Journal of Spinal Cord Medicine最新文献

{"title":"Shockwave therapy in persons with a spinal cord injury and spasticity: A multiple single-case experimental design study.","authors":"Boris S G Hellenbrand, Charlotte C M van Laake-Geelen, Henk A M Seelen","doi":"10.1080/10790268.2024.2379067","DOIUrl":"10.1080/10790268.2024.2379067","url":null,"abstract":"<p><strong>Objective: </strong>To determine whether ESWT is able to safely and positively influence specific ADL activities in people with SCI and spasticity, measured by Goal Attainment Scaling (GAS).</p><p><strong>Study design: </strong>Multiple single-case experimental design with a randomized baseline length.</p><p><strong>Setting: </strong>Rehabilitation centre.</p><p><strong>Subjects: </strong>This study included 11 participants with SCI, aged >18 years (mean (SD) 63 (12.2) years), mean (SD) duration after injury 9 (8.1) years, with hindering spasticity in the upper or lower limb.</p><p><strong>Methods: </strong>During the 3-week treatment phase, radial ESWT in the plantar flexors of the calf (<i>n</i> = 6) or in the flexors of the wrist/hand (<i>n</i> = 5) was applied weekly, followed by a 12-week follow-up phase. The primary outcome measure consisted of the Goal Attainment Scaling (GAS), in which three individual goals were set. Secondary outcome measures included range of joint motion, pain (0-10), 10-m walking test and Van-Lieshout-hand-function-test-for-Tetraplegia (short form).</p><p><strong>Results: </strong>At descriptive level, in total, 28 of the 33 GAS items improved after ESWT and these effects generally were maintained during the follow-up phase. The results of all secondary outcome measures varied. No serious adverse events occurred.</p><p><strong>Conclusions: </strong>In this study, ESWT resulted in improved performance of specific ADL items in most persons with SCI. More research is needed to confirm these results in a larger cohort.</p>","PeriodicalId":50044,"journal":{"name":"Journal of Spinal Cord Medicine","volume":" ","pages":"429-437"},"PeriodicalIF":1.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142803124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Buyang Huanwu decoction facilitates the repair of red nucleus neurons subsequent to spinal cord injury in rats via autophagy.","authors":"Jianxiong Deng, Yihui Zhang, Weiqi Xie, Liang Li, Qiang Li","doi":"10.1080/10790268.2025.2460303","DOIUrl":"https://doi.org/10.1080/10790268.2025.2460303","url":null,"abstract":"<p><strong>Background: </strong>To explore the effects of Buyang Huanwu Decoction (BYHWD) on neurons in the red nucleus of rats with spinal cord injury (SCI) based on autophagy.</p><p><strong>Methods: </strong>120 Sprague-Dawley (SD) rats were randomly divided into 6 groups: Control Group, SCI Group, Bafilomycin A1 Group, Rapamycin Group, BYHWD low-dose group (BL Group, 6.25 g/kg), BYHWD high-dose group (BH Group, 25.00 g/kg), with 20 animals in each group. A rat rubrospinal tract (RST) transection model was established and treated for 28 days. The recovery of motor function of rats was observed through inclined plate test and spontaneous upright exploratory behavior test. Nissl's staining was used to observe the cell morphology of injured red nucleus neurons. Reverse Transcription PCR (RT-PCR) and immunofluorescence were used to detect the expression of ATG5 and Beclin1 mRNA. The Western blot method was used to observe the expression levels of Synaptophysin (SYP), Synaptosomal-associated Protein of 25 kDa (SNAP-25), Postsynaptic density protein 95 (PSD-95), ATG5, and Beclin1 proteins in red nucleus tissue.</p><p><strong>Results: </strong>Compared with the SCI group, both BL and BH groups significantly improved the forelimb motor function and improved the status of red nucleus neurons in SCI rats. BYHWD increased SYP, SNAP-25, PSD-95, and decreased the red core Beclin1 and ATG5.</p><p><strong>Conclusions: </strong>BYHWD enhances synaptic regeneration and limb activity in red nucleus neurons of SCI rats by inhibiting autophagy.</p>","PeriodicalId":50044,"journal":{"name":"Journal of Spinal Cord Medicine","volume":" ","pages":"1-12"},"PeriodicalIF":1.8,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144055543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is the handgrip pressure influenced by the same factors in typical children and adolescents and those with spina bifida?","authors":"Emanuela Juvenal Martins, Camila Scarpino Barboza Franco, Ana Claudia Mattiello-Sverzut","doi":"10.1080/10790268.2025.2488572","DOIUrl":"https://doi.org/10.1080/10790268.2025.2488572","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the factors influencing handgrip pressure (HGP) in typical children and adolescents and those with spina bifida (SB).</p><p><strong>Methods: </strong>This cross-sectional study enrolled 126 typical participants and 58 with SB, aged 8-16 years, categorized into subgroups: typical children (typical prepubertal; <i>n</i> = 20), typical adolescents (typical pubertal and post-pubertal; <i>n</i> = 106), SB children (SB prepubertal; <i>n</i> = 11), and SB adolescents (SB pubertal and post-pubertal; <i>n</i> = 47). Data on sex, height (or wingspan), lean and fat body mass, and levels of physical activity and spinal cord injury were collected. Participants performed three maximal voluntary isometric contractions of HGP using a bulb dynamometer. Multiple linear regression analyses examined the relationship between variables and HGP.</p><p><strong>Results: </strong>In typical children, decreases in height, fat and lean body mass were associated with decreased HGP. In typical adolescents, females exhibited higher HGP than males, and increases in lean body mass and height were positively associated with HGP; and sedentary individuals exhibited higher HGP compared to active counterparts. In SB adolescents, increases in fat and lean body mass were associated with higher HGP, and greater physical activity was associated with stronger HGP. Participants with sacral injury level showed higher HGP than those with thoracic injury level. No association was observed for SB children.</p><p><strong>Conclusion: </strong>Except for SB children, various factors, mainly the lean body mass, significantly influenced the HGP in all groups. When the outcome is HGP, it is important to monitor body composition and physical activity in typical children and adolescents and those with SB.</p>","PeriodicalId":50044,"journal":{"name":"Journal of Spinal Cord Medicine","volume":" ","pages":"1-10"},"PeriodicalIF":1.8,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144030182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of virtual reality on psychological distress in individuals with spinal cord injury: A systematic review.","authors":"Anas R Alashram","doi":"10.1080/10790268.2025.2488567","DOIUrl":"https://doi.org/10.1080/10790268.2025.2488567","url":null,"abstract":"<p><strong>Context: </strong>Psychological distress is common among individuals with spinal cord injury (SCI). Virtual reality (VR) is an innovative technology used in treating patients with neurological disorders.</p><p><strong>Objectives: </strong>This systematic review aims to explore the effects of VR on psychological distress in individuals with SCI.</p><p><strong>Methods: </strong>A comprehensive search was conducted in \"PubMed, PEDro, REHABDATA, MEDLINE, SCOPUS, EMBASE, CINAHL, and Web of Science\" databases from inception to November 1, 2024. Studies included individuals with SCI with various levels or completeness of injury, administrated VR intervention independently or in combination with other treatments, compared with passive, active, or no control interventions, and evaluated psychological distress were included. The \"Physiotherapy Evidence Database (PEDro)\" scale was used to assess the risk of bias in eligible studies.</p><p><strong>Results: </strong>Eight out of 405 studies were included in this systematic review. A total of 159 individuals with SCI (male 67%, mean age 49.6 years) were included in this systematic review. The results were synthesized using a a descriptive analysis. The included studies showed that administrating multiple sessions of VR independently or in combination with cognitive training or conventional physiotherapy reduces depression, anxiety, and stress in individuals with SCI.</p><p><strong>Conclusions: </strong>VR has potential immediate benefits on psychological distress in individuals with SCI. SCI individuals with various severity, level, and duration of injury might benefit from the intervention. However, these findings should be interpreted with caution. Further studies are strongly recommended to understand the long-term effects of VR, determine the most effective treatment protocol, and identify which SCI populations are more likely to benefit from the intervention.</p>","PeriodicalId":50044,"journal":{"name":"Journal of Spinal Cord Medicine","volume":" ","pages":"1-10"},"PeriodicalIF":1.8,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144013579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of ultra-early, early and delayed decompression on neurological and clinical outcomes in spinal cord injury: A systematic review and meta-analysis.","authors":"Chao Yu, Jiaxi Wang, Jingjie Wang, Leisheng Wang, Yan Ding, Yuan Ji","doi":"10.1080/10790268.2025.2483074","DOIUrl":"https://doi.org/10.1080/10790268.2025.2483074","url":null,"abstract":"<p><strong>Objective: </strong>This study investigates the impact of various surgical timing strategies on neurological and clinical outcomes in patients with spinal cord injury (SCI) through a meta-analysis. Specifically, it compares the effectiveness of early, ultra-early, and delayed decompression surgeries in optimizing patient recovery.</p><p><strong>Methods: </strong>A comprehensive literature search was conducted across multiple databases, including PubMed, Embase, Cochrane Library, and Web of Science, to identify studies on surgical timing for SCI. Studies evaluating ultra-early surgery (≤8 h or ≤12 h), early surgery (≤24 h), and delayed surgery (>24 h) were included. A total of 16 studies were included, involving outcome indicators such as American Spinal Injury Association (ASIA) score, length of stay, complications, and mortality.</p><p><strong>Results: </strong>Compared with delayed surgery, early surgery (≤24 h) significantly shortened the length of stay (MD = -2.31 days, 95% CI: -4.18, -0.43; <i>P</i> = 0.02) and reduced the risk of complications (OR = 0.70, 95% CI: 0.55, 0.89; <i>P</i> = 0.003), but there was no significant difference in the improvement of ASIA score. Ultra-early surgery (≤8 h) significantly improved the ASIA score (OR = 2.64, 95% CI: 1.29, 5.40; <i>P</i> = 0.008), but no statistical difference was found in the comparison of 12 h. Early or delayed surgery did not affect the mortality of patients.</p><p><strong>Conclusion: </strong>The timing of surgical intervention significantly influences recovery in SCI patients. Early and ultra-early surgery can shorten hospital stay, reduce the risk of complications, and improve neurological outcomes in some cases.</p>","PeriodicalId":50044,"journal":{"name":"Journal of Spinal Cord Medicine","volume":" ","pages":"1-10"},"PeriodicalIF":1.8,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144036580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation and management of autonomic functions in patients with spinal cord injury: A scoping review.","authors":"Ram Lochan Yadav, Jessica Catherine Martin, Mary Pauline Galea","doi":"10.1080/10790268.2025.2485509","DOIUrl":"https://doi.org/10.1080/10790268.2025.2485509","url":null,"abstract":"<p><strong>Context: </strong>Individuals with high-level spinal cord injury (SCI) face serious cardiovascular (CV) autonomic complications, contributing to increased mortality and morbidity. The assessment of CV autonomic function in SCI is challenging and varies widely across studies, with no clear or definitive interventions to restore hemodynamic stability or prevent complications.</p><p><strong>Objectives: </strong>This review outlines available clinical data on measuring and managing CV autonomic dysfunction after SCI and identifies gaps in these domains.</p><p><strong>Methods: </strong>A scoping review was conducted, using a search strategy targeting broad keywords related to SCI, autonomic function parameters, and management from six relevant databases, as well as reference lists and gray literatures.</p><p><strong>Results: </strong>Of 2,749 articles identified, 92 were included. Studies categorized CV autonomic complications by acute and chronic stages. High-level SCI was commonly associated with bradycardia, low BP, orthostatic hypotension, and autonomic dysreflexia, compared to lower thoracic SCI. However, the correlation between these complications and SCI completeness was unclear. Various measurement methods were used, including 24-hour ambulatory BP monitoring (ABPM), ECG derivatives, heart rate variability, sympathetic skin response, cold pressor test, head-up tilt, the International Standards to document Autonomic Function following SCI (ISAFSCI) and the Autonomic Dysfunction Following SCI (ADFSCI) tools. Of these, 24-hour ABPM demonstrated superiority in identifying diurnal variation and activity effects on CV conditions. Studies reported mixed outcomes for both pharmacological and non-pharmacological management of CV complications.</p><p><strong>Conclusion: </strong>Research gaps persist, especially in sub-acute stages and in standardized tools for assessing CV autonomic dysfunction. Chronic complications have a long-term impact on health and CV disease risk. While promising methodologies exist, such as 24-hour ABPM and questionnaire-based assessments, further refinement is needed. Comprehensive management strategies should also be developed. This includes emerging techniques like spinal neuromodulation, which require extensive research and clinical trials.</p>","PeriodicalId":50044,"journal":{"name":"Journal of Spinal Cord Medicine","volume":" ","pages":"1-61"},"PeriodicalIF":1.8,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143796804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hybrid assistive limb treatment for patients with severe cervical and thoracic myelopathy due to ossification of the posterior longitudinal ligament and ligamentum flavum: Feasibility, safety, and efficacy in the acute and chronic phases.","authors":"Yuichiro Soma, Shigeki Kubota, Hideki Kadone, Yukiyo Shimizu, Masao Koda, Yasushi Hada, Yoshiyuki Sankai, Masashi Yamazaki","doi":"10.1080/10790268.2024.2448047","DOIUrl":"https://doi.org/10.1080/10790268.2024.2448047","url":null,"abstract":"<p><strong>Objective: </strong>To assess the feasibility, safety, and efficacy of hybrid assistive limb (HAL) training in patients with varying levels of gait impairment caused by ossification of the posterior longitudinal ligament (OPLL) or ligamentum flavum (OLF).</p><p><strong>Design: </strong>Prospective study.</p><p><strong>Setting: </strong>July 2014 to May 2019; in - and out-patient rehabilitation unit. Participants: Twenty-five patients with varying levels of ossified lesions and acute, subacute, or chronic postoperative OPLL or OLF.</p><p><strong>Interventions: </strong>Ten HAL training sessions (sixty min) in total; three times per week (acute/subacute patients) or one time per two months (chronic patients).</p><p><strong>Outcome measures: </strong>Walking Index for Spinal Cord Injury, American Spinal Injury Association (ASIA) Impairment Scale, ASIA motor score, Functional Independence Measure (FIM) motor score for activities of daily living, Berg Balance Scale, and Japanese Orthopedic Association score. Walking capabilities, including gait speed, step length, and cadence, were assessed using 10-meter and 2-minute walking tests (10/2MWT).</p><p><strong>Results: </strong>All patients completed 10 HAL training sessions without severe adverse events. In the acute/subacute group, all measures showed significant improvements, except the 2MWT. In the chronic group, the gait speed, step length, and ASIA motor, FIM motor, and 2MWT scores significantly improved. Baseline and after-10-sessions estimated marginal means were compared for the acute, subacute, and chronic groups. All items were significant in the acute/subacute groups. In the chronic group, gait speed, step length, ASIA motor score, and 2MWT results were significant.</p><p><strong>Conclusion: </strong>HAL treatment is feasible, safe, and effective in patients with different degrees of ossified lesions, specifically in those with OPLL or OLF.<b>Trial Registration:</b> UMIN000014336.</p>","PeriodicalId":50044,"journal":{"name":"Journal of Spinal Cord Medicine","volume":" ","pages":"1-9"},"PeriodicalIF":1.8,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143796805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors related to traumatic spinal cord injury outcomes: An analysis of the US National Trauma Data Bank.","authors":"Alexa R Lauinger, Samuel Blake, Alan Fullenkamp, Gregory M Polites, Paul M Arnold","doi":"10.1080/10790268.2024.2417118","DOIUrl":"https://doi.org/10.1080/10790268.2024.2417118","url":null,"abstract":"<p><strong>Introduction: </strong>Traumatic spinal cord injuries (TSCIs) are associated with high morbidity rates that can affect motor, sensory, and autonomic function. SCIs commonly result from sports, motor vehicle accidents, and other blunt traumas.</p><p><strong>Objective: </strong>To determine risk factors for in-hospital mortality, in-hospital complications, and increased length of stay (LOS) following TSCI.</p><p><strong>Methods: </strong>Data from the United States (US) National Trauma Data Bank (NTDB) from 2017 to 2021 was collected and used to assess risk factors for increased in-hospital mortality, complications, and hospital length of stay. Univariable analysis was completed on the 2017-2018 data. Variable importance was calculated, and a logistic regression was performed using the most important variables. Internal and external validation was completed using a testing cohort and 2020-2021 data.</p><p><strong>Results: </strong>Spinal fusion was associated with decreased mortality but increased complications and LOS. Increased age and injury severity score was associated with increased mortality, complications, and LOS, while the emergency department Glasgow Coma Score was inversely related to all outcomes. Each model had moderate to high prediction ability based on internal area under the curves (AUCs) ranging from 0.757 to 0.899 and external AUCs between 0.744 and 0.884.</p><p><strong>Conclusion: </strong>Understanding the factors that contribute to poorer outcomes following TSCI can help inform physicians of best treatment practices and patient prognosis. We highlighted five risk factors that correlate with short-term patient outcomes. Future research will further explore how treatment can impact both short - and long-term outcomes.</p>","PeriodicalId":50044,"journal":{"name":"Journal of Spinal Cord Medicine","volume":" ","pages":"1-10"},"PeriodicalIF":1.8,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143796813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health-related outcomes of different levels of physical activity among individuals with spinal cord injuries: An exploratory cross-sectional study.","authors":"Kazuki Kaneda, Noriaki Maeda, Takumi Nagao, Ayano Ishida, Tsubasa Tashiro, Shogo Tsutsumi, Satoshi Arima, Makoto Komiya, Yukio Urabe","doi":"10.1080/10790268.2025.2460302","DOIUrl":"https://doi.org/10.1080/10790268.2025.2460302","url":null,"abstract":"<p><strong>Background: </strong>The necessary and optimal physical activity for individuals with spinal cord injury remains unclear, and the development of interventions adapted to the needs of individuals with spinal cord injury is inadequate.</p><p><strong>Objective: </strong>To investigate the implications and health-related outcomes of different levels of physical activity on individuals with spinal cord injuries.</p><p><strong>Methods: </strong>The participants comprised 67 individuals, aged 18-65 years, with spinal cord injuries, who resided in Japan. Participants' demographic information was obtained, and their activities of daily living independence, physical activity level, mental health status, lifestyle, and social capital were assessed using online questionnaires. Participants were divided into three groups, based on their level of physical activity. Outcome measures were compared among the participants for different PA levels using one-way ANOVA. And, Pearson's product-moment correlation coefficient was used to examine the relationships between different levels of PA and the other outcome measures.</p><p><strong>Results: </strong>A one-way analysis of variance demonstrated a significant interaction between sports time, exercise time, the International Physical Activity Questionnaire-Short Form score, and Health-Related Social Capital among the groups. Participants with low activity correlated negatively with sports time and health practice index, and positively with exercise time and psychological distress. Participants with moderate activity also showed a positive correlation with exercise time and distress.</p><p><strong>Conclusions: </strong>The differences observed in the sports time emphasize the potential benefits of higher physical activity levels among individuals with spinal cord injuries and the existence of challenges associated with different levels of physical activity.</p>","PeriodicalId":50044,"journal":{"name":"Journal of Spinal Cord Medicine","volume":" ","pages":"1-7"},"PeriodicalIF":1.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143755511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spinal cord injury and male infertility: Effect of the inflammasome proteins on semen quality.","authors":"Karla Pacheco de Melo, Giovana Salla Siqueira de Souza, Emad Ibrahim, Charles M Lynne, Nancy L Brackett, Ricardo Pimenta Bertolla, Mariana Camargo","doi":"10.1080/10790268.2025.2472095","DOIUrl":"https://doi.org/10.1080/10790268.2025.2472095","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate seminal plasma levels of Biglycan, Cystatin-S, β-2 microglobulin and inflammasome proteins and to investigate their role in seminal toxicity in men with spinal cord injury (SCI).</p><p><strong>Study design: </strong>cross-sectional study.</p><p><strong>Setting: </strong>Miami Project to Cure Paralysis - University of Miami / Miller School of Medicine and Federal University of Sao Paulo.</p><p><strong>Participants: </strong>Eight men with spinal cord injury and eight men without spinal cord injury (controls).</p><p><strong>Intervention: </strong>none. Outcome measures: semen analysis as per WHO 2010 guidelines; seminal plasma ELISA for IL-1β, IL-18 and caspase-1; and Western blotting for Biglycan, β-2microglobulin and Cystatin-S proteins.</p><p><strong>Results: </strong>Proteins from the inflammasome complex are elevated in men with SCI, as previously described. In addition, β-2-microgobulin, Cystatin-S and two different isoforms of Byglican are elevated in men with SCI.</p><p><strong>Conclusion: </strong>a different pathway to activate the inflammasome complex is present in men with spinal cord injury. This pathway can be a potential target for new interventions in the future.</p>","PeriodicalId":50044,"journal":{"name":"Journal of Spinal Cord Medicine","volume":" ","pages":"1-7"},"PeriodicalIF":1.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143755527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}