孕妇血清碘浓度及其与甲状腺功能的关系。

IF 3.6 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Trace Elements in Medicine and Biology Pub Date : 2025-02-01 DOI:10.1016/j.jtemb.2024.127584

Dongdong Yu , Yinyin He , Hongsen He , Zhengyan Hu , Yun Huang , Jun Tang

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引用次数: 0

摘要

目的：本研究旨在探讨轻度缺碘地区孕妇血清碘浓度（SIC）与甲状腺功能相关参数的关系，并探讨其预测孕妇个体碘营养状况的潜力。方法：最终招募2021年3月至2022年5月在浙江大学医学院附属妇产医院接受妊娠中期产前检查的孕妇741例。采集静脉血和晨尿。测定血清游离三碘甲状腺原氨酸（FT3）、游离甲状腺素（FT4）、促甲状腺激素（TSH）、总甲状腺素（TT4）、总三碘甲状腺原氨酸（TT3）、甲状腺过氧化物酶抗体（TPOAb）、甲状腺球蛋白抗体（TgAb）、尿碘浓度（UIC）和SIC。结果：中位SIC为54.44 μg/L。SIC与FT4浓度呈线性正相关[β = 0.10,95 % CI: (0.07, 0.12), TT4 [β = 0.29,95 % CI: (0.26, 0.33)], TT3 [β = 0.14,95 % CI:(0.09, 0.18)]。SIC与FT3呈倒“U”型关系。当排除服用特定药物的参与者时，SIC与甲状腺激素之间的关联仍然很强。结论：SIC与妊娠中期孕妇甲状腺功能相关参数相关，提示SIC可能具有预测孕妇个体碘营养状况的潜力。

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Serum iodine concentration in pregnant women and its association with thyroid function

Objective

This study aims to investigate the association of serum iodine concentration (SIC) with thyroid function-associated parameters in pregnant women in mild iodine deficient area, and explore its potential to predict individual iodine nutrition status in pregnant women.

Methods

A total of 741 pregnant women undergoing prenatal examinations in their second trimester at the Women's Hospital, Zhejiang University School of Medicine, from March 2021 to May 2022 were finally recruited into the study. Venous blood and morning urine were collected. Serum free triiodothyronine (FT3), free thyroxine (FT4), thyro-stimulating hormone (TSH), total thyroxine (TT4), total triiodothyronine (TT3), thyroid peroxidase antibody (TPOAb), thyroglobulin antibody (TgAb), UIC (urinary iodine concentration) and SIC were measured.

Results

The median SIC was 54.44 μg/L. SIC was linearly and positively associated with concentrations of FT4 [ β = 0.10, 95 % CI: (0.07, 0.12), TT4 [ β = 0.29, 95 % CI: (0.26, 0.33), TT3 [ β = 0.14, 95 % CI: (0.09, 0.18). There was an inverted "U" shaped relationship between SIC and FT3. The associations between SIC and thyroid hormones remained robust when participants taking specific drug were excluded.

Conclusions

SIC is associated with thyroid function-related parameters in pregnant women in their second trimester, indicating that the SIC may have the potential to predict individual iodine nutrition status in pregnant women.

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来源期刊

Journal of Trace Elements in Medicine and Biology 医学-内分泌学与代谢

CiteScore

6.60

自引率

2.90%

发文量

202

审稿时长

85 days

期刊介绍： The journal provides the reader with a thorough description of theoretical and applied aspects of trace elements in medicine and biology and is devoted to the advancement of scientific knowledge about trace elements and trace element species. Trace elements play essential roles in the maintenance of physiological processes. During the last decades there has been a great deal of scientific investigation about the function and binding of trace elements. The Journal of Trace Elements in Medicine and Biology focuses on the description and dissemination of scientific results concerning the role of trace elements with respect to their mode of action in health and disease and nutritional importance. Progress in the knowledge of the biological role of trace elements depends, however, on advances in trace elements chemistry. Thus the Journal of Trace Elements in Medicine and Biology will include only those papers that base their results on proven analytical methods. Also, we only publish those articles in which the quality assurance regarding the execution of experiments and achievement of results is guaranteed.