Journal of Research in Medical Sciences最新文献

{"title":"High amylase concentration in drainage liquid can early predict proximal and distal intestinal anastomotic leakages: A prospective observational study.","authors":"Koceila Amroun,&nbsp;Sophie Deguelte,&nbsp;Zoubir Djerada,&nbsp;Laurent Ramont,&nbsp;Cyril Perrenot,&nbsp;Linda Rached,&nbsp;Yohan Renard,&nbsp;Rami Rhaiem,&nbsp;Reza Kianmanesh","doi":"10.4103/jrms.jrms_273_21","DOIUrl":"https://doi.org/10.4103/jrms.jrms_273_21","url":null,"abstract":"<p><strong>Background: </strong>Anastomotic leak (AL) is a serious complication in digestive surgery. Early diagnosis might allow clinicians to anticipate appropriate management. The aim of this study was to assess the predictive value of amylase concentration in drain fluid for the early diagnosis of digestive tract AL.</p><p><strong>Materials and methods: </strong>Hundred and fourteen consecutive patients \"at risk\" of AL, in whom a flexible drainage was placed by surgeon's choice after digestive anastomosis were included. Patients with eso-gastric, bilio-digestive, and pancreatic anastomoses were excluded. Drain amylase measurement (DAM) was routinely performed on postoperative day (POD) 1, 3, 5-7. DAM values were compared between patients with postoperative AL versus patients without AL. A receiver-operating curve (ROC) with calculation of the areas under the ROC curves area under curves was performed and a cutoff value of DAM was calculated.</p><p><strong>Results: </strong>AL occurred in 25 patients (AL group) and 89 patients did not present AL (C group). The mean DAM was significantly higher in AL group versus C Group on POD 1, 3, and 5. A cutoff value of 307 IU/L predicted the occurrence of AL with a sensitivity and specificity of 91% and 100%, respectively. Positive and negative predictive values were 100% and 97.5%, respectively. Patients with AL had an elevated DAM prior to the appearance of any clinical signs of AL.</p><p><strong>Conclusion: </strong>High level DAM could accurately predict AL for proximal and distal digestive tract anastomoses. This simple, noninvasive, and low-cost method can accurately predict early AL and help physicians to perform appropriate imaging and treatment.</p>","PeriodicalId":50062,"journal":{"name":"Journal of Research in Medical Sciences","volume":"28 ","pages":"5"},"PeriodicalIF":1.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c1/9d/JRMS-28-5.PMC10039101.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9198144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A study on the fungal rhinosinusitis: Causative agents, symptoms, and predisposing factors.","authors":"Ebrahim Taghian,&nbsp;Sayed Hamidreza Abtahi,&nbsp;Abdolrasoul Mohammadi,&nbsp;Seyed Mostafa Hashemi,&nbsp;Kazem Ahmadikia,&nbsp;Somayeh Dolatabadi,&nbsp;Rasoul Mohammadi","doi":"10.4103/jrms.jrms_270_22","DOIUrl":"https://doi.org/10.4103/jrms.jrms_270_22","url":null,"abstract":"<p><strong>Background: </strong>In natural conditions, inhaled fungi are considered a part of the microflora of nasal cavities and sinuses. However, subsequent to the protracted use of corticosteroids and antibacterial agents, suppression of the immune system by chemotherapy, and poor ventilation, these fungi can become pathogens. Fungal colonization in the nose and paranasal sinuses is a prevalent medical issue in immunocompetent and immunosuppressed patients. In this study, we aimed to categorize fungal rhinosinusitis (FRS) among immunocompetent and immunosuppressed patients and identified the etiologic agents of disease by molecular methods.</p><p><strong>Materials and methods: </strong>A total of 74 cases were evaluated for FRS. Functional endoscopic sinus surgery was performed for sampling. The clinical samples were examined by direct microscopy with potassium hydroxide 20% and subcultured on Sabouraud Dextrose Agar with chloramphenicol. Polymerase chain reaction sequencing was applied to identify causative agents.</p><p><strong>Results: </strong>Thirty-three patients (44.6%) had FRS. Principal predisposing factors were antibiotic consumption (<i>n</i> = 31, 93.9%), corticosteroid therapy (<i>n</i> = 22, 66.6%), and diabetes mellitus (<i>n</i> = 21, 63.6%). Eyesore (<i>n</i> = 22, 66.6%), proptosis (<i>n</i> = 16, 48.5%), and headache (<i>n</i> = 15, 45.4%) were the most common clinical manifestations among patients. <i>Rhizopus oryzae</i> (<i>n</i> = 15, 45.4%) and <i>Aspergillus flavus</i> (<i>n</i> = 10, 30.3%) were the most prevalent fungal species.</p><p><strong>Conclusion: </strong>Diagnosis and classification of FRS are crucial, and a lack of early precise diagnosis can lead to a delay in any surgical or medical management. Since there are a variety of treatments for FRS, accurate identification of etiologic agents should be performed based on phenotypic and molecular methods.</p>","PeriodicalId":50062,"journal":{"name":"Journal of Research in Medical Sciences","volume":"28 ","pages":"12"},"PeriodicalIF":1.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e7/c3/JRMS-28-12.PMC10098138.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9316597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differentiation between alcohol-associated cirrhosis and hepatitis B-associated cirrhosis based on hepatic complications and psychological symptoms.","authors":"Yun-Fang Liang,&nbsp;Si-Qi Wang,&nbsp;Zhao-Yu Pan,&nbsp;Zhi-He Deng,&nbsp;Wen-Rui Xie","doi":"10.4103/jrms.jrms_187_22","DOIUrl":"https://doi.org/10.4103/jrms.jrms_187_22","url":null,"abstract":"<p><strong>Background: </strong>The prognosis of and occurrence of complications in patients with different clinical features of cirrhosis differ, and cirrhosis with different etiologies has varying clinical characteristics. The aim of this study was to describe the liver function markers, hepatic complications, and psychological features differentiating patients with hepatitis B virus (HBV) infection-related and alcohol-related cirrhosis.</p><p><strong>Materials and methods: </strong>This was a retrospective and observational study that analyzed the medical data of inpatients with alcohol-related or HBV infection-related cirrhosis from May 2014 to May 2020. Markers of liver function, portal hypertension, and psychological symptoms were compared between the two groups.</p><p><strong>Results: </strong>Patients with alcohol-related cirrhosis showed higher Self-Rating Anxiety Scale scores and prevalence of hypoproteinemia, fatty liver, and depression than those with HBV infection-related cirrhosis (all <i>P</i> < 0.05). After adjustment for potential confounders, patients with alcohol-related cirrhosis also showed higher risks of increased total cholesterol (odds ratio [OR] =2.671, 95% confidence interval [CI]: 1.160-6.151, <i>P</i> = 0.021), increased high-density lipoprotein-cholesterol (OR = 2.714, 95% CI: 1.009-7.299, <i>P</i> = 0.048), and fatty liver (OR = 2.713, 95% CI: 1.002-7.215, <i>P</i> = 0.048); however, splenomegaly and splenectomy were significantly associated with HBV infection-related cirrhosis (OR = 2.320, 95% CI: 1.066-5.050, <i>P</i> = 0.034).</p><p><strong>Conclusion: </strong>Patients with alcohol-related cirrhosis were more likely to develop hyperlipidemia, fatty liver, and psychological symptoms, whereas those with HBV-related cirrhosis had a higher risk of splenomegaly.</p>","PeriodicalId":50062,"journal":{"name":"Journal of Research in Medical Sciences","volume":"28 ","pages":"37"},"PeriodicalIF":1.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ea/6b/JRMS-28-37.PMC10199369.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9503218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A protocol-based checklist for the management of coronavirus disease 2019.","authors":"Behjat Taheri,&nbsp;Amirhossein Akhavan Sigari,&nbsp;Leili Kamali,&nbsp;Ahmad Zarei,&nbsp;Firouzeh Moeinzadeh,&nbsp;Marzieh Salimi Bani,&nbsp;Saeed Abbasi","doi":"10.4103/jrms.jrms_169_22","DOIUrl":"https://doi.org/10.4103/jrms.jrms_169_22","url":null,"abstract":"| 2023 | 1 been dedicated to corticosteroid treatment. Usually, 8 mg of dexamethasone is given daily intravenously for up to 10 days. Higher doses can cause adverse events such as osteoporosis and elevated blood glucose levels[2] 4. Cytokine storm: This section is divided into two sections: diagnostic criteria and treatment. When cytokine storm clinical data are met, the syndrome is confirmed with laboratory testing. Management is l imited to dexamethasone and methylprednisolone in different doses. Tocilizumab is also mentioned at the end of the checklist under the subheading “miscellaneous treatments”[3] 5. Anticoagulation and gastrointestinal care: Based on national protocols, we provide these two sections for prophylactic measures. Prophylactic anticoagulation based on patient body mass index and hospitalization status is provided. Acid blocking agents are also given based on patient risk factors and hospitalization status[4] 6. Antibiotics and antiviral therapy: Based on designated criteria such as refractory fever, decreased consciousness, and oxygen saturation, as well as the physician’s expert opinion, antiviral therapy (remdesivir) and antibiotic treatment are initiated.","PeriodicalId":50062,"journal":{"name":"Journal of Research in Medical Sciences","volume":"28 ","pages":"9"},"PeriodicalIF":1.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/12/85/JRMS-28-9.PMC10039103.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9552622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Family-centered collaborative care for patients with chronic mental illness: A systematic review.","authors":"Raziye Dehbozorgi,&nbsp;Mohsen Shahriari,&nbsp;Malek Fereidooni-Moghadam,&nbsp;Ebrahim Moghimi-Sarani","doi":"10.4103/jrms.jrms_410_22","DOIUrl":"https://doi.org/10.4103/jrms.jrms_410_22","url":null,"abstract":"<p><strong>Background: </strong>Chronic mental illnesses (CMI) are long lasting and reoccurring and require continuous care as well as an integrated and collaborative approach to organize the care. This study sought to examine whether family centered collaborative care is an acceptable treatment option for individuals with CMI.</p><p><strong>Materials and methods: </strong>From the years 2000 to 2021, ten electronic databases relating to family centered collaborative care for mental illness were searched adopting Preferred Reporting Items for Systematic Reviews and Meta Analysis checklist. Twenty seven relevant articles and a thesis from among 6956 studies retrieved, were assessed their quality appraisal through four standardized tools. The studies were rated as good, moderate, or poor. Studies were calibrated, different opinions were discussed, and extracted data were done.</p><p><strong>Results: </strong>Evidence included 11 randomized controlled trials (from 19 articles), one randomized control trial, three mixed methods studies (from 3 articles and 1 thesis), and a qualitative study (from 4 articles). The quality of seven studies was good, 15 were moderate quality, and seven were poor quality. According to moderate to high quality qualitative research, family centered collaborative care was considered an acceptable intervention; though a few studies supported it.</p><p><strong>Conclusion: </strong>The findings demonstrated that family involvement in the care of patients with CMI affects no recurrence of the disease, and no re hospitalization of patients with this disorder. As a result, engaging family members in the care process can have a positive impact on the health and well being of these patients.</p>","PeriodicalId":50062,"journal":{"name":"Journal of Research in Medical Sciences","volume":"28 ","pages":"6"},"PeriodicalIF":1.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/34/28/JRMS-28-6.PMC10039105.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9567385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Designing a tool for measuring determinants of eye self-care and evaluating its psychometric properties.","authors":"Rahmat Chatripour,&nbsp;Awat Feizi,&nbsp;Fereshteh Zamani-Alavijeh,&nbsp;Afsaneh Naderi Beni,&nbsp;Maryam Amidi Mazaheri","doi":"10.4103/jrms.jrms_368_22","DOIUrl":"https://doi.org/10.4103/jrms.jrms_368_22","url":null,"abstract":"<p><strong>Background: </strong>Eye care is crucial for maintaining healthy vision. This study aimed to design a determinants assessment instrument related to eye self-care in the student community and evaluate its psychometric properties.</p><p><strong>Materials and methods: </strong>The present mixed-method cross-sectional study was conducted in two sections using Creswell and Plano Clark methods for instrument development. The study was conducted in Isfahan, Iran, in 2021. The first section (textual analysis and qualitative research) explained and developed the instrument's fundamental items. This section included in-depth, semi-structured interviews with 21 students and eight experts. In the second, the psychometric properties of the designed instrument have been evaluated. Twenty students assessed the instrument's qualitative and quantitative face validity. The instrument's content was measured by computing the content validity ratio and content validity index. In addition, exploratory factor analysis (performed on 251 students) was used to establish construct validity. Internal and test-retest reliability was determined using Cronbach's alpha and intraclass correlation coefficients (ICC), respectively.</p><p><strong>Results: </strong>During face and content validity assessment, a 39-item questionnaire was finalized. Exploratory factor analysis led to the extraction of seven factors, including \"perceived self-efficacy and self-regulation,\" \"outcome expectation,\" \"perceived barriers,\" \"motivation,\" \"perceived susceptibility,\" \"normative beliefs,\" and \"perceived severity.\" The seven extracted factors explained 48.6% of the total variance. Cronbach's alpha was obtained to be 0.780, indicating good internal consistency, and the ICC for the total score of the questionnaire was 0.892 (95% confidence interval: 0.822-0.944), indicating excellent test-retest reliability.</p><p><strong>Conclusion: </strong>Our developed questionnaire was a valid and reliable instrument for assessing eye care determinants among students, a vulnerable population afflicted with eye defects and disorders.</p>","PeriodicalId":50062,"journal":{"name":"Journal of Research in Medical Sciences","volume":"28 ","pages":"34"},"PeriodicalIF":1.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/9e/85/JRMS-28-34.PMC10199367.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9857827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the effects of preoperative celecoxib and gabapentin on pain, functional recovery, and quality of life after total knee arthroplasty: A randomized controlled clinical trial.","authors":"Mehdi Motififard,&nbsp;Saeed Hatami,&nbsp;Awat Feizi,&nbsp;Arash Toghyani,&nbsp;Mohammad Parhamfar","doi":"10.4103/jrms.jrms_416_22","DOIUrl":"https://doi.org/10.4103/jrms.jrms_416_22","url":null,"abstract":"<p><strong>Background: </strong>Acute pain is one of the main complaints of patients after total knee arthroplasty (TKA), which causes delayed mobility, increased morphine consumption, and subsequently increased costs. Therefore, the present study was performed to evaluate the preventive effect of preoperative celecoxib and gabapentin on reducing patient pain as a primary outcome after TKA surgery.</p><p><strong>Materials and methods: </strong>This randomized, double-blind controlled clinical trial was performed on 270 patients with osteoarthritis that were candidates for TKA surgery allocated into three groups. In the first group, 900 mg of gabapentin was administered orally on a daily basis for 3 days before surgery. In the second group, 200 mg of oral celecoxib was administered twice daily for 3 days before surgery. In the third group, oral placebo was administered twice daily for 3 days before the surgery. The patients' pain score and knee and its functional score were recoded.</p><p><strong>Results: </strong>The mean of reduction pain in gabapentin and celecoxib groups was significantly lower than that of the control group at 12, 24, and 48 h after surgery (<i>P</i> < 0.001); however, two groups were not significantly different from each other (<i>P</i> > 0.05). Furthermore, the two medication groups were not significantly different in this regard (<i>P</i> > 0.05). In addition, the knee score in the gabapentin group with the means of 85.40 ± 5.47 and the celecoxib group with the means of 87.03 ± 3.97 were significantly higher than those of the control group with the means of 78.90 ± 4.39 in the 1^st month after the surgery (<i>P</i> < 0.001).</p><p><strong>Conclusion: </strong>According to the results of the present study, the preventive administration of gabapentin and celecoxib showed a significant and similar effectiveness on reducing patient pain after TKA surgery and on improving the KSS and quality of life scores.</p>","PeriodicalId":50062,"journal":{"name":"Journal of Research in Medical Sciences","volume":"28 ","pages":"50"},"PeriodicalIF":1.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d4/e9/JRMS-28-50.PMC10366981.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9872668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reference values for ductus venosus Doppler velocity indices between 11 and 13+6 weeks of gestation: A single-center prospective study in Iran.","authors":"Somayeh Hajiahmadi,&nbsp;Alireza Rezaei Adariani,&nbsp;Ehsan Amini,&nbsp;Sina Rasti","doi":"10.4103/jrms.jrms_808_22","DOIUrl":"https://doi.org/10.4103/jrms.jrms_808_22","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to investigate reference Doppler velocimetry indices (DVIs) of the fetal ductus venosus (DV) during 11-13 + 6 gestational weeks.</p><p><strong>Materials and methods: </strong>In a prospective observation over referrals to a single tertiary care center in a 2-year interval, normal singleton pregnancies with fetal crown-rump lengths (CRLs) of 43-80 mm were examined by a single experienced sonographer for their DV pulsatility index (DVPI), DV resistance index (DVRI), and S-wave maximum velocity/A-wave minimum velocity (S/A ratio). Multinomial and quantile regression functions were used to analyze the effect of gestational age (estimated by CRL) on reference values (5^th and 95^th percentiles of the distribution in each gestational day/week). <i>P</i> < 0.05 was considered significant.</p><p><strong>Results: </strong>Over a sample of 415 participants with a mean/median gestational age of 12 + 1 weeks, no significant correlations were found between the CRL and DVIs using multinomial regression functions (linear model best fitted for all [DVPI: B coefficient = 0.001, <i>P</i> = 0.235] [DVRI: B coefficient = 0.001, <i>P</i> = 0.287] [DV S/A: B coefficient = 0.010, <i>P</i> = 283]). Quantile regression analyses of DVIs' reference values were nonsignificant across the CRL range except for the DVRI ([5^th regression line: coefficient = -0.004, <i>P</i> = 0.018] [95^th regression line: coefficient = -0.001, <i>P</i> = 0.030]).</p><p><strong>Conclusion: </strong>Reference values for DVPI, DVRI, and DV S/A ratios were established as 0.80-1.39, 0.62-0.88, and 2.57-6.70, respectively. Future meta-analyses and multicenter studies are required to incorporate DV DVIs into an updated universal version of the practice.</p>","PeriodicalId":50062,"journal":{"name":"Journal of Research in Medical Sciences","volume":"28 ","pages":"55"},"PeriodicalIF":1.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/27/67/JRMS-28-55.PMC10366976.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9872673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The feasibility of PETHEMA ALL-96 regimen on treatment of patients with acute lymphoid leukemia.","authors":"Farzaneh Ashrafi,&nbsp;Alireza Sadeghi,&nbsp;Ali Derakhshandeh,&nbsp;Padideh Oghab","doi":"10.4103/jrms.jrms_4_22","DOIUrl":"https://doi.org/10.4103/jrms.jrms_4_22","url":null,"abstract":"<p><strong>Background: </strong>Asparaginase-based treatment regimen for acute lymphocytic leukemia (ALL) is considered as feasible, but there is still a lack of data. In this study, considering the results of other regimen that were not optimum in previous studies. Here, we aimed to investigate the feasibility of PETHEMA ALL-96 treatment regimen.</p><p><strong>Materials and methods: </strong>This is a retrospective feasibility study that was performed in 2019-2021 on 13 patients diagnosed with B-cell ALL. Patients were treated by PETHEMA ALL-96 regimen during induction, consolidation, reinduction, and maintenance phases. Patients were followed for 2 years after initiation of PETHEMA ALL-96 regimen for disease-free survival (DFS) and overall survival (OS) of all patients were evaluated after 2 years.</p><p><strong>Results: </strong>Data of 11 patients were analyzed. Within 28 days after treatments, all patients (100%) had no blasts in the bone marrow that was considered as complete remission (CR). The CR rate was 100% within 6 months and 12 months and 81.8% within 2 years after the treatments. Evaluation of OS, CR, and DFS regarding 6, 12, and 24 months showed 100% for all items after 6 and 12 months. After 24 months, the CR was 90.9%, the OS was 81.8% and the DFS was 90.9%. None of the patients died during the induction phase and during the 12 months study. No side effects were observed.</p><p><strong>Conclusion: </strong>The PETHEMA ALL-96 had high feasibility and survival rates with no side effects during the study course. It is believed that PETHEMA ALL-96 regimen has beneficial outcomes in young patients with ALL.</p>","PeriodicalId":50062,"journal":{"name":"Journal of Research in Medical Sciences","volume":"28 ","pages":"30"},"PeriodicalIF":1.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/15/ab/JRMS-28-30.PMC10199372.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9873597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"C-reactive protein, D-dimer, erythrocyte sedimentation rate, and troponin in intensive care unit patients with COVID-19 in Iran.","authors":"Hassan Salehi,&nbsp;Bahram Pakzad,&nbsp;Marzieh Salehi,&nbsp;Saeed Abbasi,&nbsp;Mohammad Mahdi Salehi,&nbsp;Maryam Kazemi Naeini","doi":"10.4103/jrms.jrms_352_22","DOIUrl":"https://doi.org/10.4103/jrms.jrms_352_22","url":null,"abstract":"<p><strong>Background: </strong>The coronavirus disease 2019 (COVID-19) pandemic in Iran has led to a lack of intensive care unit (ICU) facilities. This study examines C-reactive protein (CRP), D-dimer, erythrocyte sedimentation rate (ESR), and troponin in ICU patients with COVID-19 in comparison to COVID-19 patients admitted to the wards in Iran.</p><p><strong>Materials and methods: </strong>In a case-control study, troponin, CRP, ESR, and D-dimer were compared in the case samples of 109 COVID-19 patients admitted to the ICU, and in the control group, 140 COVID-19 patients admitted to the wards.</p><p><strong>Results: </strong>The mean of CRP (<i>P</i> < 0.001) and D-dimer (<i>P</i> < 0.001) was higher, whereas troponin (<i>P</i> < 0.001) was lower in patients admitted to the ICU, but no significant difference was observed between the values of ESR (<i>P</i> = 0.292) in the two groups.</p><p><strong>Conclusion: </strong>This study showed that the values of CRP and D-dimer were higher in patients admitted to the ICU, but no significant difference was observed between the values of ESR in the two groups.</p>","PeriodicalId":50062,"journal":{"name":"Journal of Research in Medical Sciences","volume":"28 ","pages":"56"},"PeriodicalIF":1.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d5/ca/JRMS-28-56.PMC10366978.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9879699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}