Journal of Veterinary Medical Science最新文献

筛选
英文 中文
Acquired hypocalciuric hypercalcemia in a dog. 犬获得性低钙高钙血症。
IF 1.1 4区 农林科学
Journal of Veterinary Medical Science Pub Date : 2025-08-01 Epub Date: 2025-06-17 DOI: 10.1292/jvms.25-0112
Takahiro Teshima, Tomokazu Nagashima, Yuyo Yasumura, Akiko Yasuda, Yuichi Miyagawa, Masaki Michishita, Ryohei Suzuki, Hirotaka Matsumoto
{"title":"Acquired hypocalciuric hypercalcemia in a dog.","authors":"Takahiro Teshima, Tomokazu Nagashima, Yuyo Yasumura, Akiko Yasuda, Yuichi Miyagawa, Masaki Michishita, Ryohei Suzuki, Hirotaka Matsumoto","doi":"10.1292/jvms.25-0112","DOIUrl":"10.1292/jvms.25-0112","url":null,"abstract":"<p><p>A 12-year-old castrated male Labrador Retriever presented with asymptomatic hypercalcemia. Based on elevated parathyroid hormone levels and an enlarged parathyroid gland, primary hyperparathyroidism was suspected, and parathyroidectomy was performed, but the hypercalcemia did not improve. Histopathology of three resected parathyroid glands revealed hyperplasia and hypertrophy of the principal cells. After surgery, the fractional excretion of calcium examined in a spot urine sample was close to that in healthy dogs, but lower than that in a dog with primary hyperparathyroidism. Autoantibodies against calcium-sensing receptor (CaSR) were confirmed by incubating a cell line expressing canine CaSR with a serum sample from the hypercalcemic dog. Our report is the first to describe the diagnosis of acquired hypocalciuric hypercalcemia in a dog.</p>","PeriodicalId":49959,"journal":{"name":"Journal of Veterinary Medical Science","volume":" ","pages":"876-880"},"PeriodicalIF":1.1,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12344318/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144327573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Participation of autophagy in D-galactosamine-induced acute rat liver injury. 自噬在d -半乳糖胺诱导的急性大鼠肝损伤中的作用。
IF 1.1 4区 农林科学
Journal of Veterinary Medical Science Pub Date : 2025-08-01 Epub Date: 2025-06-12 DOI: 10.1292/jvms.25-0131
Nahid Rahman, Takeshi Izawa, Mitsuru Kuwamura, Jyoji Yamate
{"title":"Participation of autophagy in D-galactosamine-induced acute rat liver injury.","authors":"Nahid Rahman, Takeshi Izawa, Mitsuru Kuwamura, Jyoji Yamate","doi":"10.1292/jvms.25-0131","DOIUrl":"10.1292/jvms.25-0131","url":null,"abstract":"<p><p>Autophagy is an intracellular degradation system that generates autophagosomes. Autophagy was investigated in rat hepatic lesions induced by a single intraperitoneal injection of D-galactosamine (D-GalN) that can induce hepatic lesions mimicking human viral hepatitis. Lesions consisting of hepatocyte necrosis were sporadically seen within hepatic lobules on post-injection days 1 and 2, and recovered on days 3 and 5. The number of LC3B-immunopositive cytoplasmic granules (autophagosomes) increased significantly in hepatocytes on days 1 and 2 with increased Toll-like Receptor-2 (TLR-2) mRNA. Interestingly, there were some abnormal autophagosomes with vacuolated or irregular structures, being related to decreased mRNA level of Lamp2 at 8 hr and on days 2-5. These results indicated that autophagy may participate in the development of D-GalN-induced rat acute liver lesions through its activation or degradation.</p>","PeriodicalId":49959,"journal":{"name":"Journal of Veterinary Medical Science","volume":" ","pages":"881-886"},"PeriodicalIF":1.1,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12344380/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144276470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Understanding Pb contamination in wild mammals and birds and examining the potential contamination related to ammunition in Japan. 了解野生哺乳动物和鸟类的铅污染,并检查与日本弹药有关的潜在污染。
IF 1.1 4区 农林科学
Journal of Veterinary Medical Science Pub Date : 2025-08-01 Epub Date: 2025-06-19 DOI: 10.1292/jvms.24-0504
Nana Ushine, Mizuki Maruyama, Emmanuel Temiotan Ogbomida, Shouta Mm Nakayama, Mayumi Ishizuka, Takuya Kato, Shin-Ichi Hayama
{"title":"Understanding Pb contamination in wild mammals and birds and examining the potential contamination related to ammunition in Japan.","authors":"Nana Ushine, Mizuki Maruyama, Emmanuel Temiotan Ogbomida, Shouta Mm Nakayama, Mayumi Ishizuka, Takuya Kato, Shin-Ichi Hayama","doi":"10.1292/jvms.24-0504","DOIUrl":"10.1292/jvms.24-0504","url":null,"abstract":"<p><p>This study investigates lead (Pb) contamination in wild animals in Japan. Pb is a known environmental toxin that can cause several issues in wildlife. Pb is still used in human society, and among Pb products, ammunition is reported to harm human and animal health. In Japan, few instances of Pb contamination in wild animals have been reported outside Hokkaido. Possible reasons for this include the absence of Pb contamination and insufficient investigation. This study aimed to understand the current state of Pb contamination in Japan and clarify the extent of Pb contamination related to ammunition. Blood lead concentrations (BLLs) were measured in wild birds and mammals from 25 municipalities, and an analysis was conducted based on ammunition-related factors. More than half of the avian and mammalian taxonomic groups were found to exhibit Pb contamination from environmental sources. Overall, this study suggests that Pb contamination is also present in wild birds and mammals living outside Hokkaido, Japan, and highlights the risks of mass mortality during infectious disease outbreaks as well as the potential health hazards of Pb exposure upon their consumption by humans. The results of this study highlight the importance of monitoring Pb contamination, particularly in hunting areas of Japan. Further, it indicates the need to reconsider the use of Pb-based ammunition for protecting the health and welfare of both humans and wildlife.</p>","PeriodicalId":49959,"journal":{"name":"Journal of Veterinary Medical Science","volume":" ","pages":"911-918"},"PeriodicalIF":1.1,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12344314/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144327575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Expression of α-smooth muscle actin in the lateral ventricle wall of spontaneous hydrocephalus animals. 自发性脑积水动物侧脑室壁α-平滑肌肌动蛋白的表达。
IF 1.1 4区 农林科学
Journal of Veterinary Medical Science Pub Date : 2025-08-01 Epub Date: 2025-06-24 DOI: 10.1292/jvms.25-0153
Nure Jannat, Miyuu Tanaka, Takeshi Izawa, Yoshiyasu Kobayashi, Mitsuru Kuwamura
{"title":"Expression of α-smooth muscle actin in the lateral ventricle wall of spontaneous hydrocephalus animals.","authors":"Nure Jannat, Miyuu Tanaka, Takeshi Izawa, Yoshiyasu Kobayashi, Mitsuru Kuwamura","doi":"10.1292/jvms.25-0153","DOIUrl":"10.1292/jvms.25-0153","url":null,"abstract":"<p><p>Hydrocephalus is a brain disorder in which cerebrospinal fluid accumulates in the ventricles. Our previous study identified aberrant α-smooth muscle actin (α-SMA) expression in the lateral ventricle lining of hydrocephalic coiled-coil domain containing 85c (Ccdc85c) mutant rats. Here, we investigate α-SMA expression in spontaneous hydrocephalic rat, dogs, cats, and cattle. Immunohistochemistry revealed distinct α-SMA expression in a hydrocephalic rat (3 weeks old) and cattle (9 months old), but not in dogs or cats, suggesting species-specific differences. Co-expression of α-SMA and vimentin was observed in cattle, along with strong glial fibrillary acidic protein (GFAP) and vimentin expression in rat and cattle, particularly in ependymal cells. These findings suggest that α-SMA expression in the lateral ventricle wall of hydrocephalic rat and cattle reflects a reactive or pathological response, potentially linked to gliosis.</p>","PeriodicalId":49959,"journal":{"name":"Journal of Veterinary Medical Science","volume":" ","pages":"934-939"},"PeriodicalIF":1.1,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12344303/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144509188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Histopathology of nasopharyngeal and palatine tonsils in Japanese black calves naturally infected with Mycoplasma bovis. 自然感染牛支原体的日本黑犊牛鼻咽和腭扁桃体的组织病理学。
IF 1.1 4区 农林科学
Journal of Veterinary Medical Science Pub Date : 2025-08-01 Epub Date: 2025-07-02 DOI: 10.1292/jvms.25-0188
Amaal Ezzat Ahmed, Mutsumi Nakai, Miho Kakiya, Naoyuki Fuke, Asmaa A Hegazy, Hiroaki Kondo, Takuya Hirai
{"title":"Histopathology of nasopharyngeal and palatine tonsils in Japanese black calves naturally infected with Mycoplasma bovis.","authors":"Amaal Ezzat Ahmed, Mutsumi Nakai, Miho Kakiya, Naoyuki Fuke, Asmaa A Hegazy, Hiroaki Kondo, Takuya Hirai","doi":"10.1292/jvms.25-0188","DOIUrl":"10.1292/jvms.25-0188","url":null,"abstract":"<p><p>Mycoplasma bovis (M. bovis) is an important bacterium in the bovine respiratory disease complex (BRDC), which causes significant economic losses. The nasopharyngeal and palatine tonsils are mucosal-associated lymphoid tissue components that are the initial barrier to respiratory pathogens. In the present study, we investigated 5 pneumonic Japanese black and 3 control calves (2 Japanese black and 1 Holstein). The localization of M. bovis in the nasopharyngeal, palatine tonsils, and lungs was examined using nested and multiplex polymerase chain reaction (PCR), histopathology, and in situ hybridization (ISH) techniques. Nested PCR revealed that all examined tissues from all pneumonic calves were positive for M. bovis infection, but not the control. Histopathology revealed suppurative nasopharyngeal tonsillitis and palatine tonsillar cryptitis in all cases. Surprisingly, prominent histologic changes were observed in the palatine tonsils but not in the nasopharyngeal tonsils. Necrotizing suppurative bronchopneumonia was observed in 4 pneumonic calves. In ISH analysis, positive hybridization signals adherent to and/or within the surface epithelium of nasopharyngeal tonsils and crypt epithelium of nasopharyngeal and palatine tonsils were observed. Additionally, these signals were seen in the palatine tonsillar cryptic detritus. In the lungs, ISH signals were observed in necrotic areas, the bronchial epithelium, and pulmonary inflammatory exudate. These findings suggest that the nasopharyngeal and palatine tonsils are the primary sites of M. bovis infection. Also, M. bovis can colonize the detritus in the crypts of the palatine tonsils of the pneumonic animals.</p>","PeriodicalId":49959,"journal":{"name":"Journal of Veterinary Medical Science","volume":" ","pages":"924-933"},"PeriodicalIF":1.1,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12344299/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144555565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Detection of felipivirus in feces samples from cats in an animal shelter in Japan. 日本动物收容所猫粪便样本中费利皮病毒的检测。
IF 1.1 4区 农林科学
Journal of Veterinary Medical Science Pub Date : 2025-08-01 Epub Date: 2025-06-05 DOI: 10.1292/jvms.25-0228
Sheikhi Mohammad Jafar, Shwe Thiri Maung Maung Khin, Hitoshi Takemae, Tetsuya Mizutani, Tetsuya Furuya
{"title":"Detection of felipivirus in feces samples from cats in an animal shelter in Japan.","authors":"Sheikhi Mohammad Jafar, Shwe Thiri Maung Maung Khin, Hitoshi Takemae, Tetsuya Mizutani, Tetsuya Furuya","doi":"10.1292/jvms.25-0228","DOIUrl":"10.1292/jvms.25-0228","url":null,"abstract":"<p><p>Felipivirus is a feline picornavirus that was first discovered in fecal samples from stray cats in Hong Kong in 2012, and has been reported only in a few cases. We previously reported next-generation sequencing (NGS) analyses of fecal samples from 20 adult cats in an animal shelter in Tokyo, Japan, and now, in this study, report detection of felipivirus A2 from the same samples. Reverse transcription (RT)-PCR demonstrated the presence of the same virus in the 8 cats. Phylogenetic analyzes demonstrated a close relationship of the virus with some picornaviruses from wild animals such as raccoon dog and marmot. This study highlights the importance of surveillance of cats in animal shelters to detect viruses potentially originated from wild animals.</p>","PeriodicalId":49959,"journal":{"name":"Journal of Veterinary Medical Science","volume":" ","pages":"902-905"},"PeriodicalIF":1.1,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12344455/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144227396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A pilot study investigating renal biomarkers in dogs with pulmonary hypertension: a comparison between cystatin-C, symmetric dimethylarginine, and creatinine. 一项调查肺动脉高压犬肾脏生物标志物的初步研究:胱他汀- c、对称二甲基精氨酸和肌酐的比较。
IF 1.1 4区 农林科学
Journal of Veterinary Medical Science Pub Date : 2025-08-01 Epub Date: 2025-06-13 DOI: 10.1292/jvms.25-0034
Zi Ping Leong
{"title":"A pilot study investigating renal biomarkers in dogs with pulmonary hypertension: a comparison between cystatin-C, symmetric dimethylarginine, and creatinine.","authors":"Zi Ping Leong","doi":"10.1292/jvms.25-0034","DOIUrl":"10.1292/jvms.25-0034","url":null,"abstract":"<p><p>Pulmonary hypertension (PH) can affect renal function, yet renal dysfunction in canine PH is relatively underexplored. Cystatin C (CYS-C), a useful marker for evaluating renal function in humans with PH, has not been studied in dogs. This study aimed to compare seventeen dogs with PH to a control group, evaluating the relationship between PH and renal parameters such as symmetric dimethylarginine (SDMA), creatinine, and CYS-C. The mean tricuspid regurgitation maximal velocity (TRmax) and systolic pulmonary arterial pressure (SPAP) in dogs with PH was 4.24 m/sec and 74.48 mmHg, respectively. Dogs with PH exhibited significantly higher SDMA (15.47 μg/dL vs. 10.55 μg/dL) and CYS-C (1.36 mg/L vs. 0.88 mg/L) compared to controls. SDMA showed moderate positive correlations with SPAP (r=0.682) and TRmax (r=0.662), and a negative moderate correlation with mean arterial pressure (r=-0.590). CYS-C moderately correlated with SPAP (r=0.529), TRmax (r=0.485), heart rate (r=0.506), and body weight (r=0.691). Creatinine did not vary significantly between PH group (122.21 μmol/L) and controls (93.70 μmol/L), nor did it correlate with any parameters. Multivariate analysis revealed that CYS-C was significantly influenced by PH severity, while SDMA and creatinine were not. These findings suggest that renal dysfunction is prevalent in dogs with PH. CYS-C may be a more sensitive marker for detecting early renal changes linked to PH severity, while SDMA appears to be more specific to true renal dysfunction and creatinine was the least informative biomarker.</p>","PeriodicalId":49959,"journal":{"name":"Journal of Veterinary Medical Science","volume":" ","pages":"868-875"},"PeriodicalIF":1.1,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12344298/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144303405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Surveillance of amyloid A deposits in commercial beef liver and assessment of food hygiene risks. 商品牛肝中淀粉样蛋白A沉积的监测及食品卫生风险评价。
IF 1.1 4区 农林科学
Journal of Veterinary Medical Science Pub Date : 2025-08-01 Epub Date: 2025-06-12 DOI: 10.1292/jvms.25-0177
Susumu Iwaide, Natsumi Kobayashi, Kenta Owaku, Niki Sedghi Masoud, Naoki Ujike, Yoshiyuki Itoh, Takuma Kozono, Miki Hisada, Kumiko Kimura, Tomoyuki Shibahara, Tomoaki Murakami
{"title":"Surveillance of amyloid A deposits in commercial beef liver and assessment of food hygiene risks.","authors":"Susumu Iwaide, Natsumi Kobayashi, Kenta Owaku, Niki Sedghi Masoud, Naoki Ujike, Yoshiyuki Itoh, Takuma Kozono, Miki Hisada, Kumiko Kimura, Tomoyuki Shibahara, Tomoaki Murakami","doi":"10.1292/jvms.25-0177","DOIUrl":"10.1292/jvms.25-0177","url":null,"abstract":"<p><p>Bovine amyloid A (AA) amyloidosis has been reported to be experimentally transmitted to mice, like prion disease. Although the prevalence of AA amyloidosis in cattle at slaughterhouses has been reported in several studies, how much bovine AA is distributed in retail stores remains unknown. In this study, to clarify the food hygienic risk of bovine AA, we collected beef livers from seven commercial retail stores in Japan to investigate the deposition rate and the transmissibility of bovine AA. Congo red staining and immunohistochemistry revealed bovine AA deposition in two of 185 commercial beef livers (1.08%). No differences were observed between the gross appearance of amyloid-laden and amyloid-free livers. Administration of bovine AA from commercial beef liver to mice, either intraperitoneally or into the spleen, did not promote the development of AA amyloidosis. This contrasts with previous studies demonstrating cross-species transmission of AA amyloidosis via intraperitoneal or even oral administration of bovine AA. Although the cause of this discrepancy is unknown, the low transmissibility may be related to the species-barrier. These results support that the actual food hygienic risk of AA amyloidosis associated with consuming commercial beef liver may not be significant.</p>","PeriodicalId":49959,"journal":{"name":"Journal of Veterinary Medical Science","volume":" ","pages":"887-893"},"PeriodicalIF":1.1,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12344302/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144276472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Deposition pattern and amino acid sequence analysis of amyloid-β in Felidae species. Felidae种淀粉样蛋白-β沉积模式及氨基酸序列分析。
IF 1.1 4区 农林科学
Journal of Veterinary Medical Science Pub Date : 2025-08-01 Epub Date: 2025-06-24 DOI: 10.1292/jvms.25-0172
Hiroto Fukui, James K Chambers, Shin-Ichi Nakamura, Sho Kadekaru, Yumi Une, Kazuyuki Uchida
{"title":"Deposition pattern and amino acid sequence analysis of amyloid-β in Felidae species.","authors":"Hiroto Fukui, James K Chambers, Shin-Ichi Nakamura, Sho Kadekaru, Yumi Une, Kazuyuki Uchida","doi":"10.1292/jvms.25-0172","DOIUrl":"10.1292/jvms.25-0172","url":null,"abstract":"<p><p>Amyloid β (Aβ) deposition is a hallmark of Alzheimer's disease. Humans and many animal species have identical Aβ amino acid sequences and develop senile plaques. Domestic and leopard cats have a unique Aβ sequence and show indistinct diffuse granular Aβ deposits in their brains. We aimed to elucidate whether these characteristics are conserved among Felidae species. The Aβ amino acid sequence and deposition pattern were conserved among Felidae species. Aβ deposits were also found in the cerebral vascular walls. Colocalization of apolipoprotein E and Aβ was observed in the parenchyma and cerebral vascular walls. These results support previous findings that a unique Aβ amino acid sequence may have a significant effect on the aggregation properties of this protein in Felidae.</p>","PeriodicalId":49959,"journal":{"name":"Journal of Veterinary Medical Science","volume":" ","pages":"940-946"},"PeriodicalIF":1.1,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12344300/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144509187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In vitro antiviral efficacy of amenamevir against feline herpesvirus 1. 阿莫那韦对猫疱疹病毒1型的体外抗病毒作用。
IF 1.1 4区 农林科学
Journal of Veterinary Medical Science Pub Date : 2025-08-01 Epub Date: 2025-06-24 DOI: 10.1292/jvms.25-0086
Aoi Kikuiri, Haruka Nishigaki, Hikaru Fujii, Shumpei Watanabe, Isshu Kojima, Shigeru Morikawa
{"title":"In vitro antiviral efficacy of amenamevir against feline herpesvirus 1.","authors":"Aoi Kikuiri, Haruka Nishigaki, Hikaru Fujii, Shumpei Watanabe, Isshu Kojima, Shigeru Morikawa","doi":"10.1292/jvms.25-0086","DOIUrl":"10.1292/jvms.25-0086","url":null,"abstract":"<p><p>Amenamevir (AMNV), a helicase-primase inhibitor, has recently received approval for treating human herpesvirus infections. Herein, we evaluated the efficacy of AMNV against feline herpesvirus 1 (FHV-1) in three different cell lines and compared it with that of acyclovir (ACV) and penciclovir (PCV)-nucleoside analogs currently used against FHV-1 infection. The 50% inhibitory concentrations of AMNV against FHV-1 were comparable to those of ACV in all cell lines tested, although they were 2.0 to 21.0-fold higher than those of PCV. This is the first study to have evaluated the efficacy of AMNV against animal herpesvirus, and the results suggest that AMNV could be a new option for treating FHV-1 infection with a novel mechanism of action.</p>","PeriodicalId":49959,"journal":{"name":"Journal of Veterinary Medical Science","volume":" ","pages":"906-910"},"PeriodicalIF":1.1,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12344317/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144509190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信