Seyyed Majid Bagheri, Mohammad Allahtavakoli, Elham Hakimizadeh
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引用次数: 0
Abstract
Background: In recent years, stroke and ischemia-reperfusion injury has motivated researchers to find new ways to reduce the complications. Although reperfusion is essential for brain survival, it is like a double-edged sword that may cause further damage to the brain. Ischemic postconditioning (IPostC) refers to the control of blood flow in postischemia-reperfusion that can reduce ischemia-reperfusion injuries.
Materials and methods: Articles were collected by searching for the terms: Ischemic postconditioning and neuroprotective and ischemic postconditioning and hyperperfusion. Suitable articles were collected from electronic databases, including ISI Web of Knowledge, Medline/PubMed, ScienceDirect, Embase, Scopus, Biological Abstract, Chemical Abstract, and Google Scholar.
Results: New investigations show that IPostC has protection against hyperperfusion by reducing the amount of blood flow during reperfusion and thus reducing infarction volume, preventing the blood-brain barrier damage, and reducing the rate of apoptosis through the activation of innate protective systems. Numerous mechanisms have been suggested for IPostC, which include reduction of free radical production, apoptosis, inflammatory factors, and activation of endogenous protective pathways.
Conclusion: It seems that postconditioning can prevent damage to the brain by reducing the flow and blood pressure caused by hyperperfusion. It can protect the brain against damages such as stroke and hyperperfusion by activating various endogenous protection systems. In the present review article, we tried to evaluate both useful aspects of IPostC, neuroprotective effects, and fight against hyperperfusion.
背景：近年来，中风和缺血再灌注损伤促使研究人员寻找减少并发症的新方法。虽然再灌注对大脑存活至关重要，但它就像一把双刃剑，可能会对大脑造成进一步损伤。缺血后调节（IPostC）是指在缺血再灌注后控制血流，从而减轻缺血再灌注损伤：通过搜索以下词条收集文章：缺血后条件和神经保护以及缺血后条件和高灌注。从 ISI Web of Knowledge、Medline/PubMed、ScienceDirect、Embase、Scopus、Biological Abstract、Chemical Abstract 和 Google Scholar 等电子数据库中收集合适的文章：新的研究表明，IPostC 对高灌注有保护作用，它能减少再灌注时的血流量，从而减少梗死体积，防止血脑屏障损伤，并通过激活先天保护系统降低细胞凋亡率。IPostC 的作用机制众多，包括减少自由基产生、细胞凋亡、炎症因子和激活内源性保护途径：结论：后调节似乎可以通过减少高灌注引起的血流和血压来防止脑损伤。它可以通过激活各种内源性保护系统来保护大脑免受中风和高灌注等损伤。在这篇综述文章中，我们试图评估 IPostC 的两个有用方面：神经保护作用和抗高灌注。
期刊介绍：
Journal of Research in Medical Sciences, a publication of Isfahan University of Medical Sciences, is a peer-reviewed online continuous journal with print on demand compilation of issues published. The journal’s full text is available online at http://www.jmsjournal.net. The journal allows free access (Open Access) to its contents and permits authors to self-archive final accepted version of the articles on any OAI-compliant institutional / subject-based repository.
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