Journal of Spinal Cord Medicine最新文献

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Meta-analysis of risk factors for pulmonary infection in patients with cervical spinal cord injury. 颈脊髓损伤患者肺部感染危险因素荟萃分析。
IF 1.3 4区 医学
Journal of Spinal Cord Medicine Pub Date : 2026-09-01 Epub Date: 2025-12-08 DOI: 10.1080/10790268.2025.2588899
Yichen Gong, Ning Li
{"title":"Meta-analysis of risk factors for pulmonary infection in patients with cervical spinal cord injury.","authors":"Yichen Gong, Ning Li","doi":"10.1080/10790268.2025.2588899","DOIUrl":"10.1080/10790268.2025.2588899","url":null,"abstract":"<p><strong>Objective: </strong>To conduct a meta-analysis of the literature to summarize the risk factors for pulmonary infection in patients with cervical spinal cord injury.</p><p><strong>Methods: </strong>Computer-based searches were performed in CNKI, CBM, Wanfang Database, VIP Series Databases, The Cochrane Library, WOS, PubMed, Springer Link, EBSCO, MEDLINE and other databases. The time frame was from January 1, 2000 to April 1, 2025. Case-control studies and cohort studies related publications were searched according to subject terms and free words. According to inclusion and exclusion criteria, 7 publications were identified, and finally meta-analysis was performed on them by Review Manager 5.3 software.</p><p><strong>Results: </strong>Seven publications met the inclusion criteria, with a total of 912 cases and 742 controls. The results of meta-analysis showed that the risk factors for pulmonary infection in patients with cervical spinal cord injury were: American Spinal Injury Association (ASIA) Impairment Scale (AIS) - AIS A and AIS B (OR: 3.90, 95% CI: 2.74-5.53), high-level injury (OR: 2.73, 95% CI: 1.69-4.40), hormone shock therapy (OR: 4.14, 95% CI: 2.58-6.62), smoking history (OR = 2.34, 95% CI: 1.54-3.55), operation time (P < 0.00001, <i>I</i><sup>2</sup> = 96%), hypoalbuminemia (P < 0.00001, <i>I</i><sup>2</sup> = 96%), and age (P < 0.00001, <i>I</i><sup>2</sup> = 95%).</p><p><strong>Conclusion: </strong>AIS A and B, high-level injury, hormone shock therapy and smoking history are risk factors for pulmonary infection in patients with cervical spinal cord injury. Controlling the above factors can effectively reduce the incidence of pulmonary infection in patients with cervical spinal cord injury.</p>","PeriodicalId":50044,"journal":{"name":"Journal of Spinal Cord Medicine","volume":" ","pages":"1152-1159"},"PeriodicalIF":1.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13591954/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145702502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tailored transcutaneous electrical nerve stimulation improves dysesthesia in individuals with spinal cord injury: A randomized N-of-1 trial. 量身定制的经皮神经电刺激改善脊髓损伤患者的感觉障碍:一项随机N-of-1试验
IF 1.3 4区 医学
Journal of Spinal Cord Medicine Pub Date : 2026-09-01 Epub Date: 2025-06-17 DOI: 10.1080/10790268.2025.2517929
Yuki Nishi, Koki Ikuno, Yuji Minamikawa, Michihiro Osumi, Shu Morioka
{"title":"Tailored transcutaneous electrical nerve stimulation improves dysesthesia in individuals with spinal cord injury: A randomized N-of-1 trial.","authors":"Yuki Nishi, Koki Ikuno, Yuji Minamikawa, Michihiro Osumi, Shu Morioka","doi":"10.1080/10790268.2025.2517929","DOIUrl":"10.1080/10790268.2025.2517929","url":null,"abstract":"<p><strong>Context: </strong>Current therapeutic interventions are often ineffective for dysesthesia, including tingling and allodynia, caused by spinal cord injury (SCI). Dysesthesia-matched TENS (DM-TENS) is an innovative approach for dysesthesias that customizes stimulation parameters to align with an individual's specific dysesthesia characteristics.</p><p><strong>Objective: </strong>We aimed to evaluate the efficacy of DM-TENS for dysesthesia in individuals with SCI.</p><p><strong>Design: </strong>A randomized, placebo-controlled, aggregated N-of-1 trial was conducted in six individuals with SCI.</p><p><strong>Methods: </strong>Participants received either DM-TENS as an intervention or sham TENS as a control. Each treatment was administered for 60 min/day over a 7-day period. The outcome measures included the Numeric Rating Scale (NRS) for dysesthesia and Short-Form McGill Pain Questionnaire-2 (SF-MPQ2).</p><p><strong>Results: </strong>Using a hierarchical Bayesian model, we found that dysesthesia-matched TENS provided clinically meaningful improvements in dysesthesia among individuals with SCI, with a high posterior probability (96-100%) exceeding the minimal clinically meaningful difference (NRS of 2.70) at both the individual and population levels. The mean NRS was 5.79 (95% credible interval [95% CI]: 4.58-7.01) during the placebo period, and 1.12 (95% CI: 0.59-1.66) during the DM-TENS period. In the SF-MPQ-2, the dysesthesia-matched TENS effects showed decisive evidence (BF<sub>10</sub> > 1000) for items on tender, pain caused by light touch, tingling or pins and needles, and numbness.</p><p><strong>Conclusions: </strong>This series of N-of-1 trials comparing dysesthesia-matched TENS with placebo indicated a reduction in dysesthesia in individuals with SCI. Thus, dysesthesia-matched TENS is a promising therapeutic option for managing dysesthesia in this population.<b>Trial registration:</b> UMIN Japan identifier: UMIN000050250..</p>","PeriodicalId":50044,"journal":{"name":"Journal of Spinal Cord Medicine","volume":" ","pages":"1064-1073"},"PeriodicalIF":1.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13591953/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144318540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advancing prognostic accuracy for walking recovery after spinal cord injury: The 2026 Ernest Bors, MD Award for Scientific Development. 提高脊髓损伤后步行恢复的预后准确性:2026年欧内斯特·鲍斯医学博士科学发展奖。
IF 1.3 4区 医学
Journal of Spinal Cord Medicine Pub Date : 2026-09-01 Epub Date: 2026-09-18 DOI: 10.1080/10790268.2026.2689286
Carol Ann Murphy, Florian P Thomas
{"title":"Advancing prognostic accuracy for walking recovery after spinal cord injury: The 2026 Ernest Bors, MD Award for Scientific Development.","authors":"Carol Ann Murphy, Florian P Thomas","doi":"10.1080/10790268.2026.2689286","DOIUrl":"https://doi.org/10.1080/10790268.2026.2689286","url":null,"abstract":"","PeriodicalId":50044,"journal":{"name":"Journal of Spinal Cord Medicine","volume":"49 5","pages":"851-852"},"PeriodicalIF":1.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148992278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Loneliness in spinal cord injury: A systematic review and comparison with the general population. 脊髓损伤中的孤独感:系统回顾和与一般人群的比较。
IF 1.3 4区 医学
Journal of Spinal Cord Medicine Pub Date : 2026-09-01 Epub Date: 2025-12-15 DOI: 10.1080/10790268.2025.2593074
Louisa M C O'Donnell, Diana S Dorstyn, Linda Barclay
{"title":"Loneliness in spinal cord injury: A systematic review and comparison with the general population.","authors":"Louisa M C O'Donnell, Diana S Dorstyn, Linda Barclay","doi":"10.1080/10790268.2025.2593074","DOIUrl":"10.1080/10790268.2025.2593074","url":null,"abstract":"<p><strong>Context: </strong>The psychosocial consequences of a Spinal Cord Injury or Disorder (SCI/D) can include increased loneliness. However, differences in the measurement of loneliness confound the available evidence.</p><p><strong>Objectives: </strong>To compare levels of loneliness between adults with a SCI/D and the general population (Touch Test data) using the UCLA Loneliness Scale (any version). A secondary aim was to explore potential subgroups vulnerable to loneliness.</p><p><strong>Methods: </strong>Observational studies examining loneliness in SCI/D were identified via CINAHL, PubMed, PsycINFO, MEDLINE, Embase, Web of Science (up until 9th Sept 2025), Google Scholar (first 100 results), and targeted citation searching. Standardized mean group differences (Hedges' <i>g</i>) were pooled using random effects modelling and the methodological quality of included studies evaluated (QualSyst tool). Study characteristics and bivariate correlations of loneliness in SCI/D were additionally examined.</p><p><strong>Results: </strong>Thirteen observational studies (<i>N</i> = 3029 adults with SCI/D) were included in the analysis. Average UCLA scores (revised Version 3, 20-item and 3-item) for the pooled SCI/D sample and the general population were comparable, with both groups reporting moderate levels of loneliness (<i>g</i><sub>w</sub> = .01; CI: -.43 to .46, <i>P</i> = .951). Individual effect estimates among the SCI/D studies were, however, characterized by imprecision and heterogeneity. Associations between loneliness, demographic and SCI/D characteristics were inconsistent although those who were lonely did report adverse health and social outcomes.</p><p><strong>Conclusions: </strong>The underlying personal, social and environmental factors which contribute to loneliness in SCI/D should be monitored and addressed. Ongoing research is also needed to develop a more culturally nuanced understanding of loneliness in disability. Protocol registration: https://osf.io/s6723/.</p>","PeriodicalId":50044,"journal":{"name":"Journal of Spinal Cord Medicine","volume":" ","pages":"916-926"},"PeriodicalIF":1.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13591955/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145758093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interventional spine therapy for neuropathic pain in individuals with paraplegia. 截瘫患者神经性疼痛的介入脊柱治疗。
IF 1.3 4区 医学
Journal of Spinal Cord Medicine Pub Date : 2026-09-01 Epub Date: 2026-03-24 DOI: 10.1080/10790268.2025.2598981
Tugrul Kocak, Yorck-Bernhard Kalke, Jianming Nie, Semra Kocak, Tobias Freitag, Heiko Reichel, Thomas Caffard, Hassan Awan Malik
{"title":"Interventional spine therapy for neuropathic pain in individuals with paraplegia.","authors":"Tugrul Kocak, Yorck-Bernhard Kalke, Jianming Nie, Semra Kocak, Tobias Freitag, Heiko Reichel, Thomas Caffard, Hassan Awan Malik","doi":"10.1080/10790268.2025.2598981","DOIUrl":"10.1080/10790268.2025.2598981","url":null,"abstract":"<p><strong>Background: </strong>Infiltrations of the spine can be used to treat nociceptive or neuropathic pain. There is little data in the literature on the use of spinal injections in patients with paraplegia.</p><p><strong>Objective: </strong>The aim of this study is to determine whether patients with spinal cord injury experienced improvement in pain and spasticity following spinal injection.</p><p><strong>Methods: </strong>19 (9 female, 10 male) patients (5 patients AIS A, 5 patients AIS C, 9 patients AIS D), including 9 tetraplegic and 10 paraplegic patients, with 22 injection techniques and a follow-up of 4.2 months (1-12 months) were retrospectively examined in our spinal cord injury Center in 2022 and 2023. The pain intensity on the NRS (Numerical Rating Scale), the MAS (Modified Ashworth Scale) for the graduation of muscle tone and the Spinal Cord Independence Measurement (SCIM) were assessed before infiltration and as part of the follow-up examination.</p><p><strong>Results: </strong>Image intensifier-assisted facet and sacroiliac joint infiltrations were performed in 12 patients, CT-guided nerve root infiltrations and epidural injections in 10 patients with corresponding symptoms and image morphological correlate without complications. In all patients, a statistically significant reduction in pain on the NRS could be achieved (4.05 ± 1.84; <i>p</i> < 0.0001). A trend towards improvement was documented in the analysis of the MAS (0.14 ± 0.35; <i>p</i> = 0.08), whereas a significant improvement was statistically detected in the analysis of the SCIM (-15.59 ± 18.23; <i>p</i> = 0.0006).</p><p><strong>Conclusion: </strong>Our study represents the first retrospective exploratory analysis (phase I-style feasibility study) after spinal injection in patients with spinal cord injury. The primary results in terms of pain intensity, muscle tone and independence are promising and, in our view, represent a further therapeutic approach in addition to pharmacological and non-pharmacological therapy options. However, further investigations are necessary for this.</p>","PeriodicalId":50044,"journal":{"name":"Journal of Spinal Cord Medicine","volume":" ","pages":"1045-1053"},"PeriodicalIF":1.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13591970/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147505104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Trends in management of central cord syndrome: Insights from the New York State SPARCS database. 中央脊髓综合征管理的趋势:来自纽约州SPARCS数据库的见解。
IF 1.3 4区 医学
Journal of Spinal Cord Medicine Pub Date : 2026-09-01 Epub Date: 2025-10-08 DOI: 10.1080/10790268.2025.2563957
Kevin Yoon, Clarke I Cady-McCrea, Gabriel Ramirez, Caroline Thirukumaran, Lancelot Benn, Addisu Mesfin
{"title":"Trends in management of central cord syndrome: Insights from the New York State SPARCS database.","authors":"Kevin Yoon, Clarke I Cady-McCrea, Gabriel Ramirez, Caroline Thirukumaran, Lancelot Benn, Addisu Mesfin","doi":"10.1080/10790268.2025.2563957","DOIUrl":"10.1080/10790268.2025.2563957","url":null,"abstract":"<p><strong>Context: </strong>Multiple surgical and non-surgical management options exist for treating central cord syndrome (CCS) patients. However, the final treatment decision is based on a patient's presentation and surgeon's choice.</p><p><strong>Objectives: </strong>We aim to identify patient factors associated with decisions for surgical management versus non-surgical management of CCS and compare the outcomes of length of stay (LOS), patient disposition, readmission, complications, mortality, and total cost.</p><p><strong>Methods: </strong>This retrospective analysis of the New York Statewide Planning and Research Cooperative System (SPARCS) database identified CCS patients from January 1, 2012, to December 31, 2021. Surgical treatments were determined using International Classification of Diseases (ICD) and Current Procedural Terminology (CPT) codes. Chi-square, T-test, and multivariable regression were used to compare outcomes, with random intercepts and effects for facilities. P < 0.05 was considered significant.</p><p><strong>Results: </strong>Of 2214 patients, 41.24% (<i>n</i> = 891) underwent surgery. The majority (46.88%, <i>n</i> = 1038) were aged 40-65, followed by 46.48% (<i>n</i> = 1029) older than 65. Compared to non-surgically managed patients, surgically treated patients had a lower 90-day readmission rate, but a significantly longer length of stay, likelihood of non-home discharge, and total charge and cost. Of surgical modalities, posterior cervical decompression had the shortest mean LOS, probability of readmission, probability of readmission, and lowest mean total charge.</p><p><strong>Conclusion: </strong>Our study points toward surgery as having more favorable outcomes versus non-surgical management. The current study found that surgical management is associated with decreased probability of 90-day readmission and a non-significate decreased probability of mortality within 90 days of discharge.</p>","PeriodicalId":50044,"journal":{"name":"Journal of Spinal Cord Medicine","volume":" ","pages":"1032-1044"},"PeriodicalIF":1.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13591945/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145253466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Presence of midsagittal tissue bridges and walking ability 1-year post spinal cord injury. 脊髓损伤后1年矢状中组织桥的存在和行走能力。
IF 1.3 4区 医学
Journal of Spinal Cord Medicine Pub Date : 2026-09-01 Epub Date: 2026-02-11 DOI: 10.1080/10790268.2025.2609475
Wesley A Thornton, Candace Tefertiller, Kenneth A Weber Ii, Mark Mañago, Laura Wiley, Jordan Connor, Jennifer Stevens-Lapsley, Dario Pfyffer, Andrew C Smith
{"title":"Presence of midsagittal tissue bridges and walking ability 1-year post spinal cord injury.","authors":"Wesley A Thornton, Candace Tefertiller, Kenneth A Weber Ii, Mark Mañago, Laura Wiley, Jordan Connor, Jennifer Stevens-Lapsley, Dario Pfyffer, Andrew C Smith","doi":"10.1080/10790268.2025.2609475","DOIUrl":"10.1080/10790268.2025.2609475","url":null,"abstract":"<p><strong>Context/objective: </strong>Providing accurate walking prognosis following spinal cord injury (SCI) is challenging. Assessment of SCI lesion characteristics, captured on T2-weighted MRI, may improve return-to-walking prediction. One characteristic, the midsagittal tissue bridge (MSTB), has shown promising association with a return of sensorimotor function. The purpose of this study was to determine the association between the presence or absence of early-assessed MSTBs and walking ability 1-year post-SCI.</p><p><strong>Setting: </strong>Inpatient Rehabilitation Facility.</p><p><strong>Methods: </strong>This retrospective cohort study examined the imaging and walking outcome data of 264 individuals with traumatic SCI. Contingency tables were built to analyze the odds of a return to walking based on the presence or absence of a MSTB.</p><p><strong>Results: </strong>For the entire sample, the odds of walking with present versus absent MSTBs was 8.5 (95%CI: 4.2, 16.8, P < .0001). Similar results were found when isolating only individuals with American Spinal Injury Association Impairment Scale (AIS) B and C injuries. For this AIS B/C subgroup, the odds of walking with present versus absent MSTBs was 4.96 (95%CI: 1.08, 22.89, P < .0401).</p><p><strong>Conclusion: </strong>This study found a strong association between the presence or absence of early-assessed MSTBs and walking ability 1-year post-SCI for individuals throughout the SCI severity spectrum. These findings suggest the potential importance of having MRI evidence of this spared neural tissue to increase the likelihood of walking recovery. The assessment of MSTBs presence/absence in the subacute phase of injury may assist clinicians in developing plans of care appropriately balanced between walking recovery strategies and maximizing independence with alternate modes of locomotion.</p>","PeriodicalId":50044,"journal":{"name":"Journal of Spinal Cord Medicine","volume":" ","pages":"895-903"},"PeriodicalIF":1.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13591982/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146167568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The combined effects of rTMS and upper extremity robotic therapy for restoring upper extremity function in patients with spinal cord injury: A randomized controlled trial. rTMS联合上肢机器人治疗对脊髓损伤患者上肢功能恢复的影响:一项随机对照试验。
IF 1.3 4区 医学
Journal of Spinal Cord Medicine Pub Date : 2026-09-01 Epub Date: 2025-09-29 DOI: 10.1080/10790268.2025.2554019
Jung Eun Lim, Hye-Jin Lee, Duk Youn Cho, Onyoo Kim
{"title":"The combined effects of rTMS and upper extremity robotic therapy for restoring upper extremity function in patients with spinal cord injury: A randomized controlled trial.","authors":"Jung Eun Lim, Hye-Jin Lee, Duk Youn Cho, Onyoo Kim","doi":"10.1080/10790268.2025.2554019","DOIUrl":"10.1080/10790268.2025.2554019","url":null,"abstract":"<p><strong>Context/objective: </strong>Non-invasive neuromodulation may be an effective treatment for stimulating motor and functional recovery of the upper extremities after spinal cord injury (SCI). We aimed to investigate the effects of combining repetitive transcranial magnetic stimulation (rTMS) with robotic therapy. We compared upper extremity function in patients who received rTMS and robot therapy to those who received sham rTMS and robot therapy.</p><p><strong>Design: </strong>Randomized controlled trial.</p><p><strong>Setting: </strong>Rehabilitation center.</p><p><strong>Participants: </strong>Thirty patients with SCI were randomized into two groups: an intervention group (IG) receiving rTMS plus robotic therapy and a control group (CG) receiving sham rTMS with robotic therapy.</p><p><strong>Interventions: </strong>The IG received 15 sessions of combined rTMS and robotic therapy over 5 weeks (3 sessions per week), while the CG received sham rTMS with robotic therapy.</p><p><strong>Outcome measures: </strong>Functional assessments pre- and post-intervention included the Graded Redefined Assessment of Strength, Sensibility, and Prehension (GRASSP), grip strength, pain levels, the modified Ashworth scale (MAS), and the Korean version of the Spinal Cord Independence Measure III (KSCIM-III).</p><p><strong>Results: </strong>Both groups showed significant post-treatment improvements in GRASSP domains (Strength, Sensation, Quantitative Prehension), with no significant intergroup differences. Grip strength, pain, and MAS scores improved in both groups without significant differences. In KSCIM-III, the IG showed significant gains in feeding and grooming, while the CG significantly improved in wheelchair-to-toilet/tub transfers.</p><p><strong>Conclusions: </strong>This study suggests that combining rTMS with upper extremity robotic therapy may have potential benefits for upper extremity function in patients with SCI. However, the addition of rTMS did not demonstrate clear superiority over robotic therapy alone. Further research with larger cohorts and optimized protocols is warranted to clarify its therapeutic value.<b>Trial registration:</b> Clinical Research Information Service, Republic of Korea identifier: KCT0004443.</p>","PeriodicalId":50044,"journal":{"name":"Journal of Spinal Cord Medicine","volume":" ","pages":"952-961"},"PeriodicalIF":1.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13591965/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145193724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acute effects of neuromuscular electrical stimulation on lactate, IGF-1 and cognition in chronic spinal cord injury: A pilot randomized cross-over study. 神经肌肉电刺激对慢性脊髓损伤患者乳酸、IGF-1和认知的急性影响:一项先导随机交叉研究
IF 1.3 4区 医学
Journal of Spinal Cord Medicine Pub Date : 2026-09-01 Epub Date: 2025-09-02 DOI: 10.1080/10790268.2025.2545067
Wouter A J Vints, Ugnė Mazuronytė, Orgesa Qipo, Oron Levin, Swathi Gujral, Jeanine Verbunt, Charlotte C M van Laake-Geelen, Vaida Pokvytytė, Nerijus Masiulis
{"title":"Acute effects of neuromuscular electrical stimulation on lactate, IGF-1 and cognition in chronic spinal cord injury: A pilot randomized cross-over study.","authors":"Wouter A J Vints, Ugnė Mazuronytė, Orgesa Qipo, Oron Levin, Swathi Gujral, Jeanine Verbunt, Charlotte C M van Laake-Geelen, Vaida Pokvytytė, Nerijus Masiulis","doi":"10.1080/10790268.2025.2545067","DOIUrl":"10.1080/10790268.2025.2545067","url":null,"abstract":"<p><strong>Introduction: </strong>Individuals with spinal cord injuries (SCI) exhibit an accelerated age-related cognitive decline compared to healthy individuals, even after adjusting for mood factors and concomitant traumatic brain injury. We hypothesized that neuromuscular electrical stimulation (NMES) on hamstring and gluteal muscles may induce a dose-dependent increase in lactate and insulin-like growth factor-1 (IGF-1) which is hypothesized to be associated with a temporary enhancement of cognitive performance.</p><p><strong>Methods: </strong>Twenty-two individuals with chronic SCI participated in a randomized cross-over study, receiving NMES on one of both visits. Participants randomly underwent a single session of 30 or 60-minute NMES. Lactate, IGF-1 levels and processing speed on the Symbol Digit Modalities test (SDMT) were tested before, immediately after and 30 minutes after intervention or 60 minutes rest.</p><p><strong>Results: </strong>Lactate levels increased significantly immediately after NMES conditions compared to control (<i>p</i> = 0.004). Lactate increases were larger in the 30-minute NMES group compared to the 60-minute NMES group, consistent with the higher current amplitude applied in the former (100 mA compared to 40 mA). IGF-1 increases did not significantly differ between groups (<i>p</i> = 0.262), and there were no significant differences in SDMT performance changes over time between groups (<i>p</i> = 0.892).</p><p><strong>Conclusion: </strong>Acute NMES did not induce changes in IGF-1 levels or cognitive performance in individuals with SCI. However, 30 min of 100 mA of NMES significantly increased lactate levels, and could be used as a marker of NMES intensity in this population. Further research is required to explore various NMES protocols and their impact on cognitive domains in individuals with SCI.</p>","PeriodicalId":50044,"journal":{"name":"Journal of Spinal Cord Medicine","volume":" ","pages":"1095-1108"},"PeriodicalIF":1.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13591980/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144976653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Facts and Figures 2025. 事实和数据2025。
IF 1.3 4区 医学
Journal of Spinal Cord Medicine Pub Date : 2026-09-01 Epub Date: 2026-09-18 DOI: 10.1080/10790268.2026.2712889
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