Journal of Pediatric Ophthalmology & Strabismus最新文献_第8页

Familial Exudative Vitreoretinopathy-Associated Secondary Ocular Hypertension and Glaucoma: Clinical Features and Outcomes. 家族性渗出性玻璃体视网膜病变相关继发性高眼压和青光眼：临床特征和结果。

IF 1.4 4区医学

Journal of Pediatric Ophthalmology & Strabismus Pub Date : 2026-04-17 DOI: 10.3928/01913913-20260318-01

Sakaorat Petchyim, Kasem Seresirikachorn, Abdelrahman M Elhusseiny, Arnan Limmahachai, Supredee Pongrujikorn, Theerajate Phongsuphan, Pawita Kongthanasomboon, La-Ongsri Atchaneeyasakul

{"title":"Familial Exudative Vitreoretinopathy-Associated Secondary Ocular Hypertension and Glaucoma: Clinical Features and Outcomes.","authors":"Sakaorat Petchyim, Kasem Seresirikachorn, Abdelrahman M Elhusseiny, Arnan Limmahachai, Supredee Pongrujikorn, Theerajate Phongsuphan, Pawita Kongthanasomboon, La-Ongsri Atchaneeyasakul","doi":"10.3928/01913913-20260318-01","DOIUrl":"10.3928/01913913-20260318-01","url":null,"abstract":"Purpose: To report clinical characteristics and treatment outcomes of ocular hypertension (OHT) and glaucoma in familial exudative vitreoretinopathy (FEVR).Methods: This retrospective chart review included patients diagnosed as having FEVR and OHT or glaucoma at Siriraj Hospital, Bangkok, Thailand, between June 2001 and May 2021. Demographics, clinical features, treatments, and outcomes were collected.Results: Among 93 patients (174 eyes) with FEVR, 6 patients (5.2%; 9 eyes, 3 bilateral cases) developed secondary OHT (6 eyes) and glaucoma (3 eyes), and all had bilateral FEVR stage 3A or greater. Median age at FEVR diagnosis was 4 months (interquartile range [IQR]: 3 to 23 months), and median age at OHT and glaucoma diagnosis was 43 months (IQR: 15 to 52 months). All eyes presented with elevated intraocular pressure (IOP). Treatment outcomes showed stable visual acuity in stage 3A; in stage 4A or higher, 3 eyes remained stable and 2 developed phthisis bulbi. OHT and glaucoma were controlled with one to two topical medications in all patients except one with a shallow anterior chamber, who required peripheral iridotomy. Median intraocular pressure decreased from 30 mmHg at presentation (IQR: 25.5 to 37.5 mmHg; n = 9) to 16 mmHg at last visit (IQR: 14 to 17.5 mmHg; n = 5). None of the eyes required glaucoma surgery. No patient experienced ocular pain.Conclusions: Secondary OHT and glaucoma is a late complication of advanced FEVR and may present as asymptomatic IOP elevation. IOP control is achievable with topical therapy or peripheral iridotomy in a shallow anterior chamber; however, visual prognosis is largely stage dependent.","PeriodicalId":50095,"journal":{"name":"Journal of Pediatric Ophthalmology & Strabismus","volume":" ","pages":"1-7"},"PeriodicalIF":1.4,"publicationDate":"2026-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147718829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ocular Motility Changes After Macular Buckle for Myopic Traction Maculopathy. 近视牵引性黄斑病变黄斑扣环后眼球运动的改变。

IF 1.4 4区医学

Journal of Pediatric Ophthalmology & Strabismus Pub Date : 2026-04-17 DOI: 10.3928/01913913-20260317-02

Roberta Penzani, Barbara Parolini, Aurelio Apuzzo

{"title":"Ocular Motility Changes After Macular Buckle for Myopic Traction Maculopathy.","authors":"Roberta Penzani, Barbara Parolini, Aurelio Apuzzo","doi":"10.3928/01913913-20260317-02","DOIUrl":"10.3928/01913913-20260317-02","url":null,"abstract":"Purpose: To evaluate ocular motility changes after NPB macular buckling surgery (AJL Ophthalmic). Myopic traction maculopathy is a sight-threatening complication of pathologic myopia. Macular buckling surgery, particularly with the novel NPB model, has shown high anatomical success, but concerns remain regarding possible orthoptic complications.Methods: Consecutive patients with myopic traction maculopathy who underwent NPB macular buckling surgery at Eyecare Clinic, Brescia, Italy (January 2023 to July 2024) were retrospectively analyzed. Exclusion criteria included preexisting ocular motility disorders and monocular status. Preoperative and postoperative examinations included best corrected visual acuity, axial length, orthoptic evaluation (cover tests, ocular motility, binocular vision, and stereopsis), and diplopia assessment. The minimum follow-up was 6 months.Results: Forty-two patients were enrolled; 12 (29%) were excluded because they showed preoperative ocular motility alterations. The remaining 30 patients achieved complete anatomical resolution of myopic traction maculopathy after surgery. Postoperatively, 13 patients (43%) developed elevation deficits, 10 (33%) hypotropia, and 9 (30%) diplopia in primary gaze. Diplopia was managed with prismatic correction, using glasses or soft prismatic contact lenses, in 7 patients, whereas 2 declined treatment. No patient required buckle removal.Conclusions: NPB macular buckling surgery effectively resolved myopic traction maculopathy in all cases, but induced mild ocular motility abnormalities in a subset of patients. These complications-mainly elevation deficit, hypotropia, and diplopia-were manageable with prismatic correction and appear acceptable when weighed against the anatomical and visual benefits.","PeriodicalId":50095,"journal":{"name":"Journal of Pediatric Ophthalmology & Strabismus","volume":" ","pages":"1-5"},"PeriodicalIF":1.4,"publicationDate":"2026-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147718894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Distinct Pattern Observed After Intermittent Exotropia Surgery: Characteristics of Patients Exhibiting Postoperative Rebound Esodrift. 间歇性外斜视手术后观察到的独特模式：术后反弹内斜患者的特征。

IF 1.4 4区医学

Journal of Pediatric Ophthalmology & Strabismus Pub Date : 2026-03-23 DOI: 10.3928/01913913-20260105-02

Hye Jun Joo, Seong-Joon Kim

{"title":"Distinct Pattern Observed After Intermittent Exotropia Surgery: Characteristics of Patients Exhibiting Postoperative Rebound Esodrift.","authors":"Hye Jun Joo, Seong-Joon Kim","doi":"10.3928/01913913-20260105-02","DOIUrl":"10.3928/01913913-20260105-02","url":null,"abstract":"Purpose: To investigate the unique postoperative pattern following intermittent exotropia (IXT) surgery.Methods: A retrospective review of patients younger than 18 years who underwent bilateral lateral rectus (BLR) recession or unilateral lateral rectus weakening and medial rectus strengthening surgery for IXT, with a postoperative follow-up period of 2 years or more was done. Patients who developed esodeviation after initially recovering to orthotropia within 1 month postoperatively were classified as having delayed-onset consecutive esotropia. The clinical characteristics of these patients were analyzed and the associated preoperative factors were assessed.Results: Delayed-onset consecutive esotropia was observed in 6.4% of patients after IXT surgery. This phenomenon was observed approximately 4 months postoperatively. Risk factors were younger age, larger preoperative deviation angles, and undergoing BLR recession. Similar phenomenon of worsening of the deviation angle toward esotropia (rebound esodrift) was also observed in the patient groups with constant exotropia and continuous consecutive esotropia. Patients showing rebound esodrift shared the same risk factors as those with delayed-onset consecutive esotropia.Conclusions: This study identified patients exhibiting delayed-onset consecutive esotropia in the early postoperative period following IXT surgery. Close monitoring and suitable treatment of these patients are essential for optimal outcomes.","PeriodicalId":50095,"journal":{"name":"Journal of Pediatric Ophthalmology & Strabismus","volume":" ","pages":"1-8"},"PeriodicalIF":1.4,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147488261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Do Exotropic Patients Show More Exotropic Drift Postoperatively Than Esotropic Patients? 外向性患者术后是否比内向性患者表现出更多的外向性漂移？

IF 1.4 4区医学

Journal of Pediatric Ophthalmology & Strabismus Pub Date : 2026-03-23 DOI: 10.3928/01913913-20260130-03

Colin R LeSage, Laura Andaluz-Scher, John W Simon, Jitka Zobal-Ratner, Nicole Storey, Peter Ness, Gerard Barry

{"title":"Do Exotropic Patients Show More Exotropic Drift Postoperatively Than Esotropic Patients?","authors":"Colin R LeSage, Laura Andaluz-Scher, John W Simon, Jitka Zobal-Ratner, Nicole Storey, Peter Ness, Gerard Barry","doi":"10.3928/01913913-20260130-03","DOIUrl":"10.3928/01913913-20260130-03","url":null,"abstract":"Purpose: To quantify changes in ocular alignment following strabismus surgery and identify relevant variables. It was hypothesized that exotropic patients would exhibit greater postoperative exotropic drift than esotropic patients.Methods: A retrospective chart review was conducted on all patients who underwent horizontal strabismus surgery between 2018 and 2023. Of the 629 charts reviewed, 243 were excluded due to insufficient data, nystagmus, or concomitant superior rectus, inferior rectus, or superior oblique surgery. Postoperative drift was calculated by subtracting alignment measured between postoperative days 1 to 14 and days 30 to 150. An unpaired t test was used to compare postoperative drift between exotropic and esotropic patients. Additional variables collected included preoperative magnitude of deviation, age, and surgical technique.Results: A total of 386 patients met the inclusion criteria. Among 208 exotropic patients, mean postoperative drift was exotropic 9.94 △ ± 9.78 △. Among 178 esotropic patients, mean postoperative drift was esotropic 1.26 △ ± 9.81 △. Exotropic patients demonstrated significantly greater exotropic drift than esotropic patients (P < .001).Conclusions: Postoperative drift varies significantly between exotropic and esotropic patients, with exotropic patients exhibiting greater drift. These findings may inform pre- and postoperative counseling, prognostic expectations, and surgical planning. The wide range of observed postoperative drift highlights the variability in surgical outcomes.","PeriodicalId":50095,"journal":{"name":"Journal of Pediatric Ophthalmology & Strabismus","volume":" ","pages":"1-7"},"PeriodicalIF":1.4,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147488271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Features and Prognostic Factors in Pediatric Open Globe Injuries. 儿童开放性球损伤的临床特征和预后因素。

IF 1.4 4区医学

Journal of Pediatric Ophthalmology & Strabismus Pub Date : 2026-03-23 DOI: 10.3928/01913913-20260130-01

Victoria Vought, Peter Khouri, Christopher Khouri, Rita Vought, Roger Henry, Marko Oydanich, Rudoph S Wagner

{"title":"Clinical Features and Prognostic Factors in Pediatric Open Globe Injuries.","authors":"Victoria Vought, Peter Khouri, Christopher Khouri, Rita Vought, Roger Henry, Marko Oydanich, Rudoph S Wagner","doi":"10.3928/01913913-20260130-01","DOIUrl":"10.3928/01913913-20260130-01","url":null,"abstract":"Purpose: To characterize the features of open globe injuries (OGIs) and the visual outcomes of pediatric patients using a modified Pediatric Ocular Trauma Score (POTS).Methods: A retrospective chart review was conducted of pediatric patients presenting to a Level I Trauma Center with unilateral OGIs from 2015 to 2023. Demographic data, injury characteristics, clinical findings at presentation, surgical timing, and visual outcomes were analyzed. The POTS was calculated to assess its prognostic value.Results: A total of 53 individuals were analyzed (mean age: 9.3 ± 5.3 years). Blunt trauma accounted for 69.8% of injuries, most of which occurred at home (54.7%). More than half (52.8%) were transferred from outside facilities, and surgical repair was performed within 48 hours in 60.4% of cases. Most injuries were zone I (83.0%). Uveal prolapse (71.7%) and traumatic cataract (39.6%) were frequently observed. At presentation, 5.7% had no light perception (NLP) and 35.8% had light perception/hand motion (LP/HM). Three-month follow-up best corrected visual acuity (BCVA) was available for 25 patients (47.2%); among these, 76% achieved a final BCVA of 0.1 or better. The POTS for all patients was 53.9 ± 19.9. For individuals with follow-up, mean POTS were correlated with final BCVA: LP/HM (47.5), CF (37.5), 0.1 to 0.5 (56.5), and 0.6 to 1.0 (70.0).Conclusions: This evaluation of pediatric OGIs found mainly zone I injuries causing LP/HM visual acuity. The incorporation of POTS highlights the potential for visual recovery in some patients, with 24% achieving 20/32 BCVA at 3 months of follow-up. These data support POTS as a prognostic tool for physicians managing OGIs in children.","PeriodicalId":50095,"journal":{"name":"Journal of Pediatric Ophthalmology & Strabismus","volume":" ","pages":"1-6"},"PeriodicalIF":1.4,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147488250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictors for Surgical Success in Pediatric Esotropia: A Large Retrospective Cohort Study. 儿童内斜视手术成功的预测因素：一项大型回顾性队列研究。

IF 1.4 4区医学

Journal of Pediatric Ophthalmology & Strabismus Pub Date : 2026-03-23 DOI: 10.3928/01913913-20260130-02

Fountane Chan, Allison Summers, Annie Kuo, Lorri Wilson, Leah Reznick, Michelle Hribar, Elizabeth White, Allison R Loh

{"title":"Predictors for Surgical Success in Pediatric Esotropia: A Large Retrospective Cohort Study.","authors":"Fountane Chan, Allison Summers, Annie Kuo, Lorri Wilson, Leah Reznick, Michelle Hribar, Elizabeth White, Allison R Loh","doi":"10.3928/01913913-20260130-02","DOIUrl":"10.3928/01913913-20260130-02","url":null,"abstract":"Purpose: To evaluate a large cohort of patients treated by multiple surgeons to identify key predictors of surgical success and evaluate short-term surgical outcomes in pediatric patients with esotropia.Methods: A retrospective chart review was conducted from 2016 to 2023 at a single academic institution, collecting demographic and eye examination data from preoperative and 4- to 12-week postoperative visits. Patients younger than 18 years with esotropia undergoing their first strabismus surgery with either bilateral medial rectus recession (BMRc) or recession and resection (RR) were included. Success was defined as a postoperative distance deviation angle of 10 prism diopters or less. Statistical analysis was performed using R software (The R Project for Statistical Computing).Results: A total of 730 patients and 13 surgeons were included. The majority (494/730) of children undergoing their first esotropia surgery achieved success, with both BMRc (67.3%) and RR (69.6%) demonstrating high success rates. Surgical success was significantly associated with preoperative deviation angle (P < .05), but not with age, sex, race, ethnicity, insurance type, presence of preoperative gross stereoacuity, interocular difference in logarithm of the minimum angle of resolution (logMAR) visual acuity of 0.2 or better, or Area Deprivation Index national rank (P > .05).Conclusions: Surgical management of pediatric esotropia is largely successful in the short term both for BMRc and RR. Lower preoperative deviation angles emerged as a key predictor of surgical success.","PeriodicalId":50095,"journal":{"name":"Journal of Pediatric Ophthalmology & Strabismus","volume":" ","pages":"1-7"},"PeriodicalIF":1.4,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147488274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Eye Movements and Visual Perception in Children With Autism Spectrum Disorder. 自闭症谱系障碍儿童的眼球运动和视觉知觉。

IF 1.4 4区医学

Journal of Pediatric Ophthalmology & Strabismus Pub Date : 2026-03-23 DOI: 10.3928/01913913-20251204-05

Rituparna Ghoshal, Guganathan Vinayagamoorthy, Somnath Ghosh

{"title":"Eye Movements and Visual Perception in Children With Autism Spectrum Disorder.","authors":"Rituparna Ghoshal, Guganathan Vinayagamoorthy, Somnath Ghosh","doi":"10.3928/01913913-20251204-05","DOIUrl":"10.3928/01913913-20251204-05","url":null,"abstract":"Purpose: To quantify eye movements and visual perception of children with autism spectrum disorder (ASD) and to compare the same parameters with children with typical development (TD). The association between eye movements and visual perception among study children was also evaluated.Methods: Children with ASD who were verbal and children with TD as age-matched controls were recruited. All children underwent a developmental eye movement (DEM) test and Motor-Free Visual Perception Test-4 (MVPT-4) following standard protocol.Results: Ninety-one children (ASD group = 54, TD group = 37) were evaluated. In the DEM test, mean scores of horizontal and vertical saccades (HT, VT) were significantly (P < .001) extended in children with ASD (mean HT = 262.22 ± 101.152 seconds, mean VT = 121.66 ± 39.72 seconds) compared to children with TD (mean HT = 80.316 ± 32.73 seconds, mean VT = 55.08 ± 16.95 seconds). The majority (88.84%) of children with ASD showed type IV error, indicating both oculomotor and automaticity disorders. Average MVPT-4 scores along with MVPT-4 domain scores were significantly lower (P < .05) in the ASD group. Although a multiple regression model with age, HT, VT, and DEM ratio could explain 71% of the variation in the visual perception score of the TD group, 42% of the variation in the same was explained in the ASD group.Conclusions: This study reports a significantly increased duration of saccades and impaired visual perception scores among children with ASD compared to those with TD. Although a strong association between MVPT-4 and DEM scores was observed in the TD group, DEM scores failed to associate strongly with visual perception scores in the ASD group.","PeriodicalId":50095,"journal":{"name":"Journal of Pediatric Ophthalmology & Strabismus","volume":" ","pages":"1-9"},"PeriodicalIF":1.4,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147488282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association Between Neighborhood Opportunity Levels and Requiring Retinopathy of Prematurity Treatment. 邻里机会水平与早产儿视网膜病变需要治疗之间的关系。

IF 1.4 4区医学

Journal of Pediatric Ophthalmology & Strabismus Pub Date : 2026-03-23 DOI: 10.3928/01913913-20260130-04

Akshara R Legala, Shira L Robbins, Eric Nudleman, Euyhyun Lee, Lin Liu, Lauren Hennein

{"title":"Association Between Neighborhood Opportunity Levels and Requiring Retinopathy of Prematurity Treatment.","authors":"Akshara R Legala, Shira L Robbins, Eric Nudleman, Euyhyun Lee, Lin Liu, Lauren Hennein","doi":"10.3928/01913913-20260130-04","DOIUrl":"10.3928/01913913-20260130-04","url":null,"abstract":"Purpose: To determine the relationship between neighborhood-level socioeconomic status and requiring retinopathy of prematurity (ROP) treatment, using the Child Opportunity Index (COI).Methods: Electronic medical records for all patients who received ROP treatment from January 2010 to March 2024 at a tertiary care center were retrospectively reviewed. Controls were obtained by matching pediatric ophthalmology patients with the closest clinic visit date and no history of retinopathy of prematurity. Demographic and clinical information were collected. The patient's 5-digit ZIP code was used to determine the COI score and level.Results: This study included 245 study patients and 735 matched controls, of which 110 (44.9%) and 329 (44.8%) were female, respectively. The study group had a significantly lower mean COI score (48 ± 29) compared to controls (56 ± 31, P < .001). Additionally, the study group had a higher percentage of Hispanic/Latino patients compared to the control group (51.8% vs 41.9%, respectively, P = .01). When stratified into type 1 (n = 195) and type 2 (n = 50) ROP, patients in the ROP groups continued to have lower mean COI scores (50 ± 29 and 44 ± 28, respectively) than the control group (56 ± 31; P = .01 and P = .006, respectively). The type 1 ROP group had a greater number of patients with Medi-Cal insurance compared to the control group (50.8% vs 46.4%, respectively, P = .04).Conclusions: Neighborhood socioeconomic status may play a critical role in the management of ROP. It is important to understand the synergistic relationship between social determinants of health when addressing health disparities and developing community-level interventions.","PeriodicalId":50095,"journal":{"name":"Journal of Pediatric Ophthalmology & Strabismus","volume":" ","pages":"1-8"},"PeriodicalIF":1.4,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147488237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intravitreal Anti-vascular Endothelial Growth Factor in Retinopathy of Prematurity: A Bibliometric Analysis. 玻璃体内抗血管内皮生长因子在早产儿视网膜病变中的应用：文献计量学分析。

IF 1.4 4区医学

Journal of Pediatric Ophthalmology & Strabismus Pub Date : 2026-03-23 DOI: 10.3928/01913913-20251106-02

Onkar H Pirdankar, Amit S Nene, Renu Thakur, Smitesh Shah, Pratik Shenoy, Pushpanjali Badole

{"title":"Intravitreal Anti-vascular Endothelial Growth Factor in Retinopathy of Prematurity: A Bibliometric Analysis.","authors":"Onkar H Pirdankar, Amit S Nene, Renu Thakur, Smitesh Shah, Pratik Shenoy, Pushpanjali Badole","doi":"10.3928/01913913-20251106-02","DOIUrl":"10.3928/01913913-20251106-02","url":null,"abstract":"Retinopathy of prematurity (ROP) is one of the leading cause of blindness in premature infants. A bibliometric analysis on intravitreal anti-vascular endothelial growth factor (VEGF) in ROP was conducted. A comprehensive search of the article on the Scopus database was conducted with the terms related to \"anti-vascular endothelial growth factor and retinopathy of prematurity.\" Only original research and review articles published in the English language were considered. VOSviewer version 1.6.20 was used for the visualization and analysis of the data. Publication trend, productive countries, researchers' details, commonly cited documents, source and influential journals, and keyword occurrence were analyzed. A total of 329 studies were considered, of which 270 were original articles and 59 were review articles. The highest numbers of publications were seen in the year 2022. The United States, China, Turkey, India, and Taiwan were the top 5 countries that published research on the use of anti-VEGF in ROP. The most documents were published by Wei-Chi Wu (22) and Chi-Chun Lai (14), and Falavarjani et al's article had the most citations (737). A total of 2,504 keywords were identified. All keyword analysis revealed the occurrence of \"retinopathy of prematurity\" and \"human\" as a keyword was 290 and 286 times, respectively. Most articles and citations were found in Retina. The use of anti-VEGF in ROP is constantly evolving and bibliometric analysis highlights a research trend and influential authors and journals that have published significant work on it. This article can serve as a guide to conduct a literature review for future researchers.","PeriodicalId":50095,"journal":{"name":"Journal of Pediatric Ophthalmology & Strabismus","volume":" ","pages":"1-10"},"PeriodicalIF":1.4,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147488234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characterizing the Treatment Courses of Ranibizumab and Panretinal Photocoagulation for Retinopathy of Prematurity. 雷尼单抗和全视网膜光凝治疗早产儿视网膜病变的疗程特征。

IF 1.4 4区医学

Journal of Pediatric Ophthalmology & Strabismus Pub Date : 2026-03-11 DOI: 10.3928/01913913-20251204-07

Victoria Vought, Rita Vought, Alexander B Crane, Suqin Guo, Neelakshi Bhagat, Marco A Zarbin, Rudolph S Wagner

{"title":"Characterizing the Treatment Courses of Ranibizumab and Panretinal Photocoagulation for Retinopathy of Prematurity.","authors":"Victoria Vought, Rita Vought, Alexander B Crane, Suqin Guo, Neelakshi Bhagat, Marco A Zarbin, Rudolph S Wagner","doi":"10.3928/01913913-20251204-07","DOIUrl":"10.3928/01913913-20251204-07","url":null,"abstract":"Purpose: This study characterizes the treatment course and outcomes of infants with retinopathy of prematurity (ROP) treated with ranibizumab, panretinal photo-coagulation (PRP), or combined therapy.Methods: This retrospective chart review analyzed electronic health record data of infants treated for ROP between 2016 and 2024 at a single academic center.Results: Thirty-seven infants (72 eyes) were analyzed (59.05% male, average 24.7 ± 1.4 weeks). At first treatment, most eyes were zone II, stage 3+ (59.7%). All eyes had plus disease except six treated for persistent avascular retina. PRP was administered as initial therapy for 30 (41.7%) eyes and ranibizumab for 42 (58.3%). Thirty-five eyes (48.6%) underwent only one treatment of either PRP (26 eyes; 36.1%) or ranibizumab (9 eyes; 12.5%). A second treatment consisting of ranibizumab was administered in 4 (13.3%) of 30 eyes treated with PRP and 21 (50%) of 42 eyes injected with ranibizumab. Eight eyes (11.1%) had three treatments: two ranibizumab injections followed by PRP. Four eyes (5.6%) had four treatments: three ranibizumab injections followed by PRP. ROP reactivation occurred in 14 (19.4%) eyes that all received ranibizumab injection initially (mean 50.6 ± 16.7 days after most recent injection). Final outcomes included PRP for persistent avascular retina in 22 (30.6%) eyes, unknown final outcomes due to lost follow-up for 16 (22.2%), documented resolution in 33 (45.8%), and scleral buckling for a peripheral retinal detachment (stage 4a) for one (1.4%).Conclusions: Ranibizumab was initiated at a younger age with higher retreatment and reactivation events compared to PRP, underscoring variability in real-world ROP treatment patterns and outcomes.","PeriodicalId":50095,"journal":{"name":"Journal of Pediatric Ophthalmology & Strabismus","volume":" ","pages":"1-9"},"PeriodicalIF":1.4,"publicationDate":"2026-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147436866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0