Journal of Spinal Cord Medicine最新文献

{"title":"Epidemiology of spinal cord injury and spinal cord injury-induced urinary tract stones in Taiwan: A 2005-2015 population-based cohort study.","authors":"Mei-Hua Cheng, Shu-O Chiang, Chen-Yi Wang, Kuo-Ting Chang, Wei-Jie Wang","doi":"10.1080/10790268.2023.2293326","DOIUrl":"10.1080/10790268.2023.2293326","url":null,"abstract":"<p><strong>Context: </strong>Patients with spinal cord injury (SCI) can develop urinary tract stones (UTSs) up to years after the injury, which is especially common in the first few months. However, relevant epidemiological studies and up-to-date epidemiological data for SCI in Taiwan are lacking.</p><p><strong>Purpose: </strong>To estimate SCI and SCI-induced UTS incidence and trauma severity, neurological deficits, and injury site in patients with SCI-induced UTSs in Taiwan.</p><p><strong>Design: </strong>Retrospective cohort study.Patient sample: Taiwan National Health Insurance Research Database (NHIRD) data and death data from the Department of Health and Welfare Data Science Center (HWDC) collected over 2005-2015 from 13,977 patients with SCI aged >18 years.</p><p><strong>Outcome measures: </strong>Cumulative incidence (CI), incidence density (ID), relative ratios (RRs), odds ratios (ORs), and hazard ratios (HRs) were measured.</p><p><strong>Methods: </strong>By using Cox regression, we assessed UTS risk in patients with SCI.</p><p><strong>Results: </strong>Although standardized SCI incidence demonstrated a decreasing trend annually, the average annual incidence remained at 60.4 per million. Most (65.7%) of the included patients were men. SCI incidence was 1.98 times higher in men than in women. The most common injury site was the cervical spine (63.8%); the incidence at this site was 2.83 times higher in men than in women. Most (76.1%) of the patients had traumatic SCI (TSCI), and the standardized incidence of TSCI and non-TSCI was 45.9 and 14.4 per million, respectively. 46.1% of the patients had severe SCI (RISS ≥ 16). Over the 11-year follow-up period, UTSs occurred in 10.4% of the patients, with a standardized incidence of 2.39 per 100 person-years, and UTS risk was 1.56 times higher in men than in women. Age of 45-65 years, SCIs at multiple sites, and neurological deficits (e.g. paraplegia) were noted to be UTS risk factors. Finally, UTS onset mainly occurred in the first year after SCI.</p><p><strong>Conclusion: </strong>The risk of UTS among patients with SCI is influenced by age, sex, injury site, and paraplegia but not by paralysis resulting from other neurological deficits. Even though SCI incidence is declining annually, severe SCI remains a significant issue. Therefore, continuing to reduce SCI incidence and strengthening urinary tract management in patients with SCI are essential for reducing UTS occurrence and their impact on health.</p>","PeriodicalId":50044,"journal":{"name":"Journal of Spinal Cord Medicine","volume":" ","pages":"248-258"},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11864027/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139492531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing surgeries to restore upper extremity function in tetraplegia: Impact on function during the perioperative period.","authors":"Caitlin A Francoisse, Blair R Peters, Catherine M Curtin, Christine B Novak, Stephanie A Russo, Katharine Tam, Doug T Ota, Katherine C Stenson, John D Steeves, Carie R Kennedy, Ida K Fox","doi":"10.1080/10790268.2023.2283238","DOIUrl":"10.1080/10790268.2023.2283238","url":null,"abstract":"<p><strong>Context/objective: </strong>To assess short-term changes in health outcomes in people with cervical-level spinal cord injury (SCI) who underwent upper extremity (UE) reconstruction via either novel nerve transfer (NT) or traditional tendon transfer (TT) surgery with individuals who did not undergo UE surgical reconstruction.</p><p><strong>Design: </strong>Prospective, comparative cohort pilot study.</p><p><strong>Participants: </strong>34 participants with cervical SCI met the following inclusion criteria: age 18 or older, greater than 6 months post-injury, and mid-cervical level SCI American Spinal Injury Association Impairment Scale (AIS) A, B or C.</p><p><strong>Setting: </strong>Two tertiary academic hospitals and their affiliated veterans' hospitals.</p><p><strong>Methods: </strong>Health outcomes were assessed using two previously validated measures, the Spinal Cord Independence Measure (SCIM) and Short-Form Health Survey (SF-36). Demographic, surgical, and survey data were collected at the initial evaluation and one month postoperatively/post-baseline.</p><p><strong>Results: </strong>34 participants with cervical SCI were recruited across three cohorts: no surgery (<i>n</i> = 16), NT (<i>n</i> = 10), and TT (<i>n</i> = 8). The TT group had a decline in SCIM and SF-36 scores whereas the NT and no surgery groups experienced little change in independence or health status in the immediate perioperative period.</p><p><strong>Conclusions: </strong>Surgeons and rehabilitation providers must recognize differences in the perioperative needs of people with cervical SCI who chose to have restorative UE surgery. Future work should focus on further investigation of health outcomes, change in function, and improving preoperative counseling and cross-disciplinary management.</p>","PeriodicalId":50044,"journal":{"name":"Journal of Spinal Cord Medicine","volume":" ","pages":"300-311"},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11864012/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139484673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing open science: The evolving role of preprints in biomedical research.","authors":"Carol Ann Murphy, Florian P Thomas","doi":"10.1080/10790268.2025.2466373","DOIUrl":"10.1080/10790268.2025.2466373","url":null,"abstract":"","PeriodicalId":50044,"journal":{"name":"Journal of Spinal Cord Medicine","volume":"48 2","pages":"159-160"},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11864035/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143494555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility of a community-based structured exercise program for persons with spinal cord injury.","authors":"Kerri A Morgan, Kelly L Taylor, Rachel Heeb Desai, Kimberly Walker, Susan Tucker, Carla Wilson Walker, Holly Hollingswoth, W Todd Cade","doi":"10.1080/10790268.2023.2293327","DOIUrl":"10.1080/10790268.2023.2293327","url":null,"abstract":"<p><strong>Objectives: </strong>(1) Examine the feasibility of a community-based exercise intervention for persons with spinal cord injury and (2) compare the cardiorespiratory fitness, skeletal muscle strength, and psychosocial well-being of participants in the intervention group versus control group.</p><p><strong>Design: </strong>Community-based pilot randomized controlled trial. <i>Setting</i>: Accessible community-based health and wellness center. <i>Participants</i>: Thirty-two sedentary community-dwelling adults with any level of spinal cord injury. <i>Interventions:</i> Participants were randomized to a 36-session/12-week community-based exercise program (intervention; EG) or to a 36-session/12-week physical activity education group (control; CG). <i>Outcome measures</i>: Primary outcome measures included cardiorespiratory fitness measured by a VO₂peak test, a composite score of four upper extremity musculoskeletal strength 1-repetition maximum exercises, and feasibility measured by EG participants' adherence and exercise intensity achieved during the program. EG participants' acceptance of the program was also evaluated using a self-reported satisfaction scale. Self-efficacy, motivation, pain, and goal performance and satisfaction were secondary outcome measures. Adherence and acceptability were also measured.</p><p><strong>Results: </strong>Fifteen participants (<i>n</i> = 15) completed the community-based exercise intervention and seventeen (<i>n</i> = 17) completed the education program. While no statistically significant differences were found, the EG experienced changes of moderate effect size in cardiorespiratory fitness, strength, motivation, and satisfaction with their goals. The EG attended, on average, two sessions per week. The community-based exercise intervention was highly accepted by and satisfying for participants to engage in.</p><p><strong>Conclusions: </strong>The EG had improvements in the two primary measures, cardiorespiratory fitness and musculoskeletal strength, following the intervention. The community-based exercise intervention was feasible and accepted by participants.</p>","PeriodicalId":50044,"journal":{"name":"Journal of Spinal Cord Medicine","volume":" ","pages":"338-350"},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11864005/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139492533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use and experienced effectiveness of non-pharmacological treatments for chronic spinal cord injury related pain in The Netherlands: A cross-sectional survey.","authors":"Tim C Crul, Aline J Hakbijl-van der Wind, Charlotte M van Laake-Geelen, Johanna Ma Visser-Meily, Marcel Wm Post, Janneke M Stolwijk-Swüste","doi":"10.1080/10790268.2024.2345448","DOIUrl":"10.1080/10790268.2024.2345448","url":null,"abstract":"<p><strong>Context/objective: </strong>Chronic pain is a common secondary condition in spinal cord injury (SCI). Pharmacological interventions to reduce pain are associated with side effects. The reported effects of non-pharmacological treatments are unclear. This study aims to examine the self-reported presence and type of pain, and the use, effectiveness and side effects of non-pharmacological treatments for pain.</p><p><strong>Design: </strong>Cross-sectional survey regarding SCI-related pain and non-pharmacological treatments.</p><p><strong>Setting: </strong>Community, the Netherlands.</p><p><strong>Participants: </strong>Outpatients with SCI from two rehabilitation centers.</p><p><strong>Interventions: </strong>Not applicable.</p><p><strong>Outcome measures: </strong>Self-reported presence and type of pain, use, effectiveness and side effects of non-pharmacological treatments.</p><p><strong>Results: </strong>A total of 371 patients (41.5%) returned the questionnaire. Median time since onset of SCI was 7 years. Pain following SCI was reported by 262 patients (70.6%). Neuropathic pain was reported most often (74.4%), followed by musculoskeletal pain (51.5%). Of patients with pain, 204 (77.9%) reported past or current use of non-pharmacological treatments. Non-pharmacological treatments used most were physiotherapy (67.6%), physical exercise (44.7%) and massage (22.5%). Of patients using non-pharmacological treatments, 152 patients (74.5%) reported the effect of their treatment. Most treatments for which the effect was reported, were described as moderately effective. Most side effects were reported for cannabis.</p><p><strong>Conclusion: </strong>Patients with SCI experiencing pain often use non-pharmacological treatments. Most treatments were described as moderately effective. Research on specific non-pharmacological treatments and different types of pain separately is needed to further determine the effectiveness of non-pharmacological treatments.</p>","PeriodicalId":50044,"journal":{"name":"Journal of Spinal Cord Medicine","volume":" ","pages":"199-207"},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11864019/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140870990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Embracing Inclusion, Diversity, Equity and Access (IDEA): Cultivating understanding internally to foster external change.","authors":"Jeffrey P Jaramillo, Sigmund Hough, Jillian Walker, Trisha Hicks, Florian P Thomas, Ellia Ciammaichella, Samantha Harfenist, Katharine Tam, Jessica Whitchurch","doi":"10.1080/10790268.2024.2426312","DOIUrl":"10.1080/10790268.2024.2426312","url":null,"abstract":"<p><strong>Context: </strong>Healthcare institutions acknowledge the value of diverse workforces for enhancing programs and meeting the varied needs of individuals with Spinal Cord Injury. This survey conducted at the 2023 Academy of Spinal Cord Injury Professions (ASCIP) conference assesses healthcare professionals' views on workplace Diversity, Equity, and Inclusion (DEI) and their support for integrating related educational content in future events.</p><p><strong>Methods: </strong>: The survey was distributed digitally to ASCIP attendees, ensuring anonymity and voluntary participation. It aimed to collect data on demographic backgrounds, perceptions of DEI at work, and the relevance of educational topics regarding Inclusion, Diversity, Equity, and Access (IDEA) for upcoming conference agendas.</p><p><strong>Results: </strong>: Seventy percent of respondents felt able to achieve success and express their genuine feelings in the workplace, with their opinions valued. While economic disparities were often discussed (56%) in relation to patient care, other aspects like religion, cultural racism, racial inequalities, and LGBTQ + issues were less frequently addressed. Approximately 55% reported that their organizations had recently started or were initiating DEI efforts.</p><p><strong>Conclusions: </strong>: There is a clear need for inclusive work environments and patient care that values the diverse intersectionality of the community served. Strong support exists for further educational initiatives on IDEA concepts, highlighting a significant opportunity to enhance early-stage DEI programs in healthcare settings.</p>","PeriodicalId":50044,"journal":{"name":"Journal of Spinal Cord Medicine","volume":" ","pages":"161-169"},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11864015/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142689374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"All day in bed, all night in the wheelchair: Unmet attendant care needs of people with spinal cord injury.","authors":"James S Krause, Philip A Edles, Jon Laursen-Roesler, Melinda Jarnecke","doi":"10.1080/10790268.2024.2362505","DOIUrl":"10.1080/10790268.2024.2362505","url":null,"abstract":"<p><strong>Context: </strong>Having dependable attendant care is essential to the health and well-being of those most severely impacted by a spinal cord injury (SCI). Our objective was to identify how often people with SCI who require assistance for transfers either spend a full day in bed or all night in a wheelchair because they do not have paid or unpaid assistance.</p><p><strong>Findings: </strong>Of the 918 respondents, 319 (34.7%) indicated they needed someone's help for basic activities of daily living and 229 (24.9%) relied on someone's assistance for wheelchair-to-bed transfers. Nearly a quarter of participants (22.2%) reported staying in bed all day for at least one once on during the past year, with a median of 10 times among those with at least one day. Men reported a higher rate than women (25.6%, 13.6%) and nonwhites-Hispanics (33.3%) reported a higher percentage than non-Hispanic whites (18.6%). Just over one in every 20 participants (5.3%) reported staying in the wheelchair at least one night because they did not have attendant care, with a median of 2.5 times among those with at least one night. Over one in 10 (11.7%) nonwhites and Hispanics reported at least one overnight in the wheelchair compared with only (3.1%) for non-Hispanic whites.</p><p><strong>Conclusion/clinical relevance: </strong>Staying in bed all day and staying in the chair all night due to lack of attendant care represents a breakdown in the attendant care system and a threat to the well-being of those with SCI, particularly nonwhites and Hispanics, and men.</p>","PeriodicalId":50044,"journal":{"name":"Journal of Spinal Cord Medicine","volume":" ","pages":"351-356"},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12047189/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141307282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gait training using a wearable robotic hip device for incomplete spinal cord injury: A preliminary study.","authors":"Kenichi Yoshikawa, Hirotaka Mutsuzaki, Kazunori Koseki, Koichi Iwai, Ryoko Takeuchi, Yutaka Kohno","doi":"10.1080/10790268.2023.2273587","DOIUrl":"10.1080/10790268.2023.2273587","url":null,"abstract":"<p><strong>Context/objective: </strong>To explore changes in gait functions for patients with chronic spinal cord injury (SCI) before and after standard rehabilitation and rehabilitation with a wearable hip device, explore the utility of robot-assisted gait training (RAGT), and evaluate the safety and dose of RAGT.</p><p><strong>Design: </strong>Single-arm, open-label, observational study.</p><p><strong>Setting: </strong>A rehabilitation hospital.</p><p><strong>Participants: </strong>Twelve patients with SCI.</p><p><strong>Interventions: </strong>Standard rehabilitation after admission in the first phase. RAGT for two weeks in the second phase.</p><p><strong>Outcome measures: </strong>Self-selected walking speed (SWS), step length, cadence, and the 6-minute walking distance were the primary outcomes. Walking Index for SCI score, lower extremity motor score, and spasticity were measured. Walking abilities were compared between the two periods using a generalized linear mixed model (GLMM). Correlations between assessments and changes in walking abilities during each period were analyzed.</p><p><strong>Results: </strong>After standard rehabilitation for 66.1 ± 36.9 days, a period of 17.6 ± 3.3 days of RAGT was safely performed. SWS increased during both periods. GLMM showed that the increase in cadence was influenced by standard rehabilitation, whereas the limited step length increase was influenced by RAGT. During RAGT, the increase in step length was related to an increase in hip flexor function.</p><p><strong>Conclusions: </strong>Gait speed in patients with SCI increased after rehabilitation, including RAGT, in the short-term. This increase was associated with improved muscle function in hip flexion at the start of RAGT.<b>Trial Registration:</b> This study was registered with the UMIN Clinical Trials Registry (UMIN-CTR; UMIN000042025).</p>","PeriodicalId":50044,"journal":{"name":"Journal of Spinal Cord Medicine","volume":" ","pages":"208-220"},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11864017/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71488207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adherence and perceptions of a home sports video gaming program in persons with spinal cord injuries: A pilot study.","authors":"Jeffrey P Jaramillo, M Elise Johanson, B Jenny Kiratli","doi":"10.1080/10790268.2023.2268328","DOIUrl":"10.1080/10790268.2023.2268328","url":null,"abstract":"<p><strong>Objective: </strong>Sports video-gaming can facilitate increased activity levels in persons with limited exercise options. Understanding how persons with spinal cord injuries (SCI) participate in home-based video-gaming and its potential impact on maintaining or enhancing physical function remains largely unexplored. The purpose of this study was to evaluate adherence, perceptions, and potential physical effects of a home sports video-game program for persons with chronic SCI.</p><p><strong>Participants: </strong>Fourteen individuals with chronic SCI (9 tetraplegia, 5 paraplegia).</p><p><strong>Design: </strong>This was a prospective study. Wii video-gaming systems that included four sports games were provided to participants for home use. Participants were instructed to play for 8 weeks 3-4 days/week. The video consoles recorded the time and number of sessions played.</p><p><strong>Outcome measures: </strong>At baseline and at the conclusion of the program, measurements were made of upper extremity strength, perceived exertion, active heart rate, pain, balance, and a functional upper extremity (UE) test. The total time and number of sessions were compared to the prescribed game play as a measure of adherence. Scores from a self-reported survey were used to gauge participants' satisfaction and perceptions of their gaming experience.</p><p><strong>Results: </strong>Overall mean gaming adherence was 85% during the first 4 weeks and 69% for the second 4 weeks. There were no significant changes in upper extremity strength, active heart rate, balance, pain, or functional UE test for either group. All of the participants rated video gaming as enjoyable and 85.7% perceived that it could be used as a form of exercise.</p><p><strong>Conclusion: </strong>The Wii sports home video-gaming intervention elicited overall high adherence rates and was well received by study participants indicating that it may have value as an adjunctive tool for increasing physical activity for individuals with SCI.</p>","PeriodicalId":50044,"journal":{"name":"Journal of Spinal Cord Medicine","volume":" ","pages":"272-282"},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11864001/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136400094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Whole-body vibration may not affect bone mineral density and bone turnover in persons with chronic spinal cord injury: A preliminary study.","authors":"Laurent Maïmoun, Anthony Gelis, Chris Serrand, Thibault Mura, Severine Brabant, Patrick Garnero, Denis Mariano-Goulart, Charles Fattal","doi":"10.1080/10790268.2023.2268893","DOIUrl":"10.1080/10790268.2023.2268893","url":null,"abstract":"<p><strong>Context: </strong>Spinal-cord injury (SCI) induces bone loss and dramatically increases the risk of fracture.</p><p><strong>Objectives: </strong>Determine the effects of whole-body vibration (WBV) on areal bone mineral density (aBMD), whole body composition and bone biological parameters in individuals with chronic-state SCI.</p><p><strong>Design: </strong>Randomized study.</p><p><strong>Setting: </strong>Centre Neurologique PROPARA.</p><p><strong>Participants: </strong>Fourteen subjects were randomly assigned to a WBV or a control group.</p><p><strong>Interventions: </strong>WBV (20-45 min, 30-45 Hz, 0.5 g) was performed in verticalized persons twice weekly for 6 months.</p><p><strong>Outcome measures: </strong>aBMD was measured by DXA at baseline and 6 months and bone biological parameters at baseline, 1, 3 and 6 months.</p><p><strong>Results: </strong>No significant aBMD change was found in either the WBV or control group after 6 months of follow-up. Similarly, periostin, sclerostin and bone turnover markers remained relatively stable throughout follow-up and no difference in variation was observed within-group and between groups. Except for whole-body fat mass, which showed a significant decrease in the WBV group compared to controls, no difference in changes was observed, whatever the localization for fat and lean body mass.</p><p><strong>Conclusions: </strong>During the chronic phase, aBMD and bone remodeling reach a new steady state. However, the DXA technique and the bone markers, including sclerostin and periostin, both of which reflect bone cell activity influenced by mechanical strain, showed that the bone tissue of individuals with SCI was insensitive to 6 months of WBV training at the study dose. Nevertheless, results of this preliminary study that was underpowered need to be confirmed and other modalities of WBV may be more effective in improving aBMD of this population.</p><p><strong>Trials registration: </strong>N°IDRCB:2011-A00224-37.</p>","PeriodicalId":50044,"journal":{"name":"Journal of Spinal Cord Medicine","volume":" ","pages":"259-271"},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11864013/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71488209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}