Journal of Veterinary Medical Science最新文献

The effect of storage temperature and time before centrifugation on coagulation parameters in neonatal Japanese Black calves. 离心前贮藏温度和时间对新生日本黑犊牛凝血参数的影响。

IF 1.1 4区农林科学

Journal of Veterinary Medical Science Pub Date : 2025-10-14 DOI: 10.1292/jvms.25-0143

Riko Ito, Keinosuke Sanada, Satoshi Inoue, Toko Maehara, Hiroshi Satoh

引用次数: 0

Pathogenicity analysis and control strategies to combat avian diseases: mechanisms of increased virulence of Marek's disease virus and the development of vaccines against poultry red mites. 防治禽类疾病的致病性分析和控制策略：马立克病病毒毒力增强的机制和家禽红螨疫苗的研制。

IF 1.1 4区农林科学

Journal of Veterinary Medical Science Pub Date : 2025-10-13 DOI: 10.1292/jvms.25-0304

Shiro Murata

{"title":"Pathogenicity analysis and control strategies to combat avian diseases: mechanisms of increased virulence of Marek's disease virus and the development of vaccines against poultry red mites.","authors":"Shiro Murata","doi":"10.1292/jvms.25-0304","DOIUrl":"https://doi.org/10.1292/jvms.25-0304","url":null,"abstract":"The occurrence of avian diseases has been greatly reduced by improved sanitation on poultry farms and the development of prevention programs through vaccination and other measures. However, the poultry industry still faces several concerns. Marek's disease (MD) has caused significant economic losses to the poultry industry in the past; however, the introduction of vaccines has successfully contributed to a reduction in MD occurrences. Nevertheless, sporadic MD occurrences are still observed, and increased virulence has been reported owing to the changes in viral characteristics. In addition to infectious diseases, infestation with poultry red mites (PRMs; Dermanyssus gallinae), which are small hematophagous ectoparasites of poultry, has caused severe declines in productivity of the poultry industry worldwide. Furthermore, in addition to animal hygiene, problems caused by PRMs are of concern in terms of public health and animal welfare. The emergence of acaricide-resistant PRMs has made their control difficult. Therefore, the establishment of novel control strategies is eagerly awaited. Among the issues of avian diseases facing the poultry industry, this review highlights research on the mechanisms of increased virulence of MD virus and the development of a novel approach for PRM control.","PeriodicalId":49959,"journal":{"name":"Journal of Veterinary Medical Science","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145287560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Feline vitamin D-dependent rickets type 2 caused by a missense variant in the vitamin D receptor gene. 猫维生素D依赖性佝偻病2型由维生素D受体基因错义变异引起。

IF 1.1 4区农林科学

Journal of Veterinary Medical Science Pub Date : 2025-10-12 DOI: 10.1292/jvms.25-0307

Sora Suzuki, Hitomi Masuyama, Jiro Miyamae, Hiroaki Hemmi, Naoaki Matsuki, Kohei Murakami

引用次数: 0

Clinical efficacy of anti-programmed death ligand 1 antibody HFC-L1/c4G12 in dogs with malignant tumors: an exploratory study. 抗程序性死亡配体1抗体HFC-L1/c4G12对犬恶性肿瘤临床疗效的探索性研究

IF 1.1 4区农林科学

Journal of Veterinary Medical Science Pub Date : 2025-10-10 DOI: 10.1292/jvms.25-0303

Satoshi Takagi, Michihito Tagawa, Naoya Maekawa, Satoru Konnai, Yumiko Kagawa, Kenji Hosoya, Akinori Yamauchi, Ayano Kudo, Shintaro Kamo, Sangho Kim, Ryohei Kinoshita, Tatsuya Deguchi, Ryo Owaki, Yurika Tachibana, Madoka Yokokawa, Hiroto Takeuchi, Hayato Nakamura, Yukinari Kato, Shigeki Kanazawa, Tomoyuki Abe, Takuya Furuta, Keiichi Yamamoto, Yasuhiko Suzuki, Tomohiro Okagawa, Shiro Murata, Kazuhiko Ohashi

{"title":"Clinical efficacy of anti-programmed death ligand 1 antibody HFC-L1/c4G12 in dogs with malignant tumors: an exploratory study.","authors":"Satoshi Takagi, Michihito Tagawa, Naoya Maekawa, Satoru Konnai, Yumiko Kagawa, Kenji Hosoya, Akinori Yamauchi, Ayano Kudo, Shintaro Kamo, Sangho Kim, Ryohei Kinoshita, Tatsuya Deguchi, Ryo Owaki, Yurika Tachibana, Madoka Yokokawa, Hiroto Takeuchi, Hayato Nakamura, Yukinari Kato, Shigeki Kanazawa, Tomoyuki Abe, Takuya Furuta, Keiichi Yamamoto, Yasuhiko Suzuki, Tomohiro Okagawa, Shiro Murata, Kazuhiko Ohashi","doi":"10.1292/jvms.25-0303","DOIUrl":"https://doi.org/10.1292/jvms.25-0303","url":null,"abstract":"Cancer in dogs remains a major challenge in modern veterinary medicine. Immunotherapy using immune checkpoint inhibitors (ICIs) is available for various human tumor types, and recent veterinary clinical studies have shown that ICIs are a promising approach for treating canine cancers. A canine chimeric anti-PD-L1 antibody, c4G12 (HFC-L1), has been investigated for canine cancer immunotherapy; however, its clinical benefits have not been well characterized in tumors other than pulmonary metastatic (stage IV) oral malignant melanoma (OMM). To explore the efficacy and safety of HFC-L1, we conducted a clinical study in dogs with stage I-III OMM or other tumor types (n=12). HFC-L1 treatment at a dose of 5 mg/kg every 2 weeks was well tolerated, and no grade 3 or higher treatment-related adverse events were reported. Among the dogs eligible for response evaluation (n=10), a partial response was observed in one dog with squamous cell carcinoma, resulting in an objective response rate of 10%. In addition, in a dog with ceruminous cell carcinoma, clinical evidence of a tumor response was observed in metastatic lung lesions. Together, these results suggest that the HFC-L1 therapy is applicable for the treatment of various tumor types, although its clinical benefits should be further evaluated in clinical studies involving a larger number of dogs with each tumor type.","PeriodicalId":49959,"journal":{"name":"Journal of Veterinary Medical Science","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145287558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Timing of human chorionic gonadotropin administration affects conception rates after embryo transfer in crossbred beef heifers. 人绒毛膜促性腺激素给药时间影响杂交肉牛胚胎移植后受孕率。

IF 1.1 4区农林科学

Journal of Veterinary Medical Science Pub Date : 2025-10-09 DOI: 10.1292/jvms.25-0224

Ken Hazano, Akira Goto, Shingo Haneda, Motozumi Matsui

{"title":"Timing of human chorionic gonadotropin administration affects conception rates after embryo transfer in crossbred beef heifers.","authors":"Ken Hazano, Akira Goto, Shingo Haneda, Motozumi Matsui","doi":"10.1292/jvms.25-0224","DOIUrl":"https://doi.org/10.1292/jvms.25-0224","url":null,"abstract":"This study aimed to determine the effect of the timing of human chorionic gonadotropin (hCG) administration to embryo transfer (ET) recipients on the reproductive outcome of ET in crossbred beef heifers. Heifers (n=1,887) were randomly assigned to the non-treatment group (n=1,160), and hCG was administered on day 5 (n=201), 6 (n=210), 7 (n=213), or 8 (n=103) after estrus. The chi-square test showed that the conception rates in the hCG administration on day 5 (79.6%, P=0.0001) and day 6 (75.2%, P=0.0047) were higher than those in the non-treatment group (65.2%). However, the conception rates with hCG administration on day 7 (70.9%, P=0.1103) and day 8 (70.9%, P=0.2499) were comparable to the non-treatment. A multiple logistic regression analysis, furthermore, showed that early treatment (hCG on day 5 or 6 after estrus) positively affected the conception rates compared to non-treatment (odds ratios (OR) = 1.723 [95% confidence intervals (CI) = 1.316-2.257]), but not late treatment (hCG on day 7 or 8 after estrus) (OR = 1.299 [95% CI = 0.981-1.719]). None of the confounding variables, including years, season at the time of ET, age in months, and number of ET, significantly affected the conception rate. In conclusion, hCG administration on day 5 or 6 after estrus for ET recipients improved the conception rate, but not on day 7 or 8, in beef heifers.","PeriodicalId":49959,"journal":{"name":"Journal of Veterinary Medical Science","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145253463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of two human diagnostic agarose gel electrophoresis kits for bovine serum protein fractionation. 两种用于牛血清蛋白分离的琼脂糖凝胶电泳试剂盒的评价。

IF 1.1 4区农林科学

Journal of Veterinary Medical Science Pub Date : 2025-10-09 DOI: 10.1292/jvms.25-0272

Norio Yamagishi, Khaing Shwe Sin Soe, Hijiri Suyama, Akari Kawamura, Shinobu Tsuchiaka, Kouki Itagaki, Sueun Kim, Shingo Ishikawa

引用次数: 0

Effect of pimobendan on myocardial injury and systolic dysfunction in a canine model of supraventricular tachyarrhythmia. 匹莫苯丹对犬室上性心动过速模型心肌损伤和收缩功能障碍的影响。

IF 1.1 4区农林科学

Journal of Veterinary Medical Science Pub Date : 2025-10-08 DOI: 10.1292/jvms.25-0193

Daiki Hirao, Shohei Morita, Hiroshi Hasegewa, Aritada Yoshimura, Takae Kawaguchi, Shusaku Yamada, Takahiro Oomori, Kazuhiko Suzuki, Ryuji Fukushima

{"title":"Effect of pimobendan on myocardial injury and systolic dysfunction in a canine model of supraventricular tachyarrhythmia.","authors":"Daiki Hirao, Shohei Morita, Hiroshi Hasegewa, Aritada Yoshimura, Takae Kawaguchi, Shusaku Yamada, Takahiro Oomori, Kazuhiko Suzuki, Ryuji Fukushima","doi":"10.1292/jvms.25-0193","DOIUrl":"https://doi.org/10.1292/jvms.25-0193","url":null,"abstract":"Supraventricular tachyarrhythmia (SVTA) in dogs can cause cardiac dysfunction and may progress to heart failure. Pimobendan, an inotropic agent with calcium-sensitizing and phosphodiesterase III inhibition, is widely used in veterinary medicine. However, its influence on myocardial injury under persistent SVTA remains incompletely understood. This study aimed to evaluate whether pimobendan improves systolic function without exacerbating myocardial injury, using a canine model of rapid atrial pacing (RAP). Fourteen healthy Beagle dogs were allocated to either a control or pimobendan group. RAP was performed for three weeks at 390 bpm. Cardiac function was assessed by echocardiography before (baseline) and after RAP (3W). Concurrently, cardiac troponin I (cTnI) concentrations were measured to assess myocardial injury. In the control group, a significant increase in cTnI was observed at 3W compared with baseline (0.023 ± 0.029 ng/mL vs. 0.176 ± 0.173 ng/mL). Additionally, in the control group, echocardiographic parameters worsened, including fractional shortening (FS) (37.8 ± 4.6% vs. 24.5 ± 6.8%) and stroke volume (SV) (15.8 ± 3.1 mL vs. 10.5 ± 2.0 mL) at 3W compared with baseline. In contrast, the pimobendan group showed no significant differences in these echocardiographic parameters. cTnI concentrations also remained within the normal range without significant differences. These results suggest that pimobendan preserved systolic function without aggravating myocardial injury during sustained SVTA. Pimobendan may therefore be safe and effective cardiac inotropic agent for the treatment of dogs with SVTA.","PeriodicalId":49959,"journal":{"name":"Journal of Veterinary Medical Science","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145253455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of lactoferrin on biofilm formation of bovine mastitis-causing Staphylococcus species. 乳铁蛋白对牛乳腺炎葡萄球菌生物膜形成的影响。

IF 1.1 4区农林科学

Journal of Veterinary Medical Science Pub Date : 2025-10-06 DOI: 10.1292/jvms.25-0230

Kumala Seraphina, Rin Furukido, Naoki Isobe, Takahiro Nii, Yuzo Kurokawa, Naoki Suzuki

{"title":"Effect of lactoferrin on biofilm formation of bovine mastitis-causing Staphylococcus species.","authors":"Kumala Seraphina, Rin Furukido, Naoki Isobe, Takahiro Nii, Yuzo Kurokawa, Naoki Suzuki","doi":"10.1292/jvms.25-0230","DOIUrl":"https://doi.org/10.1292/jvms.25-0230","url":null,"abstract":"The most common bovine mastitis pathogen is the Staphylococcus species, consisting of Staphylococcus aureus and non-aureus staphylococci (NAS). Lactoferrin (Lf) is an iron-binding protein with antimicrobial and antibiofilm properties. Lf has a metal-free form (apo-Lf) and a natural form (native-Lf), and their differences were reported to affect their activity against bacteria. However, its effects on bovine mastitis-causing Staphylococcus spp. remain unclear. Fifteen S. aureus and 49 NAS strains were isolated from bovine mastitis cases, and their growth and biofilm-forming abilities were observed. Bacterial growth and biofilm formation were observed by culturing each strain with/without bovine milk apo-/native-lactoferrin (200 μg/mL). Without Lf treatment, the growth and biofilm formation abilities of S. aureus were significantly higher and lower, respectively, than those of NAS. The growth of S. aureus and NAS significantly decreased during apo-Lf treatment and significantly reduced the total amount of biofilm produced by S. aureus whereas native-LF treatment did not affect the growth and biofilm formation of Staphylococcus species. These results confirmed the ability of Lf to act as an antimicrobial and antibiofilm substance against mastitis-causing Staphylococcus spp., although various responses from each strain were observed. Additionally, the iron-binding state of Lf affected growth but did not affect the biofilm formation ability. Differences in the responses of Staphylococcus strains to Lf may help explain their pathogenicity, requiring further research.","PeriodicalId":49959,"journal":{"name":"Journal of Veterinary Medical Science","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145233875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intestinal expression of diamine oxidase (DAO) and the relationship between blood DAO activity and haptoglobin concentration in diarrheal calves. 腹泻犊牛肠道二胺氧化酶（DAO）表达及血DAO活性与触珠蛋白浓度的关系

IF 1.1 4区农林科学

Journal of Veterinary Medical Science Pub Date : 2025-10-03 DOI: 10.1292/jvms.25-0324

Akihiro Kozutsumi, Minoru Okamoto, Hana Takeuchi, Marina Otsuka, Kenji Tsukano, Nao Kondo, Kana Kamitani, Keiko Ikeda, Natsuki Takami, Haruyuki Hirata, Kazuyuki Suzuki

{"title":"Intestinal expression of diamine oxidase (DAO) and the relationship between blood DAO activity and haptoglobin concentration in diarrheal calves.","authors":"Akihiro Kozutsumi, Minoru Okamoto, Hana Takeuchi, Marina Otsuka, Kenji Tsukano, Nao Kondo, Kana Kamitani, Keiko Ikeda, Natsuki Takami, Haruyuki Hirata, Kazuyuki Suzuki","doi":"10.1292/jvms.25-0324","DOIUrl":"https://doi.org/10.1292/jvms.25-0324","url":null,"abstract":"The objectives of this study were (1) to confirm the expression of diamine oxidase (DAO) in the intestines of healthy calves immune-histologically and to clarify whether the expression of DAO in the intestines of calves with diarrhea differs from that of healthy animals, and (2) to clarify the relationship between DAO and intestinal inflammation using haptoglobin (HPT), a biomarker commonly used to evaluate inflammation. The abomasum, duodenum, jejunum and ileum, cecum, colon, and rectum of each animal were sampled at necropsy for immunohistochemical staining targeting DAO. DAO was diffusely expressed in all areas from the abomasum to the rectum in healthy calves, whereas its expression was reduced in calves with diarrhea. Four Japanese black calves with mild dehydration caused by diarrhea were included in the study to investigate the potential relationship between DAO and HPT. DAO activity was extremely low in diarrhea cases, whereas HPT levels were high. When an oral rehydration solution (ORS) was administered to these cases for three consecutive days, HPT significantly decreased logarithmically and fecal properties returned to normal on the fourth day of treatment. In contrast, DAO activities were significantly increased by oral rehydration therapy (ORT), and DAO activities were significantly negatively correlated with HPT concentrations. The present results confirmed that DAO is expressed in the epithelial cells of the intestinal mucosa in cattle, and that both the small and large intestines significantly contribute to blood DAO levels. Furthermore, DAO expression was reduced by enteritis.","PeriodicalId":49959,"journal":{"name":"Journal of Veterinary Medical Science","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145233923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hematological and blood biochemical parameters of Tokara horses in Kaimon Foothills Nature Park. 开曼山麓自然公园托卡拉马血液学和血液生化指标。

IF 1.1 4区农林科学

Journal of Veterinary Medical Science Pub Date : 2025-10-03 DOI: 10.1292/jvms.25-0340

Noriyuki Yamashita, Takashi Hatazoe, Kazuhiro Misumi, Seiji Hobo

引用次数: 0