Journal of Research in Medical Sciences最新文献_第2页

Status and outlook of pulmonary tuberculosis coinfection. 肺结核合并感染的现状与展望。

IF 1.5 4区医学

Journal of Research in Medical Sciences Pub Date : 2025-07-15 eCollection Date: 2025-01-01 DOI: 10.4103/jrms.jrms_446_23

Yichen Wu, Chengfei Wang, Yongtao Li

引用次数: 0

Assessing arrhythmic risk in chronic kidney disease: A study of the index of cardiac-electrophysiological balance. 评估慢性肾脏疾病的心律失常风险：心电生理平衡指数的研究。

IF 1.5 4区医学

Journal of Research in Medical Sciences Pub Date : 2025-07-15 eCollection Date: 2025-01-01 DOI: 10.4103/jrms.jrms_67_25

Serdar Söner, Adnan Duha Cömert, Yusuf Hosoglu

{"title":"Assessing arrhythmic risk in chronic kidney disease: A study of the index of cardiac-electrophysiological balance.","authors":"Serdar Söner, Adnan Duha Cömert, Yusuf Hosoglu","doi":"10.4103/jrms.jrms_67_25","DOIUrl":"10.4103/jrms.jrms_67_25","url":null,"abstract":"Background: Chronic kidney disease (CKD) patients are at high risk of cardiovascular death and malignant arrhythmia. We aimed to determine at which CKD stage, the change in the index of cardiac-electrophysiological balance (ICEB) value is more evident. Consequently, we included patients across all CKD stages in our research.Materials and methods: A total of 429 patients were followed up at the nephrology and cardiology outpatient clinics between April and November 2023 enrolled in the study. Patients were categorized into five groups based on their glomerular filtration rate (GFR) - Group 1: GFR ≥90, Group 2: GFR = 60-89, Group 3: GFR = 30-59, Group 4: GFR = 15-29 and not on hemodialysis, and Group 5: GFR ≤15 and on hemodialysis. Electrocardiograms were recorded, and ICEB and corrected ICEB (ICEBc) values were calculated for all patients.Results: The mean age was 52.52 ± 14.58 years, and the total number of female patients was 235 (54.8%). In post hoc analysis, the difference of ICEBc value differed between Groups 1 and 5 (95% confidence interval: 0.0217-0.5226; P = 0.024). There were no statistically significant differences between Group 1 and the other groups. Corrected QT values were significantly different between Group 5 and Groups 1, 2, and 3 (P < 0.001, P < 0.001, and P = 0.005, respectively). The QT intervals were different between Group 1 and Groups 3, 4, and 5 (P = 0.003, P = 0.003, and P = 0.008, respectively).Conclusion: The study demonstrated that the ICEBc value gradually increased with the progression of CKD stages, with a statistically significant change observed in stage 5. However, there was no significant difference in ICEB values across stages.","PeriodicalId":50062,"journal":{"name":"Journal of Research in Medical Sciences","volume":"30 ","pages":"36"},"PeriodicalIF":1.5,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12352688/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144876503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of retinal blood flow changes in early Parkinson's disease: An optical coherence tomography angiography study. 评估早期帕金森病视网膜血流变化：一项光学相干断层扫描血管造影研究。

IF 1.5 4区医学

Journal of Research in Medical Sciences Pub Date : 2025-07-15 eCollection Date: 2025-01-01 DOI: 10.4103/jrms.jrms_250_24

Serhat Eker, Yalcin Karakucuk, Haluk Gumus, Sevde Tekneci, Ugur Acar

{"title":"Assessment of retinal blood flow changes in early Parkinson's disease: An optical coherence tomography angiography study.","authors":"Serhat Eker, Yalcin Karakucuk, Haluk Gumus, Sevde Tekneci, Ugur Acar","doi":"10.4103/jrms.jrms_250_24","DOIUrl":"10.4103/jrms.jrms_250_24","url":null,"abstract":"Background: To evaluate retinal microvasculature and choroidal thickness in patients with Parkinson's disease (PD) with optical coherence tomography angiography (OCTA).Materials and methods: Forty-one eyes from 41 patients diagnosed with PD and 41 eyes of 41 healthy subjects underwent retinal and choroidal assessment using swept source DRI Triton OCT (Topcon, Tokyo, Japan). Macular perfusion parameters, including superficial and deep foveal avascular zones (FAZs and FAZd, respectively), superficial capillary plexus (vascular density [VDs]), deep capillary plexus (VDd), and choriocapillaris (VDc), were compared with healthy controls.Results: The central sectors of the VDs, VDd, and VDc measurements (P = 0.001; P = 0.001; P = 0.001, respectively) and the superior sectors of VDs and VDc (P = 0.001; P = 0.001, respectively) were found to be significantly higher in the study group compared to the control group. FAZs and FAZd values were found to be decreased significantly in PD patients (P = 0.001 and P = 0.001, respectively). Choroidal thickness was significantly reduced (P = 0.007). Central macular thickness measurement did not differ between the groups (P > 0.05). In the multivariate regression model, VDs superior, FAZs, and choroidal thickness variables were determined to have a significant and independent effect in differentiating patients with PD from the individuals in the control group.Conclusion: PD seems to affect macular and choroidal microcirculation. The reduced choroidal thickness and increased central sectors of the VDs, VDd, and VDc measurements may provide disease activity information. However, more comprehensive studies on OCTA demonstrating clinical utility in PD are needed to support our findings.","PeriodicalId":50062,"journal":{"name":"Journal of Research in Medical Sciences","volume":"30 ","pages":"35"},"PeriodicalIF":1.5,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12352690/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144876504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Persian medicine remedies a new approach for head lice infestation control. 波斯医学疗法是控制头虱侵扰的新方法。

IF 1.5 4区医学

Journal of Research in Medical Sciences Pub Date : 2025-07-15 eCollection Date: 2025-01-01 DOI: 10.4103/jrms.jrms_650_24

Farzane Safa, Mehdi Shafieibafti, Ali Ghobadi

引用次数: 0

Spatiotemporal epidemiology of brucellosis in Iran from 2009 to 2018: A mixed ecological study. 2009 - 2018年伊朗布鲁氏菌病时空流行病学：一项混合生态学研究

IF 1.5 4区医学

Journal of Research in Medical Sciences Pub Date : 2025-07-15 eCollection Date: 2025-01-01 DOI: 10.4103/jrms.jrms_728_23

Sajjad Rahimi Pordanjani, Ghobad Moradi, Behrad Pourmohammadi, Elaheh Mazaheri, Farshid Farivar, Somayeh Derakhshan

{"title":"Spatiotemporal epidemiology of brucellosis in Iran from 2009 to 2018: A mixed ecological study.","authors":"Sajjad Rahimi Pordanjani, Ghobad Moradi, Behrad Pourmohammadi, Elaheh Mazaheri, Farshid Farivar, Somayeh Derakhshan","doi":"10.4103/jrms.jrms_728_23","DOIUrl":"10.4103/jrms.jrms_728_23","url":null,"abstract":"Background: Brucellosis is one of the most common zoonotic diseases in the world. The present study was carried out to determine the epidemiological status of the brucellosis and identify the high-risk and low-risk clusters in different provinces of Iran.Materials and methods: This was an ecological study conducted in the exploratory mixed design. The study population was the individuals with brucellosis in Iran whose data were related to the years 2009-2018. Data analysis has been done using Anselin Local Moran's I, Global Moran's I, Getis-Ord General G, Optimized Hot Spot Analysis, and Pearson correlation coefficient (PCC) in double range α and a significance level of 0.05.Results: The average annual incidence rate of the disease during the studied years was 19.91 per one hundred thousand. The three provinces with the highest cumulative prevalence rate included Lorestan, Hamedan, Kurdistan and the three provinces with the lowest prevalence rate involved Hormozgan, Tehran and Bushehr. Coldspots of brucellosis prevalence are in south and southwest of Iran and hotspots were observed in the west and northwest. The PCC between the prevalence rate and latitude was negative and not significant (r = -0.253; P = 0.169). However, a negative and significant correlation was found between the prevalence rate and longitude (r = -0.358; P < 0.05), indicating that as longitude increases, the prevalence of brucellosis decreases significantly.Conclusion: The prevalence of brucellosis in Iran is higher than developed countries and like many developing countries. High-risk areas of brucellosis were found in the western provinces and low-risk areas in the central and southern provinces of Iran. It appears essential to implement prevention and treatment measures in high-risk areas.","PeriodicalId":50062,"journal":{"name":"Journal of Research in Medical Sciences","volume":"30 ","pages":"32"},"PeriodicalIF":1.5,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12352691/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144876511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigating outcomes and treatment of long coronavirus disease 2019 in patients with multiple sclerosis treated with rituximab: A case series study. 利妥昔单抗治疗多发性硬化症患者2019年长冠状病毒病的疗效和治疗：一项病例系列研究

IF 1.5 4区医学

Journal of Research in Medical Sciences Pub Date : 2025-05-26 eCollection Date: 2025-01-01 DOI: 10.4103/jrms.jrms_150_25

Kiana Shirani, Farzin Khorvash, Alireza Karamshahi, Asieh Maghamimehr

{"title":"Investigating outcomes and treatment of long coronavirus disease 2019 in patients with multiple sclerosis treated with rituximab: A case series study.","authors":"Kiana Shirani, Farzin Khorvash, Alireza Karamshahi, Asieh Maghamimehr","doi":"10.4103/jrms.jrms_150_25","DOIUrl":"10.4103/jrms.jrms_150_25","url":null,"abstract":"Multiple sclerosis (MS) is a chronic autoimmune disease affecting the central nervous system, characterized by the destruction of the myelin sheath of nerves. MS patients treated with rituximab, an immunosuppressive drug, experience reduced immunoglobulin levels, which increases their risk of various infections, including coronavirus disease 2019 (COVID-19). During the COVID-19 pandemic, many of these patients developed long-term symptoms following infection. These chronic symptoms have led to significant complications and, in some cases, increased mortality. In this case series study, we investigated long COVID-19 symptoms in MS patients treated with rituximab and the effects of intravenous immunoglobulin (IVIG) therapy in alleviating chronic symptoms. The results demonstrated that the patients' long-term symptoms responded to IVIG treatment, with significant improvements in respiratory symptoms, fever, immune parameters, and a reduction in C-reactive protein levels. This study highlights the importance of targeted management of long COVID-19 in immunocompromised populations and suggests that COVID-19 patients with immune deficiencies require specific therapeutic approaches.","PeriodicalId":50062,"journal":{"name":"Journal of Research in Medical Sciences","volume":"30 ","pages":"26"},"PeriodicalIF":1.5,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12156028/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144276483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integration of three-dimensional multicolor holography with microfluidic three-dimensional biofilm-on-a-chip technology for advancing the treatment of diabetic foot ulcers: An innovation in phage therapy. 整合三维多色全息与微流控三维生物膜芯片技术推进糖尿病足溃疡的治疗：噬菌体治疗的一项创新。

IF 1.5 4区医学

Journal of Research in Medical Sciences Pub Date : 2025-05-26 eCollection Date: 2025-01-01 DOI: 10.4103/jrms.jrms_155_25

Ankit K Badge, Ishmita Sharma, Nandkishor J Bankar, Obaid Noman

引用次数: 0

Diagnostic value of circular RNAs as promising hematological biomarkers in acute myeloid leukemia: A systematic review and meta-analysis. 环状rna作为有希望的血液生物标志物在急性髓系白血病中的诊断价值：一项系统综述和荟萃分析。

IF 1.5 4区医学

Journal of Research in Medical Sciences Pub Date : 2025-05-26 eCollection Date: 2025-01-01 DOI: 10.4103/jrms.jrms_287_24

Amir Hossein Aghayan, Yasin Mirazimi, Zahra Sadat Hosseini, Mohammad Rafiee

{"title":"Diagnostic value of circular RNAs as promising hematological biomarkers in acute myeloid leukemia: A systematic review and meta-analysis.","authors":"Amir Hossein Aghayan, Yasin Mirazimi, Zahra Sadat Hosseini, Mohammad Rafiee","doi":"10.4103/jrms.jrms_287_24","DOIUrl":"10.4103/jrms.jrms_287_24","url":null,"abstract":"Despite significant advancements in the diagnosis and treatment of acute myeloid leukemia (AML), patients still face poor diagnosis with unsatisfactory survival, so it is imperative to explore novel diagnostic biomarkers to improve early detection and treatment outcomes. Thus, here, the potential role of circular RNAs (circRNAs) in AML diagnosis is reviewed. PubMed, Scopus, WOS, ProQuest databases, and Google Scholar search engines were searched for studies published through March 2023. The results were assessed using the modified method of GRADE assessment. The sensitivity (SEN), specificity (SPE), positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and area under the summary receiver operating characteristic curve (AUC) were combined to investigate the diagnostic role of circRNAs in AML. The number of studies included in this systematic review and meta-analysis was 18. For the diagnostic value of circRNAs in AML, the pooled SEN, SPE, PLR, and NLR were 0.85 (95% confidence interval [CI]: 0.80-0.89), 0.85 (95% CI: 0.82-0.88), 5.74 (95% CI: 4.49-7.33), and 0.18 (95% CI: 0.13-0.24), respectively. Furthermore, the pooled DOR and AUC were 32.71 (95% CI: 20.09-53.24) and 0.91 (95% CI: 0.88-0.93), respectively. Furthermore, through subgroup analysis, it is better to have a sample size above 120 and a control/patient ratio above 50%. In addition, Deek's funnel plot demonstrated nonconsiderable publication bias (P = 0.65). Finally, according to the GRADE assessment for diagnostic tests, the certainty of evidence regarding sensitivity and specificity was moderate. Our systematic review and meta-analysis suggest the analysis of circRNAs expression as promising and valuable biomarkers related to the diagnosis of AML and also can be helpful in the diagnosis of AML patients as a noninvasive and low-cost method.","PeriodicalId":50062,"journal":{"name":"Journal of Research in Medical Sciences","volume":"30 ","pages":"31"},"PeriodicalIF":1.5,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12156066/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144276481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comment on "Significant association between insulin-like growth factor 2 mRNA-binding protein 2, interleukin-6 polymorphisms, and type 2 diabetes mellitus". 对“胰岛素样生长因子2 mrna结合蛋白2、白细胞介素6多态性与2型糖尿病的显著相关性”的评论。

IF 1.5 4区医学

Journal of Research in Medical Sciences Pub Date : 2025-05-26 eCollection Date: 2025-01-01 DOI: 10.4103/jrms.jrms_727_24

Saurabh RamBihariLal Shrivastava

引用次数: 0

The effectiveness of mobile health intervention in colorectal cancer screening in Iran. 流动健康干预在伊朗结直肠癌筛查中的有效性

IF 1.5 4区医学

Journal of Research in Medical Sciences Pub Date : 2025-05-26 eCollection Date: 2025-01-01 DOI: 10.4103/jrms.jrms_21_25

Zivar Rostami, Sareh Shakerian

{"title":"The effectiveness of mobile health intervention in colorectal cancer screening in Iran.","authors":"Zivar Rostami, Sareh Shakerian","doi":"10.4103/jrms.jrms_21_25","DOIUrl":"10.4103/jrms.jrms_21_25","url":null,"abstract":"Background: This study aimed to evaluate the impact of mobile health (mHealth) intervention on colorectal cancer (CRC) screening.Materials and methods: This semiexperimental study collected data from individuals aged 50-70 years who had no history of CRC screening. Participants (n = 350) were randomly assigned to one control and five intervention groups. The data were collected by theory-based CRC screening questionnaire before and after the mHealth intervention.Results: The results indicated a significant improvement in screening rates when utilizing mHealth interventions, which included text messages, videos, and telephone calls from health workers, showing a rate of 68.6% (P < 0.001) compared to 5.7% of individuals in the routine care group. Logistic regression analysis revealed that \"perceived severity\" and \"perceived benefits\" were significantly associated with increased screening uptake, compared to the routine care group.Conclusion: The current study indicates that mobile phone technology significantly impacts the outreach efforts for encouraging the covered population to participate in screening.","PeriodicalId":50062,"journal":{"name":"Journal of Research in Medical Sciences","volume":"30 ","pages":"29"},"PeriodicalIF":1.5,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12156048/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144276484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0