Journal of Veterinary Medical Science最新文献_第3页

High-fat/high-sucrose diet-induced renal changes in obese diabetic mice: a comparison with db/db and KK-Ay mice.

IF 1.1 4区农林科学

Journal of Veterinary Medical Science Pub Date : 2024-12-11 DOI: 10.1292/jvms.24-0313

Chika Oki, Kinuko Uno, Tomohiko Sasase, Takahiro Tsutsui, Keita Sekiguchi, Ayane Yamaguchi, Kouhei Mandai, Masami Shinohara, Miki Sugimoto, Tatsuya Maekawa, Katsuhiro Miyajima, Takeshi Ohta

{"title":"High-fat/high-sucrose diet-induced renal changes in obese diabetic mice: a comparison with db/db and KK-Ay mice.","authors":"Chika Oki, Kinuko Uno, Tomohiko Sasase, Takahiro Tsutsui, Keita Sekiguchi, Ayane Yamaguchi, Kouhei Mandai, Masami Shinohara, Miki Sugimoto, Tatsuya Maekawa, Katsuhiro Miyajima, Takeshi Ohta","doi":"10.1292/jvms.24-0313","DOIUrl":"https://doi.org/10.1292/jvms.24-0313","url":null,"abstract":"Many genetic and environmental factors are involved in the development and progression of diabetic kidney disease (DKD), and its pathology shows various characteristics. Animal models of DKD play an important role in elucidating its pathogenesis and developing new therapies. In this study, we investigated the pathophysiological features of two DKD animal models: db/db mice (background of hyperglycemia) and KK-Ay mice (background of hyperinsulinemia). Male and female mice were fed a high-fat/high-sucrose (HFS) diet for eight weeks. Two mouse models fed the HFS diet showed increases in urinary protein, kidney weight, and glomerular size, but these changes were pronounced in KK-Ay mice. Pathological examination revealed tubulointerstitial fibrosis in KK-Ay mice fed the HFS diet, but not in db/db mice. In addition, fat accumulation was observed in the macula densa of db/db mice and in the glomeruli of KK-Ay mice fed with the HFS diet. In conclusion, a HFS diet exacerbates renal lesions with tubulointerstitial fibrosis in KK-Ay mice, and KK-Ay mice fed a HFS diet are expected to be useful as a DKD model.","PeriodicalId":49959,"journal":{"name":"Journal of Veterinary Medical Science","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142814717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In vitro susceptibility testing of essential oils and their main components against antifungal-resistant Malassezia pachydermatis.

IF 1.1 4区农林科学

Journal of Veterinary Medical Science Pub Date : 2024-12-11 DOI: 10.1292/jvms.24-0342

Honoka Nojo, Nobuo Murayama, Sanae A Ishijima, Rui Kano

{"title":"In vitro susceptibility testing of essential oils and their main components against antifungal-resistant Malassezia pachydermatis.","authors":"Honoka Nojo, Nobuo Murayama, Sanae A Ishijima, Rui Kano","doi":"10.1292/jvms.24-0342","DOIUrl":"https://doi.org/10.1292/jvms.24-0342","url":null,"abstract":"Canine Malassezia dermatitis (CMD) and otitis externa are generally treated by antifungal drugs. However, azole-resistant strains have been isolated from canine skin and ear canals worldwide. Phytochemicals isolated from essential oils are effective alternatives for inhibiting Malassezia pachydermatis. To evaluate the usefulness of phytochemicals against azole-resistant isolates, we performed in vitro susceptibility testing using the phytochemicals carvacrol, citral, and thymol. Eight antifungal-resistant isolates were obtained from 7 cases of dermatitis and 1 case of otitis externa during 2022 and 2023 from dogs in Tokyo and Kanagawa, Japan. Fungal susceptibility to carvacrol, citral, and thymol was assessed using the modified broth microdilution method. The minimum inhibitory concentrations (MICs) of the phytochemicals in all isolates were as follows: 0.03 to 0.125% for carvacrol; 0.03 to 0.125% for thymol; and 0.03% to 0.125% for citral. Based on these results, carvacrol, citral, and thymol appear to be effective against azole-resistant strains. The phytochemicals appear to be effective for treating antifungal-resistant cases of CMD and otitis externa.","PeriodicalId":49959,"journal":{"name":"Journal of Veterinary Medical Science","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142814755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Disseminated proliferative mesocestoidosis caused by Mesocestoides vogae (Cestoda: Cyclophyllidae) in a French bulldog in Japan.

IF 1.1 4区农林科学

Journal of Veterinary Medical Science Pub Date : 2024-12-06 DOI: 10.1292/jvms.24-0411

Toshihiro Tokiwa, Hisashi Yoshimura, Mami Takase, Eigo Kato, Masateru Morisaki, Tatsushi Morita, Mitsuru Koutaka

引用次数: 0

Distribution of keratin subtypes in the thymus of Japanese black calves during acute thymic involution.

IF 1.1 4区农林科学

Journal of Veterinary Medical Science Pub Date : 2024-12-05 DOI: 10.1292/jvms.24-0413

Shoichi Wakitani, Risako Kawabata, Sora Shirataki, Masahiro Yasuda

引用次数: 0

Administration of 1-kestose to beluga reduces intestinal Turicibacter andcollagenase gene levels, and blood creatinine levels.

IF 1.1 4区农林科学

Journal of Veterinary Medical Science Pub Date : 2024-12-05 DOI: 10.1292/jvms.24-0131

Tadashi Fujii, Takashi Kamio, Yuichiro Akune, Hideaki Takahashi, Nobuhiro Kondo, Kohei Funasaka, Eizaburo Ohno, Yoshiki Hirooka, Takumi Tochio

{"title":"Administration of 1-kestose to beluga reduces intestinal Turicibacter andcollagenase gene levels, and blood creatinine levels.","authors":"Tadashi Fujii, Takashi Kamio, Yuichiro Akune, Hideaki Takahashi, Nobuhiro Kondo, Kohei Funasaka, Eizaburo Ohno, Yoshiki Hirooka, Takumi Tochio","doi":"10.1292/jvms.24-0131","DOIUrl":"https://doi.org/10.1292/jvms.24-0131","url":null,"abstract":"In recent years, an increased emphasis on enhancing the care and health management of captive marine mammals has been observed. Belugas (White Whale, Delphinapterus leucas), belonging to the family Monodontidae, are of considerable importance and often the centerpiece of aquarium collections worldwide. This study aimed to investigate the effects of the administration of prebiotics on the gut microbiota and overall health of the beluga. Prebiotic 1-kestose, a fructooligosaccharide comprising sucrose and fructose, was administered to three belugas, alongside their regular vitamin supplements for a duration of 8 weeks. 16S rRNA gene amplicon sequencing of intestinal DNA revealed that the relative abundance of the genus Turicibacter, a potentially pathogenic bacteria, significantly reduced after 1-kestose administration when compared to that at baseline (P=0.050). In addition, a quantitative PCR analysis revealed that the levels of collagenase gene, a putative virulence factor gene of Turicibacter, significantly reduced after 1-kestose administration (P=0.050). Blood creatinine levels that were initially above the normal value also reduced after 1-kestose administration (P=0.023). Therefore, this study demonstrated the potential of 1-kestose to improve the health and welfare of aquarium belugas.","PeriodicalId":49959,"journal":{"name":"Journal of Veterinary Medical Science","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142781712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case of anaplastic oligodendroglioma in a rabbit (Oryctolagus cuniculus).

IF 1.1 4区农林科学

Journal of Veterinary Medical Science Pub Date : 2024-12-03 DOI: 10.1292/jvms.24-0438

Hisaki Tokuno, Miyuu Tanaka, Takeshi Izawa, Hiroshi Sasai, Mitsuru Kuwamura

引用次数: 0

Profile of cytokine gene expression of the endometrium and its relationship to inflammation and fertility in postpartum dairy cows.

IF 1.1 4区农林科学

Journal of Veterinary Medical Science Pub Date : 2024-12-03 DOI: 10.1292/jvms.24-0177

Kanami Naramoto, Go Kitahara, Sayed Ahmad Nazhat, Masahiro Yasuda, Takeshi Osawa

引用次数: 0

Reduction of urinary felinine in domestic cats with renal diseases leads to decreased catty odor.

IF 1.1 4区农林科学

Journal of Veterinary Medical Science Pub Date : 2024-12-03 DOI: 10.1292/jvms.24-0370

Ayaka Suka, Reiko Uenoyama, Shota Ichizawa, Masaaki Katayama, Masao Miyazaki, Tamako Miyazaki

{"title":"Reduction of urinary felinine in domestic cats with renal diseases leads to decreased catty odor.","authors":"Ayaka Suka, Reiko Uenoyama, Shota Ichizawa, Masaaki Katayama, Masao Miyazaki, Tamako Miyazaki","doi":"10.1292/jvms.24-0370","DOIUrl":"https://doi.org/10.1292/jvms.24-0370","url":null,"abstract":"Cats with progressive renal diseases often exhibit a weakened urinary odor, in contrast to normal cat urine which emits odorants with catty odor, such as 3-mercapto-3-methyl-1-butanol, 3-mercapto-3-methylbutyl formate, 3-methyl-3-methylthio-1-butanol, and 3-methyl-3-(2-methyldisulfanyl)-1-butanol. Felinine, an amino acid, is a precursor of these odorants and metabolized from its precursor, 3-methylbutanol glutathione (MBG), via 3-methylbutanol-cysteinylglycine (MBCG). While previous studies have reported felinine excretion in normal cats, its levels in cats with renal diseases remain unclear. This study investigates the urinary excretion of felinine and its precursors in cats with renal diseases and explores whether changes in these metabolites are linked to reduced volatile felinine derivatives with catty odor. Liquid chromatography/mass spectrometry quantified urinary felinine, MBCG, and MBG in 40 normal cats and 66 cats with renal diseases (classified into mild, moderate, and severe renal diseases), revealing a significant decrease in urinary felinine levels in cats with advanced renal disease, while urinary MBG levels increased. The felinine-to-MBG ratio was significantly lower in cats with severe renal disease compared to normal cats and those with mild renal disease. Gas chromatography/mass spectrometry analysis further showed that the emission of felinine derivatives decreased markedly with renal disease progression. A significant correlation was found between urinary felinine excretion and its major derivative, 3-methyl-3-methylthio-1-butanol. These findings suggest that impaired felinine metabolism, likely due to reduced kidney enzyme activity, contributes to both diminished urinary felinine levels and reduced sulfurous odor in cats with renal diseases.","PeriodicalId":49959,"journal":{"name":"Journal of Veterinary Medical Science","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142781717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

First detection of NADC34-like porcine reproductive and respiratory syndrome virus strains in Japan.

IF 1.1 4区农林科学

Journal of Veterinary Medical Science Pub Date : 2024-12-02 DOI: 10.1292/jvms.24-0451

Yoriko Yonezawa, Osamu Taira, Takashi Omori, Nobuyuki Tsutsumi, Katsuaki Sugiura

引用次数: 0

Prevalence of four infectious diseases (Porcine Circovirus Type 2, Aujeszky's Disease, Porcine Reproductive and Respiratory Syndrome, Mycoplasma hyopneumoniae) in wild boars in South Korea.

IF 1.1 4区农林科学

Journal of Veterinary Medical Science Pub Date : 2024-12-02 DOI: 10.1292/jvms.24-0205

Kidong Son, Rury Lee, Dongbin Lee, Yeonji Kim, Ji-Yun Sung, Hyesung Jeong, Suwoong Lee, Jae-Ku Oem

引用次数: 0