Journal of Research in Medical Sciences最新文献

{"title":"Combination treatment with interferon-γ may be a potential strategy to improve the efficacy of cytotherapy for rheumatoid arthritis: A network meta-analysis.","authors":"Da-Qing Nie, Gui-Xiu Yan, Zheng-Yi Wang, Xue Yan, Gui-Mei Yu, Jin-Liang Gao, Di Liu, Hong-Bo Li","doi":"10.4103/jrms.jrms_697_21","DOIUrl":"10.4103/jrms.jrms_697_21","url":null,"abstract":"<p><strong>Background: </strong>Mesenchymal stem cells (MSCs) are considered a promising therapeutic strategy for rheumatoid arthritis (RA), but the current clinical results are varied. This study is to analyze the therapeutic effect of cell-based strategies on RA.</p><p><strong>Materials and methods: </strong>The searches were performed with public databases from inception to June 17, 2021. Randomized controlled trials researching cell-based therapies in RA patients were included.</p><p><strong>Results: </strong>Eight studies, including 480 patients, were included in the analysis. The results showed that compared to the control, MSC treatment significantly reduced the disease activity score (DAS) at the second standardized mean difference (SMD): -0.70; 95% confidence interval (CI): -1.25, -0.15; <i>P</i> = 0.01) and 3^rd month (SMD: -1.47; 95% CI: -2.77, -0.18; <i>P</i> < 0.01) and significantly reduced the rheumatoid factor (RF) level at the first (SMD: -0.38; 95% CI: -0.72, -0.05; <i>P</i> = 0.03) and 6^th months (SMD: -0.81; 95% CI: -1.32, -0.31; <i>P</i> < 0.01). In the network meta-analysis, MSCs combined with interferon-γ (MSC_IFN) had a significant effect on increasing the American college of rheumatology criteria (ACR) 20, ACR50, and DAS <3.2 populations, had a significant effect on reducing the DAS, and decreased the RF level for a long period.</p><p><strong>Conclusion: </strong>MSCs could relieve the DAS of RA patients in the short term and reduce the level of RF. MSC_IFN showed a more obvious effect, which could significantly improve the results of ACR20, ACR50, and DAS <3.2 and reduce the DAS and RF levels.</p>","PeriodicalId":50062,"journal":{"name":"Journal of Research in Medical Sciences","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11376714/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142141633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Technology-based suicide prevention: An umbrella review.","authors":"Sima Siadat, Ziba Farajzadegan, Narges Motamedi, Rasool Nouri, Nastaran Eizadi-Mood","doi":"10.4103/jrms.jrms_791_23","DOIUrl":"10.4103/jrms.jrms_791_23","url":null,"abstract":"<p><strong>Background: </strong>The objective is to summarize evidence from systematic reviews, scoping reviews, and meta-analyses evaluating the effects of any format of Internet-based, mobile-, or telephone-based intervention as a technology-based intervention in suicide prevention.</p><p><strong>Materials and methods: </strong>This is an umbrella review, that followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 statement guidelines. An electronic search was done on September 29, 2022. Data were extracted by reviewers and then methodological quality and risk of bias were assessed by A Measurement Tool to Assess Systematic Reviews-2. Statistical analysis was done by STATA version 17. Standard mean difference was extracted from these studies and by random effect model, the overall pooled effect size (ES) was calculated. I2 statistic was used to assess the heterogeneity between studies. For publication bias, the Egger test was used.</p><p><strong>Results: </strong>Six reviews were included in our study, all with moderate quality. The overall sample size was 24631. The ES for standard mean differences of the studies is calculated as - 0.20 with a confidence interval of (-0.26, -0.14). The heterogeneity is found as 58.14%, indicating a moderate-to-substantial one. The Egger test shows publication bias.</p><p><strong>Conclusion: </strong>Our results show that technology-based interventions are effective. We propose more rigorous randomized controlled trials with different control groups to assess the effectiveness of these interventions.</p>","PeriodicalId":50062,"journal":{"name":"Journal of Research in Medical Sciences","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11376711/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142141648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Negative association of apelin plasma levels with epicardial fat thickness in patients with stable angina and acute myocardial infarction: A case-control study.","authors":"Behzad Babapour, Hossein Doustkami, Leli Avesta, Peyman Kiamehr, Mohammad Reza Aslani","doi":"10.4103/jrms.jrms_478_22","DOIUrl":"10.4103/jrms.jrms_478_22","url":null,"abstract":"<p><strong>Background: </strong>Apelin is one of the endogenous peptides that play a key role in the homeostasis of cardiovascular diseases. The purpose of the current study was to evaluate the correlation between apelin levels and epicardial fat thickness (EFT) in patients with stable angina and acute myocardial infarction (AMI).</p><p><strong>Materials and methods: </strong>In a case-control study, 90 patients nominated for angiography were enrolled in the study and divided into three groups: healthy subjects without angiographic findings (Con), stable angina pectoris group (SAP), and acute AMI group. Data collected from all subjects included biochemical, echocardiographic, and angiographical parameters. The Gensini score analyzed the severity of coronary artery disease (CAD).</p><p><strong>Results: </strong>A decrease in adjusted apelin levels was evident in the AMI and SAP groups compared with healthy individuals (for both <i>P</i> < 0.001), especially in the AMI group. In addition, a detectable negative association was identified between apelin and Gensini score <i>(</i>r = -0.288<i>, P</i> = 0.006), Ck-MB <i>(</i>r = -0.300<i>, P</i> = 0.004), EFT <i>(</i>r = -0.300<i>, P</i> = 0.004), and troponin-T <i>(</i>r = -0.288<i>, P</i> = 0.006).</p><p><strong>Conclusion: </strong>Myocardial injury in patients with CAD appears to play a significant role in apelin concentration independent of the role of adipose tissue, which requires further studies.</p>","PeriodicalId":50062,"journal":{"name":"Journal of Research in Medical Sciences","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11376709/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142141640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Success rate and complications of performing elective ureteroscopy in <1 week versus over 1 week from renal colic initiation in ureteral stones larger than 6 mm.","authors":"Reza Kazemi, Amir Javid, Amir Hossein Ghandehari, Hanieh Salehi","doi":"10.4103/jrms.jrms_43_23","DOIUrl":"10.4103/jrms.jrms_43_23","url":null,"abstract":"<p><strong>Background: </strong>The aim of this study was to compare the outcomes, success rate, and complications of performing elective ureteroscopy at different times: <1 week from renal colic initiation (early) and more than 1 week from renal colic initiation (late) in patients with ureteral stone larger than 6 mm.</p><p><strong>Materials and methods: </strong>This comparative observational study was conducted on 338 consecutive patients. Patients were evaluated in two groups: patients who underwent ureteroscopy in <1 week (A) and patients who underwent ureteroscopy in more than 1 week (B) from renal colic initiation. Helical unenhanced computed tomography was used to assess the size, location, and hardness of stone for all patients. Operation success was defined as complete clearance of stone with no stone residue (stone free) at 2-week postoperative ultrasonography with no need to further interventions. Operation data were collected using medical records, and postoperative complications were investigated at 2 weeks postoperative follow-up visits.</p><p><strong>Results: </strong>Group A included 165 patients and Group B included 173 patients. The overall mean stone size was 8.60 ± 1.12 mm: for Group A 9.13 ± 0.94 mm and for Group B 8.10 ± 1.04 mm (<i>P</i> < 0.001). Stone residues were found in 11 patients: 9 in Group A (5.4%) and 2 in Group B (1.1%) (<i>P</i> = 0.026). Nine patients needed repeated ureteroscopy: 8 (4.8%) in Group A and 1 (0.6%) in Group B (<i>P</i> = 0.015). A double-J stent was used for 85 (51.5%) patients in Group A and 66 (38.2%) patients in Group B (<i>P</i> = 0.016). Major intraoperative complications did not happen in any patients. Fifty-three (32.1%) patients in Group A and 28 (16.2%) patients in Group B suffered from postoperative complications (<i>P</i> = 0.001).</p><p><strong>Conclusion: </strong>Our study revealed that performing elective ureteroscopy with an interval of more than 1 week from the onset of renal colic in combination with medical treatments was associated with less need for double-J stent placement, less need for repeated ureteroscopy, and fewer postoperative complications compared to performing elective ureteroscopy in <1 week from the renal colic onset in nonemergent patients with ureteral stone larger than 6 mm. Although the rate of ureteroscopy failure was higher among the patients who underwent ureteroscopy in <1 week from their renal colic initiation, there was no statistically significant relationship between performing ureteroscopy in <1 week and an increased risk for ureteroscopy failure.</p>","PeriodicalId":50062,"journal":{"name":"Journal of Research in Medical Sciences","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11376710/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142141647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of the first Iranian clinical practice guidelines for the diagnosis, treatment, and secondary prevention of acute coronary syndrome.","authors":"Nizal Sarrafzadegan, Fahimeh Bagherikholenjani, Shahla Shahidi, Golsa Ghasemi, Ehsan Shirvani, Fatemeh Rajati, Farid Najafi, Samad Ghaffari, Alireza Khosravi, Ahmadreza Assareh, Seyed Mohammad Hassan Adel, Javad Kojuri, Niloufar Samiei, Farzad Masoudkabir, Hossein Farshidi, Mohammad Kermani-Alghoraishi, Masoumeh Sadeghi, Davood Shafei, Masoumeh Jorjani, Mansour Siavash, Fariborz Khorvash, Mehdi Nasr Isfahani, Behzad Fatemi, Majid Davari, Mitra Moradinia, Ramesh Hoseinkhani, Valiollah Hajhashemi, Noushin Mohammadifard, Majid Ghayour Mobarhan, Ali Momeni, Mojgan Mortazavi, Mohammad Akbari, Fereshteh Sattar, Fereidoun Noohi, Maryam Kheiri, Mosa Tabatabaeilotfi, Sanaz Bakhshandeh, Parisa Janjani, Sajad Fakhri, Alireza Abdi","doi":"10.4103/jrms.jrms_851_23","DOIUrl":"10.4103/jrms.jrms_851_23","url":null,"abstract":"<p><strong>Background: </strong>This article introduces the first national guidelines for the management including diagnosis, treatment, and secondary prevention of acute coronary syndrome (ACS) in Iran.</p><p><strong>Materials and methods: </strong>The members of the guideline development group (GDG) were specialists and experts in fields related to ACS and were affiliated with universities of medical sciences or scientific associations in the country. They carefully examined the evidence and clinical concerns related to ACS management and formulated 13 clinical questions that were sent to systematic review group who developed related evidence using Grade method. Finally the GDG developed the recommendations and suggestions of the guideline.</p><p><strong>Results: </strong>The first three questions in the guideline focus on providing recommendations for handling a patient who experience chest pain at home, in a health house or center, during ambulance transportation, and upon arrival at the emergency department (ED) as well as the initial diagnostic measures in the ED. Subsequently, the recommendations related to the criteria for categorizing patients into low, intermediate and high-risk groups are presented. The guideline addressed primary treatment measures for ACS patients in hospitals with and without code 247 or having primary percutaneous coronary intervention (PCI) facilities, and the appropriate timing for PCI based on the risk assessment. In addition, the most efficacious antiplatelet medications for ACS patients in the ED as well as its optimal duration of treatment are presented. The guideline details the recommendations for therapeutic interventions in patients with ACS and acute heart failure, cardiogenic shock, myocardial infarction with nonobstructive coronary arteries (MINOCA), multivessel occlusion, as well as the indication for prescribing a combined use of anticoagulants and antiplatelet during hospitalization and upon discharge. Regarding secondary prevention, while emphasizing the referral of these patients to rehabilitation centers, other interventions that include pharmaceutical and nonpharmacological ones are addressed, In addition, necessary recommendations for enhancing lifestyle and posthospital discharge pharmaceutical treatments, including their duration, are provided. There are specific recommendations and suggestions for subgroups, such as patients aged over 75 years and individuals with heart failure, diabetes, and chronic kidney disease.</p><p><strong>Conclusion: </strong>Developing guidelines for ACS diagnosis, treatment and secondary prevention according to the local context in Iran can improve the adherence of our health care providers, patients health, and policy makers plans.</p>","PeriodicalId":50062,"journal":{"name":"Journal of Research in Medical Sciences","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11376720/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142141634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased rate of skin and soft-tissue infections after chickenpox: Is it related to the COVID-19 pandemic?","authors":"Shirin Sayyahfar","doi":"10.4103/jrms.jrms_516_23","DOIUrl":"10.4103/jrms.jrms_516_23","url":null,"abstract":"","PeriodicalId":50062,"journal":{"name":"Journal of Research in Medical Sciences","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11162085/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141297112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of single absorbable tacker vs. conventional method in fixating the mesh in bilateral inguinal hernia undergoing laparoscopic transabdominal preperitoneal (TAPP): A randomized control trial study.","authors":"Pouya Mir Mohammad Sadeghi, Amir Hosein Naseri, Azita Shishegar, Hamid Melali, Ali Ashjaei","doi":"10.4103/jrms.jrms_161_23","DOIUrl":"10.4103/jrms.jrms_161_23","url":null,"abstract":"<p><strong>Background: </strong>The current study aims to investigate the superior mesh fixation method, single absorbable tacker versus conventional method, in patients undergoing bilateral inguinal hernia repair through the laparoscopic total abdominal preperitoneal (TAPP) approach.</p><p><strong>Materials and methods: </strong>The current randomized clinical trial has been conducted on 81 patients undergoing bilateral hernia repair through TAPP. The patients were randomly assigned into one of the mesh fixation groups including single absorbable tacker (Group S) (<i>n</i> = 41) and conventional method (Group C) (<i>n</i> = 40). All patients were assessed during the hospital stay and 1 month postoperatively to assess the surgery-associated complications and days for return to daily activity. Eura-Hs questionnaire was applied to assess the quality of life (QOL) after hernia surgery during 12-month follow-up.</p><p><strong>Results: </strong>The duration of bilateral inguinal hernia operation (<i>P</i> = 0.067), postoperative urinary catheterization (<i>P</i> = 0.813), and hospital stay duration (<i>P</i> = 0.779) did not differ between the groups; whereas Group C significantly required a longer time for returning to daily activity (<i>P</i> < 0.001). Only a patient in Group C represented hematoma (<i>P</i> = 0.494). Seroma incidence was not statistically different between the two groups (<i>P</i> = 0.712). Postoperative pain was statistically less in Group S (<i>P</i> < 0.001 for all the assessments). Postoperative QOL within a year after hernia repair revealed an insignificant difference between the groups in general (<i>P</i> > 0.05); however, a pain subscale was significantly less in Group S (<i>P</i> = 0.002).</p><p><strong>Conclusion: </strong>Based on the findings of this study, a single absorbable tacker was generally superior to the conventional method considering its less pre- and postoperative complications. However, the two methods did not differ regarding 1-year follow-up QOL.</p>","PeriodicalId":50062,"journal":{"name":"Journal of Research in Medical Sciences","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11162083/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141297111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Significance of fragmented QRS and predictors of outcome in ST-elevation myocardial infarction.","authors":"Serdar Türkmen, Mehmet Bozkurt, Yusuf Hoşoğlu, Mehmet Göl","doi":"10.4103/jrms.jrms_68_23","DOIUrl":"10.4103/jrms.jrms_68_23","url":null,"abstract":"<p><strong>Background: </strong>Fragmented QRS (fQRS) might be associated with certain characteristics in ST-elevation myocardial infarction (STEMI) patients and inhospital adverse events.</p><p><strong>Materials and methods: </strong>A sum of 500 patients were gone over retrospectively. Patients with STEMI, all undergone percutaneous coronary intervention, were grouped as fQRS (-) and fQRS (+). Characteristics of the patients, major adverse cardiac event (MACE), death in hospital, nonfatal myocardial infarction (MI), stent thrombosis, slow flow myocardial perfusion, development of ventricular tachycardia (VT) and fibrillation, cardiogenic shock and cardiopulmonary arrest were filtered.</p><p><strong>Results: </strong>FQRS (-) group was composed of 207 patients whose mean age was 61.1 ± 12.1, whereas 293 patients were there in fQRS (+) with a mean age of 66.7 ± 10.6 (<i>P</i> < 0.001). Thrombolysis in MI (TIMI) (<i>P</i> < 0.01), the global registry of acute coronary events (GRACE) (<i>P</i> < 0.01) scores, white blood cell count, neutrophil/lymphocyte ratio, MACE and the ratio of death in hospital and VT in the hospital were significantly higher in fQRS (+) group (<i>P</i> < 0.001, for remaining all). In multivariate logistic regression analysis, TIMI scores above 2 and GRACE scores above 109 were determined as independent predictors of MACE in the entire patient group (odds ratio [OR]: 2.022; 95% confidence interval [CI]; 1.321-3.424<i>, P</i> = 0.003; OR: 1.712; 95% CI: 1.156-2.804<i>, P</i> = 0.008).</p><p><strong>Conclusion: </strong>FQRS (+) and fQRS (-) patients markedly differ from each other in terms of certain demographic and clinical features and TIMI and GRACE scores have a significant predictive value for MACE in all STEMI patients' group.</p>","PeriodicalId":50062,"journal":{"name":"Journal of Research in Medical Sciences","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11162084/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141297114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The evaluation of human endogenous retroviral env expression in normal and cancerous tissues of the breast.","authors":"Shaian Tavakolian, Hossein Goudarzi, Ebrahim Faghihloo","doi":"10.4103/jrms.jrms_141_23","DOIUrl":"10.4103/jrms.jrms_141_23","url":null,"abstract":"<p><strong>Background: </strong>Both internal and external risk factors can accelerate the progression of breast cancer which is the reason why clinicians have tried to find new biomarkers for this health problem. Human endogenous retrovirus-W (HERV-W) can be one of these biomarkers, as it has been mentioned that some genes of this virus are able to have either higher or lower expression in numerous cancerous cells. In this study, we aimed to compare HERV-W envelope expression in breast cancer tissues and normal ones since its effects on this malignancy have not been clear.</p><p><strong>Materials and methods: </strong>We collected 46 breast cancer tissues and their normal adjacent ones. After extracting the RNA of breast samples, we evaluated the expression of HERV-W envelope syncytin-1 and 2 using quantitative real-time polymerase chain reaction (PCR) in different kinds of breast cancer stages.</p><p><strong>Results: </strong>Data showed that more than 13% of patients had a family history of breast cancer; moreover, approximately half of the tissues were estrogen receptor or progesterone receptor positive. Lymph node metastasis was seen in 52% of the patients, and about 40% of tumors were larger than 2 cm. Real-time PCR showed that syncytin-1 and 2 had upward regulation with (*<i>P</i> < 0.05) and (**<i>P</i> < 0.01), respectively.</p><p><strong>Conclusion: </strong>As the expression of HERV-W Env (syncytin-1, syncytin-2) was higher in breast cancerous tissues in comparison with normal ones, we believe that these genes may have a role to play in monitoring patients suffering from this type of cancer. However, further studies are needed to confirm this hypothesis.</p>","PeriodicalId":50062,"journal":{"name":"Journal of Research in Medical Sciences","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11162086/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141297116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of recurrence of joint symptoms after COVID-19 in patients with rheumatoid arthritis: Cross-sectional study.","authors":"Afsaneh Akbarpour, Mansour Salesi, Anahita Babak","doi":"10.4103/jrms.jrms_782_22","DOIUrl":"10.4103/jrms.jrms_782_22","url":null,"abstract":"<p><strong>Background: </strong>In this study, the relationship between involvement by COVID-19 and the recurrence of symptoms of rheumatoid arthritis (RA) was investigated.</p><p><strong>Materials and methods: </strong>This cross-sectional study was conducted on 112 patients with RA with and without a history of COVID-19. The severity and recurrence of RA symptoms were measured and recorded by the Disease Activity Score in 28 joints (DAS-28) index and clinical evaluations by a rheumatologist.</p><p><strong>Results: </strong>The results showed that the recurrence of RA in patients with and without a history of COVID-19 had a statistically significant difference (<i>P</i> < 0.001). In addition, there was a statistically significant relationship between erythrocyte sedimentation rate, visual analogue scale (VAS), tender joint count, swollen joint count, and DAS-28 and the history of COVID-19 (<i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>The present study showed that infection with COVID-19 leads to the recurrence of joint symptoms in RA patients.</p>","PeriodicalId":50062,"journal":{"name":"Journal of Research in Medical Sciences","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11162082/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141297113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}