Journal of Trace Elements in Medicine and Biology最新文献

{"title":"Iodine intakes of pregnant females from Québec, Canada","authors":"Jesse Bertinato ,&nbsp;Philip Griffin ,&nbsp;Cunye Qiao ,&nbsp;Deborah Cavalcanti ,&nbsp;Louise Ghesquière ,&nbsp;Emmanuel Bujold","doi":"10.1016/j.jtemb.2025.127601","DOIUrl":"10.1016/j.jtemb.2025.127601","url":null,"abstract":"<div><h3>Background</h3><div>Adequate maternal iodine intake is important for fetal brain development. Based on iodine intakes of non-pregnant females of reproductive age from the Canadian Health Measures Survey (2016 −2017) it can be extrapolated that most pregnant females in Canada will not meet iodine requirements without supplementation.</div></div><div><h3>Objectives</h3><div>To assess iodine intakes of 500 pregnant, nulliparous females from Québec, Canada and report on use of multivitamin/mineral (MVM) supplements and coverage of iodized salt.</div></div><div><h3>Methods</h3><div>Duplicate spot urine samples were collected at 10.1 −14.9 weeks (T1) and 19.7 −24.9 weeks (T2) of gestation. Median urinary iodine concentrations (UIC) were compared with WHO/UNICEF/ICCIDD reference ranges. Daily iodine intakes were calculated from UIC using a formula that corrects for urine dilution using creatinine and accounts for urinary iodine excretion rate. Usual (adjusted for within-person variation) iodine intakes were estimated from duplicate daily intake measurements (T1 and T2 measures) using the National Cancer Institute method. Prevalence of inadequate or excessive intakes were determined from usual intakes by the Estimated Average Requirement (EAR) or Tolerable Upper Intake Level (UL) cut-point method, respectively.</div></div><div><h3>Results</h3><div>Females (median: 30.1 years) were mostly white race (94.4 %), highly educated and consumed iodized salt (92 %). Median UIC at T1 (136 µg/L, IQR: 71 −230) was lower (p&lt;0.001) than at T2 (193 µg/L, IQR: 112 −390). Almost all females used a MVM supplement (98.2 %) with 35.6 % starting supplementation preconception and 0.6 %, 28.4 %, 19.8 %, 7.2 % and 6.0 % starting 1 −2 weeks, 3 −4 weeks, 5 −8 weeks, 8 −12 weeks and &gt; 12 weeks postconception, respectively. Almost all (99 %, 95 % CI: 98, 100) had usual iodine intakes ≥EAR and ≤UL.</div></div><div><h3>Conclusions</h3><div>Prevalence of inadequate or excessive usual iodine intakes was low. However, about two-thirds of females started MVM supplementation postconception and median UIC at T1 was below the adequate range of 150 −249 µg/L.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"88 ","pages":"Article 127601"},"PeriodicalIF":3.6,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143030611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute arsenic exposure induces cyto-genotoxicity and histological alterations in Labeo rohita","authors":"Fakhira Khalid,&nbsp;Hamda Azmat","doi":"10.1016/j.jtemb.2025.127600","DOIUrl":"10.1016/j.jtemb.2025.127600","url":null,"abstract":"<div><h3>Background</h3><div>Arsenic emerges as most potent hazardous element ranked as number one in ATSDR (Agency for Toxic Substances and Disease Registry) list, can easily accumulate in fish, transported to humans via consumption and affect humans and aquatic organisms. Considering above, current experiment designed to evaluate cyto-genotoxicity and histological alterations induced by arsenic in <em>Labeo rohita</em> used as an animal model<em>.</em></div></div><div><h3>Methods</h3><div>By applying complete randomized design sampling acclimatized individuals of <em>Labeo rohita</em> (10 batches of 10 each with triplicates) were exposed to nine definitive doses (12, 14, 16, 18, 20, 22, 24, 26 and 28 mgL⁻¹) of arsenic in glass aquaria to determine 96-h lethal concentration (LC₅₀) of arsenic. Control group without arsenic was also run simultaneously. After 96-h exposure various histo-biochemical parameters were evaluated in all experimental groups.</div></div><div><h3>Results</h3><div>The 96-h lethal concentration of arsenic was found to be 20.2 mgL⁻¹. Upon arsenic exposure, oxidative stress biomakers: catalase (CAT), superoxide dismutase (SOD) and lipid per oxidation (LPO) and accumulation of arsenic in all targeted organs were considerably (p ≤ 0.05) increased in dose dependent manner and in comparison, to unexposed (control) group. Serum liver function enzymes, immunological status (albumin, globulin and total protein), cortisol level and cytochrome P450 gene expression remarkably (p ≤ 0.05) altered on arsenic exposure. The histological analysis also showed destructive alterations on exposure to arsenic in gill and liver tissues.</div></div><div><h3>Conclusion</h3><div>These results confirmed that exposure of arsenic led to pronounced deleterious alterations in <em>Labeo rohita</em> and evidencing the need for monitoring alarmingly increasing concentration of arsenic.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"88 ","pages":"Article 127600"},"PeriodicalIF":3.6,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143030607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between the magnesium depletion score and all-cause and cardiovascular mortality among asthma patients: A Study based on the NHANES population from 2005–2018","authors":"Lanxin Fan ,&nbsp;Xueqing Gong ,&nbsp;Hongling Jia","doi":"10.1016/j.jtemb.2025.127602","DOIUrl":"10.1016/j.jtemb.2025.127602","url":null,"abstract":"<div><h3>Background</h3><div>This study aimed to investigate the potential association between magnesium depletion score (MDS), a novel assessment of magnesium status in vivo, and all-cause and cardiovascular mortality in asthma patients.</div></div><div><h3>Methods</h3><div>Using data from the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2018, 4757 asthmatics were included in the study and were categorized into four groups based on their MDS levels (MDS=0, MDS=1, MDS=2, and MDS≥3). Survival differences between the different MDS groups were analysed using Kaplan-Meier curves, and weighted multivariate Cox regression models assessed the relationship between MDS and mortality. In addition, non-linear relationships between MDS and all-cause and cardiovascular mortality were explored using restricted cubic spline (RCS) regression models, and subgroup analyses were performed to validate the results.</div></div><div><h3>Results</h3><div>Kaplan-Meier curves showed that both all-cause and cardiovascular mortality were significantly higher in the group with higher levels of MDS (P &lt; 0.001). After controlling for all confounders, asthmatics in the higher MDS group faced a higher risk of death compared with the lower MDS group, as evidenced by a 3.29-fold increase in all-cause mortality (95 % CI: 2.05, 5.29) and a 4.68-fold increase in cardiovascular mortality (95 % CI: 1.77, 12.35). Fully adjusted Cox regression models further confirmed the significant positive association of high MDS with the risk of all-cause and cardiovascular mortality.RCS plots revealed a linear dose-response relationship between MDS and mortality. In the subgroup analyses, no interaction factors other than cardiovascular disease were found to significantly influence the relationship between MDS and mortality.</div></div><div><h3>Conclusion</h3><div>Higher levels of MDS independently predicted the risk of mortality, especially cardiovascular mortality, in US adults with asthma. Therefore, the MDS may become a cost-effective and widely applicable prognostic assessment tool for asthma, providing an important reference for clinical decision-making and patient management.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"88 ","pages":"Article 127602"},"PeriodicalIF":3.6,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143019011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Selenium ameliorates cognitive impairment through activating BDNF/TrkB pathway","authors":"Yu Liu ,&nbsp;Ye Liu ,&nbsp;Liping Shi ,&nbsp;Xue Zhang ,&nbsp;Kunmei Liu ,&nbsp;Shulan He","doi":"10.1016/j.jtemb.2025.127599","DOIUrl":"10.1016/j.jtemb.2025.127599","url":null,"abstract":"<div><h3>Background</h3><div>Alzheimer's disease (AD) is a neurodegenerative disorder that primarily affects older adults. Selenium, an essential micronutrient for humans, plays a crucial role in the body's normal physiological and metabolic processes. A long-term deficiency in selenium intake can lead to various diseases and even contribute to the ageing process. This study aims to explore the ameliorative effect of selenium on cognitive impairment in 3 × Tg-AD mice and to determine if its effects are related to the BDNF/TrkB pathway.</div></div><div><h3>Methods</h3><div>We employed the APP/PS1/tau 3 × Tg-AD mouse model for dietary selenium intervention. Behavioural experiments were conducted to assess learning and memory. Additionally, we measured selenium and GSH-Px levels in whole blood and brain tissue. Neuronal apoptosis in the hippocampus was observed using transmission electron microscopy. The expressions of Aβ, P-tau, BDNF, TrkB, and CREB were measured via RT-qPCR, while the expressions of Aβ, P-tau, BDNF, TrkB, p-CREB, and CREB were quantified using Western blot analysis.</div></div><div><h3>Results</h3><div>Our findings indicate that selenium supplementation can improve spatial learning and memory deficiencies in 3 × Tg-AD mice. Selenium supplementation increased selenium and GSH-Px levels in the brain tissue of 3 × Tg-AD mice and significantly enhanced neuronal conditions. Furthermore, the expression levels of proteins related to the BDNF/TrkB pathway significantly increased following selenium supplementation.</div></div><div><h3>Conclusions</h3><div>Our study demonstrates that selenium can ameliorate memory impairment in 3 × Tg-AD mice by activating the BDNF/TrkB pathway.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"88 ","pages":"Article 127599"},"PeriodicalIF":3.6,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143019014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mitigative effects of didymin against cadmium-induced renal injury via regulating Nrf-2/Keap-1, apoptosis, inflammation and oxidative stress","authors":"Ali Hamza ,&nbsp;Sayda Snober Fatima Zadi ,&nbsp;Muhammad Zaid Salar ,&nbsp;Muhammad Umar Ijaz ,&nbsp;Khalid A. Al-Ghanim ,&nbsp;Ayesha Ishtiaq","doi":"10.1016/j.jtemb.2025.127597","DOIUrl":"10.1016/j.jtemb.2025.127597","url":null,"abstract":"<div><h3>Background</h3><div>Cadmium (Cd) is a toxic heavy metal present in environment that has potential to instigate renal toxicity. Didymin (DDM) is a natural flavone, which shows anti-oxidant, anti-inflammatory and antiapoptotic nature. Therefore, the current study was formulated to appraise attenuative potential of DDM against Cd instigated nephrotoxicity.</div></div><div><h3>Methods</h3><div>Forty-eight albino rats were divided into four equal groups, including control, Cd (5 mg/kg) inebriated group, Cd + DDM (5 mg/kg + 1 mg/kg) concurrent-treated group, as well as DDM (1 mg/kg) alone treated group. The trial was conducted for 30 days and then the rats were anesthetized, decapitated and further analyses were performed.</div></div><div><h3>Results</h3><div>The results demonstrated that Cd treatment lowered the expressions of Nrf-2 and its anti-oxidant genes while escalating Keap-1 expression. Cd exposure downregulated the activities of antioxidant enzymes, SOD, GSR, CAT, HO-1, GPx, GST &amp; GSH contents, while the levels of MDA and ROS were escalated. Furthermore, Cd exposure lowered the levels of creatinine clearance and albumin, while increasing the levels of urobilinogen, urinary proteins, urea, creatinine, NGAL and KIM-1. Moreover, Cd intoxication also augmented the levels of inflammatory indices including, IL-1β, NF-κB, TNF-α, IL-6 and COX-2. Additionally, Cd exposure reduced the expressions of Bcl-2, while increasing Bax and caspase-3 expressions. In addition to this, Cd also provoked multiple histological injuries in the renal tissues of the rats. However, DDM supplementation markedly recovered the renal tissues from the Cd induced damages.</div></div><div><h3>Conclusion</h3><div>In conclusion, DDM protected the renal tissues from Cd-provoked damages due to its antiapoptotic, anti-oxidant and anti-inflammatory efficacy.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"88 ","pages":"Article 127597"},"PeriodicalIF":3.6,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143061894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis, crystal structure, characterization and antimicrobial activities of ternary chiral mononuclear Schiff base copper(II) complexes","authors":"Santha Lakshmi Sundaramurthy ,&nbsp;Kannappan Geetha ,&nbsp;Ganesh Shanmugam ,&nbsp;Thandapani Gomathi ,&nbsp;Ganesan Logesh ,&nbsp;Sekar Vijayakumar","doi":"10.1016/j.jtemb.2025.127590","DOIUrl":"10.1016/j.jtemb.2025.127590","url":null,"abstract":"<div><div>[CuL^1–4(tmen)] is a sequence of four ternary mononuclear Schiff base copper(II) complexes that are derived from L-valine, suitable 5′-substituted-2′-hydroxyacetophenones (where the substituents are -Cl for L¹, -Me for L², -OMe for L³, and -H for L⁴), and tmen (where tmen-N,N,N′,N′ tetramethyl ethylenediamine). Without isolating the Schiff base ligand or producing any other intermediate products, all of the complexes were synthesised. These compounds were identified using elemental analysis, molar conductance, UV-Vis, FTIR, EPR, VSM-RT, and CD spectra. Single crystal XRD was used to characterise the structure of Complex 1. The crystalline structure exhibits a distorted square pyramidal shape wherein the Schiff base forms an axial bond with the Cu(II) ion through the ONO-donor, while the chelating ligand tmen exhibits both an equatorial and an axial mode of binding through the NN-donor atoms. Hydrogen bonding and non-covalent CH(methyl)<img>π(phenyl) interaction are two intriguing aspects of compound 1's packing diagram. By calculating the minimum inhibitory concentration (MIC) against harmful bacteria, the synthesised complexes' antimicrobial activity was assessed. According to the bioactivity experiments, the microorganisms employed in this investigation were susceptible to the antibacterial and antifungal properties of copper(II) complexes 1–4. According to the bioactivity experiments, the microorganisms employed in this investigation were susceptible to the antibacterial and antifungal properties of copper(II) complexes 1–4.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"88 ","pages":"Article 127590"},"PeriodicalIF":3.6,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143025666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FESTEM","authors":"","doi":"10.1016/S0946-672X(24)00197-4","DOIUrl":"10.1016/S0946-672X(24)00197-4","url":null,"abstract":"","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"86 ","pages":"Article 127577"},"PeriodicalIF":3.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143148081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SFERETE","authors":"","doi":"10.1016/S0946-672X(24)00196-2","DOIUrl":"10.1016/S0946-672X(24)00196-2","url":null,"abstract":"","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"86 ","pages":"Article 127576"},"PeriodicalIF":3.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143148080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spatial distribution and the ecological risks posed by heavy metals and total petroleum hydrocarbons (TPHs) in the sediments of mangrove and coral habitats of Northeast Persian Gulf","authors":"Mohammad Seddiq Mortazavi,&nbsp;Sana Sharifian,&nbsp;Seyedeh Laili Mohebbi Nozar,&nbsp;Hadi Koohkan","doi":"10.1016/j.jtemb.2024.127574","DOIUrl":"10.1016/j.jtemb.2024.127574","url":null,"abstract":"<div><h3>Background</h3><div>Heavy metals and total petroleum hydrocarbons (TPHs) are important pollutants in the aquatic ecosystem, and their long-term resistance, bio-accumulation, and bio-magnification during the food chain may cause adverse ecological and health risks.</div></div><div><h3>Methods</h3><div>In here, the distribution and risk assessment of six heavy metals Cd, Pb, Ni, Cu, Zn, Cr, and TPHs were performed in the sediments of 32 regions situated in two mangroves (Tiab and Azini estuaries, Hara Mangrove forest protected area) and coral habitats (Larak and Hengam Islands) in Northeast of the Persian Gulf during 2020–2021. An atomic absorption device was used to determine the concentrations of heavy metals. Ecological risk of heavy metals is assessed through indices contamination factor (CF), contamination degree (CD), modified contamination degree (MCD), pollution load index (PLI), potential ecological risk index (PERI), and geoaccumulation index (Igeo). The spatial distribution of heavy metals was mapped through the inverse distance weighting (IDW) method in ArcMap.</div></div><div><h3>Results</h3><div>The concentration of heavy metals indicated significant differences in spatial distribution. The maximum concentration of Cd 1.64 ± 0.001, Cr 18.41 ± 0.41 and Cu 40.5 ± 0.28 µg/g was observed at the regions situated in the Hara Mangrove forest protected area. Azini estuary had the maximum value of Zn 94.61 ± 30.74 and TPHs 4.47 ± 1.93 µg/g and finally, the highest value of concentration Ni 135.22 ± 1.85 µg/g and Pb 17.87 ± 2.17 g/gµ was found in Tiab estuary. The studied regions in the Tiab estuary and Hara Mangrove forest protected area were more contaminated than others and had considerable risks of Ni and Cd. Average ecological indices indicated the sediments of these areas especially Tiab, Hara Mangrove forest protected area, and Azini are moderately to considerably contaminated with Cd and Ni. Tiab was identified as the most contaminated area and all stations except Hengam Island were exposed to considerable ecological risks. Cadmium was found to be the riskiest heavy metal in the investigated region. The distribution of TPHs indicated there is no pollution of TPHs in the region. In all studied stations, the PELq (Toxicity of TPHs) and CF values showed the absence of potential risks of TPHs in sediments.</div></div><div><h3>Conclusions</h3><div>The findings indicated considerable contamination of Cd and Ni in the mangrove areas, especially Tiab, and it seems necessary to identify, manage, and control possible sources of contamination.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"87 ","pages":"Article 127574"},"PeriodicalIF":3.6,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142759780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between serum selenium and serum lipids in adolescents aged 12–19: A cross-sectional study","authors":"Huan He ,&nbsp;Li Yang ,&nbsp;Bailing Liu ,&nbsp;Zhan Zhang","doi":"10.1016/j.jtemb.2024.127572","DOIUrl":"10.1016/j.jtemb.2024.127572","url":null,"abstract":"<div><h3>Background</h3><div>Selenium is an essential trace element in the human body and is important in lipid metabolism. Previous studies on the relationship between selenium and serum lipids were almost conducted in adults, and the research conclusions were inconsistent. Evidence linking selenium and lipids in adolescents is very limited. As an important stage of growth and development, studying the effects of trace elements on the body during adolescence is meaningful.</div></div><div><h3>Objective</h3><div>This study examined the association between serum selenium and serum lipids in adolescents aged 12–19.</div></div><div><h3>Methods</h3><div>This cross-sectional study analyzed 2209 adolescents aged 12–19 years from NHANES 2011 to 2016. Multiple linear regression analyses were performed to evaluate selenium’s association with serum lipids (containing TC, TG, LDL-C, and HDL-C). Moreover, a generalized additive model (GAM) and a fitted smoothing curve (penalized spline method) were conducted to explore the exact curve shape between them.</div></div><div><h3>Results</h3><div>In the fully adjusted model, it showed a positive association between selenium and TC, TG, LDL-C [TC (β = 0.144 (, 95 % CI (0.084, 0.204), P &lt; 0.001), TG (β = 0.285, 95 % CI (0.134, 0.437), P &lt; 0.001), LDL-C (β = 0.098, 95 % CI (0.022, 0.174), P = 0.011)], whereas a negative association [(β = -0.031, 95 % CI (-0.054, − 0.009), P = 0.006)] between Se and HDL-C. Subgroup analysis showed that the above associations were more significant in females aged 12–19 (P for trend &lt; 0.05). Furthermore, linear associations were performed in Se between TC and LDL-C.</div></div><div><h3>Conclusion</h3><div>This is the first study to find evidence demonstrating associations between serum Se and serum lipids in adolescents aged 12–19. The validation of our findings will require further research.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"87 ","pages":"Article 127572"},"PeriodicalIF":3.6,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142759779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}