Journal of Spinal Cord Medicine最新文献

{"title":"Evolving our commitment to advancing care and research in spinal cord injury: The ASCIP Committee for Health Sustainability 2026.","authors":"Christopher L White, Ellia Ciammaichella, Florian P Thomas, Kathleen Decina, Sigmund Hough, Jilian M Walker, Kelly Spellman","doi":"10.1080/10790268.2026.2721074","DOIUrl":"https://doi.org/10.1080/10790268.2026.2721074","url":null,"abstract":"","PeriodicalId":50044,"journal":{"name":"Journal of Spinal Cord Medicine","volume":" ","pages":"1-2"},"PeriodicalIF":1.3,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148889192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful leadless intracardiac pacemaker for delayed onset bradyarrhythmia after spinal cord injury.","authors":"John Paul S Khouzam, Timothy C Frommeyer, Ajay Agarwal","doi":"10.1080/10790268.2025.2517933","DOIUrl":"10.1080/10790268.2025.2517933","url":null,"abstract":"<p><strong>Context: </strong>Bradyarrhythmias are typically an early consequence of spinal cord injury (SCI).</p><p><strong>Findings: </strong>A 30-year-old woman with high cervical SCI developed symptomatic delayed-bradyarrhythmia six years post-injury.</p><p><strong>Conclusion/clinical relevance: </strong>This case provides evidence of delayed-bradyarrhythmia status due to autonomic dysfunction after SCI. Leadless permanent pacemakers are an effective and safe treatment alternative to traditional pacemakers.</p>","PeriodicalId":50044,"journal":{"name":"Journal of Spinal Cord Medicine","volume":" ","pages":"1181-1184"},"PeriodicalIF":1.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13591971/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144318539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of transcutaneous tibial nerve stimulation on anticholinergic refractory neurogenic detrusor overactivity in individuals with suprasacral spinal cord injury: A urodynamic study.","authors":"Zuhal Ozisler, Meric Selim Sipal, Sinem Yildirim","doi":"10.1080/10790268.2025.2545064","DOIUrl":"10.1080/10790268.2025.2545064","url":null,"abstract":"<p><strong>Context: </strong>Individuals with suprasacral spinal cord injury (SCI) often face significant clinical and quality-of-life (QoL) burdens due to neurogenic detrusor overactivity (NDO). Transcutaneous tibial nerve stimulation (TTNS) is a non-invasive neuromodulation technique that may serve as a treatment option, but evidence regarding its effectiveness in anticholinergic-refractory NDO remains limited.</p><p><strong>Objectives: </strong>To evaluate the effectiveness of TTNS on urodynamic parameters in individuals with SCI who have anticholinergic-refractory NDO.</p><p><strong>Methods: </strong>Twenty-one patients with suprasacral SCI completed the study, of whom 42.9% had complete injuries. Twelve TTNS sessions (20 Hz, 200 ms, 30 minutes) were administered twice weekly. Urodynamic outcomes were assessed using reflex volume (RV), maximal cystometric capacity (MCC), maximal detrusor pressure (Pdet-max), and bladder compliance (BC). TTNS was considered positive if RV and/or MCC increased by ≥100 mL or ≥50% from baseline. The Neurogenic Bladder Symptom Score (NBSS) was used to assess symptom severity.</p><p><strong>Results: </strong>Significant improvements were observed in RV, MCC, Pdet-max, and BC after TTNS (P < 0.001). No statistically significant differences in urodynamic parameter changes following TTNS were observed between groups categorized by either injury severity or duration (P > 0.05). TTNS was considered positive in 9 patients (42.9%) based on RV and/or MCC improvements. Following TTNS, significant improvements were observed in the incontinence, storage and voiding, QoL subdomains of the NBSS (P < 0.05).</p><p><strong>Conclusion: </strong>Although Pdet-max remained >40 cmH₂O in nearly half of the patients after TTNS, improvements in both urodynamic parameters and NBSS scores indicate that TTNS may provide clinical benefit in patients with anticholinergic-refractory NDO.</p>","PeriodicalId":50044,"journal":{"name":"Journal of Spinal Cord Medicine","volume":" ","pages":"1109-1115"},"PeriodicalIF":1.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13592002/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144976661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retrospective analysis of stage IV pressure injuries managed without operative closure in veterans admitted to a spinal cord injuries/disorders unit.","authors":"Stephanie Cowherd Ryder, Krista King, Scott Schubert, Bennett Lee","doi":"10.1080/10790268.2025.2571823","DOIUrl":"10.1080/10790268.2025.2571823","url":null,"abstract":"<p><strong>Objective: </strong>Patients with spinal cord injuries/disorders (SCI/D) have one of the highest risks of developing pressure injuries, but surgical closure of these wounds has significant pre-operative and post-operative requirements with a high rate of complications. Limited data exists on the outcomes of stage IV pressure injuries that are not managed with surgical closure. Our objective was to review outcomes of patients with stage IV pressure injuries that close by secondary intention.</p><p><strong>Design: </strong>Retrospective case series review Setting: Veterans Affairs hospital.</p><p><strong>Methods: </strong>Records of veterans hospitalized on an SCI/D inpatient unit during March 2022 to June 2023 were reviewed to determine if patients were admitted with a stage IV pressure injury. These charts were then further reviewed to determine wound characteristics, medical and surgical management, and wound outcomes.</p><p><strong>Results: </strong>Charts of twenty-three Veterans with a total of 25 pressure injuries were reviewed.</p><p><strong>Conclusions: </strong>Ninety-two percent of stage IV pressure injuries improved with complete healing in 36%, though over half of these wounds had imaging concerning for osteomyelitis and required surgical debridement and/or antibiotics. Additionally, these wounds improved or closed though 91.30% were prescribed a progressive sitting program.</p>","PeriodicalId":50044,"journal":{"name":"Journal of Spinal Cord Medicine","volume":" ","pages":"974-980"},"PeriodicalIF":1.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13591989/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145356697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive fusion as a mediator between pain interference and depressive and anxiety symptoms among adults with spinal cord injury.","authors":"Areum Han, Ickpyo Hong, Jereme D Wilroy, Ukamaka Oruche","doi":"10.1080/10790268.2026.2663663","DOIUrl":"10.1080/10790268.2026.2663663","url":null,"abstract":"<p><strong>Context/objective: </strong>This study examined whether cognitive fusion statistically mediated the cross-sectional associations of pain interference with depressive and anxiety symptoms among individuals with spinal cord injury (SCI).</p><p><strong>Design: </strong>Cross-sectional mediation models estimated using path analysis were used to test cognitive fusion as a mediator between pain interference and depressive or anxiety symptoms.</p><p><strong>Setting: </strong>Online survey completed by adults with SCI in the United States.</p><p><strong>Participants: </strong>156 adults (51.3% female; mean age = 42.1 years) with traumatic (78.2%) or non-traumatic (21.8%) SCI.</p><p><strong>Outcome measures: </strong>Pain interference was measured using the spinal cord injury - Quality of Life (SCI-QOL) Pain Interference Short Form. Cognitive fusion was assessed with the Cognitive Fusion Questionnaire-7. Depressive and anxiety symptoms were measured using the Patient Health Questionnaire-9 and Generalized Anxiety Disorder-7, respectively. Grief due to SCI, measured using the SCI-QOL Grief and Loss Short form, was retained as a covariate.</p><p><strong>Results: </strong>Pain interference was significantly associated with higher cognitive fusion and greater depressive and anxiety symptoms. After controlling for SCI-related grief, cognitive fusion partially mediated these relationships, accounting for 45.4% of the total effect of pain interference on depressive symptoms and 42.3% of the total effect on anxiety.</p><p><strong>Conclusion: </strong>Cross-sectional path analyses supported an indirect statistical association between pain interference and depressive/anxiety symptoms through cognitive fusion. These findings highlight cognitive fusion as a critical, modifiable psychological mechanism underlying this relationship. Targeting cognitive fusion in interventions such as acceptance and commitment therapy may help mitigate the psychological impact of pain interference and improve mental health.</p>","PeriodicalId":50044,"journal":{"name":"Journal of Spinal Cord Medicine","volume":" ","pages":"853-863"},"PeriodicalIF":1.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13591972/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147934953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Commentary on cognitive fusion as a mediator between pain interference and depressive and anxiety symptoms among adults with spinal cord injury.","authors":"Anna Derbaly-Basenese, Elizabeth Kera","doi":"10.1080/10790268.2026.2682626","DOIUrl":"10.1080/10790268.2026.2682626","url":null,"abstract":"<p><p>A recent study exploring the mediating relationship of cognitive fusion between pain interference and depressive/anxiety symptoms in individuals with SCI found that focusing on cognitive fusion intervention in psychotherapy can help to alleviate the psychological impact of pain interference (<i>Cognitive Fusion as a Mediator Between Pain Interference and Depressive and Anxiety Symptoms Among Adults with spinal cord injury</i>). We discuss the theoretical underpinnings of cognitive fusion and defusion as well as psychological flexibility which are points of focus in acceptance and commitment therapy. We review how each can impact quality of life, and outline additional factors which can mediate therapeutic success in individuals with SCI. Lastly, the difference between pain intensity and pain perception is highlighted, with a brief discussion as to how these two concepts, along with pain interference, can impact adjustment to illness and therapeutic interventions.</p>","PeriodicalId":50044,"journal":{"name":"Journal of Spinal Cord Medicine","volume":" ","pages":"864-865"},"PeriodicalIF":1.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13591944/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148297137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COVID-19 test positivity, vaccine uptake, and mortality among Veterans with SCI/D.","authors":"Marinella Galea, Steven Knezevic, Lance Washington, Mengfei Yu, Jennifer Sippel, B Jenny Kiratli, Ann M Spungen, Ona Bloom, Doug Ota, Andrea K Finlay","doi":"10.1080/10790268.2025.2593075","DOIUrl":"10.1080/10790268.2025.2593075","url":null,"abstract":"<p><strong>Background: </strong>Between January 2020 and December 2023, the United States reported over 103 million COVID-19 cases and 1.1 million related deaths. Veterans with spinal cord injuries and disorders (VSCI/D) are particularly vulnerable due to chronic health conditions and comorbidities, which increases COVID-19 infection and mortality risk from exposure to others who they depend on for care. This manuscript highlights factors associated with COVID-19 vaccine uptake in VSCI/D.</p><p><strong>Objective: </strong>This study aimed to explore Veteran demographic and clinical factors associated with COVID-19 test positivity, vaccine uptake, and COVID-19-related mortality among VSCI/D in the 2-year period following the start of the pandemic.</p><p><strong>Methods: </strong>This observational cohort study used the Veterans Health Administration's (VHA) Spinal Cord Injuries and Disorders Registry to identify VSCI/D alive on March 20, 2020. Outcome measures included COVID-19 test positivity, vaccine uptake, and mortality within 30 days of a positive test over a 2-year period.</p><p><strong>Results: </strong>Among 17,522 VSCI/D, 12% had a positive COVID-19 test at least once in the two-year period following March 20, 2020, 73% received at least one COVID-19 vaccine dose in the 2-year period, and 47% received at least three doses. COVID-related mortality occurred in 67 (0.4%; 67/17,522) VSCI/D in the first year of the pandemic and 46 in the second year (0.6% two-year mortality; 113/17,522).</p><p><strong>Conclusion: </strong>Less than half of VSCI/D received three COVID-19 vaccine doses, suggesting opportunities for quality improvement efforts. Peer support services may help improve vaccine uptake among VSCI/D in the future.</p>","PeriodicalId":50044,"journal":{"name":"Journal of Spinal Cord Medicine","volume":" ","pages":"1128-1139"},"PeriodicalIF":1.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12755074/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145758161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of short-chain fatty acids in spinal cord injury: A systematic review of human and animal evidence.","authors":"Sina Rinderknecht, Alessandro Bertolo, Ezra Valido, Stevan Stojic, Samford Wong, Gary J Farkas, Priya Iyer, Ivana Jaric, Jivko Stoyanov, Marija Glisic","doi":"10.1080/10790268.2025.2607831","DOIUrl":"10.1080/10790268.2025.2607831","url":null,"abstract":"<p><strong>Context: </strong>Spinal cord injury (SCI) disrupts gut microbiota composition, resulting in dysbiosis that can worsen neuroinflammation and impede post-injury recovery. Short-chain fatty acids (SCFA), metabolites produced by the gut microbiome with anti-inflammatory properties, offer a promising avenue for improving recovery and rehabilitation outcomes.</p><p><strong>Objective: </strong>We aimed to compile a summary of the human and animal evidence on the potential benefits of SCFA or SCFA  - producing bacteria in individuals with SCI.</p><p><strong>Methods: </strong>Three databases (EMBASE, Medline (Ovid) and Web of Science) were searched from inception until 19 October 2023. No language restrictions were applied. Title and abstract screening, data extraction and risk of bias assessments were done independently by two reviewers.</p><p><strong>Results: </strong>A total of 2492 studies were retrieved, 69 full-text studies were reviewed, and 13 studies were included (11 animal and 2 human). Human studies, which involved participants with chronic SCI, linked gut dysbiosis (a proxy for low SCFA production) and human metabolic profiles, suggesting a potential role for microbiome-targeted interventions even in later stages of injury. Evidence from animal studies, predominantly in acute and sub-acute models of SCI, consistently associated SCFA interventions with improved motor function, reduced tissue damage and favorable changes in inflammatory and oxidative stress markers. Fecal microbiota transplantation and probiotics improved motor function and reduced lesion size in animal models. Gut microbiome modulations through treatments such as melatonin, moxibustion, and intermittent fasting was correlated with improved motor outcomes and increased abundance of SCFA-producing bacteria.</p><p><strong>Conclusions: </strong>This review highlights the potential of targeting the gut microbiota and SCFAs as therapeutic strategies for SCI recovery. However, despite promising results in animal models, human evidence remains limited.</p>","PeriodicalId":50044,"journal":{"name":"Journal of Spinal Cord Medicine","volume":" ","pages":"927-940"},"PeriodicalIF":1.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13591990/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146229543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors for complications in traumatic spinal cord injury: A retrospective analysis of a cohort of patients identified from administrative data.","authors":"Michael Bond, Aidan Beresford, Vanessa K Noonan, Naama Rotem-Kohavi, Nader Fallah, Marcel F Dvorak, Brian K Kwon, Guiping Liu, Jason M Sutherland","doi":"10.1080/10790268.2025.2571822","DOIUrl":"10.1080/10790268.2025.2571822","url":null,"abstract":"<p><strong>Study design: </strong>Retrospective data analysis of a population-based observational cohort. Setting: TSCI in British Columbia, Canada Participants: 3,433 TSCI patients included in the study.</p><p><strong>Methods: </strong>Hospital records linked with administrative databases were utilized to measure in-hospital mortality, adverse event rate, and LOS between 2001 and 2021. Adverse events included all documented complications during hospital admission. Multivariable logistic regression and Cox proportional hazard models were used to identify factors associated with mortality, adverse events, and LOS.</p><p><strong>Results: </strong>All cause in-hospital mortality was 6.4%. The average age of patients was 53.2 years (SD 19.7), 75.4% were males and 70% incurred a cervical spinal cord injury. Multivariable analysis demonstrated that patients 35 years old, multiple medical comorbidities, cervical injury, neurologically complete, high injury severity score (25), concomitant brain injury, lower socioeconomic status, and no surgical management were at higher risk for death. Factors associated with adverse events were similar with the exception of non-operative patients who had lower adverse events. Cox modeling for LOS demonstrated similar findings to mortality analysis.</p><p><strong>Conclusions: </strong>This study found that spinal cord injury patients were more likely to have adverse outcomes with older age, cervical injury, multiple comorbidities, complete neurological injury, or higher severity initial traumatic injuries. This study identified risks associated with complications in TSCI, future research should address ways to improve outcomes in these targeted groups.</p>","PeriodicalId":50044,"journal":{"name":"Journal of Spinal Cord Medicine","volume":" ","pages":"1116-1127"},"PeriodicalIF":1.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13591940/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145356694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Upper limb splinting for people following spinal cord injury: A scoping review.","authors":"Sushmita Mohapatra, Morsal Noori, Samantha Higgins, Rokhsaneh Tehrany","doi":"10.1080/10790268.2025.2548054","DOIUrl":"10.1080/10790268.2025.2548054","url":null,"abstract":"<p><strong>Context: </strong>Upper limb (UL) splinting interventions are commonly delivered to people following spinal cord injury (SCI) as part of multi-modal rehabilitation; however, their clinical efficacy remains unclear and a wide variety of splinting interventions are used in clinical practice and described in the literature.</p><p><strong>Objective: </strong>This study aimed to map out the available evidence and guidelines on the topic, to summarize the breadth of knowledge and identify knowledge gaps.</p><p><strong>Methods: </strong>A scoping review was conducted using the Arksey & O'Malley's methodological framework. Seven electronic databases were searched for literature evaluating upper limb splinting interventions for SCI rehabilitation. Two independent reviewers screened results. Findings were synthesized narratively and reported according to the PRISMA-ScR checklist.</p><p><strong>Results: </strong>21 primary studies evaluating traditional (n = 13) and non-traditional (n = 3) splints, five qualitative studies and 15 clinical guidelines were included. Most studies evaluated hand and wrist-based splints, which were predominantly used to optimize hand function. Large variations in terms of purpose, type, dosage, outcome assessment and impact of splinting interventions were identified. All clinical guidelines lacked detail and acknowledged the need for tailoring.</p><p><strong>Conclusion: </strong>Considerable heterogeneity amongst the UL splinting literature and guidelines for SCI rehabilitation exists, with sub-optimal reporting of recommendation for the interventions. Studies were limited by weak methodological designs and small samples sizes, highlighting the need for high-quality mixed-methods trials that have been co-designed by patient and clinical stakeholders. There is a need to develop more robust clinical guidelines specifically for SCI rehabilitation.</p>","PeriodicalId":50044,"journal":{"name":"Journal of Spinal Cord Medicine","volume":" ","pages":"866-885"},"PeriodicalIF":1.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13591996/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146133424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}