甲氨蝶呤玻璃体内联合CAR-T治疗前段b细胞急性淋巴细胞白血病复发。

IF 1 4区医学 Q4 OPHTHALMOLOGY

Journal of Pediatric Ophthalmology & Strabismus Pub Date : 2025-03-01 Epub Date: 2024-03-01 DOI:10.3928/01913913-20250117-01

Chathuranka De Silva, Alan Connor, Wing Roberts

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引用次数: 0

摘要

作者提出一个儿童与一个罕见的病例单侧假性低视和升高眼压作为急性淋巴细胞白血病复发的唯一表现。用玻璃体内甲氨蝶呤和嵌合抗原受体t细胞疗法（CAR-T）治疗，随后缓解。本病例证明玻璃体内甲氨蝶呤是一种安全有效的CAR-T辅助治疗伴有眼部受累的复发性急性淋巴细胞白血病。CAR-T疗法和玻璃体内甲氨蝶呤治疗累及眼部的急性淋巴细胞白血病需要进一步的研究。[J].儿童眼斜视，2015;62(2):e18-e21。

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Intravitreal Methotrexate and CAR-T Therapy for Anterior Segment B-Cell Acute Lymphoblastic Leukemia Relapse.

The authors present a child with a rare case of unilateral pseudo-hypopyon and raised intraocular pressure as the only manifestation of acute lymphoblastic leukemia recurrence. This was treated with intravitreal methotrexate and chimeric antigen receptor T-cell therapy (CAR-T) with subsequent remission. This case demonstrates intravitreal methotrexate is a safe and effective adjunct to use with CAR-T therapy for relapsing acute lymphoblastic leukemia with ocular involvement. Further research should be sought on both CAR-T therapy and intravitreal methotrexate for acute lymphoblastic leukemia with ocular involvement. [J Pediatr Ophthalmol Strabismus. 2025;62(2):e18-e21.].

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来源期刊

Journal of Pediatric Ophthalmology & Strabismus 医学-小儿科

CiteScore

1.80

自引率

8.30%

发文量

115

审稿时长

>12 weeks

期刊介绍： The Journal of Pediatric Ophthalmology & Strabismus is a bimonthly peer-reviewed publication for pediatric ophthalmologists. The Journal has published original articles on the diagnosis, treatment, and prevention of eye disorders in the pediatric age group and the treatment of strabismus in all age groups for over 50 years.