Journal of Research in Medical Sciences最新文献

Investigating outcomes and treatment of long coronavirus disease 2019 in patients with multiple sclerosis treated with rituximab: A case series study. 利妥昔单抗治疗多发性硬化症患者2019年长冠状病毒病的疗效和治疗：一项病例系列研究

IF 1.5 4区医学

Journal of Research in Medical Sciences Pub Date : 2025-05-26 eCollection Date: 2025-01-01 DOI: 10.4103/jrms.jrms_150_25

Kiana Shirani, Farzin Khorvash, Alireza Karamshahi, Asieh Maghamimehr

{"title":"Investigating outcomes and treatment of long coronavirus disease 2019 in patients with multiple sclerosis treated with rituximab: A case series study.","authors":"Kiana Shirani, Farzin Khorvash, Alireza Karamshahi, Asieh Maghamimehr","doi":"10.4103/jrms.jrms_150_25","DOIUrl":"10.4103/jrms.jrms_150_25","url":null,"abstract":"Multiple sclerosis (MS) is a chronic autoimmune disease affecting the central nervous system, characterized by the destruction of the myelin sheath of nerves. MS patients treated with rituximab, an immunosuppressive drug, experience reduced immunoglobulin levels, which increases their risk of various infections, including coronavirus disease 2019 (COVID-19). During the COVID-19 pandemic, many of these patients developed long-term symptoms following infection. These chronic symptoms have led to significant complications and, in some cases, increased mortality. In this case series study, we investigated long COVID-19 symptoms in MS patients treated with rituximab and the effects of intravenous immunoglobulin (IVIG) therapy in alleviating chronic symptoms. The results demonstrated that the patients' long-term symptoms responded to IVIG treatment, with significant improvements in respiratory symptoms, fever, immune parameters, and a reduction in C-reactive protein levels. This study highlights the importance of targeted management of long COVID-19 in immunocompromised populations and suggests that COVID-19 patients with immune deficiencies require specific therapeutic approaches.","PeriodicalId":50062,"journal":{"name":"Journal of Research in Medical Sciences","volume":"30 ","pages":"26"},"PeriodicalIF":1.5,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12156028/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144276483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integration of three-dimensional multicolor holography with microfluidic three-dimensional biofilm-on-a-chip technology for advancing the treatment of diabetic foot ulcers: An innovation in phage therapy. 整合三维多色全息与微流控三维生物膜芯片技术推进糖尿病足溃疡的治疗：噬菌体治疗的一项创新。

IF 1.5 4区医学

Journal of Research in Medical Sciences Pub Date : 2025-05-26 eCollection Date: 2025-01-01 DOI: 10.4103/jrms.jrms_155_25

Ankit K Badge, Ishmita Sharma, Nandkishor J Bankar, Obaid Noman

引用次数: 0

Diagnostic value of circular RNAs as promising hematological biomarkers in acute myeloid leukemia: A systematic review and meta-analysis. 环状rna作为有希望的血液生物标志物在急性髓系白血病中的诊断价值：一项系统综述和荟萃分析。

IF 1.5 4区医学

Journal of Research in Medical Sciences Pub Date : 2025-05-26 eCollection Date: 2025-01-01 DOI: 10.4103/jrms.jrms_287_24

Amir Hossein Aghayan, Yasin Mirazimi, Zahra Sadat Hosseini, Mohammad Rafiee

{"title":"Diagnostic value of circular RNAs as promising hematological biomarkers in acute myeloid leukemia: A systematic review and meta-analysis.","authors":"Amir Hossein Aghayan, Yasin Mirazimi, Zahra Sadat Hosseini, Mohammad Rafiee","doi":"10.4103/jrms.jrms_287_24","DOIUrl":"10.4103/jrms.jrms_287_24","url":null,"abstract":"Despite significant advancements in the diagnosis and treatment of acute myeloid leukemia (AML), patients still face poor diagnosis with unsatisfactory survival, so it is imperative to explore novel diagnostic biomarkers to improve early detection and treatment outcomes. Thus, here, the potential role of circular RNAs (circRNAs) in AML diagnosis is reviewed. PubMed, Scopus, WOS, ProQuest databases, and Google Scholar search engines were searched for studies published through March 2023. The results were assessed using the modified method of GRADE assessment. The sensitivity (SEN), specificity (SPE), positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and area under the summary receiver operating characteristic curve (AUC) were combined to investigate the diagnostic role of circRNAs in AML. The number of studies included in this systematic review and meta-analysis was 18. For the diagnostic value of circRNAs in AML, the pooled SEN, SPE, PLR, and NLR were 0.85 (95% confidence interval [CI]: 0.80-0.89), 0.85 (95% CI: 0.82-0.88), 5.74 (95% CI: 4.49-7.33), and 0.18 (95% CI: 0.13-0.24), respectively. Furthermore, the pooled DOR and AUC were 32.71 (95% CI: 20.09-53.24) and 0.91 (95% CI: 0.88-0.93), respectively. Furthermore, through subgroup analysis, it is better to have a sample size above 120 and a control/patient ratio above 50%. In addition, Deek's funnel plot demonstrated nonconsiderable publication bias (P = 0.65). Finally, according to the GRADE assessment for diagnostic tests, the certainty of evidence regarding sensitivity and specificity was moderate. Our systematic review and meta-analysis suggest the analysis of circRNAs expression as promising and valuable biomarkers related to the diagnosis of AML and also can be helpful in the diagnosis of AML patients as a noninvasive and low-cost method.","PeriodicalId":50062,"journal":{"name":"Journal of Research in Medical Sciences","volume":"30 ","pages":"31"},"PeriodicalIF":1.5,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12156066/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144276481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comment on "Significant association between insulin-like growth factor 2 mRNA-binding protein 2, interleukin-6 polymorphisms, and type 2 diabetes mellitus". 对“胰岛素样生长因子2 mrna结合蛋白2、白细胞介素6多态性与2型糖尿病的显著相关性”的评论。

IF 1.5 4区医学

Journal of Research in Medical Sciences Pub Date : 2025-05-26 eCollection Date: 2025-01-01 DOI: 10.4103/jrms.jrms_727_24

Saurabh RamBihariLal Shrivastava

引用次数: 0

The effectiveness of mobile health intervention in colorectal cancer screening in Iran. 流动健康干预在伊朗结直肠癌筛查中的有效性

IF 1.5 4区医学

Journal of Research in Medical Sciences Pub Date : 2025-05-26 eCollection Date: 2025-01-01 DOI: 10.4103/jrms.jrms_21_25

Zivar Rostami, Sareh Shakerian

{"title":"The effectiveness of mobile health intervention in colorectal cancer screening in Iran.","authors":"Zivar Rostami, Sareh Shakerian","doi":"10.4103/jrms.jrms_21_25","DOIUrl":"10.4103/jrms.jrms_21_25","url":null,"abstract":"Background: This study aimed to evaluate the impact of mobile health (mHealth) intervention on colorectal cancer (CRC) screening.Materials and methods: This semiexperimental study collected data from individuals aged 50-70 years who had no history of CRC screening. Participants (n = 350) were randomly assigned to one control and five intervention groups. The data were collected by theory-based CRC screening questionnaire before and after the mHealth intervention.Results: The results indicated a significant improvement in screening rates when utilizing mHealth interventions, which included text messages, videos, and telephone calls from health workers, showing a rate of 68.6% (P < 0.001) compared to 5.7% of individuals in the routine care group. Logistic regression analysis revealed that \"perceived severity\" and \"perceived benefits\" were significantly associated with increased screening uptake, compared to the routine care group.Conclusion: The current study indicates that mobile phone technology significantly impacts the outreach efforts for encouraging the covered population to participate in screening.","PeriodicalId":50062,"journal":{"name":"Journal of Research in Medical Sciences","volume":"30 ","pages":"29"},"PeriodicalIF":1.5,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12156048/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144276484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of fibrinogen-to-albumin ratio in patients with isolated coronary artery ectasia. 孤立性冠状动脉扩张患者纤维蛋白原与白蛋白比值的关系。

IF 1.5 4区医学

Journal of Research in Medical Sciences Pub Date : 2025-05-26 eCollection Date: 2025-01-01 DOI: 10.4103/jrms.jrms_104_25

Okan Tanriverdi, Alper Sercelik

{"title":"Association of fibrinogen-to-albumin ratio in patients with isolated coronary artery ectasia.","authors":"Okan Tanriverdi, Alper Sercelik","doi":"10.4103/jrms.jrms_104_25","DOIUrl":"10.4103/jrms.jrms_104_25","url":null,"abstract":"Background: Previous research has indicated that chronic inflammation plays a significant role in the development of coronary artery ectasia (CAE). However, there is limited data on the role of plasma fibrinogen-to-albumin ratio (PFAR) in CAE patients. Our study aimed to explore the connection between PFAR and the presence of CAE.Materials and methods: This research used a case-control methodology. We included a total of 108 consecutive patients who had CAE without any stenosis. Among them, there were 65 males and 43 females, with a mean age of 58.2 ± 8.5 years. The control group included 102 consecutive participants with angiographically normal coronary arteries, consisting of 62 males and 40 women, with a mean age of 57.3 ± 8.6 years. Statistical analyses were conducted using Student's-t-test, Mann-Whitney U-test, Chi-square test, linear regression, logistic regression, and receiver operating characteristic (ROC) curve analysis.Results: PFAR in the CAE group was significantly higher compared to the controls (84.8 ± 7.4 vs. 70.1 ± 9.5, P < 0.001). Using multiple logistic regression showed a strong link between PFAR and CAE, with an odds ratio for PFAR of 1.818 (95% confidence interval [CI] 1.092-6.201; P = 0.005). PFAR was exceeded 72.6, the sensitivity and specificity were 80.2% and 72.6%, respectively. The area under the ROC curve (area under the curve) was 0.731 (95% CI: 0.659-0.803, P = 0.028).Conclusion: In our study, we found that PFAR levels were notably higher in the CAE group compared to the control group, and we observed a significant correlation between PFAR and CAE.","PeriodicalId":50062,"journal":{"name":"Journal of Research in Medical Sciences","volume":"30 ","pages":"30"},"PeriodicalIF":1.5,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12165309/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144303447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sonographic features of internal carotid artery in patients with opioid use disorder: Is opium a new risk factor for atherosclerosis of internal carotid artery? 阿片类药物使用障碍患者颈内动脉超声特征：鸦片是颈内动脉粥样硬化的新危险因素吗？

IF 1.5 4区医学

Journal of Research in Medical Sciences Pub Date : 2025-04-30 eCollection Date: 2025-01-01 DOI: 10.4103/jrms.jrms_706_24

Zahra Masoumi, Mohammad Amin Najafi, Amir Soroush Mohammadi, Mohammad Saadatnia

{"title":"Sonographic features of internal carotid artery in patients with opioid use disorder: Is opium a new risk factor for atherosclerosis of internal carotid artery?","authors":"Zahra Masoumi, Mohammad Amin Najafi, Amir Soroush Mohammadi, Mohammad Saadatnia","doi":"10.4103/jrms.jrms_706_24","DOIUrl":"10.4103/jrms.jrms_706_24","url":null,"abstract":"Background: Opium use disorder (OUD) is prevalent worldwide. Despite its traditional use, recent studies suggest that OUD may exacerbate atherosclerosis and ischemic stroke. This study investigates the effect of OUD on internal carotid artery sonographic findings using B-mode Doppler sonography.Materials and methods: A case-control study was conducted in Isfahan, Iran, from 2021 to 2023. A total of 295 patients, including 95 with OUD and 200 without, were evaluated through medical records and B-mode Doppler sonography to assess atherosclerotic plaques, vulnerability of plaques, carotid artery stenosis, and carotid artery intima-media thickness (CIMT). Data on age, sex, smoking, and medical history were also collected.Results: The OUD group had a higher prevalence of tobacco smoking (56% vs. 18%; P < 0.001). Atherosclerotic plaques were more common in OUD patients (83% vs. 65%; P = 0.001). Vulnerable plaques were more frequent in OUD patients (19% vs. 9%; P = 0.039). OUD patients were three times more likely to have carotid artery stenosis (85% vs. 65%; P < 0.001) and had a higher incidence of more than 70% stenosis (33.8% vs. 16%; P = 0.003). CIMT was significantly higher in the OUD group (0.95 mm vs. 0.87 mm; P < 0.001). Logistic regression analysis revealed that OUD was independently associated with atherosclerotic plaque, carotid stenosis, stenosis of more than 70%, and CIMT (P < 0.05).Conclusion: This study highlights a significant association between OUD and sonographic markers of carotid atherosclerosis, including increased intima-media thickness, higher prevalence of atherosclerotic plaques, and stenosis of more than 70%. We suggest OUD as a potential risk factor for carotid artery atherosclerosis.","PeriodicalId":50062,"journal":{"name":"Journal of Research in Medical Sciences","volume":"30 ","pages":"21"},"PeriodicalIF":1.5,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12087906/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144102593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of complete blood count parameters in different severity of proteinuria among patients with type 2 diabetes mellitus. 2型糖尿病不同程度蛋白尿患者全血细胞计数参数的比较。

IF 1.5 4区医学

Journal of Research in Medical Sciences Pub Date : 2025-04-30 eCollection Date: 2025-01-01 DOI: 10.4103/jrms.jrms_715_24

Mahboubeh Neamatshahi, Aghil Keykhosravi

引用次数: 0

Assessment of nutritional status and associated factors among hemodialysis patients in Isfahan, Iran. 伊朗伊斯法罕血液透析患者营养状况及相关因素评估

IF 1.5 4区医学

Journal of Research in Medical Sciences Pub Date : 2025-04-30 eCollection Date: 2025-01-01 DOI: 10.4103/jrms.jrms_26_25

Elham Kabiri Naeini, Elahe Zakizade, Milad Maghsoudi, Mohammad Javad Tarrahi, Shirin Meshkinfar, Zahra Iraj, Narges Heydari

{"title":"Assessment of nutritional status and associated factors among hemodialysis patients in Isfahan, Iran.","authors":"Elham Kabiri Naeini, Elahe Zakizade, Milad Maghsoudi, Mohammad Javad Tarrahi, Shirin Meshkinfar, Zahra Iraj, Narges Heydari","doi":"10.4103/jrms.jrms_26_25","DOIUrl":"10.4103/jrms.jrms_26_25","url":null,"abstract":"Background: This study aims to evaluate the nutritional condition of individuals undergoing hemodialysis (HD) in Isfahan, Iran.Materials and methods: This cross-sectional study involved 201 HD patients. The modified quantitative subjective global assessment was employed to evaluate nutritional status, along with the collection of sociodemographic data, anthropometric measurements, and biochemical tests.Results: The participants had a mean age of 60.2 ± 16.24 years, with 70 (34.83%) being female. The prevalence of malnutrition was 63.18%, with 60.2% classified as mild-moderately malnutrition and 2.98% identified as severely malnutrition. The participants had a mean body mass index (BMI) of 24.6 ± 5.0 (kg/m2), while 7.96% of patients had a BMI below the normal range. Compared to patients who underwent HD for <5 years, patients who had been on dialysis for >5 years demonstrated 2.5 times higher odds of malnutrition (odds ratio: 2.47, 95% confidence interval: 1.25-4.9). Age, mid-arm circumference, education level, and comorbid diabetes mellitus were significantly associated with malnutrition. In addition, malnourished patients showed lower levels of serum albumin (Alb) (P < 0.001) and serum creatinine (Cr) (P < 0.001). Multivariate logistic regression demonstrated age, dialysis duration, upper diploma educational level, lower serum Alb, and lower serum Cr may independently be associated with malnutrition in HD patients.Conclusion: Malnutrition is prevalent among HD patients. Regular assessment of nutritional status may enhance nutritional outcomes and overall well-being in this patient population.","PeriodicalId":50062,"journal":{"name":"Journal of Research in Medical Sciences","volume":"30 ","pages":"23"},"PeriodicalIF":1.5,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12087909/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144103145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of sevoflurane and propofol for elderly patients: A systematic review and meta-analysis. 七氟醚和异丙酚对老年患者的影响：系统回顾和荟萃分析。

IF 1.5 4区医学

Journal of Research in Medical Sciences Pub Date : 2025-04-30 eCollection Date: 2025-01-01 DOI: 10.4103/jrms.jrms_154_24

Qi Wang, Jing Luan, Wenli Yu

{"title":"Effects of sevoflurane and propofol for elderly patients: A systematic review and meta-analysis.","authors":"Qi Wang, Jing Luan, Wenli Yu","doi":"10.4103/jrms.jrms_154_24","DOIUrl":"10.4103/jrms.jrms_154_24","url":null,"abstract":"Background: To evaluate the safety of propofol and sevoflurane for general anesthesia in elderly.Materials and methods: All studies on sevoflurane, propofol, and hyperamylasemia from the establishment of Embase, Ovid, Cochrane Library, and Google Scholar from database establishment to December 2024 were searched. Literatures were screened, and data were extracted on the grounds of inclusion and exclusion criteria. Review Manager (RevMan) (Version 5.4. The Cochrane Collaboration.) was used for statistical analysis. Outcomes assessed included time to spontaneous eye opening, extubation time, incidence rate of postoperative cognitive dysfunction (POCD), postoperative delirium, agitation, nausea and vomiting.Results: Fourteen trials were identified and included in this meta-analysis. The results showed no significant difference in time to spontaneous eye opening (P = 0.54), the incidence of POCD (P = 0.07), postoperative delirium (P = 0.37), and postoperative nausea and vomiting (P = 0.8) between the sevoflurane and propofol groups. Compared with propofol groups, extubation time (P < 0.0001) was significantly shortened by sevoflurane groups. Conversely, compared with sevoflurane, the incidence of postoperative agitation in the propofol group was significantly reduced (P = 0.04).Conclusion: There was no difference in time to spontaneous eye-opening, the incidence of POCD, postoperative delirium, postoperative nausea, and vomiting between the sevoflurane and propofol groups. However, compared with propofol, sevoflurane can significantly shorten intubation time. The incidence of postoperative agitation (P = 0.04) was significantly lower in the propofol group compared with sevoflurane.","PeriodicalId":50062,"journal":{"name":"Journal of Research in Medical Sciences","volume":"30 ","pages":"22"},"PeriodicalIF":1.5,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12087908/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144102374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0