Journal of Spinal Cord Medicine最新文献

{"title":"Impact of secondary health conditions on the quality of life and wellbeing of Canadians living with spinal cord injury: A comparison of preference-weighted index scores derived from generic standardized instruments.","authors":"Nazafarin Esfandiari, Hasina Samji, David G T Whitehurst","doi":"10.1080/10790268.2024.2391597","DOIUrl":"https://doi.org/10.1080/10790268.2024.2391597","url":null,"abstract":"<p><strong>Context/objectives: </strong>To compare the assessment of the impact of secondary health conditions (SHCs) on the quality of life and wellbeing of Canadians living with spinal cord injury (SCI) using four preference-based outcome measures.</p><p><strong>Design: </strong>Secondary analysis of data from a cross-sectional, online survey.</p><p><strong>Setting: </strong>Community.</p><p><strong>Participants: </strong>Community-dwelling adults (n = 364) living with traumatic or non-traumatic spinal cord injury at least one year post-injury (70% at least 10 years post-injury).</p><p><strong>Outcome measures: </strong>A modified version of the Spinal Cord Injury Secondary Conditions Scale (SCI-SCS); three health-related instruments (EQ-5D-5L, Health Utilities Index Mark 3 (HUI3), and the Assessment of Quality of Life 8-dimension questionnaire (AQoL-8D)) and a capability wellbeing instrument (ICEpop CAPability measure for Adults (ICECAP-A)).</p><p><strong>Results: </strong>Across unadjusted and controlled analyses (i.e. controlling for associations between index scores and sociodemographic and impairment characteristics), trends were observed that identified lower levels of quality of life/wellbeing with higher problem ratings for each of the SHCs. Despite the trends, there was considerable variation in mean index scores across instruments, with HUI3 scores the lowest of the health-related instruments and ICECAP-A scores the highest overall. Respiratory problems, depression/mood problems, pressure sores, and autonomic dysreflexia were associated with the lowest levels of quality of life and wellbeing.</p><p><strong>Conclusions: </strong>Higher problem ratings for SHCs are negatively associated with scores derived from preference-based quality of life and wellbeing instruments. Variation in index scores across instruments - including across the health-related instruments alone - highlights the critical importance of assessing the <i>relative</i> merits of preference-based instruments when using (or considering using) these instruments/estimates in comparative effectiveness research and economic evaluation.</p>","PeriodicalId":50044,"journal":{"name":"Journal of Spinal Cord Medicine","volume":" ","pages":"1-12"},"PeriodicalIF":1.8,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142121003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The efficacy, safety, and satisfaction of telehealth-delivered hypnotic cognitive therapy for chronic pain in spinal cord injury: A pilot study with historical controls.","authors":"Charles H Bombardier, Joy F Chan, Emily Stensland, Jason Barber, Mark P Jensen","doi":"10.1080/10790268.2024.2395080","DOIUrl":"https://doi.org/10.1080/10790268.2024.2395080","url":null,"abstract":"<p><strong>Context/objective: </strong>In-person hypnotic cognitive therapy (HYP-CT) is a promising treatment for chronic spinal cord injury-related pain. We describe the effects of HYP-CT delivered via Zoom (Z-HYP-CT) and compare the effects to historical controls who received hypnosis, cognitive therapy, or HYP-CT in-person.</p><p><strong>Design: </strong>Open pilot trial of HYP-CT versus historical controls.</p><p><strong>Setting: </strong>Telehealth study that recruited people with chronic SCI.</p><p><strong>Participants: </strong>Adults with moderate to severe chronic SCI-related pain.</p><p><strong>Interventions: </strong>Four weekly sessions of HYP-CT delivered via Zoom.</p><p><strong>Outcome measures: </strong>The primary outcome was average pain intensity on a 0-10 numerical rating scale measured at end of treatment (4 weeks) and 12 weeks. Secondary outcomes included pain interference, depression, sleep, pain catastrophizing, and pain self-efficacy.</p><p><strong>Results: </strong>23 individuals with SCI-related pain participated in the open trial and were compared to 21 historical controls. Average age was 54 years, 70% were male, and the majority were White. The participants were 11.6-13.1 years post-SCI and average pain intensity was 4.8-5.4/10. After Z-HYP-CT mixed-effects linear regressions showed that pain intensity was significantly less at 4 weeks (-1.28, <i>P</i> < .0001) and 12 weeks (-1.50, <i>P</i> < .0001) relative to baseline. Pain interference, depression, and pain catastrophizing also decreased significantly at both time points. There were no significant differences between the effects of Z-HYP-CT versus historical controls on any outcome variable.</p><p><strong>Conclusion: </strong>HYP-CT delivered via telehealth was associated with reduced pain intensity and other benefits that were comparable to the effect achieved by in-person historical controls. The effects of Z-HYP-CT should be evaluated using a randomized controlled design.</p>","PeriodicalId":50044,"journal":{"name":"Journal of Spinal Cord Medicine","volume":" ","pages":"1-12"},"PeriodicalIF":1.8,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142121005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nuances of gender affirming therapy for transgender women with spinal cord injury.","authors":"Deanna Claus, Darryl Etter, Stephanie Cowherd Ryder","doi":"10.1080/10790268.2024.2396644","DOIUrl":"https://doi.org/10.1080/10790268.2024.2396644","url":null,"abstract":"<p><strong>Case description: </strong>56-year-old transgender woman with new spinal cord injury (SCI) on gender affirming hormonal therapy (GAHT) with estrogen and spironolactone.</p><p><strong>Findings: </strong>After her injury, estrogen and spironolactone were discontinued, for blood clots and hypotension, respectively. Alternative options were explored.</p><p><strong>Clinical relevance: </strong>Little is known about GAHT in SCI for transgender women. Shared decision making should be used to navigate risks, benefits, and alternative options.</p>","PeriodicalId":50044,"journal":{"name":"Journal of Spinal Cord Medicine","volume":" ","pages":"1-3"},"PeriodicalIF":1.8,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142121004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perceived job quality among persons with spinal cord injury: The contribution of sociodemographic characteristics, health-related factors, and person-job match.","authors":"Mayra Galvis Aparicio, Immaculate Mwake, Marina Ronca-Nützi, Stefan Staubli, Urban Schwegler","doi":"10.1080/10790268.2023.2194974","DOIUrl":"10.1080/10790268.2023.2194974","url":null,"abstract":"<p><strong>Context/objective: </strong>Perceived job quality is a key indicator of sustainable work among persons with spinal cord injuries (PwSCI). This study aimed at (a) describing three indicators of perceived job quality (<i>i.e.</i> job satisfaction, job performance, and work stress) among working PwSCI, and (b) identifying whether and how different person-job match dimensions (<i>i.e.</i> interest congruence, demands-abilities fit, needs-supplies fit, and effort-reward imbalance) as well as sociodemographic and health-related factors (<i>e.g.</i> age, sex, SCI-related characteristics, pain problems, and depressive symptoms) are associated with perceived job quality.</p><p><strong>Design: </strong>Cross-sectional, self-report survey.</p><p><strong>Setting: </strong>Community.</p><p><strong>Participants: </strong>549 working-age PwSCI who participated in the 2017 community survey of the Swiss Spinal Cord Injury Cohort study and reported being engaged in paid work.</p><p><strong>Outcome measures: </strong>Job satisfaction, job performance, and work stress.</p><p><strong>Results: </strong>Higher interest congruence, better needs-supplies fit and lower effort-reward imbalance, as well as female sex, were associated with higher job satisfaction, while higher effort-reward imbalance, poorer demands-abilities fit (underqualification), and - surprisingly - better needs-supplies fit were associated with higher work stress. Moreover, underqualification, worse needs-supplies fit as well as pain, depressive symptoms, and language region were associated with lower job performance.</p><p><strong>Conclusion: </strong>Integrating individuals in jobs that match their abilities, interests and needs, and which adequately reward their efforts may contribute to better job quality among PwSCI. Beyond that, common secondary health conditions and comorbidities such as pain and depressive symptoms should receive particular attention in interventions that aim to promote job quality and ultimately sustainable work in the SCI population.</p>","PeriodicalId":50044,"journal":{"name":"Journal of Spinal Cord Medicine","volume":" ","pages":"733-743"},"PeriodicalIF":1.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11378652/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9214342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiometabolic risk factor clustering in persons with spinal cord injury: A principal component analysis approach.","authors":"Shawn K Gilhooley, William A Bauman, Michael F La Fountaine, Gregory T Cross, Steven C Kirshblum, Ann M Spungen, Christopher M Cirnigliaro","doi":"10.1080/10790268.2023.2215998","DOIUrl":"10.1080/10790268.2023.2215998","url":null,"abstract":"<p><strong>Context/objective: </strong>To identify cardiometabolic (CM) measurements that cluster to confer increased cardiovascular disease (CVD) risk using principal component analysis (PCA) in a cohort of chronic spinal cord injury (SCI) and healthy non-SCI individuals.</p><p><strong>Approach: </strong>A cross-sectional study was performed in ninety-eight non-ambulatory men with chronic SCI and fifty-one healthy non-SCI individuals (ambulatory comparison group). Fasting blood samples were obtained for the following CM biomarkers: lipid, lipoprotein particle, fasting glucose and insulin concentrations, leptin, adiponectin, and markers of inflammation. Total and central adiposity [total body fat (TBF) percent and visceral adipose tissue (VAT) percent, respectively] were obtained by dual x-ray absorptiometry (DXA). A PCA was used to identify the CM outcome measurements that cluster to confer CVD risk in SCI and non-SCI cohorts.</p><p><strong>Results: </strong>Using PCA, six factor-components (FC) were extracted, explaining 77% and 82% of the total variance in the SCI and non-SCI cohorts, respectively. In both groups, FC-1 was primarily composed of lipoprotein particle concentration variables. TBF and VAT were included in FC-2 in the SCI group, but not the non-SCI group. In the SCI cohort, logistic regression analysis results revealed that for every unit increase in the FC-1 standardized score generated from the statistical software during the PCA, there is a 216% increased risk of MetS (<i>P</i> = 0.001), a 209% increased risk of a 10-yr. FRS ≥ 10% (<i>P</i> = 0.001), and a 92% increase in the risk of HOMA2-IR ≥ 2.05 (<i>P</i> = 0.01).</p><p><strong>Conclusion: </strong>Application of PCA identified 6-FC models for the SCI and non-SCI groups. The clustering of variables into the respective models varied considerably between the cohorts, indicating that CM outcomes may play a differential role on their conferring CVD-risk in individuals with chronic SCI.</p>","PeriodicalId":50044,"journal":{"name":"Journal of Spinal Cord Medicine","volume":" ","pages":"627-639"},"PeriodicalIF":1.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11378671/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10571276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Studies in the Falls Efficacy Scale-International for patients with cervical compressive myelopathy: Reliability, validity, and minimum clinically important difference.","authors":"Hiromichi Hirai, Takashi Fujishiro, Toma Yano, Takuya Obo, Masahiro Mizutani, Yoshitada Usami, Sachio Hayama, Yoshiharu Nakaya, Atsushi Nakano, Masashi Neo","doi":"10.1080/10790268.2023.2192849","DOIUrl":"10.1080/10790268.2023.2192849","url":null,"abstract":"<p><strong>Context: </strong>Patients with cervical compressive myelopathy (CCM) often complain of body balance problems, such as fear of falling and bodily unsteadiness. However, no accepted patient-reported outcome measures (PROMs) for this symptomatology exist. The Falls Efficacy Scale-International (FES-I) is one of the most widely used PROMs for evaluating impaired body balance in various clinical fields.</p><p><strong>Objective: </strong>To examine reliability, validity, and minimum clinically important difference (MCID) of the FES-I for the evaluation of impaired body balance in patients with CCM.</p><p><strong>Methods: </strong>Patients who underwent surgery for CCM were retrospectively reviewed. The FES-I was administered preoperatively and at 1 year postoperatively. Further, cJOA-LE score (subscore for lower extremities in the Japanese Orthopaedic Association score for cervical myelopathy) and stabilometric data, obtained at the same time points of the FES-I administration, were analyzed. Reliability was examined through internal consistency with Cronbach's alpha. Convergent validity was studied using correlation analysis. The MCID was estimated using anchor- and distribution-based methods.</p><p><strong>Results: </strong>Overall, 151 patients were included for analysis. Cronbach's alpha coefficient was the acceptable value of 0.97 at both baseline and 1 year postoperatively. As for convergent validity, the FES-I had significant correlations with the cJOA-LE score and stabilometric parameters both at baseline and 1 year postoperatively. The MCID calculated using anchor- and distribution-based methods was 5.5 and 10, respectively.</p><p><strong>Conclusion: </strong>FES-I is a reliable and valid PROM to evaluate body balance problems for the CCM population. The established thresholds of MCID can help clinicians recognize the clinical significance of changes in patient status.</p>","PeriodicalId":50044,"journal":{"name":"Journal of Spinal Cord Medicine","volume":" ","pages":"712-722"},"PeriodicalIF":1.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11378661/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9198677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Construct validity and reliability of the participation scale (P-scale) in individuals with spinal cord injury.","authors":"Patrícia Avelar Viana Espindula, Alessandra de Carvalho Bastone, Ana Paula Santos","doi":"10.1080/10790268.2023.2183327","DOIUrl":"10.1080/10790268.2023.2183327","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the reliability and the construct validity of the Participation Scale (P-scale) in adults with Spinal Cord Injury (SCI).</p><p><strong>Design: </strong>A cross-sectional study.</p><p><strong>Setting: </strong>: SARAH Network of Rehabilitation Hospitals, Brazil.</p><p><strong>Participants: </strong>: One hundred individuals with SCI.</p><p><strong>Interventions: </strong>: Not applicable.</p><p><strong>Outcome measures: </strong>: Sociodemographic and clinical characteristics were investigated. To assess reliability the P-scale was applied twice with a one-week interval. To assess construct validity the Functional Independence Measure, the Beck Depression Inventory, and the Accessibility Perception Questionnaire were administered.</p><p><strong>Results: </strong>The mean age of the participants was 38.9 ± 12.80 years. The majority were male (70%) and had traumatic injuries (74%). The P-scale showed significant correlations with the Functional Independence Measure motor domain (<i>r_s</i> = -0.280) and cognitive domain (<i>r_s</i> = -0.520); with the Beck Depression Inventory score (<i>r_s</i>= 0.610); with the Accessibility Perception Questionnaire displacement domain (<i>r_s</i>= -0.620) and psycho-affective domain (<i>r_s</i>= 0.530). Mean scores obtained on the P-scale differed significantly between the groups with and without depressive symptoms (<i>P</i> = 0.001), neuropathic pain (<i>P</i> = 0.033), and functional dependence (<i>P</i> = 0.001). There was no difference between the paraplegic and quadriplegic groups. The P-scale had adequate internal consistency (Cronbach's alpha = 0.873), excellent test-retest reliability (ICC_2,1= 0.992; 95% CI = 0.987-0.994), and in the Bland-Altman plot analysis, only six values fell outside the limits of agreement.</p><p><strong>Conclusion: </strong>Our results support the use of the P-scale to assess the participation of individuals with SCI in research and clinical practice.</p>","PeriodicalId":50044,"journal":{"name":"Journal of Spinal Cord Medicine","volume":" ","pages":"661-668"},"PeriodicalIF":1.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11378679/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9456346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Notice of Annual Publishing Award.","authors":"","doi":"10.1080/10790268.2024.2401275","DOIUrl":"10.1080/10790268.2024.2401275","url":null,"abstract":"","PeriodicalId":50044,"journal":{"name":"Journal of Spinal Cord Medicine","volume":"47 5","pages":"809"},"PeriodicalIF":1.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11378650/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142134297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanical diagnosis and therapy in musculoskeletal pain of individuals with spinal cord injury.","authors":"Poliana Grasser, Frederico Ribeiro Neto, João H C L Veloso, Rodrigo R Gomes Costa, Jefferson Rodrigues Dorneles","doi":"10.1080/10790268.2023.2197818","DOIUrl":"10.1080/10790268.2023.2197818","url":null,"abstract":"<p><strong>Context/objective: </strong>Musculoskeletal pain (MSKP) has high prevalence in individuals with spinal cord injury (SCI). Mechanical Diagnosis and Therapy (MDT) is a method focused on identifying the pain source in the musculoskeletal system and presents good results in pain relief in people without neurological impairment. However, no studies have investigated the use of MDT in SCI population. The objective was to evaluate the applicability and outcomes of MDT treatment in pain relief and independence improvement in daily activities of individuals with SCI presenting MSKP.</p><p><strong>Design: </strong>Single-arm trial.</p><p><strong>Setting: </strong>Rehabilitation Hospital.</p><p><strong>Participants: </strong>Twenty-four individuals with SCI who presented MSKP.</p><p><strong>Intervention: </strong>MDT-certified physical therapist conducted assessments and treatments of pain according to the MDT approach.</p><p><strong>Outcomes measures: </strong>Numeric rating scale (NRS) was used to measure pain and Pain Disability Index (PDI) and Patient-Specific Functional Scale (PSFS) to evaluate daily activities.</p><p><strong>Results: </strong>Significant median decreases were found for NRS (from 7 to 2) and PDI (from 27 to 8) after MDT, whereas PSFS score presented a significant mean increase (from 3.2-7.7). The average decrease in pain after MDT treatment was 70.9% (5.36 on the NRS).</p><p><strong>Conclusion: </strong>MDT can reduce pain and enhance independence in daily activities in individuals with SCI and MSKP.</p>","PeriodicalId":50044,"journal":{"name":"Journal of Spinal Cord Medicine","volume":" ","pages":"744-752"},"PeriodicalIF":1.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11378664/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9360963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protocatechuic aldehyde promotes the functional recovery of spinal cord injury by activating the Wnt/β-catenin signaling pathway.","authors":"Zihao Zhao, Kai Gao, Wenbo Shao, Chaoliang Lv, Zhongyang Xu","doi":"10.1080/10790268.2023.2183329","DOIUrl":"10.1080/10790268.2023.2183329","url":null,"abstract":"<p><strong>Context/objective: </strong>This study aimed to explore the anti-inflammatory and neuroprotective effects of protocatechuic aldehyde (PCA) in rats with spinal cord injury (SCI) and to clarify the molecular mechanisms underlying its pharmacological effects.</p><p><strong>Design: </strong>Male Sprague Dawley rat model of moderate spinal cord contusion were established.</p><p><strong>Setting: </strong>Third-class first-class hospital.</p><p><strong>Outcome measures: </strong>The Basso, Beattie, and Bresnahan scores and performance on the inclined plane test were evaluated. Histological analyses were performed via hematoxylin and eosin staining. Apoptosis in the spinal cord and neurons was detected by 5 terminal deoxynucleotidyl-transferase-mediated dUTP nick end labeling staining. Apoptotic factors (Bax, Bcl-2, and cleaved caspase-3) were also evaluated. INOS, IL-1β, IL-10, TNF-α, Wnt-3α, β-catenin, iBA-1, and NeuN were assessed by real-time reverse transcription-polymerase chain reaction (RT-PCR), western blotting (WB), and enzyme-linked immunosorbent assay. Cell viability and the immunofluorescence of IL-1β were measured in PC-12 cells.</p><p><strong>Results: </strong>Using WB and quantitative reverse transcription-PCR, we confirmed that PCA treatment activated the Wnt/β-catenin signaling axis in vivo and in vitro. Hematoxylin and eosin staining and hindlimb motor functional evaluation revealed that treatment with PCA improved tissue protection and functional recovery via the Wnt/β-catenin axis. The upregulation of TUNEL-positive cells, downregulation of neurons, elevated apoptosis-associated factors in rats, and increased apoptotic rates were observed in microglia and PC-12 after PCA application. Finally, PCA mitigated SCI-induced inflammation by targeting the Wnt/β-catenin axis.</p><p><strong>Conclusion: </strong>This study provided preliminary evidence that PCA inhibits neuroinflammation and apoptosis through the Wnt/β-catenin pathway, thereby attenuating the secondary injury after SCI and promoting the regeneration of injured spinal tissues.</p>","PeriodicalId":50044,"journal":{"name":"Journal of Spinal Cord Medicine","volume":" ","pages":"669-680"},"PeriodicalIF":1.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11378675/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9456347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}