Journal of Veterinary Medical Science最新文献_第2页

An ovarian sex cord-stromal tumor with fibromatous and thecomatous differentiation in an Ezo brown bear (Ursus arctos yesoensis). 棕棕熊卵巢性索间质肿瘤伴纤维瘤和瘤状分化。

IF 1.1 4区农林科学

Journal of Veterinary Medical Science Pub Date : 2026-10-06 DOI: 10.1292/jvms.26-0379

Mirei Shimada, Kyogo Hagino, Kazuya Matsuda, Yuto Sano

{"title":"An ovarian sex cord-stromal tumor with fibromatous and thecomatous differentiation in an Ezo brown bear (Ursus arctos yesoensis).","authors":"Mirei Shimada, Kyogo Hagino, Kazuya Matsuda, Yuto Sano","doi":"10.1292/jvms.26-0379","DOIUrl":"https://doi.org/10.1292/jvms.26-0379","url":null,"abstract":"A mass was found in the left ovary of a 40-year-old captive female Ezo brown bear (Ursus arctos yesoensis) during a necropsy. Histopathology revealed two morphologically distinct stromal cell populations: round to polygonal cells with cytoplasmic microvacuoles, which were positive for inhibin-α and adipose differentiation-related protein (ADRP) and were surrounded by reticulin fibers, and spindle-shaped cells expressing α-smooth muscle actin, which produced collagen and exhibited occasional ADRP-positivity. The ovary also contained cystic and cauliflower-like nodular lesions covered by ovarian surface epithelium. The mass was diagnosed as an ovarian sex cord-stromal tumor with fibromatous and thecomatous differentiation. The cystic lesions were interpreted as surface epithelial cysts, although a subsurface epithelial structures-like origin could not be excluded. The cauliflower-like nodular lesion was described as a stromal protrusion covered by ovarian surface epithelium. This case expands the spectrum of ovarian lesions reported in ursids and contributes to our understanding of reproductive pathology.","PeriodicalId":49959,"journal":{"name":"Journal of Veterinary Medical Science","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149129078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inverse relationship between the circulating plasma autotaxin activity and blood pressure in normal pregnant rats. 正常妊娠大鼠循环血浆autotaxin活性与血压的反比关系。

IF 1.1 4区农林科学

Journal of Veterinary Medical Science Pub Date : 2026-10-05 DOI: 10.1292/jvms.26-0435

Miho Tanaka, Ryota Terashima, Muneyoshi Okada, Hideyuki Yamawaki, Keiichiro Kizaki, Shiro Kurusu

引用次数: 0

Health assessment of Tokara horses on Nakanoshima island: potential chronic hepatic dysfunction induced by Leopard plant (Farfugium japonicum) ingestion. 中野岛托卡拉马的健康评估：食入豹属植物可能引起慢性肝功能障碍。

IF 1.1 4区农林科学

Journal of Veterinary Medical Science Pub Date : 2026-10-03 Epub Date: 2026-08-03 DOI: 10.1292/jvms.26-0275

Noriyuki Yamashita, Tomoko Yoshihara, Takashi Hatazoe, Kazuhiro Misumi, Seiji Hobo

引用次数: 0

Transient high-output heart failure documented by echocardiographic cardiac index measurement in a pregnant cat. 孕猫超声心动图心脏指数测量记录的短暂性高输出心力衰竭。

IF 1.1 4区农林科学

Journal of Veterinary Medical Science Pub Date : 2026-10-03 Epub Date: 2026-07-22 DOI: 10.1292/jvms.26-0227

Yasutomo Hori

引用次数: 0

Frequencies of the SERPINF2 c.605C>T variant implicated in delayed postoperative hemorrhage among dog breeds at a single referral center in Japan. 在日本的一个转诊中心，seref2 c.605C>T变异与犬种间迟发性术后出血有关。

IF 1.1 4区农林科学

Journal of Veterinary Medical Science Pub Date : 2026-10-03 Epub Date: 2026-07-22 DOI: 10.1292/jvms.26-0247

Haruhiko Maruyama, Nanako Ozaki, Kumi Kato, Saki Nishimura

{"title":"Frequencies of the SERPINF2 c.605C>T variant implicated in delayed postoperative hemorrhage among dog breeds at a single referral center in Japan.","authors":"Haruhiko Maruyama, Nanako Ozaki, Kumi Kato, Saki Nishimura","doi":"10.1292/jvms.26-0247","DOIUrl":"10.1292/jvms.26-0247","url":null,"abstract":"Delayed postoperative hemorrhage (DEPOH) is recognized in sighthound breeds and has been associated with a SERPINF2 c.605C>T variant that affects alpha-2-antiplasmin, an important inhibitor of fibrinolysis. The distribution of this variant among dogs in Japan has not been investigated. To determine the frequency of the SERPINF2 c.605C>T variant in dogs presented to a single referral hospital in Japan. Genomic DNA was extracted from peripheral blood of dogs presented to the Animal Medical Center of Nihon University between July 2021 and October 2022. Genotyping of SERPINF2 c.605C>T variant was performed by real-time PCR using a TaqMan minor groove binder SNP genotyping assay. Adequate amplification was obtained in 433 of 436 samples. Homozygous variant genotypes (T/T) were detected in one Italian Greyhound, one Whippet, and two Shiba Inu dogs. Heterozygous genotypes (C/T) were detected in Saluki, Italian Greyhound, Shiba Inu, French Bulldog, mixed-breed dog, Boston Terrier, Jack Russell Terrier, and Chihuahua. Among non-sighthound breeds, Shiba Inu dogs had the highest observed variant allele frequency in this cohort (0.25). The DEPOH-associated SERPINF2 c.605C>T variant was detected in both sighthound and non-sighthound dogs in this Japanese referral-hospital cohort. The relatively high allele frequency observed in Shiba Inu dogs warrants further multicenter studies evaluating variant frequency and its relationship with clinical DEPOH.","PeriodicalId":49959,"journal":{"name":"Journal of Veterinary Medical Science","volume":" ","pages":"1479-1481"},"PeriodicalIF":1.1,"publicationDate":"2026-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148563558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Establishment of disk diffusion national epidemiological cut-off values for Pasteurella multocida and Mannheimia haemolytica isolated from bovine respiratory diseases and characteristics of antibiograms in Japan. 日本牛呼吸道疾病分离的多杀性巴氏杆菌和溶血性曼海姆病圆盘扩散全国流行病学临界值的建立及抗生素谱特征。

IF 1.1 4区农林科学

Journal of Veterinary Medical Science Pub Date : 2026-10-03 Epub Date: 2026-08-11 DOI: 10.1292/jvms.26-0205

Tomoko Koshiishi, Akiko Kato, Mio Kumakawa, Yuta Hosoi, Michiko Kawanishi, Shunsuke Mori, Tomomi Kurumisawa, Junko Saito, Mie Kishikawa, Kazuhiro Kawai

{"title":"Establishment of disk diffusion national epidemiological cut-off values for Pasteurella multocida and Mannheimia haemolytica isolated from bovine respiratory diseases and characteristics of antibiograms in Japan.","authors":"Tomoko Koshiishi, Akiko Kato, Mio Kumakawa, Yuta Hosoi, Michiko Kawanishi, Shunsuke Mori, Tomomi Kurumisawa, Junko Saito, Mie Kishikawa, Kazuhiro Kawai","doi":"10.1292/jvms.26-0205","DOIUrl":"10.1292/jvms.26-0205","url":null,"abstract":"Antimicrobial resistance is a global public health threat, and accurate antimicrobial susceptibility testing is crucial for guiding appropriate antimicrobial use. Although the disk diffusion method is widely used in livestock, standardized breakpoints for veterinary pathogens are lacking. Bovine respiratory disease, a major cause of economic loss in calves, is commonly associated with Pasteurella multocida and Mannheimia haemolytica. This study aimed to establish inhibition zone diameter cut-off values for disk diffusion and to create an antibiogram for these pathogens. The cut-off values were calculated based on minimum inhibitory concentration (MIC) reference values: the Clinical and Laboratory Standards Institute clinical breakpoints for penicillin and tetracycline; the European Committee on Antimicrobial Susceptibility Testing epidemiological cut-off values for kanamycin and tilmicosin (P. multocida); and MIC cut-off values calculated from this study for cefazolin, marbofloxacin, thiamphenicol, and tylosin. The cut-off values for penicillin and tetracycline provide useful guidance for clinical drug selection, whereas caution is required when interpreting the results for the other agents evaluated because their cut-off values were based on epidemiological cut-offs rather than clinical breakpoints. Re-evaluation of previously reported cut-off values for kanamycin, cefazolin, and tetracycline using a larger number of isolates provided more robust thresholds that were less susceptible to strain-specific variation. The antibiogram revealed low susceptibility rates for some agents. Because antimicrobial use is associated with the development of resistance, these findings indicate the need for prudent antimicrobial stewardship and continued surveillance of resistance in livestock pathogens.","PeriodicalId":49959,"journal":{"name":"Journal of Veterinary Medical Science","volume":" ","pages":"1556-1564"},"PeriodicalIF":1.1,"publicationDate":"2026-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148724042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cytological evaluation of bone marrow in 11 cattle with enzootic bovine leukosis. 11头牛地方性白血病骨髓细胞学评价。

IF 1.1 4区农林科学

Journal of Veterinary Medical Science Pub Date : 2026-10-03 Epub Date: 2026-08-10 DOI: 10.1292/jvms.26-0330

Nao Akiyama-Nagao, Masaki Maezawa, Hisashi Inokuma

引用次数: 0

In vitro evaluation of cytotoxicity of TONS504 and blue light irradiation on porcine corneal epithelial cells. 体外评价TONS504及蓝光照射对猪角膜上皮细胞的细胞毒性。

IF 1.1 4区农林科学

Journal of Veterinary Medical Science Pub Date : 2026-10-03 Epub Date: 2026-08-04 DOI: 10.1292/jvms.26-0107

Tomoya Furujo, Norihiko Ito, Isao Sakata, Tomohiro Osaki

{"title":"In vitro evaluation of cytotoxicity of TONS504 and blue light irradiation on porcine corneal epithelial cells.","authors":"Tomoya Furujo, Norihiko Ito, Isao Sakata, Tomohiro Osaki","doi":"10.1292/jvms.26-0107","DOIUrl":"10.1292/jvms.26-0107","url":null,"abstract":"Photodynamic antimicrobial chemotherapy (PACT) for infectious keratitis has attracted increasing attention, and the clinical application of PACT with TONS504, a newly developed chlorin derivative, is anticipated. However, studies evaluating the cytotoxicity of TONS504 combined with light exposure on corneal cells are lacking. We aimed to investigate cytotoxic effects on the corneal epithelium and examined safe irradiation conditions by evaluating the cytotoxicity of TONS504, blue light (405 nm), and their combination using porcine corneal epithelium (PCEP). Additionally, the synergistic cytotoxicity of TONS504 with ethylenediaminetetraacetic acid (EDTA) under blue light-previously shown to have a synergistic antimicrobial effect with PACT-was assessed. Viability of PCEP cells exposed to various TONS504 concentrations (1-100 mg/L), irradiation intensities (5-30 J/cm2, 20 mW/cm2, 405 nm LED), and their combinations were evaluated using the Cell Counting Kit-8 assay. Inhibition of PCEP cell migration under these conditions was assessed using a primary porcine corneal explant model. The synergistic cytotoxicity of TONS504 with EDTA (0.015 M) under blue light irradiation at 5 J/cm2 was also evaluated similarly. TONS504 alone demonstrated low cytotoxicity (up to 10 mg/L), whereas the combination of TONS504 with blue light showed concentration-dependent cytotoxicity or cytotoxicity at high light irradiation intensity against PCEP cells. No clear synergistic cytotoxicity was observed between TONS504 and EDTA under blue light. These findings provide fundamental data for establishing a blue light-based TONS504-PACT protocol.","PeriodicalId":49959,"journal":{"name":"Journal of Veterinary Medical Science","volume":" ","pages":"1537-1545"},"PeriodicalIF":1.1,"publicationDate":"2026-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148680780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative analyses of the color hue and stiffness properties of organ specimens fixed by immersion into formalin solution and ethylene glycol-methanol-phenol mixture. 福尔马林溶液和乙二醇-甲醇-苯酚混合物浸泡固定器官标本的色相和刚度特性对比分析。

IF 1.1 4区农林科学

Journal of Veterinary Medical Science Pub Date : 2026-10-03 Epub Date: 2026-08-11 DOI: 10.1292/jvms.26-0064

Mutsuki Kuraoka, Mayu Shirato, Karin Watanabe, Hirotada Otsuka, Fumiyuki Kobayashi, Yoshiyuki Ohta, Sachiko Odake, Satoshi Soeta

{"title":"Comparative analyses of the color hue and stiffness properties of organ specimens fixed by immersion into formalin solution and ethylene glycol-methanol-phenol mixture.","authors":"Mutsuki Kuraoka, Mayu Shirato, Karin Watanabe, Hirotada Otsuka, Fumiyuki Kobayashi, Yoshiyuki Ohta, Sachiko Odake, Satoshi Soeta","doi":"10.1292/jvms.26-0064","DOIUrl":"10.1292/jvms.26-0064","url":null,"abstract":"When applying embalmed cadavers and organ specimens to gross anatomy practice and surgical training, their qualitative properties serve as important functional indices of how closely they resemble the living state. Among these properties, color hue and stiffness change remarkably after fixation. In the present study, we evaluated the properties of rat organs, including the brain, lung, liver, and skeletal muscle, after fixation by immersion in a 10% formalin solution and a non-formalin fixative, ethylene glycol-methanol-phenol (EMP) mixture. The colorimetric L*a*b* values, which are indicators of the lightness and chromatic components, showed that, compared with formalin fixation, EMP fixation significantly increased lightness in the lungs and livers, suggesting decoloration as a result of hemolysis and hemochrome elution, whereas deposition of a reddish pigment was induced in the brains and skeletal muscles. The ΔE values, the total color difference from the unfixed state, were higher in the EMP- than in the formalin-fixed livers. The biomechanical parameters for stiffness indicated that the EMP-fixed brains were hardened similar to those fixed by formalin, while the other EMP-fixed organs were significantly hardened compared with their formalin-fixed counterparts. These findings suggest that EMP fixation exerts a beneficial effect by enhancing reddish coloration, especially in the skeletal muscles, and would be useful for reducing the total amount of highly toxic formalin used in gross anatomy practice.","PeriodicalId":49959,"journal":{"name":"Journal of Veterinary Medical Science","volume":" ","pages":"1546-1555"},"PeriodicalIF":1.1,"publicationDate":"2026-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148725106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence and egg surface morphology of capillariid nematodes in red foxes (Vulpes vulpes) from Hokkaido, Japan. 日本北海道赤狐毛线虫的流行及卵面形态。

IF 1.1 4区农林科学

Journal of Veterinary Medical Science Pub Date : 2026-10-03 Epub Date: 2026-08-27 DOI: 10.1292/jvms.26-0088

Takashi Inoue, Yuta Kanai, Yuzaburo Oku, Nariaki Nonaka

引用次数: 0