement in the child's visual acuity. <b>[<i>J Pediatr Ophthalmol Strabismus</i>. 2025;62(3):e27-e30.]</b>.</p>","PeriodicalId":50095,"journal":{"name":"Journal of Pediatric Ophthalmology & Strabismus","volume":"62 2","pages":"e27-e30"},"PeriodicalIF":1.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mohamed M Khodeiry, Qais A Dihan, Taher K Eleiwa, Amr K Hassan, Mohamed A Hassan, Tom Kornhauser, Mohamed S Sayed, Abdelrahman M Elhusseiny
{"title":"YouTube as a Source of Knowledge for Childhood Glaucoma.","authors":"Mohamed M Khodeiry, Qais A Dihan, Taher K Eleiwa, Amr K Hassan, Mohamed A Hassan, Tom Kornhauser, Mohamed S Sayed, Abdelrahman M Elhusseiny","doi":"10.3928/01913913-20241105-04","DOIUrl":"10.3928/01913913-20241105-04","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the quality and reliability of patient-targeted videos about childhood glaucoma on the YouTube platform.</p><p><strong>Methods: </strong>On March 1, 2024, a search was performed on YouTube (www.youtube.com) using the keywords \"Infantile glaucoma,\" \"childhood glaucoma,\" \"paediatric glaucoma,\" \"congenital glaucoma,\" \"juvenile glaucoma,\" \"buphthalmos,\" and \"pediatric glaucoma.\" For each video, the time since the upload date (days), duration of the videos (minutes), number of likes, dislikes, and comments, the view ratio (number of views/time since the upload date), like ratio (likes × 100) /(likes+dislikes), view power index ([like ratio × view ratio] /100), and upload source (whether it was uploaded by medical organization versus uploaded by patients or commercial organization) were recorded. Two independent reviewers blindly evaluated the patient-targeted videos using DISCERN, the <i>Journal of American Medical Association</i> (JAMA), and the Global Quality Score (GQS) criteria.</p><p><strong>Results: </strong>Twenty-five videos were analyzed, and 19 (64%) of them were uploaded by physicians or medical organizations. The overall median (interquartile range) scores for DISCERN, JAMA, and GQS criteria were 2.5 (1.8 to 3.0), 2.5 (2.0 to 2.5), and 3.5 (2.5 to 4.0), respectively. No significant differences in scoring were noted between the two reviewers. The duration of the videos was significantly correlated with the GQS; however, no other video parameters were correlated to the quality scorings.</p><p><strong>Conclusions: </strong>YouTube videos of patient education about childhood glaucoma were of moderate quality and reliability. <b>[<i>J Pediatr Ophthalmol Strabismus</i>. 2025;62(2):116-121.]</b>.</p>","PeriodicalId":50095,"journal":{"name":"Journal of Pediatric Ophthalmology & Strabismus","volume":" ","pages":"116-121"},"PeriodicalIF":1.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142774200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}