Journal of Trace Elements in Medicine and Biology最新文献

{"title":"Fish as environmental sentinels for metal contaminants of human health concern in the Lower Mississippi River Basin","authors":"Scoty Hearst ,&nbsp;Trent Selby ,&nbsp;Joseph Kazery ,&nbsp;Steven Everman ,&nbsp;Manliang Feng ,&nbsp;Lillian Sisson ,&nbsp;Chinaza Nwaiwu ,&nbsp;Alison Cevallos ,&nbsp;James Lock ,&nbsp;Matthew Sinclair","doi":"10.1016/j.jtemb.2025.127593","DOIUrl":"10.1016/j.jtemb.2025.127593","url":null,"abstract":"<div><div>Industrial expansion and population growth have lowered water quality, polluting aquatic ecosystems world-wide. Metal pollution in the rivers across the United States are a major health concern. The level of metal contamination in fish from the Lower Mississippi River Basin and their threat to public health were last evaluated 20 years ago. The goals of this study were to measure metal contamination in various fish species from the Lower Mississippi River Basin, evaluate the human consumption risk, and estimate bioindicator potential of these species for monitoring toxic metals on a larger scale. Various fish species (n = 203) were analyzed for 15 metal contaminants (Al, As, Ba, Cd, Co, Cr, Cu, Fe, Hg, Mg, Mn, Ni, Pb, Se, and Zn). Species included: blue catfish (<em>Ictalurus furcatu</em>s), channel catfish (<em>Ictalurus punctatus</em>), flathead catfish (<em>Pylodictis olivaris</em>), bigmouth buffalo (<em>Ictiobus cyprinellus</em>), smallmouth buffalo (<em>Ictiobus bubalus</em>), alligator gar (<em>Atractosteus spatula</em>), spotted gar (<em>Lepisosteus oculatus</em>), American gizzard shad (<em>Dorosoma cepedianum</em>), freshwater drum, (<em>Aplodinotus grunniens</em>), and white crappie (<em>Pomoxis annularis</em>). Fish consumption safety revealed toxic metals (As, Cd, Cr, Hg, and Pb) are a major human health concern in the Lower Mississippi River. Non-cancerous health hazard assessments indicated blue catfish, flathead catfish, gar species, and freshwater drum as species of concern. Consumption of all species posed human cancer risks. Computational modeling, with an accuracy of 98.5 %, identified Hg, Pb, Zn, Cr, Co, As, and Cd as major drivers of fish consumption safety. Using bioaccumulation factor analysis, we estimated the bioindicator potential of toxic metals for each fish species, finding Hg and Cd to be greatly bioaccumulative in predatory gar species. Overall, our data indicated that gar can serve as select environmental sentinels useful for monitoring toxic metal pollutants of public health concerns providing valuable insight to research scientist and monitoring agencies throughout the Lower Mississippi River Basin.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"87 ","pages":"Article 127593"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143019022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SFERETE","authors":"","doi":"10.1016/S0946-672X(25)00021-5","DOIUrl":"10.1016/S0946-672X(25)00021-5","url":null,"abstract":"","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"87 ","pages":"Article 127608"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143103523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of propolis supplementation on cadmium toxicity associated with renal and hepatic dysfunction in rats","authors":"Huseyin Ayhan ,&nbsp;Caglar Adiguzel ,&nbsp;Keziban Korkmaz Bayram ,&nbsp;Ali Tugrul Akin ,&nbsp;Fatma Gokce Apaydin ,&nbsp;Yusuf Kalender","doi":"10.1016/j.jtemb.2024.127587","DOIUrl":"10.1016/j.jtemb.2024.127587","url":null,"abstract":"<div><div>Cadmium (Cd), one of the toxic heavy metals, is of great importance for public health due to its use in many industrial areas. Propolis is a natural product with antioxidant and anti-inflammatory properties collected from plants by honey bees. The aim of this study was to investigate the protective role of propolis against the potential toxic effects of cadmium chloride in blood, liver and kidney tissues. For this purpose, rats were divided into four groups. Control group, propolis (150 mg/kg b.w.) treated group, cadmium chloride (1.76 mg/kg b.w. 1/50 LD₅₀) treated group and cadmium chloride plus propolis (1.76 mg/kg b.w. and 150 mg/kg b.w. respectively) treated group. The substances were given to rats by gavage for 28 days. After 28 days of treatment, a statistically significant change was observed in serum biochemical parameters such as ALT, AST, BUN, LDH, urea, uric acid and creatinine, hematological parameters such as erythrocyte, hemoglobin and hematocrit, and IL-1β and IL-6 cytokine levels of cadmium chloride treated rats compared to the control group. In addition, significant changes were observed in mRNA expression levels of Casp-3, p53 and Tnf-α genes, HSP70, HSP90 and GRP78 protein levels and histopathological/immunohistochemical examinations. Improvement in biochemical and hematologic parameters, cytokines, mRNA expression, heat shock proteins and immunohistochemistry changes were observed in cadmium plus propolis treated group compared to cadmium treated group.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"87 ","pages":"Article 127587"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143070604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Randomized, multicenter, active-controlled open-label study of NPC-25, zinc histidine hydrate, (non-inferiority to NOBELZIN™, zinc acetate dihydrate) for patients with hypozincemia","authors":"Daisuke Asaoka ,&nbsp;Tomomi Ishihara ,&nbsp;Sachiko Ezoe ,&nbsp;Izumi Hamada ,&nbsp;Motohiro Kitamura ,&nbsp;Kuniyasu Uchino ,&nbsp;Kunio Arai ,&nbsp;Yoshihiko Kanno ,&nbsp;Hiroko Kodama","doi":"10.1016/j.jtemb.2024.127558","DOIUrl":"10.1016/j.jtemb.2024.127558","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Objective&lt;/h3&gt;&lt;div&gt;This study evaluated the efficacy and safety of NPC-25, zinc histidine hydrate, in patients with hypozincemia. This randomized multicenter active-controlled open-label trial aimed to verify the non-inferiority of NPC-25 to NOBELZIN™, zinc acetate dihydrate.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;Participants whose serum zinc concentrations were &lt;70 μg/dL at two points within 8 weeks before the start of treatment were randomized 1:1 into the NPC-25 (active drug) administration group and the NOBELZIN™ (control drug) administration group, using dynamic allocation. The initial daily doses were 50 mg or 100 mg as the baseline serum zinc levels, and administration periods were set at maximum of 24 weeks with the goal of maintaining the target serum zinc concentration (≥80 and &lt;200 μg/dL) for 8 weeks, with extension up to 52 weeks as needed in the NPC-25 group, but not the NOBELZIN group. The primary efficacy endpoint was the proportion of participants who maintained the target serum zinc concentration for 8 weeks at the same dosage within 24 weeks after the start of administration. The key secondary endpoints were the cumulative achievement percentage for target serum zinc concentration at each observation time point, the cumulative achievement percentage for maintenance of target concentration for 8 weeks at the same dosage at each observation time point, change in mean serum zinc concentration, and comparison of dosage amount. Safety assessments included the incidence of adverse events and adverse drug reactions, as well as changes in clinical laboratory and physical measurements.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;For the primary endpoint for full analysis (FAS) set (n=103, NPC-25 group; n=107, NOBELZIN group), the proportion of participants who maintained the target serum zinc concentration for 8 weeks at the same dose was 86.4 % (89/103) in the NPC-25 group and 80.4 % (86/107) in the NOBELZIN group, which confirmed the non-inferiority of NPC-25 to NOBELZIN™. For the secondary endpoint for FAS, at each observation point, although there was no significant difference between the two groups in the proportion of participants who achieved the target serum zinc concentration, there was a tendency that the maintenance of the target concentration for 8 weeks was achieved earlier with NPC-25.&lt;/div&gt;&lt;div&gt;There was also a tendency to achieve maintenance with a lower daily dose in the NPC-25 group. Furthermore, at each observation point, there was no significant difference between the two groups in terms of the mean serum zinc concentration or the average change in serum zinc concentration from baseline. In the safety assessment for safety population (SP), the incidence of nausea and vomiting was lower with NPC-25 than with NOBELZIN (2.8 % and 6.4 % with nausea, 0.9 % and 2.8 % with vomiting), but there were no significant differences in other adverse drug reactions.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;div&gt;In this study, non-in","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"87 ","pages":"Article 127558"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142873750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of organ iron levels with type 2 diabetes mellitus and glycemic traits: A bidirectional two-sample Mendelian randomization study","authors":"Akshaya Vasudevan ,&nbsp;Padmanaban Venkatesan","doi":"10.1016/j.jtemb.2024.127586","DOIUrl":"10.1016/j.jtemb.2024.127586","url":null,"abstract":"<div><h3>Introduction</h3><div>Observational studies have found that higher iron levels are associated with an increased risk of diabetes mellitus. Given the limitations of causal inferences from observational studies and the expensive and time-consuming nature of randomized controlled trials, Mendelian randomization analysis presents a reasonable alternative to study causal relationships. Previous MR analyses studying iron levels and diabetes have used indirect markers of iron levels, such as serum ferritin, and found conflicting results. In this study, we performed bidirectional Mendelian Randomization analyses using organ iron (liver, spleen, and pancreas) levels, which are more direct markers of iron status, to study the causal association of iron levels with type 2 diabetes mellitus and glycaemic traits.</div></div><div><h3>Methods</h3><div>Two sample MR analyses were employed bi-directionally to study the causal effect of liver, spleen, and pancreas iron levels on type 2 diabetes and glycaemic traits and the causal effect of type 2 diabetes on organ iron levels, using summary data from genome-wide association studies (UK-Biobank, DIAGRAM, and MAGIC consortia). SNPs associated with organ iron levels with a cut-off of P &lt; 5 × 10⁻⁷ were used as instrumental variables for the MR analyses of the effect of organ iron levels on type 2 diabetes/glycaemic traits, and SNPs associated with diabetes mellitus with a cut-off of P &lt; 5 × 10⁻⁸ were used as instrumental variables for the MR analyses of the causal effect of type 2 diabetes on organ iron levels. Serum ferritin (GWAS meta-analysis of deCODE, UK INTERVAL, and Denmark studies) and haemoglobin (Blood Cell consortium) were used as positive controls for the MR analysis with liver iron as the exposure. Primary analyses used the inverse variance weighted means of Wald’s ratio. Sensitivity analyses included inverse variance weighted median, weighted mode, and MR-Egger methods.</div></div><div><h3>Results</h3><div>Our findings reveal no causal association between liver and pancreas iron levels with type 2 diabetes (Liver iron: OR = 1.02, P = 0.1, Pancreas iron: OR = 1.11, P = 0.5). This also holds for glycaemic traits, except for the negative causal effect of liver iron levels on HbA1c (OR = 0.93, P = 0.001). Spleen iron levels had a negative causal effect on type 2 diabetes (OR = 0.94, P = 0.049). However, these exceptions are likely due to possible pleiotropy, as these associations can be explained by the effect of the genetic variants on factors that falsely decrease HbA1c levels. No causal association was found for the effect of type 2 diabetes on organ iron levels.</div></div><div><h3>Conclusion</h3><div>Organ iron levels, which are relatively more direct indicators of iron status, showed no causal association with type 2 diabetes in the European population.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"87 ","pages":"Article 127586"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142928947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between maternal serum zinc and birth weight is modified by neonatal SOD2 polymorphism and promoter methylation","authors":"Yuting Zeng ,&nbsp;Yalong Wang ,&nbsp;Yanan He ,&nbsp;Qinyang Li ,&nbsp;Ruiqin Chen ,&nbsp;Cuiping Wu ,&nbsp;Na Li ,&nbsp;Xinya Cheng ,&nbsp;Yuhui Du ,&nbsp;Fangfang Yu ,&nbsp;Yue Ba ,&nbsp;Guoyu Zhou","doi":"10.1016/j.jtemb.2025.127595","DOIUrl":"10.1016/j.jtemb.2025.127595","url":null,"abstract":"<div><h3>Background</h3><div>Conflicting findings exist regarding the association between maternal serum zinc and neonatal birth weight. This study aimed to explore the association between maternal serum zinc and birth weight, and whether this association was modified by neonatal <em>SOD2</em> polymorphism and promoter methylation.</div></div><div><h3>Methods</h3><div>We recruited 464 mother-newborn pairs at Houzhai Center Hospital from January 2010 to January 2012. Maternal serum zinc concentration was determined using atomic absorption spectrophotometry. Neonatal <em>SOD2</em> polymorphism and promoter methylation were measured by TaqMan probe assay and real-time quantitative methylation-specific PCR (QMSP), respectively. Relationships among maternal serum zinc, neonatal <em>SOD2</em> promoter methylation, and birth weight were analyzed by generalized linear model (GLM). Stratified and interaction analyses were conducted to explore the modification of neonatal <em>SOD2</em> polymorphism and promoter methylation on the association between maternal serum zinc and birth weight.</div></div><div><h3>Results</h3><div>Our findings revealed that higher maternal zinc concentrations were associated with decreased birth weight (<em>P</em>-trend &lt; 0.05). Each 1 μmol/L increment in maternal zinc level was associated with a 9.553 g (95 % <em>CI</em>: −16.370, −2.735) decrease in birth weight. A significant interaction between <em>SOD2</em> promoter methylation and maternal serum zinc in relation to birth weight was observed in the AG+GG group (<em>P</em>-interaction &lt; 0.05). Newborns carrying AA genotype were more sensitive to maternal serum zinc in the lower <em>SOD2</em> group (<em>P</em>-interaction &lt; 0.05).</div></div><div><h3>Conclusions</h3><div>Maternal serum zinc was inversely associated with birth weight, and this association was modified by neonatal <em>SOD2</em> polymorphism and promoter methylation. These findings suggest that <em>SOD2</em> polymorphism and promoter methylation may influence the relationship between maternal zinc status and fetal growth.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"87 ","pages":"Article 127595"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143019002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Occurrence and health risk assessment of selected metals in commercially available infant formulas in Jordan","authors":"Adnan Mohammad Massadeh ,&nbsp;Kawthar Zeyad Alzarieni ,&nbsp;Hebah Ziyad Alzaghol ,&nbsp;Mahmoud Mustafa Smadi","doi":"10.1016/j.jtemb.2024.127585","DOIUrl":"10.1016/j.jtemb.2024.127585","url":null,"abstract":"<div><h3>Background</h3><div>Infant formulas are the primary source of nutrition for infants and babies when breastfeeding is unavailable, as they are enriched with a variety of macro- and micronutrients to improve their nutritional value and satisfy the different needs of babies. Recently, there has been a rising concern about toxic metal levels in infant formulas, as highlighted by various studies. However, there are currently no sufficient studies focusing on toxic metal levels of infant formulas in Jordan. The current study aims to determine the levels of 25 metals, including Na, Mg, K, Ca, Cr, Fe, Mn, Co, Ni, Cu, Zn, Li, Ti, V, Ga, Sr, Ag, Ba, Bi, Th, U, Al, Cd, In, and Pb, in infant formulas (starter infant formula, follow-on formula, and growing-up formula) using inductively coupled plasma mass spectrometry (ICP-MS) and evaluate their safety and quality.</div></div><div><h3>Methods</h3><div>The metal compositions of 37 infant formula samples collected from different Jordanian pharmacies were determined using inductively coupled plasma-mass spectrometry (ICP-MS) after digesting the samples with 9 mL of HNO₃ (70 %) and 3 mL of H₂O₂ (30 %) using the microwave-assisted digestion technique. The possible health risks associated with the exposure to Cd, Pb, Al, and Ni in infant formulas were evaluated using estimated daily intake, target hazard quotient, and hazard index calculations. Also, method validation, including accuracy, precision, limit of detection, and limit of quantification, was performed.</div></div><div><h3>Results</h3><div>The results revealed that follow-on formula (intended for 7–12-month-old babies) had the highest mean concentration of all studied metals, except for zinc, which had the highest mean concentration in starter infant formula (intended for less than 6-month-old babies). Also, 72.97 % and 89.20 % of the tested samples had Pb and Cd levels that exceeded the European permissible limit, respectively. Regarding the estimated daily intake (EDI), babies aged 7–12 months were found to be the most exposed to Cd and Pb toxicity, while babies aged less than 6 months were found to be the most exposed to Ni toxicity. Unfortunately, the overall non-carcinogenic negative adverse effects (hazard index HI) of Cd and Pb for babies aged 7–12 months exceeded the acceptable threshold of 1.</div></div><div><h3>Conclusion</h3><div>Based on the results, the consumption of infant formulas sold in Jordan may pose serious health risks to babies, with Cd and Pb levels in follow-on formulas (posing the highest risk). The source of contamination in infant formulas may be contaminated raw materials, the manufacturing process, packaging, or storage. So, strict regulations ought to be established to safeguard the health of babies.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"87 ","pages":"Article 127585"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142928949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Foliar application of nitrates limits lead uptake by Cucumis sativus L. plants","authors":"Aleksandra Naziębło ,&nbsp;Olga Bemowska-Kałabun ,&nbsp;Małgorzata Wierzbicka ,&nbsp;Maksymilian Zienkiewicz","doi":"10.1016/j.jtemb.2025.127592","DOIUrl":"10.1016/j.jtemb.2025.127592","url":null,"abstract":"<div><div>Lead is a toxic heavy metal, which accumulates in the soil and is readily absorbed by plant roots. The uptake of toxic elements by crops is a serious threat to human health. For this reason, it is important to prevent the incorporation of heavy metals into the food chain. Our previous study showed that foliar application of calcium nitrate reduces the intensity of lead uptake by different plant species. A significant decrease in metal concentration was observed both in the roots and in the shoots of three crops: tomato, cucumber, and flax. The present research investigated the mechanism for limiting lead accumulation in plant tissues. The experiments were conducted on <em>Cucumis sativus</em> L. seedlings, grown in hydroponic conditions. To compare the role of Ca^2 + and NO₃^- ions in the restriction of lead uptake three different calcium salts (nitrate, chloride, and formate), and two nitrates (calcium and potassium) were applied foliarly to plants. The results show that Ca(NO₃)₂ is more efficient in decreasing lead accumulation in tissues than other calcium salts which suggests an important role of NO₃^- ions in the process. In addition, the study demonstrated that the exogenous supply of nitrates helps compensate for nitrogen deficiency caused by lead action and supports the mineral balance. The reduction in lead toxicity to plants after foliar application of nitrates may be due to the stimulation of the biosynthesis of nitric oxide – a key molecule responsible for stress response.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"87 ","pages":"Article 127592"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142974086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum iodine concentration in pregnant women and its association with thyroid function","authors":"Dongdong Yu ,&nbsp;Yinyin He ,&nbsp;Hongsen He ,&nbsp;Zhengyan Hu ,&nbsp;Yun Huang ,&nbsp;Jun Tang","doi":"10.1016/j.jtemb.2024.127584","DOIUrl":"10.1016/j.jtemb.2024.127584","url":null,"abstract":"<div><h3>Objective</h3><div>This study aims to investigate the association of serum iodine concentration (SIC) with thyroid function-associated parameters in pregnant women in mild iodine deficient area, and explore its potential to predict individual iodine nutrition status in pregnant women.</div></div><div><h3>Methods</h3><div>A total of 741 pregnant women undergoing prenatal examinations in their second trimester at the Women's Hospital, Zhejiang University School of Medicine, from March 2021 to May 2022 were finally recruited into the study. Venous blood and morning urine were collected. Serum free triiodothyronine (FT3), free thyroxine (FT4), thyro-stimulating hormone (TSH), total thyroxine (TT4), total triiodothyronine (TT3), thyroid peroxidase antibody (TPOAb), thyroglobulin antibody (TgAb), UIC (urinary iodine concentration) and SIC were measured.</div></div><div><h3>Results</h3><div>The median SIC was 54.44 μg/L. SIC was linearly and positively associated with concentrations of FT4 [ β = 0.10, 95 % CI: (0.07, 0.12), TT4 [ β = 0.29, 95 % CI: (0.26, 0.33), TT3 [ β = 0.14, 95 % CI: (0.09, 0.18). There was an inverted \"U\" shaped relationship between SIC and FT3. The associations between SIC and thyroid hormones remained robust when participants taking specific drug were excluded.</div></div><div><h3>Conclusions</h3><div>SIC is associated with thyroid function-related parameters in pregnant women in their second trimester, indicating that the SIC may have the potential to predict individual iodine nutrition status in pregnant women.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"87 ","pages":"Article 127584"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143018956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pro-inflammatory diet affects markers of iron metabolism in healthy older adults","authors":"Catrin Herpich ,&nbsp;Sophia Walter ,&nbsp;Christiane Ott ,&nbsp;Ulrike Haß ,&nbsp;Tilman Grune ,&nbsp;Ursula Müller-Werdan ,&nbsp;Kristina Norman","doi":"10.1016/j.jtemb.2024.127583","DOIUrl":"10.1016/j.jtemb.2024.127583","url":null,"abstract":"<div><h3>Background</h3><div>Inflammation and inadequate nutrition are common in older age and known to affect iron homeostasis. However, it is not known whether a pro-inflammatory diet affects iron status in older adults. We investigated the diet quality of healthy older adults considering markers of iron homeostasis and inflammation compared to a younger control.</div></div><div><h3>Methods</h3><div>Serum markers of iron metabolism (iron, transferrin, ferritin, hepcidin, soluble transferrin receptor [sTfR]) and inflammation (interleukin-6 [IL-6], IL-10 high-sensitive C- reactive protein [hsCRP]) were quantified using immunosorbent assays. Insulin resistance was determined by calculating the homeostasis model assessment index (HOMA-IR). The Dietary Inflammatory Index® (DII) was computed based on dietary intake and inflammatory (ID) or less inflammatory diet (LID) groups were created by using median DII score specific to age group and sex.</div></div><div><h3>Results</h3><div>DII did not differ by age (p = 0.668, n = 80, F: 75 %, &gt;65 years, n = 60, F: 72 %, ≤35 years). Iron and inflammation status were different between age groups in terms of higher transferrin saturation, sTfR, ferritin and IL-6 concentrations in the old (all p ≤ 0.001). Only in older adults, BMI, HOMA-IR, hsCRP, ferritin and hepcidin concentrations were significantly higher in ID compared to LID (all p &lt; 0.01). In addition, a risk-factor adjusted regression analysis showed that ID was independently associated with higher ferritin and hepcidin concentrations in older adults.</div></div><div><h3>Conclusion</h3><div>In older age, a pro-inflammatory diet is associated with systemic inflammation and disturbed iron homeostasis.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"87 ","pages":"Article 127583"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142873748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}