Journal of Toxicology and Environmental Health-Part B-Critical Reviews最新文献

{"title":"Incorporating new approach methods (NAMs) data in dose-response assessments: The future is now!","authors":"En-Hsuan Lu, Ivan Rusyn, Weihsueh A Chiu","doi":"10.1080/10937404.2024.2412571","DOIUrl":"10.1080/10937404.2024.2412571","url":null,"abstract":"<p><p>Regulatory dose-response assessments traditionally rely on <i>in vivo</i> data and default assumptions. New Approach Methods (NAMs) present considerable opportunities to both augment traditional dose-response assessments and accelerate the evaluation of new/data-poor chemicals. This review aimed to determine the potential utilization of NAMs through a unified conceptual framework that compartmentalizes derivation of toxicity values into five sequential Key Dose-response Modules (KDMs): (1) point-of-departure (POD) determination, (2) test system-to-human (e.g. inter-species) toxicokinetics and (3) toxicodynamics, (4) human population (intra-species) variability in toxicodynamics, and (5) toxicokinetics. After using several \"traditional\" dose-response assessments to illustrate this framework, a review is presented where existing NAMs, including <i>in silico</i>, <i>in vitro</i>, and <i>in vivo</i> approaches, might be applied across KDMs. Further, the false dichotomy between \"traditional\" and NAMs-derived data sources is broken down by organizing dose-response assessments into a matrix where each KDM has Tiers of increasing precision and confidence: Tier 0: Default/generic values, Tier 1: Computational predictions, Tier 2: Surrogate measurements, and Tier 3: Direct measurements. These findings demonstrated that although many publications promote the use of NAMs in KDMs (1) for POD determination and (5) for human population toxicokinetics, the proposed matrix of KDMs and Tiers reveals additional immediate opportunities for NAMs to be integrated across other KDMs. Further, critical needs were identified for developing NAMs to improve <i>in vitro</i> dosimetry and quantify test system and human population toxicodynamics. Overall, broadening the integration of NAMs across the steps of dose-response assessment promises to yield higher throughput, less animal-dependent, and more science-based toxicity values for protecting human health.</p>","PeriodicalId":49971,"journal":{"name":"Journal of Toxicology and Environmental Health-Part B-Critical Reviews","volume":" ","pages":"28-62"},"PeriodicalIF":6.4,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11614695/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142401770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>In vitro</i> models to evaluate multidrug resistance in cancer cells: Biochemical and morphological techniques and pharmacological strategies.","authors":"Maria Fernanda Madrid, Eleicy Nathaly Mendoza, Ana Lizeth Padilla, Celia Choquenaira-Quispe, Celina de Jesus Guimarães, João Victor de Melo Pereira, Francisco Washington Araújo Barros-Nepomuceno, Ingredy Lopes Dos Santos, Claudia Pessoa, Manoel Odorico de Moraes Filho, Danilo Damasceno Rocha, Paulo Michel Pinheiro Ferreira","doi":"10.1080/10937404.2024.2407452","DOIUrl":"10.1080/10937404.2024.2407452","url":null,"abstract":"<p><p>The overexpression of ATP-binding cassette (ABC) transporters contributes to the failure of chemotherapies and symbolizes a great challenge in oncology, associated with the adaptation of tumor cells to anticancer drugs such that these transporters become less effective, a mechanism known as multidrug resistance (MDR). The aim of this review is to present the most widely used methodologies for induction and comprehension of <i>in vitro</i> models for detection of multidrug-resistant (MDR) modulators or inhibitors, including biochemical and morphological techniques for chemosensitivity studies. The overexpression of MDR proteins, predominantly, the subfamily glycoprotein-1 (P-gp or ABCB1) multidrug resistance, multidrug resistance-associated protein 1 (MRP1 or ABCCC1), multidrug resistance-associated protein 2 (MRP2 or ABCC2) and cancer resistance protein (ABCG2), in chemotherapy-exposed cancer lines have been established/investigated by several techniques. Amongst these techniques, the most used are (i) colorimetric/fluorescent indirect bioassays, (ii) rhodamine and efflux analysis, (iii) release of 3,30-diethyloxacarbocyanine iodide by fluorescence microscopy and flow cytometry to measure P-gp function and other ABC transporters, (iv) exclusion of calcein-acetoxymethylester, (v) ATPase assays to distinguish types of interaction with ABC transporters, (vi) morphology to detail phenotypic characteristics in transformed cells, (vii) molecular testing of resistance-related proteins (RT-qPCR) and (viii) 2D and 3D models, (ix) organoids, and (x) microfluidic technology. Then, <i>in vitro</i> models for detecting chemotherapy MDR cells to assess innovative therapies to modulate or inhibit tumor cell growth and overcome clinical resistance. It is noteworthy that different therapies including anti-miRNAs, antibody-drug conjugates (to natural products), and epigenetic modifications were also considered as promising alternatives, since currently no anti-MDR therapies are able to improve patient quality of life. Therefore, there is also urgency for new clinical markers of resistance to more reliably reflect <i>in vivo</i> effectiveness of novel antitumor drugs.</p>","PeriodicalId":49971,"journal":{"name":"Journal of Toxicology and Environmental Health-Part B-Critical Reviews","volume":" ","pages":"1-27"},"PeriodicalIF":6.4,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142373390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The biological and sociological implications of diversity, equity, and inclusion (DEI): life within microbiomes and on earth.","authors":"David A Lawrence, Brandon O'Sullivan, Joerg Graf, Alex Hogan, Katherine W Herbst, Juan C Salazar","doi":"10.1080/10937404.2025.2497826","DOIUrl":"10.1080/10937404.2025.2497826","url":null,"abstract":"<p><p>From a biological point of view, Diversity, Equity, and Inclusion (DEI) are important at multiple levels, which include our genetics, microbiomes, diets, and all organ system interactions. Considering only DEI's sociological aspects is equivalent to the error of \"throwing out the baby with the bath water.\" Variances in microbial diversity within our microbiomes might affect our health through systemic interactions affecting metabolites, maintaining immune homeostasis, and wound healing of cellular damage from an infection, physical stress, or psychological trauma. An imbalance of our immune cell subsets, both innate and adaptive, and the microbes in any of our microbiomes might lead to more cellular damage from excessive inflammation and oxidative stress and less immune regulation. The immune dysregulation may occur due to the loss of endometrial barriers enabling the spread of microbes, environmental pollutants, and allergens. Heat waves, sleep deprivation, and increased prevalence of pollutants such as polychlorinated biphenyls, which weaken endothelial barriers, may be responsible for the enhanced prevalence of physical and psychological stresses. Leakage of our useful gut microbiota into the periphery might initiate inflammatory responses, and an altered gut microbiome might affect the gut-brain axis that influences physical and mental health.</p>","PeriodicalId":49971,"journal":{"name":"Journal of Toxicology and Environmental Health-Part B-Critical Reviews","volume":" ","pages":"561-569"},"PeriodicalIF":8.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144055915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morphine and treatment of cancer -related pain-risk or benefit?","authors":"Jie Wang, Pengfei Guo, Yanfei Bian, Jing Ma, Shumin Zhao, Zhiguo Zhang, Yunfeng Xu","doi":"10.1080/10937404.2025.2509920","DOIUrl":"10.1080/10937404.2025.2509920","url":null,"abstract":"<p><p>Morphine has been widely used to treat physical non-cancer pain as well as cancer-related pain. However, a growing body of evidence has emerged indicating that morphine in addition to alleviating pain initiates and suppresses immune functions in different types of cancer. At present the actions of morphine on tumor growth are contradictory with both inhibition and stimulation reported. Thus, the effects of morphine use needs to be identified with respect to the immune system in consideration of the therapeutic course to follow. It is known that cancer cells express various types of opioid receptors and morphine interaction with these receptors needs to be elucidated in cancer treatment. The expression and distribution of different opioid receptors for morphine binding may provide a basis for varying effects attributed to morphine actions on cancer cell promotion and suppression. Evidence indicates that knowledge regarding distribution of opioid receptors may be considered as a therapeutic tool to determine the use of morphine as a painkiller to treat cancer-related pain.</p>","PeriodicalId":49971,"journal":{"name":"Journal of Toxicology and Environmental Health-Part B-Critical Reviews","volume":" ","pages":"570-576"},"PeriodicalIF":8.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144144334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction.","authors":"","doi":"10.1080/10937404.2025.2513143","DOIUrl":"10.1080/10937404.2025.2513143","url":null,"abstract":"","PeriodicalId":49971,"journal":{"name":"Journal of Toxicology and Environmental Health-Part B-Critical Reviews","volume":" ","pages":"577"},"PeriodicalIF":8.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144181714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Drosophila</i> fruit fly an <i>in vivo</i> model to determine hazardous effects following exposure to nanoplastics utilizing the <i>One Health</i> approach.","authors":"Eşref Demir","doi":"10.1080/10937404.2025.2494992","DOIUrl":"10.1080/10937404.2025.2494992","url":null,"abstract":"","PeriodicalId":49971,"journal":{"name":"Journal of Toxicology and Environmental Health-Part B-Critical Reviews","volume":" ","pages":"531-534"},"PeriodicalIF":8.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143990449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute and repeated exposure toxicity of the insecticide sulfoxaflor on hymenopteran pollinators; sulfoxaflor environmental science review part III.","authors":"J R Purdy, K R Solomon, V J Kramer, J P Giesy","doi":"10.1080/10937404.2025.2478969","DOIUrl":"10.1080/10937404.2025.2478969","url":null,"abstract":"<p><p>To support regulatory risk assessment, standardized laboratory tests of toxicity to representative species including honeybees (<i>Apis mellifera L.)</i>, orchard bees (<i>Osmia spp</i>.), and bumblebees (<i>Bombus spp</i>.) provide the benchmark toxicity values for use in preliminary Tier 1 assessments and more detailed and realistic higher-tier assessments. In this analysis, we summarize the results of studies of toxicity of SFX to pollinators conducted by the registrant as well as results published in the literature. The geometric mean of 48-hr adult acute oral LD₅₀ values for SFX for honeybees was 0.0740 μg SFX bee^-1 (<i>n</i> = 5). Toxicity values for technical grade SFX (SFX-T) and formulated products were not significantly different. The geometric mean 48 hr adult acute contact LD₅₀ values for SFX-T and several formulated products were 0.432 (<i>n</i> = 2) and 0.202 (<i>n</i> = 3) μg SFX bee^-1, respectively. Exposures sprayed foliage was not significant after the spray had dried did not cause significant toxicity. Transformation products were not significantly toxic to adult or larval honeybees or other representative bee species. Results showed that, to complete the risk assessment, higher-tier studies were required. Differences in results between standard test methods and the nonstandard methods used in published work affect the outcome of the risk assessment. An understanding of these differences reconciled the differences in the reported findings.</p>","PeriodicalId":49971,"journal":{"name":"Journal of Toxicology and Environmental Health-Part B-Critical Reviews","volume":" ","pages":"322-349"},"PeriodicalIF":6.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143722333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atrazine's effects on mammalian physiology.","authors":"Anna G Holliman, Laci Mackay, Vinicia C Biancardi, Ya-Xiong Tao, Chad D Foradori","doi":"10.1080/10937404.2025.2468212","DOIUrl":"10.1080/10937404.2025.2468212","url":null,"abstract":"<p><p>Atrazine is a chlorotriazine herbicide that is one of the most widely used herbicides in the USA and the world. For over 60 years atrazine has been used on major crops including corn, sorghum, and sugarcane to control broadleaf and grassy weed emergence and growth. Atrazine has exerted a major economic and environmental impact over that time, resulting in reduced production costs and increased conservation tillage practices. However, widespread use and a long half-life led to a high prevalence of atrazine in the environment. Indeed, atrazine is the most frequent herbicide contaminant detected in water sources in the USA. Due to its almost ubiquitous presence and questions regarding its safety, atrazine has been well-studied. First reported to affect reproduction with potential disruptive effects which were later linked to the immune system, cancer, stress response, neurological disorders, and cardiovascular ailments in experimental models. Atrazine impact on multiple interwoven systems broadens the significance of atrazine exposure. The endeavor to uncover the mechanisms underlying atrazine-induced dysfunction in mammals is ongoing, with new genetic and pharmacological targets being reported. This review aims to summarize the prominent effects of atrazine on mammalian physiology, primarily focusing on empirical studies conducted in lab animal models and establish correlations with epidemiological human studies when relevant. In addition, current common patterns of toxicity and potential underlying mechanisms of atrazine action will be examined.</p>","PeriodicalId":49971,"journal":{"name":"Journal of Toxicology and Environmental Health-Part B-Critical Reviews","volume":" ","pages":"435-474"},"PeriodicalIF":6.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143525187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A quantitative <i>Apis mellifera</i> hazard and risk assessment model (AMHRA) illustrated with the insecticide sulfoxaflor: sulfoxaflor environmental science review part VI.","authors":"J R Purdy, K R Solomon, V J Kramer, J P Giesy","doi":"10.1080/10937404.2025.2478972","DOIUrl":"10.1080/10937404.2025.2478972","url":null,"abstract":"<p><p>In this paper, conceptual models of the exposure pathways outside the hive and the in-hive distribution of pesticide residues brought to the honeybee hive are presented. The conceptual model is based on the natural life history, behavior and diet of individual honeybees (<i>Apis mellifera</i>). Receptor groups of bees with similar diets and potential exposure are defined. From the conceptual model, a quantitative <i>A. mellifera</i> hazard and risk assessment model (AMHRA) is developed and illustrated using sulfoxaflor (SFX) as a case study. The model estimates the exposure of the receptor groups of honeybees within a colony via various routes of exposure. The user selects a deterministic mode to obtain hazard quotients (HQ) or a probabilistic mode to obtain risk quotients (RQ). The model was run in the deterministic mode using the pesticide concentrations in nectar and pollen from a field experiment in which SFX was applied to cotton crops at the highest permitted application rate of 101 g a.i. ha^-1. Acute and chronic exposure HQ values were calculated for the adult and larval receptor groups. The results showed that the SFX applied at the highest single application rate following the label directions was not hazardous to honeybees. The probabilistic mode was described but not run.</p>","PeriodicalId":49971,"journal":{"name":"Journal of Toxicology and Environmental Health-Part B-Critical Reviews","volume":" ","pages":"406-434"},"PeriodicalIF":6.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143711905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating pollinator exposures to sulfoxaflor via bee-relevant matrices: a systems-level approach using semi-probabilistic methods for assessing hazards; sulfoxaflor environmental science review part IV.","authors":"K R Solomon, J R Purdy, V J Kramer, J P Giesy","doi":"10.1080/10937404.2025.2478970","DOIUrl":"10.1080/10937404.2025.2478970","url":null,"abstract":"<p><p>Sulfoxaflor (SFX) is a newly registered IRAC Group 4C nAChR-receptor-agonist systemic insecticide that is used to control sap-sucking insects in a variety of crops. SFX has a short half-life (< 2 days) in agricultural soil and is only used as a foliar-applied product. Pollinators such as honey bees could be exposed directly to spray if application occurs shortly before or during blooming of flowers, or, as SFX is systemic, via oral exposures to nectar and pollen collected by bees. Guided by a Weight-of-Evidence rubric, this paper critically assessed studies on the fate of SFX in bee-relevant matrices submitted by the registrant in several jurisdictions as well as a few studies published in the open scientific literature. These studies provided data for residues in pollen and/or nectar from 16 crops grown in several countries in both hemispheres. SFX and transformation products were detected in nectar and pollen. Transformation products have low hazard to honeybees, so the focus was on the parent material, SFX, which was observed to dissipate rapidly from pollen and nectar after application. Dietary No-Observed-Adverse-Effect-Concentrations (NOAEC) derived from results of 10-day continuous feeding studies of adult (0.50 mg kg^-1 diet d^-1) and larval honeybees (1.69 mg kg^-1 diet d^-1) were used as precautionary toxicity benchmarks to characterize hazards. In this paper, we used a tiered process. The initial screening tier was based on the greatest concentration measured in the matrix. For scenarios that did not pass Tier-1, a second tier based on the 10-day time-weighted average (area under the curve, AUC) concentration in the matrix was used as a more realistic measure of exposure. Of the 90 scenarios of use that were characterized, 36 did not pass the initial screening benchmark based on ≥1concentration of SFX exceeding the 10-day NOAEC. When the 10-day AUC of exposure was estimated for these scenarios, 3 of 90 did not pass the more realistic toxicity benchmark. These three scenarios were for residues in pollen or anthers for alfalfa grown in California, strawberries grown in France, peaches grown in Michigan. The two-tier screening procedure for hazard assessment lessened the need for further assessment for 97% of the exposure scenarios and reduced the need for characterizing hazards in field-level whole-hive tests conducted under controlled conditions of exposure.</p>","PeriodicalId":49971,"journal":{"name":"Journal of Toxicology and Environmental Health-Part B-Critical Reviews","volume":" ","pages":"350-373"},"PeriodicalIF":6.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143711907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}