Journal of Veterinary Medical Science最新文献

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Reference values for cardiac hormones in young Japanese macaques (Macaca fascata).
IF 1.1 4区 农林科学
Journal of Veterinary Medical Science Pub Date : 2025-02-17 DOI: 10.1292/jvms.24-0446
Arao Yamaoka, Shunya Nakayama, Yasuyo Ito-Fujishiro, Ibuki Yoneda, Rie Kinoshita, Hiroshi Koie
{"title":"Reference values for cardiac hormones in young Japanese macaques (Macaca fascata).","authors":"Arao Yamaoka, Shunya Nakayama, Yasuyo Ito-Fujishiro, Ibuki Yoneda, Rie Kinoshita, Hiroshi Koie","doi":"10.1292/jvms.24-0446","DOIUrl":"https://doi.org/10.1292/jvms.24-0446","url":null,"abstract":"<p><p>Spontaneous cardiac disease in nonhuman primates offers a useful model of human cardiac disease. However, diagnosing heart disease generally requires specialized techniques such as ultrasonography. This study focused on cardiac hormones that can be used to detect cardiac disease from blood tests. We measured concentrations of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) in healthy young Japanese macaques (Macaca fuscata) housed individually indoors, with no abnormalities in thoracic X-rays, electrocardiograms, echocardiograms, or complete blood counts and serum biochemistry tests, to establish reference values. The monkeys used in this study comprised 29 males (28-47 months old) and 29 females (22-65 months old). ANP levels were determined by immunoradiometric assay. BNP levels were determined by chemiluminescent enzyme immunoassay. Mean ANP level was 25.7 ± 9.6 pg/mL for all 58 Japanese macaques, 26.7 ± 9.6 pg/mL for the 29 males, and 24.7 ± 9.5 pg/mL for the 29 females. No significant difference was identified between sexes. No correlation was seen between ANP and age but excluded monkeys showed result of outside these range. BNP was also measured, with 22 of the 58 monkeys showing levels below the lower limit of detection (<4.0 pg/mL). Taking levels in these 22 animals as 4.0 pg/mL, mean BNP level was 5.1 ± 1.6 pg/mL and BNP elevated in two excluded monkeys. These results establish mean values for cardiac hormones in young Japanese macaques. These standards may provide useful indicators for the early detection of cardiac disease in animal models.</p>","PeriodicalId":49959,"journal":{"name":"Journal of Veterinary Medical Science","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143434174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Establishing tentative cut-off values for disk diffusion method for Pasteurella multocida and Mannheimia haemolytica from livestock animals in Japan.
IF 1.1 4区 农林科学
Journal of Veterinary Medical Science Pub Date : 2025-02-17 DOI: 10.1292/jvms.24-0474
Mio Kumakawa, Ryoko Akama, Yuta Hosoi, Yukari Hiraoka, Saki Harada, Mari Matsuda, Michiko Kawanishi, Hideo Sekiguchi
{"title":"Establishing tentative cut-off values for disk diffusion method for Pasteurella multocida and Mannheimia haemolytica from livestock animals in Japan.","authors":"Mio Kumakawa, Ryoko Akama, Yuta Hosoi, Yukari Hiraoka, Saki Harada, Mari Matsuda, Michiko Kawanishi, Hideo Sekiguchi","doi":"10.1292/jvms.24-0474","DOIUrl":"https://doi.org/10.1292/jvms.24-0474","url":null,"abstract":"<p><p>Although the disk diffusion method is a useful and widely utilized antimicrobial susceptibility testing method in clinical veterinary practice, the available clinical breakpoints (CBPs) for the combination of bacterial species and antimicrobials are still limited. This study aimed to establish tentative cut-off values by analyzing the relationship between minimum inhibitory concentration and the inhibition zone diameter of the disk diffusion method for Pasteurella multocida and Mannheimia haemolytica, collected by the Japanese Veterinary Antimicrobial Resistance Monitoring system (JVARM), for the antimicrobial agents approved in Japan for the treatment of respiratory diseases in cattle and swine. Among the antimicrobial agents without CBPs for the disk diffusion method in the Clinical and Laboratory Standards Institute (CLSI), we were able to determine the tentative cut-off values of ampicillin (ABPC, S≥25 mm, R≤24 mm in swine), dihydrostreptomycin (DSM, S≥8 mm in cattle, S≥12 mm in swine), kanamycin (KM, S≥16 mm in cattle, S≥17 mm in swine), tetracycline (TC, S≥21 mm, R≤20 mm in cattle) and tiamulin (TML, S≥13 mm in swine) for P. multocida, and CEZ (S≥23 mm), DSM (S≥10 mm), KM (S≥18 mm) and TC (S≥23 mm, R≤20 mm) for M. haemolytica. These results should encourage the practical use of antimicrobial susceptibility testing in the clinical field and contribute to furthering prudent use of antimicrobial agents.</p>","PeriodicalId":49959,"journal":{"name":"Journal of Veterinary Medical Science","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143434020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Phyllodes tumor in the mammary gland of a northern tree shrew (Tupaia belangeri).
IF 1.1 4区 农林科学
Journal of Veterinary Medical Science Pub Date : 2025-02-17 DOI: 10.1292/jvms.24-0444
Tatsuro Hifumi, Yuki Tanaka, Kyoko Tsukiyama-Kohara, Noriaki Miyoshi
{"title":"Phyllodes tumor in the mammary gland of a northern tree shrew (Tupaia belangeri).","authors":"Tatsuro Hifumi, Yuki Tanaka, Kyoko Tsukiyama-Kohara, Noriaki Miyoshi","doi":"10.1292/jvms.24-0444","DOIUrl":"https://doi.org/10.1292/jvms.24-0444","url":null,"abstract":"<p><p>A rapidly growing mass was observed in the left third mammary gland of a 5-and-a-half-year-old intact female northern tree shrew (Tupaia belangeri). Histopathologically, the mass was composed of numerous irregularly dilated mammary ducts with a pericanalicular or intracanalicular pattern. These mammary ducts showed a leaf-like structure due to the proliferations of surrounding spindle-shaped neoplastic cells with moderate to severe nuclear atypia. We diagnosed this case as a phyllodes tumor in a mammary gland of a northern tree shrew (Tupaia belangeri), which closely resembled those occurring in the human breast histopathologically. To the best of our knowledge, this is the first report of a phyllodes tumor in the mammary gland of a northern tree shrew (Tupaia belangeri).</p>","PeriodicalId":49959,"journal":{"name":"Journal of Veterinary Medical Science","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143434166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anticancer potentials of chaga and notoginseng against dog bladder cancer organoids. 对犬膀胱癌类器官有抗癌潜力的白桦和三七。
IF 1.1 4区 农林科学
Journal of Veterinary Medical Science Pub Date : 2025-02-15 Epub Date: 2025-01-03 DOI: 10.1292/jvms.24-0258
Yuta Shinohara, Mohamed Elbadawy, Yishan Liu, Megumi Yamanaka, Haru Yamamoto, Yomogi Sato, Amira Augomaa, Yusuke Ishihara, Tatsuya Usui, Kazuaki Sasaki
{"title":"Anticancer potentials of chaga and notoginseng against dog bladder cancer organoids.","authors":"Yuta Shinohara, Mohamed Elbadawy, Yishan Liu, Megumi Yamanaka, Haru Yamamoto, Yomogi Sato, Amira Augomaa, Yusuke Ishihara, Tatsuya Usui, Kazuaki Sasaki","doi":"10.1292/jvms.24-0258","DOIUrl":"10.1292/jvms.24-0258","url":null,"abstract":"<p><p>Muscle-invasive bladder cancer (MIBC) is a common form of BC in dogs. Adjuvant chemotherapy administration is commonly applied in MIBC cases, but patients sometimes experience treatment failure and recurrence. Therefore, supplements with anticancer properties, such as traditional Chinese medicines (TCMs), are required, and they have been widely used in Japanese human medicine and may be useful in veterinary medicine. Furthermore, organoid cultures can mimic the characteristics of their original tissues, such as self-renewal and organization. We previously established a novel experimental model for MIBC using a dog BC organoid (DBCO) culture. Herein, we examined the antiproliferative effects and mechanisms of 39 substances, consisting of TCMs, TCM supplements, and crude drug extracts, on DBCOs. Among the TCMs, D3 (also known as Shibe-ria), which is a mixture of chaga (Inonotus obliquus) and notoginseng (Panax notoginseng), significantly diminished the cell viability of DBCOs. The expression of BC stem cell markers, CD44 and SOX2, was reduced considerably in the D3-treated DBCOs. Among the components of D3, chaga exerted an antiproliferative effect on DBCO, whereas notoginseng did not. The administration of D3 also significantly reduced the volume of DBCO xenografted tumors in mice in vivo. Overall, D3 may have benefits as a natural anticancer supplement in veterinary medicine.</p>","PeriodicalId":49959,"journal":{"name":"Journal of Veterinary Medical Science","volume":" ","pages":"232-240"},"PeriodicalIF":1.1,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11830434/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142933290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Growth kinetics and population density of a laboratory colony of the poultry red mite (Dermanyssus gallinae) established in Japan. 在日本建立的家禽红螨实验室种群的生长动力学和种群密度。
IF 1.1 4区 农林科学
Journal of Veterinary Medical Science Pub Date : 2025-02-15 Epub Date: 2025-01-01 DOI: 10.1292/jvms.24-0343
Takahiro Inoue, Keiko Mizutani, Hanako Kunisada, Danielle Ladzekpo, Kofi Dadzie Kwofie, Yuki Koike, Sana Sasaki, Kei Jimbo, Hayato Kawada, Fusako Mikami, Anisuzzaman, Md Abdul Alim, Makoto Matsubayashi, Tomoo Yoshida, Takashi Furukawa, Takahisa Ueno, Kenji Oda, Naotoshi Tsuji, Takeshi Hatta
{"title":"Growth kinetics and population density of a laboratory colony of the poultry red mite (Dermanyssus gallinae) established in Japan.","authors":"Takahiro Inoue, Keiko Mizutani, Hanako Kunisada, Danielle Ladzekpo, Kofi Dadzie Kwofie, Yuki Koike, Sana Sasaki, Kei Jimbo, Hayato Kawada, Fusako Mikami, Anisuzzaman, Md Abdul Alim, Makoto Matsubayashi, Tomoo Yoshida, Takashi Furukawa, Takahisa Ueno, Kenji Oda, Naotoshi Tsuji, Takeshi Hatta","doi":"10.1292/jvms.24-0343","DOIUrl":"10.1292/jvms.24-0343","url":null,"abstract":"<p><p>The poultry red mite (PRM), Dermanyssus gallinae, is a hematophagous ectoparasite that significantly threatens the poultry industry, not only through blood-feeding but also as a vector for deadly pathogens. With the growing challenge of acaricidal resistance, the demand for alternative control measures is urgent. However, effective PRM research, particularly in acaricidal efficacy and new drug discovery, hinges on the availability of reliable laboratory colonies. In this study, we successfully established a stable PRM laboratory colony, originally isolated from the field in 2021 and maintained under controlled conditions at the Research Institute for Animal Science in Biochemistry and Toxicology (RIAS). We investigated the growth kinetics and population dynamics of the laboratory colony within a Styrofoam-based maintenance box (SBMB) containing chicks. PRM propagation was tracked over 28 days, with mites collected every seven days. The average bulk weight of the mites in the trap increased from 4.3 ± 1.2 mg on day 7 to 201.4 ± 56.5 mg on day 28, despite seasonal variations, indicating optimal conditions for population growth. The collected mites spanned various blood-feeding developmental stages such as protonymph, deutonymph, and adult stages, enabling comprehensive assessments of molting and egg-laying efficiency. Our findings confirm that the laboratory colony of PRM can be stably maintained, providing a reliable source of PRMs for further experimental research aimed at advancing control strategies against this pervasive pest.</p>","PeriodicalId":49959,"journal":{"name":"Journal of Veterinary Medical Science","volume":" ","pages":"215-222"},"PeriodicalIF":1.1,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11830435/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142933295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Influences of the short-term dietary carbohydrate restriction on the chicken cecal tonsil. 短期饲粮碳水化合物限制对鸡盲肠扁桃体的影响。
IF 1.1 4区 农林科学
Journal of Veterinary Medical Science Pub Date : 2025-02-15 Epub Date: 2024-12-25 DOI: 10.1292/jvms.24-0409
Md Salahuddin, Md Al-Amin, Kohzy Hiramatsu, Kazumi Kita
{"title":"Influences of the short-term dietary carbohydrate restriction on the chicken cecal tonsil.","authors":"Md Salahuddin, Md Al-Amin, Kohzy Hiramatsu, Kazumi Kita","doi":"10.1292/jvms.24-0409","DOIUrl":"10.1292/jvms.24-0409","url":null,"abstract":"<p><p>This study aims to clarify influences of the short-term carbohydrate (CHO) restriction on plasma cells in chicken cecal tonsil (CT) using immunohistochemical and morphometrical techniques. Healthy male layer chickens were randomly divided into the control and three experimental groups. The three experimental groups were fed with diets containing 50%, 25%, and 0% CHO of that in the control diet, respectively. Following the experimental period for 7 days, CTs were collected from each chicken. Immunohistochemistry was performed to detect immunoglobulin (Ig) A, G and M. The density of IgA-immunoreactive cells was significantly lower in the lymphoid follicles (LFs) and diffuse lymphoid tissues (DLTs) in CTs of the 0% group compared to those of the other groups. There was a positive correlation between daily CHO intake and the density of IgA-immunoreactive cells in the DLTs and LFs. The density of IgM-immunoreactive cells was significantly decreased as daily CHO intake decreased, and there was a positive correlation between these two factors in both DLTs and LFs. The density of IgG-immunoreactive cells was significantly lower in DLTs of the 0% group than those in the control and 50% groups. The density of IgG-immunoreactive cells was significantly decreased with a decrease in daily CHO intake in DLT but not in LF. These findings demonstrated that dietary CHO had a significant effect on the density of plasma cells in the CTs exhibiting a declining trend with a decrease of ingested CHO volume.</p>","PeriodicalId":49959,"journal":{"name":"Journal of Veterinary Medical Science","volume":" ","pages":"207-214"},"PeriodicalIF":1.1,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11830445/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142899972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anti-inflammatory effects of water-dispersible hesperetin on endotoxin-induced uveitis in rats involving the nuclear factor κB and Wnt/β-catenin signaling pathways. 水分散橙皮素对内毒素诱导的大鼠葡萄膜炎的抗炎作用涉及核因子κB和Wnt/β-catenin信号通路。
IF 1.1 4区 农林科学
Journal of Veterinary Medical Science Pub Date : 2025-02-15 Epub Date: 2025-01-16 DOI: 10.1292/jvms.24-0453
Daiki Okada, Kazutaka Kanai, Yuya Otaka, Tsubasa Matsumoto, Akane Izumoto, Yumiko Uchiyama, Noriaki Nagai, Yohei Yamashita, Yoichiro Ichikawa, Misaki Sugiuchi, Kazuki Tajima
{"title":"Anti-inflammatory effects of water-dispersible hesperetin on endotoxin-induced uveitis in rats involving the nuclear factor κB and Wnt/β-catenin signaling pathways.","authors":"Daiki Okada, Kazutaka Kanai, Yuya Otaka, Tsubasa Matsumoto, Akane Izumoto, Yumiko Uchiyama, Noriaki Nagai, Yohei Yamashita, Yoichiro Ichikawa, Misaki Sugiuchi, Kazuki Tajima","doi":"10.1292/jvms.24-0453","DOIUrl":"10.1292/jvms.24-0453","url":null,"abstract":"<p><p>This study investigated the anti-inflammatory effects of water-dispersible hesperetin (WD-Hpt) in an endotoxin-induced uveitis (EIU) rat model. The rats were orally administered 10, 25, or 50 mg/kg WD-Hpt immediately after lipopolysaccharide (LPS) injection at the concentration of 200 μg. Clinical scores, cellular inflammation, the aqueous humor (ApH) protein concentration, as well as the levels of tumor necrosis factor (TNF)-α, cyclooxygenase (COX)-2 and inducible NO synthase (iNOS) in AqH, and histopathological grades were assessed. Immunohistostaining and mRNA analyses measured expressions of TNF-α, COX-2, iNOS, activated nuclear factor (NF)-κB p65, I kappa B (IκB)-α degradation, phosphorylated (p)-IκB kinase (IKK) α/β, β-catenin, and glycogen synthase kinase (GSK)-3β. Compared to LPS treated group (LPS txg), WD-Hpt treatment groups (WD-Hpt txg) resulted in the following results: 1) clinical scores improved [LPS txg; 3.90 ± 0.20, WD-Hpt txg; 2.40 ± 0.37 (P<0.05)], 2) the number of inflammatory cells in AqH decreased [LPS txg; 8.65 ± 1.41 × 105 cells/mL, WD-Hpt txg; 3.83 ± 1.20 × 105 cells/mL (P<0.05)], 3) AqH protein concentration reduced [LPS txg; 36.65 ± 2.71 mg/mL, WD-Hpt txg; 28.73 ± 2.36 mg/mL (P<0.05)], and 4) decreased levels of TNF-α [LPS txg; 69.55 ± 7.38 pg/mL, WD-Hpt txg; 35.18 ± 9.22 pg/mL (P<0.001)], iNOS [LPS txg; 153.37 ± 12.72 μM, WD-Hpt txg; 110.79 ± 13.27 μM (P<0.05)], and COX-2 [LPS txg; 1,080.56 ± 196.06 pg/mL, WD-Hpt txg; 477.80 ± 66.61 pg/mL (P<0.01)] in AqH were observed, and histopathological grades improved [LPS txg; 2.80 ± 0.40, WD-Hpt txg; 1.50 ± 0.50 (P<0.05)]. Immunostaining and mRNA analysis revealed that 50 mg/kg WD-Hpt effectively suppressed iNOS, COX-2, NF-κB p65, IκB-α degradation, p-IKKα/β, β-catenin, and GSK-3β expression. These findings suggested that WD-Hpt exerts anti-inflammatory effects by targeting the NF-κB and Wnt/β-catenin pathways.</p>","PeriodicalId":49959,"journal":{"name":"Journal of Veterinary Medical Science","volume":" ","pages":"223-231"},"PeriodicalIF":1.1,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11830440/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143015235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Developmental process and homeostasis of whale long bones lacking medullary cavity using the radius of Antarctic minke whales, Balaenoptera bonaerensis. 以南极小须鲸(Balaenoptera bonaerensis)的桡骨为例,探讨缺乏髓腔的鲸鱼长骨的发育过程和稳态。
IF 1.1 4区 农林科学
Journal of Veterinary Medical Science Pub Date : 2025-02-13 DOI: 10.1292/jvms.24-0430
Yayoi Izu, Hajime Ishikawa, Satoshi Soeta
{"title":"Developmental process and homeostasis of whale long bones lacking medullary cavity using the radius of Antarctic minke whales, Balaenoptera bonaerensis.","authors":"Yayoi Izu, Hajime Ishikawa, Satoshi Soeta","doi":"10.1292/jvms.24-0430","DOIUrl":"https://doi.org/10.1292/jvms.24-0430","url":null,"abstract":"<p><p>Whales, Earth's largest mammals and live in water, form long bones without marrow cavities. Body size and mechanical stress impact the bone formation and homeostasis, yet the specific developmental processes remain unclear. Here, we demonstrate the histological changes in whale long bones from fetal to mature stages using the radius of Antarctic minke whales in comparison with domestic cats and cattle. Through intramembranous ossification and remodeling, long bones enlarge their diameters and marrow cavities, respectively. It has been demonstrated that relatively small animals, such as cats, develop the radially arranged \"primary osteonal bone\", whereas larger animals, including cattle, form \"laminar bone\" initiated by the formation of circumferentially arranged hypercalcified lines during intramembranous ossification. Here, we demonstrated that whales form laminar bones, transitioning from circumferential in the fetus to radial during postnatal growth, and thereafter cortical bones become compact. After maturation, bone remodeling primarily occurs in the lateral and medial regions of long bones, while the bone layers in the cranial-caudal region never undergo complete resorption. As a result, these layers remain as a wire-netting structure composed of thin bone layers, without forming an open medullary cavity. These data suggest that whales enlarge their long bones through laminar bone formation and form long bones without a marrow cavity by regulating bone resorption areas during the developmental process and in maintaining homeostasis.</p>","PeriodicalId":49959,"journal":{"name":"Journal of Veterinary Medical Science","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143410894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of low-dose subchronic exposure to the phenylpyrazole insecticide fipronil in juvenile mice.
IF 1.1 4区 农林科学
Journal of Veterinary Medical Science Pub Date : 2025-02-13 DOI: 10.1292/jvms.24-0531
Ayano Yoshimoto, Sarika Nunobiki, Makiko Ito, Sakura Yonoichi, Yukako Hara, Yuya Ishida, Youhei Mantani, Toshifumi Yokoyama, Tetsushi Hirano, Yoshinori Ikenaka, Nobuhiko Hoshi
{"title":"Effects of low-dose subchronic exposure to the phenylpyrazole insecticide fipronil in juvenile mice.","authors":"Ayano Yoshimoto, Sarika Nunobiki, Makiko Ito, Sakura Yonoichi, Yukako Hara, Yuya Ishida, Youhei Mantani, Toshifumi Yokoyama, Tetsushi Hirano, Yoshinori Ikenaka, Nobuhiko Hoshi","doi":"10.1292/jvms.24-0531","DOIUrl":"https://doi.org/10.1292/jvms.24-0531","url":null,"abstract":"<p><p>Fipronil (FPN) inhibits gamma-aminobutyric acid type A receptors and exhibits strong insecticidal effects. Although FPN's adverse effects on mammals have been reported recently, few studies have examined subchronic exposure to low doses. We orally administered FPN (0.43 mg/kg) to 4-week-old male mice for 6 wk and assessed their behavior and blood characteristics. Compared with the control group, the FPN-treated group presented reduced weight gain but upward trends in locomotor activity and blood histamine levels. Fipronil sulfone (FPNS) was detected in all individuals, whereas FPN was not detected in any individual. The present study shows for the first time that subchronic exposure to low-dose FPN in mice led to FPNS conversion in the body, affecting weight gain and behavior.</p>","PeriodicalId":49959,"journal":{"name":"Journal of Veterinary Medical Science","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143411044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transthoracic echocardiographic reference intervals in 214 adult Golden retrievers.
IF 1.1 4区 农林科学
Journal of Veterinary Medical Science Pub Date : 2025-02-12 DOI: 10.1292/jvms.24-0268
Mara Bagardi, Paolo Ferrari, Chiara Locatelli, Sara Ghilardi, Francesca Zanchi, Tommaso Vezzosi, Francesco Porciello, Mark Rishniw, Paola G Brambilla
{"title":"Transthoracic echocardiographic reference intervals in 214 adult Golden retrievers.","authors":"Mara Bagardi, Paolo Ferrari, Chiara Locatelli, Sara Ghilardi, Francesca Zanchi, Tommaso Vezzosi, Francesco Porciello, Mark Rishniw, Paola G Brambilla","doi":"10.1292/jvms.24-0268","DOIUrl":"https://doi.org/10.1292/jvms.24-0268","url":null,"abstract":"<p><p>This study describes the echocardiographic reference intervals in a large sample of Golden retrievers from the database of the Italian Veterinary Observatory for Cardiac Diseases. The echocardiographic variables and the cardiac functionality indexes obtained from 2012 to 2022 in 214 (122 females, 92 males) healthy adult Golden retrievers were compared with the previously published data for this breed and with data from the general canine population and other breeds. The diastolic left ventricular internal diameter and the left ventricle's systolic and diastolic allometric indices were higher than those reported for the general canine population (P<0.05). The same was true for the left ventricular end-diastolic and end-systolic volumes measured by Simpson's method of discs (P<0.01). Fractional shortening of the left ventricle was lower (P=0.002) and aortic flow velocity was higher (P<0.001) than the value previously reported for Golden retrievers. The reference intervals obtained in this study are useful for clinical echocardiography and for echocardiographic screening programs in Golden retrievers.</p>","PeriodicalId":49959,"journal":{"name":"Journal of Veterinary Medical Science","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143411175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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