Investigation of cardiovascular risk factors in diabetic and nondiabetic patients with nonalcoholic fatty liver disease.

IF 1.5 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Journal of Research in Medical Sciences Pub Date : 2024-08-02 eCollection Date: 2024-01-01 DOI:10.4103/jrms.jrms_830_23

Mona Barati, Azam Teimouri, Awat Feizi, Bijan Iraj, Mozhgan Karimifar

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引用次数: 0

Abstract

Background: The current study aims to assess cardiovascular risk factors (CVRFs) among diabetic versus nondiabetic nonalcoholic fatty liver disease (NAFLD) patients. NAFLD is the most common hepatic disorder worldwide which is directly associated with diverse CVRFs such as type 2 diabetes mellitus (T2DM) and metabolic syndrome (MS).

Materials and methods: The current cross-sectional population-based study has been conducted on 1031 NAFLD patients. After excluding 340 prediabetes patients, the NAFLD patients were divided into T2DM and normal blood glucose (NBG). Then, CVRFs were compared between the two groups.

Results: Out of 691 NAFLD cases included in the study, 337 (48.8%) patients had T2DM. In the T2DM and NBG groups, the body mass index (BMI) was 31.2 ± 4.6 and 29.9 ± 4.3 kg/m2, respectively (P = 0.001). The waist circumference was 102.2 ± 10.2 and 97.6 ± 10.6 cm, respectively (P < 0.001). The systolic blood pressure was 123.3 ± 15.6 and 119.6 ± 13.6 mmHg, respectively (P = 0.043). The triglyceride levels were 191.9 ± 104.7 and 176.5 ± 89.6 mg/dL, respectively (P = 0.042). Generally, these factors were significantly higher among the diabetic patients. Besides, cardiovascular disease (CVD), hypertension, and MS were statistically more prevalent in NAFLD patients with T2DM (P < 0.001) than nondiabetic NAFLD patients. In multiple logistic regression models, the odds ratio of CVD, hypertension, and MS was 2.18, 2.12, and 6.63 for patients with T2DM compared with NBG, respectively. Adjustment was made for age, sex, BMI, smoking, and physical activity.

Conclusion: CVRFs were higher in NAFLD patients with T2DM than NAFLD patients with NBG.

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糖尿病和非糖尿病非酒精性脂肪肝患者心血管风险因素调查。

研究背景本研究旨在评估糖尿病与非糖尿病非酒精性脂肪肝（NAFLD）患者的心血管风险因素（CVRFs）。非酒精性脂肪肝是全球最常见的肝脏疾病，与多种心血管风险因素直接相关，如 2 型糖尿病（T2DM）和代谢综合征（MS）：本研究以人群为基础，对 1031 名非酒精性脂肪肝患者进行了横断面研究。在排除 340 名糖尿病前期患者后，非酒精性脂肪肝患者被分为 T2DM 和血糖正常 (NBG)。然后比较两组患者的 CVRF：在 691 例非酒精性脂肪肝病例中，337 例（48.8%）患者患有 T2DM。T2DM 组和 NBG 组的体重指数（BMI）分别为 31.2 ± 4.6 和 29.9 ± 4.3 kg/m2（P = 0.001）。腰围分别为 102.2 ± 10.2 厘米和 97.6 ± 10.6 厘米（P < 0.001）。收缩压分别为 123.3 ± 15.6 和 119.6 ± 13.6 mmHg（P = 0.043）。甘油三酯水平分别为 191.9 ± 104.7 和 176.5 ± 89.6 毫克/分升（P = 0.042）。总体而言，这些因素在糖尿病患者中明显较高。此外，与非糖尿病非酒精性脂肪肝患者相比，T2DM 非酒精性脂肪肝患者中心血管疾病（CVD）、高血压和多发性硬化症的发病率更高（P < 0.001）。在多元逻辑回归模型中，与 NBG 相比，T2DM 患者发生心血管疾病、高血压和多发性硬化的几率比分别为 2.18、2.12 和 6.63。对年龄、性别、体重指数、吸烟和体力活动进行了调整：结论：T2DM 非酒精性脂肪肝患者的 CVRFs 高于 NBG 非酒精性脂肪肝患者。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Research in Medical Sciences MEDICINE, GENERAL & INTERNAL-

CiteScore

2.60

自引率

6.20%

发文量

审稿时长

3-6 weeks

期刊介绍： Journal of Research in Medical Sciences, a publication of Isfahan University of Medical Sciences, is a peer-reviewed online continuous journal with print on demand compilation of issues published. The journal’s full text is available online at http://www.jmsjournal.net. The journal allows free access (Open Access) to its contents and permits authors to self-archive final accepted version of the articles on any OAI-compliant institutional / subject-based repository.