Journal of Veterinary Medical Science最新文献_第9页

Evaluation of vaccine efficacy with 2B/T epitope conjugated porcine IgG-Fc recombinants against foot-and-mouth disease virus. 用 2B/T 表位共轭猪 IgG-Fc 重组体对口蹄疫病毒进行疫苗效力评估。

IF 1.1 4区农林科学

Journal of Veterinary Medical Science Pub Date : 2024-09-20 Epub Date: 2024-07-29 DOI: 10.1292/jvms.23-0480

Byeong-Min Song, Gun-Hee Lee, Sang-Min Kang, Dongseob Tark

{"title":"Evaluation of vaccine efficacy with 2B/T epitope conjugated porcine IgG-Fc recombinants against foot-and-mouth disease virus.","authors":"Byeong-Min Song, Gun-Hee Lee, Sang-Min Kang, Dongseob Tark","doi":"10.1292/jvms.23-0480","DOIUrl":"10.1292/jvms.23-0480","url":null,"abstract":"The inactivated vaccine is effective in controlling foot-and-mouth disease (FMD), but it has drawbacks such as the need for a biosafety level 3 laboratory facility to handle live foot-and-mouth disease virus (FMDV), high production costs, and biological safety risks. In response to these challenges, we developed a new recombinant protein vaccine (2BT-pIgG-Fc) containing porcine IgG-Fc to enhance protein stability in the body. This vaccine incorporates two-repeat B-cell and one-single T-cell epitope derived from O/Jincheon/SKR/2014. Our study confirmed that 2BT-pIgG-Fc and a commercial FMDV vaccine induced FMDV-specific antibodies in guinea pigs at 28 days post-vaccination. The percentage inhibition (PI) value of 2BT-pIgG-Fc was 90.43%, and the commercial FMDV vaccine was 81.75%. The PI value of 2BT-pIgG-Fc was 8.68% higher than that of commercial FMDV vaccine. In pigs, the primary target animals for FMDV, all five individuals produced FMDV-specific antibodies 42 days after vaccination with 2BT-pIgG-Fc. Furthermore, serum from 2BT-pIgG-Fc-vaccinated pigs exhibited neutralizing ability against FMDV infection. Intriguingly, the 2BT-pIgG-Fc recombinant demonstrated FMDV-specific antibody production rates and neutralization efficiency similar to commercial inactivated vaccines. This study illustrates the potential to enhance vaccine efficacy by strategically combining well-known antigenic domains in the development of recombinant protein-based vaccines.","PeriodicalId":49959,"journal":{"name":"Journal of Veterinary Medical Science","volume":" ","pages":"999-1007"},"PeriodicalIF":1.1,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11422696/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141789681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of plasma atrial natriuretic peptide concentration in healthy bottlenose dolphins (Tursiops truncates). 评估健康瓶鼻海豚（Tursiops truncates）血浆中人类心房利钠肽的浓度。

IF 1.1 4区农林科学

Journal of Veterinary Medical Science Pub Date : 2024-09-20 Epub Date: 2024-08-01 DOI: 10.1292/jvms.23-0429

Rie Kinoshita, Chika Shirakata, Kenichiro Takubo, Kazumasa Ebisawa, Shunya Nakayama, Hiroshi Koie

{"title":"Evaluation of plasma atrial natriuretic peptide concentration in healthy bottlenose dolphins (Tursiops truncates).","authors":"Rie Kinoshita, Chika Shirakata, Kenichiro Takubo, Kazumasa Ebisawa, Shunya Nakayama, Hiroshi Koie","doi":"10.1292/jvms.23-0429","DOIUrl":"10.1292/jvms.23-0429","url":null,"abstract":"There are currently no standard methods for diagnosing cardiac diseases in dolphins. These diseases may consequently be overlooked and go undiagnosed. The presence and severity of cardiac diseases in humans can be determined using blood tests. Atrial natriuretic peptide (ANP) used in human cardiac examinations has low species specificity. There have already been reports of homology between dolphin and human ANP; however, its potential for clinical application in dolphins has not been tested. This study was conducted to establish a reference for ANP levels in healthy bottlenose dolphins. Healthy bottlenose dolphins (seven females; estimated to be 7-30 years of age) at an aquarium in Japan were sampled. Each animal was tested for ANP at least three times, and the mean value and standard deviation were calculated to be 43.4 ± 19.2 pg/mL. In humans, patients with high plasma ANP levels have a poor prognosis. In veterinary medicine, cutoff values for the diagnosis of mitral regurgitation and heart failure in dogs have been established and used to predict prognosis. The results of the present study may contribute to the health management of bottlenose dolphins, particularly in the early detection and treatment of cardiac diseases.","PeriodicalId":49959,"journal":{"name":"Journal of Veterinary Medical Science","volume":" ","pages":"1027-1031"},"PeriodicalIF":1.1,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11422697/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141861398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anti-Eimeria tenella activity of Ethanamizuril in vitro and in vivo. Ethanamizuril 在体外和体内抗天牛伊蚊的活性。

IF 1.1 4区农林科学

Journal of Veterinary Medical Science Pub Date : 2024-09-20 Epub Date: 2024-07-29 DOI: 10.1292/jvms.24-0223

Hongbo Chen, Yindi Dai, Jiyu Liu, Lianmao Duan, Juan Hu, Shaohui Sun, Guangshan Zhu, Xiaoping Ma, Jin Wan, Nini Ma, Xiao Zhang, Cong Wang, Ningning Zhao

{"title":"Anti-Eimeria tenella activity of Ethanamizuril in vitro and in vivo.","authors":"Hongbo Chen, Yindi Dai, Jiyu Liu, Lianmao Duan, Juan Hu, Shaohui Sun, Guangshan Zhu, Xiaoping Ma, Jin Wan, Nini Ma, Xiao Zhang, Cong Wang, Ningning Zhao","doi":"10.1292/jvms.24-0223","DOIUrl":"10.1292/jvms.24-0223","url":null,"abstract":"The prevalence of chicken coccidiosis in the poultry industry is a significant concern, further exacerbated by the emergence of drug-resistant coccidia resulting from the indiscriminate use of medications. Ethanamizuril, a novel triazine anti-coccidial compound, has been used to combat drug resistance. Currently, it is known that Ethanamizuril acts on the second-generation merozoites and early gametogenesis stages of Eimeria. Limited information exists regarding its impact on the early merozoites and exogenous stage of Eimeria. In the present study, the anti-coccidial properties of Ethanamizuril were evaluated both in vitro and in vivo. The in vitro experiments demonstrated that Ethanamizuril effectively inhibits the sporulation of E. tenella oocysts in a dose-dependent manner and significantly reduces the sporozoite excystation rate. Furthermore, in vivo tests revealed that treatment with 10 mg/L Ethanamizuril in drinking water significantly decreased the copy number of first-generation and secondary-generation merozoites in the chicken cecum, indicating that it can inhibit the development of whole schizonts development. Moreover, treatment with Ethanamizuril demonstrated excellent protective efficacy with an anti-coccidial index (ACI) of 180.2, which was manifested through higher body weight gains, lighter cecal lesion, lower fecal oocyst shedding score and reduced liver index. Collectively, this study suggests that Ethanamizuril effectively treats E. tenella infection by inhibiting both endogenous and exogenous stages development.","PeriodicalId":49959,"journal":{"name":"Journal of Veterinary Medical Science","volume":" ","pages":"1008-1015"},"PeriodicalIF":1.1,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11422700/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141789583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of three doses of oral trazodone and their impact on handling, activity, and physiological parameters in rabbits: a prospective, blinded, randomized cross-over study. 评估三种剂量的曲唑酮口服药及其对兔子操作、活动和生理参数的影响：一项前瞻性、盲法、随机交叉研究。

IF 1.1 4区农林科学

Journal of Veterinary Medical Science Pub Date : 2024-09-10 Epub Date: 2024-07-19 DOI: 10.1292/jvms.24-0100

Ryota Watanabe, Adalaïs Gibert, Javier Benito, Marta Garbin, Grace Ps Kwong, Marion Desmarchelier, Inga-Catalina Cruz Benedetti

{"title":"Evaluation of three doses of oral trazodone and their impact on handling, activity, and physiological parameters in rabbits: a prospective, blinded, randomized cross-over study.","authors":"Ryota Watanabe, Adalaïs Gibert, Javier Benito, Marta Garbin, Grace Ps Kwong, Marion Desmarchelier, Inga-Catalina Cruz Benedetti","doi":"10.1292/jvms.24-0100","DOIUrl":"10.1292/jvms.24-0100","url":null,"abstract":"No study has determined the minimal effective dose of trazodone required to induce behavioral changes and its safety profile in rabbits. Therefore, this study aimed to determine the minimal effective dose of trazodone to improve compliance to handling, and to evaluate associated changes in motor activity, physiological and arterial blood gas parameters. Eight intact female New Zealand White rabbits (2-month-old; 1.66 ± 0.12 kg) were included in this prospective, blinded, randomized cross-over study. After a 10-day acclimation, rabbits randomly received placebo or trazodone 10, 20 or 30 mg/kg orally (PLAC, TRAZ10, TRAZ20, TRAZ30) with a 1-week wash-out period. Compliance scoring (dynamic interactive visual analog scale; DIVAS), activity levels measured with accelerometry (T0-T600), physiological parameters (temperature, heart, and respiratory rates), and arterial blood gas parameters (up to T240) were evaluated. Compliance scores, accelerometry, physiological and arterial blood gas parameters and hypoxemia prevalence (PaO2 <60 mmHg) were analyzed using linear mixed models and Chi-squared tests, respectively (P<0.05). When compared with PLAC, DIVAS scores were significantly higher at T80-120, T40-120 and T120-200 in TRAZ10, TRAZ20 and TRAZ30 post-administration, respectively. When compared with baseline, DIVAS scores were significantly higher from T80-160, T40-240 and T80-200 in TRAZ10, TRAZ20 and TRAZ30, respectively. All other parameters were not significantly different. In TRAZ30, hypoxemia was observed in 2/8 rabbits (P=0.104). In conclusion, oral trazodone improved rabbit compliance at all studied dosages, especially 20 mg/kg improved rabbit compliance without decreasing motor activity or causing hypoxemia.","PeriodicalId":49959,"journal":{"name":"Journal of Veterinary Medical Science","volume":" ","pages":"979-985"},"PeriodicalIF":1.1,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11422698/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141735522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A clinical case of lymphoma with hindlimb paresis due to mass formation in the spinal canal in a Japanese Black cow. 日本黑牛淋巴瘤伴后肢瘫痪的临床病例，病因是椎管内形成肿块。

IF 1.1 4区农林科学

Journal of Veterinary Medical Science Pub Date : 2024-09-10 Epub Date: 2024-07-26 DOI: 10.1292/jvms.24-0152

Tatsuki Nagata, Yoshinao Oouchi, Kie Yamamoto, Masaki Maezawa, James K Chambers, Kazuyuki Uchida, Hisashi Inokuma

引用次数: 0

First report of fesavirus 4 detection from cats in Japan. 日本首次从猫体内检测到 fesavirus 4。

IF 1.1 4区农林科学

Journal of Veterinary Medical Science Pub Date : 2024-09-10 Epub Date: 2024-07-26 DOI: 10.1292/jvms.24-0243

Shwe Thiri Maung Maung Khin, Mohammad Jafar Sheikhi, Hitoshi Takemae, Tetsuya Mizutani, Tetsuya Furuya

{"title":"First report of fesavirus 4 detection from cats in Japan.","authors":"Shwe Thiri Maung Maung Khin, Mohammad Jafar Sheikhi, Hitoshi Takemae, Tetsuya Mizutani, Tetsuya Furuya","doi":"10.1292/jvms.24-0243","DOIUrl":"10.1292/jvms.24-0243","url":null,"abstract":"Fesaviruses, picorna-like RNA viruses, were discovered in 2014 in feces from cats in an animal shelter in the United States but have not since been reported elsewhere. In this study, we collected cat fecal samples from 20 adult cats from an animal shelter in Tokyo, Japan, and examined them for viral pathogens. Next generation sequencing (NGS) was performed to detect both RNA and DNA virus sequences. Sequences of a total of 7 RNA viruses including some common feline pathogenic viruses were detected across 8 samples, while no DNA virus sequences were identified in any sample. Of the RNA virus sequences detected in the samples, two sequences, 4,746 and 4,439 bp, demonstrated 90.3% and 85.0% similarity, respectively, to the fesavirus 4 sequence in the database. To confirm the NGS results, quantitative RT-PCR (qRT-PCR) assays were developed using specific primers and probes designed based on the contig sequences. Based on the qRT-PCR assays, we detected relatively high copy-numbers of fesavirus 4 RNA in the two fecal samples from which the fesavirus 4 sequences were originally obtained, and low copy numbers in other samples. These results demonstrate the presence of fesavirus 4 in cats in Japan for the first time.","PeriodicalId":49959,"journal":{"name":"Journal of Veterinary Medical Science","volume":" ","pages":"986-991"},"PeriodicalIF":1.1,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11422691/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141789682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Successful treatment of intestinal malakoplakia in a French Bulldog. 成功治疗一只法国斗牛犬的肠道恶性肿瘤。

IF 1.1 4区农林科学

Journal of Veterinary Medical Science Pub Date : 2024-09-10 Epub Date: 2024-08-07 DOI: 10.1292/jvms.24-0166

Keita Namiki, Hisashi Mizoguchi, Naohisa Fujita, Masahiro Takahashi, Yumiko Kagawa

引用次数: 0

Blood 25-hydroxyvitamin D₃ concentration of Japanese Black cattle at two farms with different rearing environments, Kagoshima prefecture, Japan. 日本鹿儿岛县两个饲养环境不同的农场中日本黑牛血液中 25- 羟维生素 D3 的浓度。

IF 1.1 4区农林科学

Journal of Veterinary Medical Science Pub Date : 2024-09-10 Epub Date: 2024-07-19 DOI: 10.1292/jvms.24-0101

Konosuke Otomaru, Hiroto Saita, Amane Usa, Naoko Tsugawa, Mai Yamada, Masanori Furukawa

引用次数: 0

Evaluation of the stress state based on fecal corticosterone metabolite concentrations in captive penguins in Japan. 根据日本圈养企鹅粪便中皮质酮代谢物的浓度评估应激状态。

IF 1.1 4区农林科学

Journal of Veterinary Medical Science Pub Date : 2024-09-10 Epub Date: 2024-08-01 DOI: 10.1292/jvms.24-0112

Megumi Itoh, Misato Kitahara, Nanako Sawayama, Naoya Matsumoto, Takahito Toyotome, Kazutaka Yamada

{"title":"Evaluation of the stress state based on fecal corticosterone metabolite concentrations in captive penguins in Japan.","authors":"Megumi Itoh, Misato Kitahara, Nanako Sawayama, Naoya Matsumoto, Takahito Toyotome, Kazutaka Yamada","doi":"10.1292/jvms.24-0112","DOIUrl":"10.1292/jvms.24-0112","url":null,"abstract":"Fecal corticosterone metabolite (FCM) concentrations, which can be determined noninvasively, have recently been explored as a stress indicator in birds. In our study, we measured FCM concentrations in penguins under nonmolting or molting conditions, cool or hot season, diseased condition, and incubation period. These measurements were conducted in an aquarium that housed king penguins, gentoo penguins, and African penguins. This study aimed to investigate the validity of fecal matter as a stress indicator. Our findings revealed that FCM concentrations were significantly higher in molting individuals than in nonmolting individuals. Compared with the cool season, FCM concentrations were significantly higher in penguins housed outdoors during the hot season. However, no differences were observed in penguins housed indoors. Diseased individuals and an incubating individual showed notably higher FCM concentrations than healthy individuals. Interestingly, the FCM concentration in king penguin that underwent cataract surgery was extremely high before the surgery. However, 1 month postsurgery, it decreased to a level similar to that of healthy individuals. We observed increased FCM concentrations in penguins considered to be exposed to stressors. Notably, FCM concentration decreased after removing the stress factor. The FCM concentration was found to be consistent with the stress state of penguins, suggesting its usefulness as a stress indicator.","PeriodicalId":49959,"journal":{"name":"Journal of Veterinary Medical Science","volume":" ","pages":"992-998"},"PeriodicalIF":1.1,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11422689/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141861399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence of Encephalitozoon hellem among companion and exhibition birds in Japan. 日本伴侣鸟和展禽中头癣蜗牛的流行情况。

IF 1.1 4区农林科学

Journal of Veterinary Medical Science Pub Date : 2024-09-01 Epub Date: 2024-07-24 DOI: 10.1292/jvms.24-0147

Mario Yorisaki, Natsume Ozawa, Koichi Wakakuri, Hayate Nishiura, Megumi Kudo, Michihiro Ueda, Naoko Ishihara, Shoko Kanno, Hitoshi Hatai, Kenji Ochiai

引用次数: 0