Journal of Research in Medical Sciences最新文献

{"title":"Association between osteoporosis and refined grain consumption in postmenopausal women: A case-control study.","authors":"Mohammad Mahdi Hajinasab, Mir Saeed Yekaninejad, Behnood Abbasi","doi":"10.4103/jrms.jrms_669_24","DOIUrl":"10.4103/jrms.jrms_669_24","url":null,"abstract":"<p><strong>Background: </strong>Osteoporosis is the leading pathological cause of skeletal fragility. The aim of this study was to investigate the relationship between the consumption of refined grain and osteoporosis in postmenopausal women with and without osteoporosis.</p><p><strong>Materials and methods: </strong>This case-control study involved 356 menopausal women aged 45-85 in Tehran, Iran. The age-matching methodology has been used to mitigate the confounding influence of age. The dual-energy X-ray absorptiometry was utilized to evaluate the bone mineral density. The bone mass status was assessed using the World Health Organization (World Health Organization) criteria. All the participants were divided into two groups based on their T-score: the osteoporosis group and the nonosteoporosis group. A convenience sampling method was applied to select the participants, comprising two groups: case (<i>n</i> = 178) and control (<i>n</i> = 178). Data were gathered utilizing demographic and anthropometric information questionnaires, a validated 147-item food frequency questionnaire, and a physical activity questionnaire. SPSS-27 was used for statistical analyses and <i>P</i> < 0.05 was considered statistically significant.</p><p><strong>Results: </strong>The findings revealed substantial disparities in body mass index (<i>P</i> < 0.001) and physical activity (<i>P</i> < 0.001). The mean ± standard error of the mean consumption of refined grains was greater in participants with osteoporosis (case) (316.76 ± 12.49) compared to the control group (271.50 ± 13.29) (<i>P</i> < 0.001). Upon adjusting for confounding variables, the consumption of refined grains was positively associated with a risk of osteoporosis (odds ratio = 3.26; 95% confidence interval: 1.16-9.17, <i>P</i> = 0.025; Nagelkerke <i>R</i>² = 0.610).</p><p><strong>Conclusions: </strong>We found an association between refined grain consumption and osteoporosis. Additional research is necessary to comprehend this relationship.</p>","PeriodicalId":50062,"journal":{"name":"Journal of Research in Medical Sciences","volume":"30 ","pages":"42"},"PeriodicalIF":1.5,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12445758/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145114542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fractional excretion of sodium and 1-year cardiovascular mortality in acute decompensated heart failure, is there any relationship?","authors":"Seyed Hossein Sharoubandi, Maryam Moshkani Farahani, Arezoo Khosravi, Najmeh Rabanipour","doi":"10.4103/jrms.jrms_153_23","DOIUrl":"10.4103/jrms.jrms_153_23","url":null,"abstract":"<p><strong>Background: </strong>Renal impairment (RI), the most common comorbidity in acute decompensated heart failure (ADHF) patients, leads to cardiorenal syndrome. Fractional excretion of sodium (FENa), an indicator of sodium handling by the kidney, is widely used to assess natriuresis, the underlying treatment of ADHF. The aim of this study was to investigate the association of FENa with RI and 1-year cardiovascular mortality.</p><p><strong>Materials and methods: </strong>This prospective study was implemented in the Persian Registry of Cardiovascular Disease/Heart Failure study context. Any individuals over 18 years suffering from ADHF admitted to the emergency department were eligible to be recruited in our study. We excluded the patients with previously untreated chronic comorbidities, who died during hospitalization, and without follow-up and other etiologies rather than cardiovascular diseases since discharge. Baseline demographic and clinical data gathered. RI was defined as a 0.3 mg/dL rise of creatinine during admission. The primary and secondary clinical outcomes were RI and cardiovascular mortality, respectively.</p><p><strong>Results: </strong>During the study period, 158 patients were recruited, with 103 (65.1%) developing RI and 25.68% of the population expired. Higher blood pressure, overall furosemide dose, as well as lower FENa, and serum creatinine on admission were prevalent among patients who developed RI. Greater serum sodium levels on admission and discharge, a lack of a history of ischemic heart disease, and hyponatremic status during admission were associated with a higher mortality rate. The Pearson correlations demonstrate the significant association of FENa with creatinine alterations (<i>P</i> = 0.001, <i>r</i> = -0.47). The linear regression analysis demonstrates the significant association of FENa with creatinine alteration during admission (<i>B</i> = -1.43, 95% confidence interval [CI] [- 1.86, -1.002], <i>P</i> = 0.001). Multiple logistic regression demonstrates no significant association of prediction of FENa with creatinine alterations (odds ratio [OR] =0.33, 95% CI [0.09-1.19], <i>P</i> = 0.091). The logistic regression analysis revealed no association between FENa and 1-year mortality (OR = 0.85, 95% CI (0.26-2.75), <i>P</i> = 0.79).</p><p><strong>Conclusion: </strong>A lower FENa on admission indirectly predicts the development of RI in patients with ADHF. Meanwhile, FENa is unable to predict 1-year cardiovascular mortality.</p>","PeriodicalId":50062,"journal":{"name":"Journal of Research in Medical Sciences","volume":"30 ","pages":"41"},"PeriodicalIF":1.5,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12445762/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145114567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology, risk factors, and antimicrobial resistance of nosocomial infections in the intensive care unit trauma patients: A cross-sectional study.","authors":"Bahar Darouei, Shiva Jafari, Soodabeh Rostami, Parto Nasri, Hossein Mahjoobipour, Saeed Abbasi","doi":"10.4103/jrms.jrms_469_25","DOIUrl":"10.4103/jrms.jrms_469_25","url":null,"abstract":"<p><strong>Background: </strong>Healthcare-associated infections (HAIs) remain a critical challenge, particularly in trauma patients admitted to intensive care units (ICUs), who are at increased risk due to invasive procedures and prolonged hospitalization. This study aimed to investigate the prevalence, types, causative pathogens, and antibiotic resistance patterns of nosocomial infections in trauma patients.</p><p><strong>Materials and methods: </strong>In this retrospective cross-sectional study conducted from March 2019 to March 2020, 45 trauma patients who developed nosocomial infections 48 h after ICU admission were analyzed. Data were collected from the hospital records and the Iranian Nosocomial Infection Surveillance System.</p><p><strong>Results: </strong>Of 557 trauma patients admitted to the ICU, 45 (7.9%) developed 65 episodes of HAIs during the study, of which 12.3% (8/65) were polymicrobial. Ventilator-associated events (VAE) were the most common infection type (58.2%), followed by bloodstream (20.9%), surgical site (14.9%), and urinary tract infections (6%). <i>Acinetobacter</i> spp. was the most frequently isolated pathogen (49.4%), followed by <i>Klebsiella</i> spp<i>.</i> (27.7%). High levels of antibiotic resistance have been observed, particularly in Gram-negative bacteria. No statistically significant associations were found between infection type, trauma severity, or underlying comorbidities.</p><p><strong>Conclusion: </strong>VAE and multidrug-resistant <i>Acinetobacter</i> species are major concerns in trauma patients in the ICU. Strengthening infection prevention protocols, especially ventilator care practices, and implementing antimicrobial stewardship programs are essential for mitigating infection risk. Furthermore, enhanced surveillance systems, targeted antibiotic therapy guided by local antibiograms, and multicenter research collaborations are strongly recommended for addressing the emerging threat of antibiotic-resistant nosocomial infections.</p>","PeriodicalId":50062,"journal":{"name":"Journal of Research in Medical Sciences","volume":"30 ","pages":"45"},"PeriodicalIF":1.5,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12445767/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145114535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Generative artificial intelligence: In the search for new landscapes in basic and clinical nephrology.","authors":"Farnoush Kiyanpour, Ali Motahharynia, Marek Ostaszewski, Yousof Gheisari","doi":"10.4103/jrms.jrms_71_25","DOIUrl":"10.4103/jrms.jrms_71_25","url":null,"abstract":"<p><p>The rise of systems biology has improved the understanding of complex disorders such as chronic kidney disease by providing predictive and comprehensive models. Despite the abundance of omics data, translation to clinical solutions remains a challenge. Artificial intelligence (AI), especially generative AI, promises to fill this gap through mining, integration, and processing of diverse and intricate raw data for the generation of actionable knowledge. Recently introduced AI tools have shown great potential in clinical nephrology for improved diagnosis and prognosis. This approach is also promising for the identification of novel therapeutic targets, repurposing of already approved drugs, and precision nephrology. The rapid advancement of this technology is definitely associated with critical ethical and legal concerns for which the scientific community needs to be prepared.</p>","PeriodicalId":50062,"journal":{"name":"Journal of Research in Medical Sciences","volume":"30 ","pages":"44"},"PeriodicalIF":1.5,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12445765/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145114622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic methods and therapeutics strategies of <i>Legionella</i> infection in postbone marrow transplantation.","authors":"Sajad Ataei Azimi, Zahra Ghorbani, Azad Khaledi, Kimia Safa","doi":"10.4103/jrms.jrms_128_25","DOIUrl":"10.4103/jrms.jrms_128_25","url":null,"abstract":"<p><p>Organ transplantation represents a critical therapeutic intervention for patients with end-stage organ failure or hematological malignancies, often serving as a last-resort treatment. Among these, bone marrow transplantation (BMT) is vital but complex, as it induces profound and long-lasting immunosuppression. Patients undergoing BMT are highly vulnerable to opportunistic infections due to concurrent chemotherapy, radiation, and immunosuppressive therapies. <i>Legionella</i> infections emerge as a significant threat, accounting for considerable morbidity and mortality in hospitalized immunocompromised individuals. These infections often progress rapidly to severe pneumonia, with high mortality rates compared to those infecting immunocompetent people. Early and accurate diagnosis remains challenging due to nonspecific clinical presentations and limitations of conventional microbiological methods. Consequently, timely detection using advanced diagnostic tools and therapeutic intervention is necessary. This comprehensive review critically observes the epidemiology, risk factors, diagnostic methods, clinical manifestations, and treatments of <i>Legionella</i> in BMT recipients. It emphasizes the need for institutional prevention protocols to alleviate the exposure risks to reduce the burden of <i>Legionella</i>-related complications in high-risk BMT recipients.</p>","PeriodicalId":50062,"journal":{"name":"Journal of Research in Medical Sciences","volume":"30 ","pages":"43"},"PeriodicalIF":1.5,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12445764/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145114550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolic surgery versus usual care effects on mortality among patients with obesity and type 2 diabetes: A systematic review and meta-analysis.","authors":"Ibrahim Altedlawi Albalawi, Hyder Mirghani","doi":"10.4103/jrms.jrms_360_24","DOIUrl":"10.4103/jrms.jrms_360_24","url":null,"abstract":"<p><p>Although bariatric surgery is recommended for obesity treatment, there is an increasing trend toward comorbidity-related indications. The effects of bariatric surgery on mortality are inconsistent. This meta-analysis aimed to assess metabolic surgery versus usual care on mortality among patients with obesity and type 2 diabetes. we searched six databases for articles comparing bariatric surgery with usual care in terms of mortality. The terms used were bariatric surgery, metabolic surgery, lifestyles, usual care, gastric banding, bypass surgery, biliopancreatic diversion, gastric bypass, sleeve gastrectomy, and Roux-en-Y gastric bypass. The search engine was set for articles from inception up to June 2024. Out of the 1960 studies retrieved, 1810 were retained after the removal of duplication; from them, 75 full texts were eligible, and only 26 studies were included in the final meta-analysis. The study included 866,159 patients (167,152 patients who underwent bariatric surgery and 699,007 usual care patients) and 91,211 deaths. Mortality was lower among patients with bariatric surgery compared to usual care (3.1% vs. 12.6%), odds ratio = 0.43, 95% confidence interval (CI), 0.32-0.58, Chi-square = 1638.20, and <i>P</i> < 0.001, <i>I</i> ² for heterogeneity = 99%, and the standard difference = 24. Mortality was higher in bariatric surgery in subgroup meta-analysis on patients with type 2 diabetes (2.6% versus 2.0%), odds ratio, 0.63, 95% CI, 0.42-0.95, Chi-square = 101.04, and <i>P</i> = 0.03 <i>I</i> ² for heterogeneity = 95%, and the standard difference = 5. Bariatric surgery was associated with lower mortality in patients with obesity compared to usual care, but higher mortality in subgroup meta-analysis in type 2 diabetes. Larger, well-controlled trials are needed.</p>","PeriodicalId":50062,"journal":{"name":"Journal of Research in Medical Sciences","volume":"30 ","pages":"41"},"PeriodicalIF":1.5,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12352692/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144876509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of cardiac sarcoidosis in Iranian patients using cardiac magnetic resonance and positron emission tomography imaging techniques.","authors":"Simin Almasi, Amir Azimi, Kiyan Heshmat-Ghahdarijani, Amir Ghaffari Jolfayi, Mahsa Ghorbani, Shahla Meshgi, Maedeh Dastmardi, Ghazaleh SalehAbadi, Ali Mohammadzadeh","doi":"10.4103/jrms.jrms_136_25","DOIUrl":"10.4103/jrms.jrms_136_25","url":null,"abstract":"<p><strong>Background: </strong>Cardiac involvement in sarcoidosis is associated with high mortality but is often underrecognized due to diagnostic challenges. Advanced imaging modalities like Cardiac Magnetic Resonance (CMR) and Fluorodeoxyglucose Positron Emission Tomography (FDG-PET) are highly sensitive for detecting myocardial inflammation and scarring, aiding in the diagnosis and management of cardiac sarcoidosis. The objective of this study was to characterize the imaging features of cardiac sarcoidosis in Iranian patients using these advanced cardiac imaging modalities.</p><p><strong>Materials and methods: </strong>This multicenter prospective study included 42 Iranian patients with biopsy-proven extracardiac sarcoidosis who met the Japanese Circulation Society criteria for cardiac involvement. All patients underwent CMR to evaluate myocardial function, edema, scarring, and strain. 28 patients also underwent FDG-PET/CT to assess active myocardial inflammation.</p><p><strong>Results: </strong>In our study of 42 cardiac sarcoidosis patients (50% male, mean age 47.14±14.33 years), CMR revealed reduced left ventricular ejection fraction (34.2±13.7%) in 83.3% of patients, with late gadolinium enhancement (LGE) present in 88.1%. LGE was most frequent in the basal anteroseptal and mid inferoseptal/anteroseptal segments, with midwall (35.5%) and subepicardial (23.7%) patterns predominating. Global strain analysis showed impaired values: longitudinal -10.08±4.14%, radial 15.38±8.55%, and circumferential -10.79±4.63%. Mean T1 and T2 values were 1054.60±50.98 ms and 52.59±4.53 ms, respectively. FDG-PET demonstrated active disease in 67.9% of cases, predominantly involving the apical septum, basal inferolateral, and mid inferolateral segments. The left anterior descending artery territory showed the highest involvement in both active inflammation (44.3% of affected segments) and scarring (39.2% of affected segments).</p><p><strong>Conclusion: </strong>CMR and FDG-PET provided comprehensive assessment of cardiac involvement in this Iranian cardiac sarcoidosis cohort, with predominant basal and lateral wall involvement. Regional differences highlight the importance of population-specific studies.</p>","PeriodicalId":50062,"journal":{"name":"Journal of Research in Medical Sciences","volume":"30 ","pages":"40"},"PeriodicalIF":1.5,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12352693/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144876505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is it time to administer the pneumococcal vaccine to healthy unvaccinated children older than 5 years of age?","authors":"Shirin Sayyahfar","doi":"10.4103/jrms.jrms_463_24","DOIUrl":"10.4103/jrms.jrms_463_24","url":null,"abstract":"","PeriodicalId":50062,"journal":{"name":"Journal of Research in Medical Sciences","volume":"30 ","pages":"37"},"PeriodicalIF":1.5,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12352687/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144876508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of serum ischemia-modified albumin levels in high-normal blood pressure category.","authors":"Okan Tanriverdi, Alper Sercelik","doi":"10.4103/jrms.jrms_43_25","DOIUrl":"10.4103/jrms.jrms_43_25","url":null,"abstract":"<p><strong>Background: </strong>High-normal blood pressure (BP), situated inside the elevated normal range and indicative of potential hypertension, is widely acknowledged as a critical worldwide health issue. High-normal BP levels consist of a systolic measurement of 130-139 mmHg and a diastolic measurement of 85-89 mmHg. Ischemia-modified albumin (IMA) is a sign that tissues are not getting enough oxygen, which is also known as tissue hypoxia. Numerous studies indicate that IMA possesses prognostic relevance in cardiovascular diseases. Our purpose was to investigate the serum IMA levels in patients with high-normal BP.</p><p><strong>Materials and methods: </strong>The study prospectively enrolled 50 participants with high-normal BP and 50 individuals with normal BP consecutively. Both groups' IMA levels were assessed and compared. All patients' echocardiograms were collected.</p><p><strong>Results: </strong>The IMA values were markedly elevated in the high-normal group (<i>P</i> < 0.001). The research identified a significant correlation between IMA and high-normal BP, with an odds ratio of 1.725 (95% confidence interval [CI] 1.212-2.506, <i>P</i> < 0.001). An IMA level of 348 ng/L demonstrated a 94% accuracy in predicting high-normal BP, with a 32% accuracy overall (area under the curve = 0.942; 95% CI, 0.894-0.991; <i>P</i> < 0.001).</p><p><strong>Conclusion: </strong>Our analysis demonstrated a strong correlation between IMA and high-normal BP.</p>","PeriodicalId":50062,"journal":{"name":"Journal of Research in Medical Sciences","volume":"30 ","pages":"38"},"PeriodicalIF":1.5,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12352686/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144876507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of rituximab in secondary progressive multiple sclerosis: Insights from magnetic resonance imaging and disability assessments.","authors":"Fereshteh Ashtari, Yousef Mokary, Iman Adibi, Vahid Shaygannejad, Neda Ramezani, Fariba Davanian, Maryam Ahmadi","doi":"10.4103/jrms.jrms_690_24","DOIUrl":"10.4103/jrms.jrms_690_24","url":null,"abstract":"<p><strong>Background: </strong>Although there are a few options for the treatment of patients with secondary progressive multiple sclerosis (SPMS), rituximab (RTX) is used as an off-label treatment. This study aimed to investigate the efficacy of RTX on disability status and volumetric magnetic resonance imaging (MRI) findings in SPMS.</p><p><strong>Materials and methods: </strong>This study was conducted on 31 patients with SPMS treated with RTX 1000 mg intravenously every 6 months. Expanded Disability Status Scale (EDSS), 25-Foot Walk Test (25-FWT), 9-Hole Peg Test (9-HPT), and brain MRI were performed at the baseline and after 12 months.</p><p><strong>Results: </strong>No significant changes were observed in EDSS, timed 25-FWT, and 9-HPT within 12 months of RTX treatment (<i>P</i> > 0.05). There was a decrease in 9-HPT time in both the right and left hands, but it was not significant. During the 12-month assessment, white matter (WM) and gray matter volumes decreased by -41.48 ± 2.36 and -31.65 ± 8.84, respectively. However, these differences were not statistically significant (<i>P</i> > 0.05). The only significant change was an increase in the volume of deep WM lesions (WMLs) (0.26 ± 0.19 vs. 0.38 ± 0.29, <i>P</i> = 0.024). A significant association was found between the EDSS at the 12^th month and baseline deep WML volume (<i>r</i> = 0.383, <i>P</i> = 0.044).</p><p><strong>Conclusion: </strong>Our results showed that the level of disability based on EDSS, timed 25-FWT, and 9-HPT did not increase significantly during 12 months of treatment with RTX. These findings suggest that RTX may play a role in disease stabilization and preventing disability progression, especially in the upper limbs. Further studies with larger sample sizes are necessary to confirm this finding.</p>","PeriodicalId":50062,"journal":{"name":"Journal of Research in Medical Sciences","volume":"30 ","pages":"39"},"PeriodicalIF":1.5,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12352689/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144876506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}