{"title":"Electroretinogram as a Screening Tool to Assess Vigabatrin-Induced Retinal Toxicity in Children With Infantile Spasms.","authors":"Suruthi Nagarajan, Rajesh Prabu, Nikulaa Parachuri, Mithun Thulasidas","doi":"10.3928/01913913-20240215-01","DOIUrl":"10.3928/01913913-20240215-01","url":null,"abstract":"<p><strong>Purpose: </strong>To assess the utility of electroretinogram (ERG) as a screening tool for vigabatrin-induced retinal toxicity in children with infantile spasms.</p><p><strong>Methods: </strong>This was an observational cohort study including children with infantile spasms receiving treatment with vigabatrin. A 30-Hz flicker potential ERG, using the RETeval system (LKC Technologies), was done at baseline before starting vigabatrin at 6 months and 1 year. The amplitudes were recorded.</p><p><strong>Results: </strong>Eleven children were included in the study. The most common etiologic factor for infantile spasms was tuberous sclerosis (36.4%) followed by West syndrome (27.3%). The mean age of the children was 7.14 ± 2.9 months, with a range of 3 to 16 months. The mean difference in amplitude was 3.21 ± 2.45 and 5.72 ± 4.18 µV at 6 and 12 months follow-up, respectively (<i>P</i> < .001). Eight of the 11 children (72.7%) showed vigabatrin-induced retinal toxicity, and all 8 children were receiving vigabatrin for more than 6 months.</p><p><strong>Conclusions: </strong>ERG can be used for vigabatrin-induced retinal toxicity monitoring in children with infantile spasms. Vigabatrin-induced retinal toxicity is related to the duration of treatment rather than cumulative dosage. <b>[<i>J Pediatr Ophthalmol Strabismus</i>. 2024;61(4):273-278.]</b>.</p>","PeriodicalId":50095,"journal":{"name":"Journal of Pediatric Ophthalmology & Strabismus","volume":" ","pages":"273-278"},"PeriodicalIF":1.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140121220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Siri Uppuluri, Julia Nguyen, Aditya Uppuluri, Paul D Langer, Neelakshi Bhagat
{"title":"Clinical Report on the Epidemiology of Pediatric Dog Bite-Associated Ocular Injuries.","authors":"Siri Uppuluri, Julia Nguyen, Aditya Uppuluri, Paul D Langer, Neelakshi Bhagat","doi":"10.3928/01913913-20240620-04","DOIUrl":"https://doi.org/10.3928/01913913-20240620-04","url":null,"abstract":"","PeriodicalId":50095,"journal":{"name":"Journal of Pediatric Ophthalmology & Strabismus","volume":"61 4","pages":"296-297"},"PeriodicalIF":1.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141753169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Julie M Shabto, Alejandro A Gru, Craig R Soderquist, James Yip, Amy Chadburn, Yue Gu, Brian Marr, Lauren Yeager, Lora R Dagi Glass
{"title":"Pediatric-Type Follicular Lymphoma of the Conjunctiva in Two Adolescents.","authors":"Julie M Shabto, Alejandro A Gru, Craig R Soderquist, James Yip, Amy Chadburn, Yue Gu, Brian Marr, Lauren Yeager, Lora R Dagi Glass","doi":"10.3928/01913913-20240517-01","DOIUrl":"https://doi.org/10.3928/01913913-20240517-01","url":null,"abstract":"<p><p>The authors present two cases of conjunctival pediatric-type follicular lymphoma. A 14-year-old Black boy and 14-year-old Black girl were each referred for evaluation of a painless salmon-colored conjunctival lesion. Both patients underwent excisional biopsy. Histopathology demonstrated follicles with germinal centers composed of atypical B-cells with high Ki67 proliferation index, positive staining for CD20, CD10, and BCL6, and negative for BCL2. This series contributes two cases to the limited literature and presents the first case reported in a female. <b>[<i>J Pediatr Ophthalmol Strabismus</i>. 2024;61(4):e33-e38.]</b>.</p>","PeriodicalId":50095,"journal":{"name":"Journal of Pediatric Ophthalmology & Strabismus","volume":"61 4","pages":"e33-e38"},"PeriodicalIF":1.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141753172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Laura E Andaluz-Scher, Omar J Farhat, Peter J Ness, John W Simon
{"title":"Reply: Late Recurrence of Anisometropic Amblyopia.","authors":"Laura E Andaluz-Scher, Omar J Farhat, Peter J Ness, John W Simon","doi":"10.3928/01913913-20240703-01","DOIUrl":"https://doi.org/10.3928/01913913-20240703-01","url":null,"abstract":"","PeriodicalId":50095,"journal":{"name":"Journal of Pediatric Ophthalmology & Strabismus","volume":"61 4","pages":"298"},"PeriodicalIF":1.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141753174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Strabismus Surgery Following Botulinum Injection for Infantile Esotropia.","authors":"Rudolph S Wagner","doi":"10.3928/01913913-20240626-01","DOIUrl":"https://doi.org/10.3928/01913913-20240626-01","url":null,"abstract":"","PeriodicalId":50095,"journal":{"name":"Journal of Pediatric Ophthalmology & Strabismus","volume":"61 4","pages":"228"},"PeriodicalIF":1.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141753251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bashaer Aldhahwani, Abdulla Shaheen, Charlotte Tibi, Hilda Capo, Kara M Cavuoto
{"title":"Gauging Public Interest in Pediatric Ophthalmology Conditions Using Google Trends.","authors":"Bashaer Aldhahwani, Abdulla Shaheen, Charlotte Tibi, Hilda Capo, Kara M Cavuoto","doi":"10.3928/01913913-20240610-01","DOIUrl":"https://doi.org/10.3928/01913913-20240610-01","url":null,"abstract":"<p><p>Google Trends data were analyzed to assess search trends for pediatric ophthalmology and strabismus terms from 2010 to 2022. The highest average search volumes were \"lazy eye,\" \"strabismus,\" and \"vision therapy.\" \"Amblyopia\" had the lowest search volume. These data highlight the importance of understanding the utilization of online resources in health care and patient education. <b>[<i>J Pediatr Ophthalmol Strabismus</i>. 2024;61(4):e39-e42.]</b>.</p>","PeriodicalId":50095,"journal":{"name":"Journal of Pediatric Ophthalmology & Strabismus","volume":"61 4","pages":"e39-e42"},"PeriodicalIF":1.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141753170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Late Recurrence of Anisometropic Amblyopia.","authors":"Robert W Arnold","doi":"10.3928/01913913-20240620-05","DOIUrl":"https://doi.org/10.3928/01913913-20240620-05","url":null,"abstract":"","PeriodicalId":50095,"journal":{"name":"Journal of Pediatric Ophthalmology & Strabismus","volume":"61 4","pages":"298"},"PeriodicalIF":1.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141753171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Imaging the Conjunctival Nevus in Children: The Utility of an \"Optical Biopsy\".","authors":"Devjyoti Tripathy","doi":"10.3928/01913913-20240208-03","DOIUrl":"10.3928/01913913-20240208-03","url":null,"abstract":"","PeriodicalId":50095,"journal":{"name":"Journal of Pediatric Ophthalmology & Strabismus","volume":" ","pages":"300"},"PeriodicalIF":1.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140121221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jaron K Pruett, Edward F Linton, Sean P Donahue, Sylvia L Groth
{"title":"Accuracy and Reproducibility of Virtual Reality Perimetry in Children.","authors":"Jaron K Pruett, Edward F Linton, Sean P Donahue, Sylvia L Groth","doi":"10.3928/01913913-20240118-03","DOIUrl":"10.3928/01913913-20240118-03","url":null,"abstract":"<p><strong>Purpose: </strong>To determine normal threshold values for the 24-2 program of the VisuALL-K (Olleyes, Inc), a portable static automated virtual reality perimeter that uses a video game-based testing modality on an updated version of the algorithm and to repeat the test to assess retest variability.</p><p><strong>Methods: </strong>This prospective cohort study included 19 participants (aged 8 to 17 years) with healthy afferent systems. Participants performed two 24-2 automated perimetry tests on the virtual reality perimeter device.</p><p><strong>Results: </strong>Mean age was 12.7 ± 2.5 years; 53% were boys and 47% were girls. Mean test location threshold was 30.5 ± 4.0 dB for test 1 and 31.3 ± 2.8 dB for test 2. Sensitivity decreased with eccentricity as expected (-0.17 dB per degree). Bland-Altman analysis showed a repeatability coefficient of ±5.1 dB for mean deviation, meaning that 95% of retest values were within ±5 dB of the threshold value for the first test. Higher thresholds for the first test regressed toward the mean values in the second test, indicating a learning effect. Intraclass correlation coefficient for mean deviation between test 1 and test 2 was 0.70 (0.55 to 0.80, <i>P</i> < .0001). Mean time to completion for the virtual reality perimeter was 5.1 ± 1.5 min/eye.</p><p><strong>Conclusions: </strong>The VisuALL-K virtual reality perimeter provided an assessment of the visual field in normal children aged 8 to 17 years. A shallow hill of vision was demonstrated. A notable learning effect was demonstrated, with repeatability difference wider than other published head-mounted display perimeters. <b>[<i>J Pediatr Ophthalmol Strabismus</i>. 2024:61(4):262-266.]</b>.</p>","PeriodicalId":50095,"journal":{"name":"Journal of Pediatric Ophthalmology & Strabismus","volume":" ","pages":"262-266"},"PeriodicalIF":1.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139913931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zeinab Hashemi Javaheri, Ali Akbar Sabermoghaddam, Mojtaba Abrishami, Mohammad Yaser Kiarudi, Mehrdad Motamed Shariati
{"title":"Evaluation of Macular Neurovasculature and Choroidal Blood Flow Following Inferior Oblique Myectomy Using Optical Coherence Tomography Angiography.","authors":"Zeinab Hashemi Javaheri, Ali Akbar Sabermoghaddam, Mojtaba Abrishami, Mohammad Yaser Kiarudi, Mehrdad Motamed Shariati","doi":"10.3928/01913913-20231221-02","DOIUrl":"10.3928/01913913-20231221-02","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the short-term effects of inferior oblique myectomy on the retinal neurovasculature, choroidal thickness, and choroidal vascularity index at the macula.</p><p><strong>Methods: </strong>Patients older than 5 years who were candidates for inferior oblique muscle myectomy surgery participated in the study. Patients with any systemic or ocular disease that could affect the macular neurovasculature were not included in the study. After recording demographic data, including age and gender, and conducting a complete ophthalmic examination, macular optical coherence tomography (OCT), enhanced depth imaging OCT, and OCT angiography imaging (AngioVue software (V.2017.1.0.151; Optovue, Inc) were performed before (1 day to 1 week) and in the specific time intervals (1 week, 1 month, and 3 months) after the surgery for all participants.</p><p><strong>Results: </strong>Eighteen patients (13 male and 5 female) who underwent inferior oblique muscle myectomy, with a mean ± standard deviation age of 24.22 ± 18.14 years, were included in this study. The baseline mean ± standard deviation of subfoveal choroidal luminal area and subfoveal total choroidal area were 0.390 ± 0.03 and 0.539 ± 0.04 mm<sup>2</sup>, respectively. The changing pattern of the subfoveal choroidal vascularity index and subfoveal choroidal luminal area was statistically significant (<i>P</i> = .013 and .035, respectively).</p><p><strong>Conclusions: </strong>Inferior oblique myectomy can lead to changes in choroid hemodynamics in the short term. However, these changes seem to be temporary. <b>[<i>J Pediatr Ophthalmol Strabismus</i>. 2024;61(4):235-244.]</b>.</p>","PeriodicalId":50095,"journal":{"name":"Journal of Pediatric Ophthalmology & Strabismus","volume":" ","pages":"235-244"},"PeriodicalIF":1.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139565267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}