{"title":"犬获得性低钙高钙血症。","authors":"Takahiro Teshima, Tomokazu Nagashima, Yuyo Yasumura, Akiko Yasuda, Yuichi Miyagawa, Masaki Michishita, Ryohei Suzuki, Hirotaka Matsumoto","doi":"10.1292/jvms.25-0112","DOIUrl":null,"url":null,"abstract":"<p><p>A 12-year-old castrated male Labrador Retriever presented with asymptomatic hypercalcemia. Based on elevated parathyroid hormone levels and an enlarged parathyroid gland, primary hyperparathyroidism was suspected, and parathyroidectomy was performed, but the hypercalcemia did not improve. Histopathology of three resected parathyroid glands revealed hyperplasia and hypertrophy of the principal cells. After surgery, the fractional excretion of calcium examined in a spot urine sample was close to that in healthy dogs, but lower than that in a dog with primary hyperparathyroidism. Autoantibodies against calcium-sensing receptor (CaSR) were confirmed by incubating a cell line expressing canine CaSR with a serum sample from the hypercalcemic dog. Our report is the first to describe the diagnosis of acquired hypocalciuric hypercalcemia in a dog.</p>","PeriodicalId":49959,"journal":{"name":"Journal of Veterinary Medical Science","volume":" ","pages":"876-880"},"PeriodicalIF":1.1000,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12344318/pdf/","citationCount":"0","resultStr":"{\"title\":\"Acquired hypocalciuric hypercalcemia in a dog.\",\"authors\":\"Takahiro Teshima, Tomokazu Nagashima, Yuyo Yasumura, Akiko Yasuda, Yuichi Miyagawa, Masaki Michishita, Ryohei Suzuki, Hirotaka Matsumoto\",\"doi\":\"10.1292/jvms.25-0112\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>A 12-year-old castrated male Labrador Retriever presented with asymptomatic hypercalcemia. Based on elevated parathyroid hormone levels and an enlarged parathyroid gland, primary hyperparathyroidism was suspected, and parathyroidectomy was performed, but the hypercalcemia did not improve. Histopathology of three resected parathyroid glands revealed hyperplasia and hypertrophy of the principal cells. After surgery, the fractional excretion of calcium examined in a spot urine sample was close to that in healthy dogs, but lower than that in a dog with primary hyperparathyroidism. Autoantibodies against calcium-sensing receptor (CaSR) were confirmed by incubating a cell line expressing canine CaSR with a serum sample from the hypercalcemic dog. Our report is the first to describe the diagnosis of acquired hypocalciuric hypercalcemia in a dog.</p>\",\"PeriodicalId\":49959,\"journal\":{\"name\":\"Journal of Veterinary Medical Science\",\"volume\":\" \",\"pages\":\"876-880\"},\"PeriodicalIF\":1.1000,\"publicationDate\":\"2025-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12344318/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Veterinary Medical Science\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://doi.org/10.1292/jvms.25-0112\",\"RegionNum\":4,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/6/17 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"VETERINARY SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Veterinary Medical Science","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.1292/jvms.25-0112","RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/6/17 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"VETERINARY SCIENCES","Score":null,"Total":0}
A 12-year-old castrated male Labrador Retriever presented with asymptomatic hypercalcemia. Based on elevated parathyroid hormone levels and an enlarged parathyroid gland, primary hyperparathyroidism was suspected, and parathyroidectomy was performed, but the hypercalcemia did not improve. Histopathology of three resected parathyroid glands revealed hyperplasia and hypertrophy of the principal cells. After surgery, the fractional excretion of calcium examined in a spot urine sample was close to that in healthy dogs, but lower than that in a dog with primary hyperparathyroidism. Autoantibodies against calcium-sensing receptor (CaSR) were confirmed by incubating a cell line expressing canine CaSR with a serum sample from the hypercalcemic dog. Our report is the first to describe the diagnosis of acquired hypocalciuric hypercalcemia in a dog.
期刊介绍：
JVMS is a peer-reviewed journal and publishes a variety of papers on veterinary science from basic research to applied science and clinical research. JVMS is published monthly and consists of twelve issues per year. Papers are from the areas of anatomy, physiology, pharmacology, toxicology, pathology, immunology, microbiology, virology, parasitology, internal medicine, surgery, clinical pathology, theriogenology, avian disease, public health, ethology, and laboratory animal science. Although JVMS has played a role in publishing the scientific achievements of Japanese researchers and clinicians for many years, it now also accepts papers submitted from all over the world.
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