Journal of Research in Medical Sciences最新文献

{"title":"Evaluating the effect of cow's milk fortified with albumin powder on malnutrition and anthropometric indices in primary-school children with mild-to-moderate underweight: A randomized double-blinded clinical trial.","authors":"Hajar Davarpanah, Roxaneh Sadat Ziaee, Zahra Esmaeilinezhad, Peyman Etemadfar, Javad Hematyar, Siavash Babajafari, Reza Barati-Boldaji","doi":"10.4103/jrms.jrms_69_21","DOIUrl":"10.4103/jrms.jrms_69_21","url":null,"abstract":"<p><strong>Background: </strong>A proper diet plan is one of the necessary conditions for maintaining the children's health. The aim of this study was to evaluate the effect of consumption of pasteurized cow's milk fortified with albumin protein in primary-school children, in Yasuj, Iran.</p><p><strong>Materials and methods: </strong>In this double-blind randomized clinical trial with 12 weeks of duration, 60 children aged 7-13 years, mild to moderate underweight (-1≥ weight-for-age <i>z</i>-score ≥-3), were randomly assigned to control and albumin groups. The albumin group and the control group received 200 cc of milk with 10 g of albumin powder and 200 cc of milk with 10 g of cornstarch powder, respectively. At the beginning and end of the study, food intake and anthropometric indices were measured.</p><p><strong>Results: </strong>After 12 weeks of intervention, none of the anthropometric indices (weight, weight-for-age <i>z</i>-score, body mass index (BMI), BMI-for-age <i>z</i>-score, and waist circumference) showed significant changes as compared to baseline in the control group, but weight-for-age <i>z</i>-score and BMI-for-age <i>z</i>-score showed significant increase as compared to baseline in the albumin group (before: -2.25 ± 0.40, after: -1.98 ± 0.35, <i>P</i> = 0.001 and before: -3.48 ± 0.86, after: -3.06 ± 0.71, <i>P</i> = 0.009, respectively). The comparison of the mean changes between the two groups showed significant difference regarding weight-for-age <i>z</i>-score (control group: -1.70 ± 0.31 in comparison with albumin group: -1.98 ± 0.35, <i>P</i> = 0.002), BMI (control group: 12.08 ± 1.96 in comparison with albumin group: 12.13 ± 1.49, <i>P</i> = 0.03), and BMI-for-age <i>z</i>-score (control group: -3.11 ± 0.91 in comparison with albumin group: -3.06 ± 0.71, <i>P</i> = 0.02).</p><p><strong>Conclusion: </strong>The consumption of albumin powder with milk can improve weight-for-age <i>z</i>-score and BMI-for-age <i>z</i>-score indices in children with mild-to-moderate underweight. Larger controlled interventional studies with longer duration are recommended.</p>","PeriodicalId":50062,"journal":{"name":"Journal of Research in Medical Sciences","volume":"28 ","pages":"78"},"PeriodicalIF":1.6,"publicationDate":"2023-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10751515/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139049693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of <i>Ganoderma lucidum</i> on serum lipid profiles: A systematic review and meta-analysis on animal studies.","authors":"Maryam Aref, Mehri Khoshhali, Pouria Ghasemi, Shaghayegh Adeli, Motahar Heidari-Beni, Roya Kelishadi","doi":"10.4103/jrms.jrms_175_23","DOIUrl":"10.4103/jrms.jrms_175_23","url":null,"abstract":"<p><strong>Background: </strong><i>Ganoderma lucidum</i> (<i>G. lucidum</i>) is one of the most popular edible mushrooms in the world which has various pharmacological components. Recently, some animal studies have investigated the lipid-lowering effects of <i>G. lucidum</i> and have shown contradictory results. This study aims to systematically review the effects of <i>G. lucidum</i> on lipid parameters in animal studies.</p><p><strong>Materials and methods: </strong>A systematic search was conducted in the Medline database (PubMed), Scopus, Web of Science, Cochrane Library, and Google Scholar up to the end of January 2022. Only animal studies and all eligible randomized controlled trials (RCTs), including cluster RCTs and randomized crossover trials were included. The English language studies that assessed the effects of <i>G. lucidum</i> on lipid profiles including total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and very low-density lipoproteins (VLDL) were selected.</p><p><strong>Results: </strong>Among 358 studies, 49 articles were included in the systematic review and meta-analysis. <i>G. lucidum</i> consumption was associated with decreased levels of TG (standardized mean difference [SMD] = -1.52, 95% CI: -1.79, -1.24), TC (SMD = -1.51, 95% CI: -1.75, -1.27), LDL-C (SMD = -2.03, 95% CI: -2.37, -1.69) and VLDL (SMD =-1.06, 95% CI: -1.638, -0.482). Furthermore, <i>G. lucidum</i> consumption was associated with increased levels of HDL-C (SMD = 1.03, 95% CI: 0.73, 1.33).</p><p><strong>Conclusion: </strong><i>G. lucidum</i> has favorable effects on TG, TC, LDL-C, HDL-C, and VLDL. Different doses of <i>G. lucidum</i> have various degrees of effectiveness on lipid profiles.</p>","PeriodicalId":50062,"journal":{"name":"Journal of Research in Medical Sciences","volume":"28 ","pages":"70"},"PeriodicalIF":1.6,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10729684/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138810198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is skin autofluorescence a novel non-invasive marker in diabetes? A systematic review and meta-analysis of case-control studies.","authors":"Mahboobeh Sadat Hosseini, Zahra Razavi, Razman Arabzadeh Bahri, Amir Houshang Ehsani, Alireza Firooz, Zeinab Aryanian, Ala Ehsani, Yasaman Sadeghi","doi":"10.4103/jrms.jrms_127_23","DOIUrl":"10.4103/jrms.jrms_127_23","url":null,"abstract":"<p><strong>Background: </strong>The advanced glycation end product (AGE) is produced from the nonenzymatic reaction between glucose and macromolecules by aging. Accumulation of AGE causes functional and structural changes in body proteins that lead to impairment of tissue protein functions. We aimed to validate AGE measurement by skin autofluorescence (SAF) in diabetes mellitus (DM) compared to the nondiabetes population.</p><p><strong>Materials and methods: </strong>We searched the PubMed, Cochrane, and Scopus databases from their inception till September 18, 2022, for casecontrol studies measuring AGE by SAF. Nonhuman studies, as well as review articles, study proposals, editorials, case reports, or congress posters, were excluded. We used a random effects model to assess the standard mean difference (MD) of age, body mass index (BMI), HbA1c, and SAF between diabetes and nondiabetes individuals.</p><p><strong>Results: </strong>Higher SAF in DM patients indicated more accumulation of AGE compared with the nondiabetic population. Furthermore, HbA1c was considerably higher in DM patients. The MD of age, male gender, and BMI were significantly different between the DM individuals, compared with nondiabetic subjects, which can lead to altered SAF level and AGE production. There was a remarkable heterogeneity between diabetes and nondiabetes when measuring age, gender, and BMI, as well as HbA1c and SAF level.</p><p><strong>Conclusion: </strong>This study could not confirm the validity of SAF as a surrogate marker in diabetes patients. Interestingly, metabolic load and high BMI can increase SAF, considerably. Altogether, SAF could be helpful in the future as a marker for metabolic syndrome or diabetes.</p>","PeriodicalId":50062,"journal":{"name":"Journal of Research in Medical Sciences","volume":"28 ","pages":"68"},"PeriodicalIF":1.6,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10729688/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138810210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reference range of testosterone and dehydroepiandrosterone sulfate levels in women during reproductive age in the Iranian population.","authors":"Rokhsareh Meamar, Awat Feizi, Ashraf Aminorroaya, Masoud Amini, Bijan Iraj, Maryam Heidarpour","doi":"10.4103/jrms.jrms_100_22","DOIUrl":"10.4103/jrms.jrms_100_22","url":null,"abstract":"<p><strong>Backgrounds: </strong>To determine the average cutoff values of serum-free and total testosterone (FT, TT) and dehydroepiandrosterone sulfate (DHEAS) among healthy premenopausal women.</p><p><strong>Materials and methods: </strong>Participants were women aged 18-55 years without signs and symptoms of hyperandrogenism (<i>n</i> = 489). Participants if Ferriman-Gallwey (FG) scores between 6 and 8 were considered a group located in the upper spectrum related to the normal hirsutism score (<i>n</i> = 30). DHEAS, TT, and FT levels were compared between different populations. Upper limits of 97.5 and 95 and lower limits of 5 and 2.5 percentiles were calculated to provide the reference intervals for DHEA, TT, and FT in the total sample and in the population with FG 6-8.</p><p><strong>Results: </strong>In the total population, the mean ± standard deviation (SD) serum FT, TT, and DHEAS levels were 1.40 ± 0.63 pg/mL, 0.42 ± 0.17 ng/mL, and 1.5 ± 0.97 µg/ml, respectively. The cutoff values of FT at 1.35 and TT at 0.49 were obtained for differentiating the patients with FG 6-8 scores from the normal population, with the corresponding specificity of 0.60, the sensitivity of 0.67, and area under the ROC curve (AUC) (confidence interval 95%) of 0.63 (0.52-0.73), <i>P</i> = 0.01 and 0.68 (0.58-0.78) <i>P</i> = 0.001, respectively.</p><p><strong>Conclusions: </strong>In our study, the mean ± SD serum FT level was 1.40 ± 0.63 pg/mL, the TT level was 0.42 ± 0.17 ng/mL, and the DHEAS level was 1.5 ± 0.97 µg/ml, in premenopausal women between 18 and 49 years of age. Furthermore, in a population with FG 6-8 score, a cutoff value of FT at 1.35 and TT at 0.49 was obtained. Although the irregular menstrual cycle did not change the reference range when compared with the normal group.</p>","PeriodicalId":50062,"journal":{"name":"Journal of Research in Medical Sciences","volume":"28 ","pages":"69"},"PeriodicalIF":1.6,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10729679/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138810221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and efficacy of dinutuximab in the treatment of neuroblastoma: A review.","authors":"Ahmed Bassam Mohd, Omar B Mohd, Yasmeen J Alabdallat, Salem Yousef Al Dwairy, Reem A Ghannam, Balqees M Hanaqtah, Khaled A Albakri","doi":"10.4103/jrms.jrms_727_22","DOIUrl":"10.4103/jrms.jrms_727_22","url":null,"abstract":"<p><p>Dinutuximab, which is a monoclonal antibody targeting GD2 expressed in neuroblasts, improves survival when included in the therapy regimen. This article reviews the importance of dinutuximab in managing neuroblastoma (NB). Dinutuximab targets high levels of GD2 expression in NB cells, thus increasing event-free survival when used in the maintenance therapy of high-risk patients with NB. Although several collaborative studies have set the standard of care for maintenance therapy, the long-term follow-up and continuous evaluation of the use of antibodies and the co-administration of other pharmacological or immunomodulatory drugs remain to be studied. Trials have shown that the use of dinutuximab for maintenance therapy can prolong the time before the first relapse and improve overall survival. However, there is uncertainty in the function of cytokines co-administered with dinutuximab, which may lead to increased toxicity without additional benefits. Recent studies on relapsed and refractory NB have shown the potential efficacy of dinutuximab. Further research is required to properly incorporate Dinutuximab in current treatment modalities.</p>","PeriodicalId":50062,"journal":{"name":"Journal of Research in Medical Sciences","volume":"28 ","pages":"71"},"PeriodicalIF":1.6,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10729685/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138810228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"One-stage total knee arthroplasty for the treatment of acute tibial varus stress fracture secondary to osteoarthritis.","authors":"Abolfazl Bagherifard, Mahmoud Jabalameli, Sina Talebi, Hooman Yahyazadeh","doi":"10.4103/jrms.jrms_182_23","DOIUrl":"10.4103/jrms.jrms_182_23","url":null,"abstract":"","PeriodicalId":50062,"journal":{"name":"Journal of Research in Medical Sciences","volume":"28 ","pages":"72"},"PeriodicalIF":1.6,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10729686/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138810216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Invasive fungal infections in hematologic malignancies: Incidence, management, and antifungal therapy.","authors":"Fatemeh Shafiee, Rasool Soltani, Mohsen Meidani","doi":"10.4103/jrms.jrms_1072_21","DOIUrl":"10.4103/jrms.jrms_1072_21","url":null,"abstract":"<p><p>The incidence of invasive fungal infections (IFIs) has increased in recent years as a result of increasing the incidence of hematologic malignancies (HMs). IFIs, as the opportunistic diseases, are the most important concern in these patients with a high mortality rate. These infections are one of the leading causes of morbidity and mortality in HM patients and an important factor in increasing the costs of patients' management because of the prolonged hospitalization and the inevitable need to use antifungal agents. Due to the changes in the pattern of organisms causing IFIs, unavailability of effective and safe antifungal drugs, and high rate of drug resistance as well as lack of fast and accurate diagnostic methods, these infections have become a serious and life-threatening problem necessitating effective prevention and treatment strategies using suitable antifungal agents, especially in high-risk patients. The aim of the present study was to review the pathogens causing various types of IFIs, diagnostic methods, and novel prophylactic and therapeutic antifungal regimens in HM patients according to the new published studies and clinical trials.</p>","PeriodicalId":50062,"journal":{"name":"Journal of Research in Medical Sciences","volume":"28 ","pages":"73"},"PeriodicalIF":1.6,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10729687/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138810205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The prevalence of varicella zoster virus, herpes simplex virus type 2, and human papillomavirus in breast cancerous tissues and their adjacent ones in Iran.","authors":"Shaian Tavakolian, Ebrahim Faghihloo","doi":"10.4103/jrms.jrms_475_22","DOIUrl":"10.4103/jrms.jrms_475_22","url":null,"abstract":"<p><strong>Background: </strong>Breast cancer is the second type of cancer in the world. Some internal and external risk factors, especially infection diseases, can progress breast cancer. As the relation between varicella zoster virus (VZV), human papillomavirus (HPV), herpes simplex virus type 2 (HSV-2), and breast cancer has not been understood, it was attempting to find the effect of these viruses and breast cancer in this study.</p><p><strong>Materials and methods: </strong>We collected 40 breast cancer and 50 healthy adjacent tissues from Taleghani and Imam Hossein Hospital, Tehran, Iran, in 3 years starting in 2017. After extracting DNA from breast tissues, multiplex polymerase chain reaction (PCR), nested PCR, and PCR were done to analyze the prevalence of HSV-2, VZV, and HPV.</p><p><strong>Results: </strong>Our results showed that HPV may be one of the important causes of breast cancer. Nested PCR illustrated nine breast cancerous tissues (mean age: 43) and three healthy adjacent ones (mean age: 41) were infected by HPV. Phylogenetic analysis illustrated that all of the infected HPV cancerous and healthy tissues were HPV 18 (except two healthy samples infected with HPV 6). Nevertheless, there were not any infected tissues by HSV-2 and VZV.</p><p><strong>Conclusion: </strong>It seems that HPV virus type 18 can have high prevalence in breast cancerous tissues in comparison with healthy adjacent ones, and it is likely to have an effect on breast cancer progression. However, the opposite trend is true for HSV-2 and VZV as we did not find any differences between different kinds of breast tissues.</p>","PeriodicalId":50062,"journal":{"name":"Journal of Research in Medical Sciences","volume":"1 1","pages":"65"},"PeriodicalIF":1.6,"publicationDate":"2023-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10668219/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70820982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The complete reversal effect following angiotensin-converting enzyme inhibitors or angiotensin receptor blockers and beta-blockers after the primary diagnosis of dilated cardiomyopathy.","authors":"Tao Liu, Ping Zhou, Xin Jiang, Na Wang, Jialing Shou, Yuqiang Fang","doi":"10.4103/jrms.jrms_626_21","DOIUrl":"10.4103/jrms.jrms_626_21","url":null,"abstract":"<p><strong>Background: </strong>Whether combination administration of angiotensin-converting enzyme inhibitors (ACEIs), angiotensin receptor blockers (ARBs), and beta-blockers (BBs) has a \"reversal\" effect on cardiac structure and function for first-diagnosed idiopathic dilated cardiomyopathy (FSIDCM) patients with unclear etiologies and inducements is unknown.</p><p><strong>Materials and methods: </strong>We studied the effect of the protocol on FSIDCM patients. The effect was investigated in 26 FSIDCM patients. The criteria of \"complete reversal\" included left ventricular end-diastolic diameter (LVEDD) ≤50 mm for females or ≤55 mm for males and left ventricular ejection fraction (LVEF) ≥45%; the criteria of \"partial reversal\" was the decreased rate of LVEDD (ΔLVEDD) >10% or the increase rate of LVEF (ΔLVEF) >10%; the criteria of \"no reversal\" included LVEDD >50 mm for females or >55 mm for males and ΔLVEDD <10%, and LVEF <45% and ΔLVEF <10%.</p><p><strong>Results: </strong>Within the follow-up period, nine patients showed \"complete reversal,\" eight \"partial reversal,\" and nine \"no reversal.\" Improvements in echocardiogram parameters were the most significant in \"complete reversal\" patients (<i>P</i> < 0.001), followed by \"partial reversal\" and \"no reversal\" patients (<i>P</i> < 0.05). The QRS (Q wave, R wave, S wave) duration and symptoms duration in \"complete reversal\" patients were the shortest, followed by \"partial reversal\" and \"no reversal\" patients.</p><p><strong>Conclusion: </strong>ACEIs or ARBs and BBs have a \"complete reversal\" effect on the left ventricular size and function of some FSIDCM patients. Patients with a narrow QRS and short symptom duration may have a good response.</p>","PeriodicalId":50062,"journal":{"name":"Journal of Research in Medical Sciences","volume":"1 1","pages":"67"},"PeriodicalIF":1.6,"publicationDate":"2023-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10668220/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70821041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation of biofilm formation, virulence factors, and phylogenetic groups among <i>Escherichia coli</i> strains causing urinary tract infection: A global systematic review and meta-analysis.","authors":"Hossein Karballaei Mirzahosseini, Farhad Najmeddin, Atabak Najafi, Arezoo Ahmadi, Hamidreza Sharifnia, Azad Khaledi, Mojtaba Mojtahedzadeh","doi":"10.4103/jrms.jrms_637_22","DOIUrl":"10.4103/jrms.jrms_637_22","url":null,"abstract":"<p><strong>Background: </strong>Different virulence factors are involved in the pathogenesis of urinary tract infection (UTI) caused by Uropathogenic <i>Escherichia coli</i> (UPEC); hence, this study aimed to study the prevalence of biofilm formation, virulence factors, and phylogenetic groups and their correlation with biofilm formation among UPEC isolates through a systematic review and meta-analysis.</p><p><strong>Materials and methods: </strong>A literature search was conducted from 1, 2000, to the end of 2021 in different databases for studies that reported biofilm together with virulence genes or phylogenetic groups in UPEC isolates from patients with UTI according to PRISMA protocol. Data were analyzed by Comprehensive meta-analysis software.</p><p><strong>Results: </strong>The pooled prevalence of biofilm formers was 74.7%. The combined prevalence of phylogenetic Groups A, B1, B2, and D (s) were reported at 19.6%, 11%, 50.7%, and 20.5%, respectively. The most common virulence genes reported worldwide were <i>fimA</i>, <i>ecpA</i>, and <i>fimH</i>, with a combined prevalence of 90.3%, 86.6%, and 64.9%, respectively. The pooled prevalence of biofilm formation in UPEC isolates with phylogenetic Groups A, B1, B2, D, C, and F were 12.4%, 8.7%, 33.7%, 12.4%, 2.6%, and 2.65%, respectively. Several studies showed a correlation between biofilm production and virulence genes, or phylogenetic groups.</p><p><strong>Conclusion: </strong>Regarding data obtained, the high level of combined biofilm formation (74.7%) and the presence of a positive correlation between biofilm production and virulence genes, or phylogenetic groups as reported by the most studies included in the present review, indicates an important role of biofilm in the persistence of UPEC in the UTI.</p>","PeriodicalId":50062,"journal":{"name":"Journal of Research in Medical Sciences","volume":"1 1","pages":"66"},"PeriodicalIF":1.6,"publicationDate":"2023-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10668210/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70821095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}