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Prostaglandin F2α exacerbates ovalbumin-induced chronic pneumonia and attenuates depression in mice. 前列腺素F2α可加重卵清蛋白诱导的小鼠慢性肺炎并减轻抑郁。
IF 1.1 4区 农林科学
Journal of Veterinary Medical Science Pub Date : 2025-10-01 Epub Date: 2025-08-05 DOI: 10.1292/jvms.25-0196
Toko Maehara, Atsuki Fujimura, Rin Segawa, Satoshi Inoue, Hiroshi Satoh
{"title":"Prostaglandin F<sub>2α</sub> exacerbates ovalbumin-induced chronic pneumonia and attenuates depression in mice.","authors":"Toko Maehara, Atsuki Fujimura, Rin Segawa, Satoshi Inoue, Hiroshi Satoh","doi":"10.1292/jvms.25-0196","DOIUrl":"10.1292/jvms.25-0196","url":null,"abstract":"<p><p>Prolonged lung inflammation leads to the development of asthma and approximately 27.8% of adult patients with asthma suffer from depression. We examined the effect of the prostaglandin F<sub>2α</sub> (PGF<sub>2α</sub>) receptor (FP receptor) agonist, fluprostenol, on ovalbumin (OVA)-induced asthma and asthma-related depression in mice. Repeated fluprostenol+OVA administration increased OVA-induced inflammatory cell infiltration and mRNA expression of inflammatory mediators in the lung. In contrast, in the tail suspension and forced swim tests, fluprostenol+OVA administration significantly reduced the immobile time compared with saline+OVA-administered mice. Fluprostenol+OVA treatment significantly upregulated serotonin 1A receptor and tryptophan hydroxylase in the hippocampus compared with the expression in saline+OVA mice. These results suggest that PGF receptor (FP receptor) stimulation promotes lung inflammation but attenuates depression, possibly via the serotonin pathway.</p>","PeriodicalId":49959,"journal":{"name":"Journal of Veterinary Medical Science","volume":" ","pages":"1136-1140"},"PeriodicalIF":1.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12508562/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144795931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Malignant peripheral nerve sheath tumor in the vagus nerve causing upper gastrointestinal signs in a dog. 犬迷走神经周围神经鞘恶性肿瘤，引起上消化道症状。
IF 1.1 4区 农林科学
Journal of Veterinary Medical Science Pub Date : 2025-10-01 Epub Date: 2025-08-28 DOI: 10.1292/jvms.25-0152
Fumitaka Shitamori, Taisuke Nakagawa, Naohiro Takahashi, Megumi Sakamoto, Yosuke Takahashi, Kie Yamamoto, James K Chambers, Kazuyuki Uchida, Hirotaka Tomiyasu
{"title":"Malignant peripheral nerve sheath tumor in the vagus nerve causing upper gastrointestinal signs in a dog.","authors":"Fumitaka Shitamori, Taisuke Nakagawa, Naohiro Takahashi, Megumi Sakamoto, Yosuke Takahashi, Kie Yamamoto, James K Chambers, Kazuyuki Uchida, Hirotaka Tomiyasu","doi":"10.1292/jvms.25-0152","DOIUrl":"10.1292/jvms.25-0152","url":null,"abstract":"<p><p>Peripheral nerve sheath tumors (PNSTs) originating from the vagus nerve are rare in dogs. This paper reports a canine case of malignant PNST originating from the vagus nerve, specifically the vagus-sympathetic trunk, which induced notable gagging and chronic vomiting. The clinical signs improved after surgery despite incomplete resection, and the dog achieved an overall survival of at least 514 days. These observations suggest that surgical intervention may be beneficial in dogs with malignant PNSTs originating from the vagus nerve.</p>","PeriodicalId":49959,"journal":{"name":"Journal of Veterinary Medical Science","volume":" ","pages":"1194-1198"},"PeriodicalIF":1.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12508570/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144976700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Concurrent incomplete atrioventricular septal defect and supravalvular mitral stenosis causing heart failure in a 13-year-old cat: a case report. 并发不完全房室间隔缺损和瓣上二尖瓣狭窄引起13岁猫心力衰竭1例报告。
IF 1.1 4区 农林科学
Journal of Veterinary Medical Science Pub Date : 2025-10-01 Epub Date: 2025-09-02 DOI: 10.1292/jvms.25-0292
Kazuki Harada, Chisato Akita, Hinako Harada, Hiroki Kubota, Yuji Sunden
{"title":"Concurrent incomplete atrioventricular septal defect and supravalvular mitral stenosis causing heart failure in a 13-year-old cat: a case report.","authors":"Kazuki Harada, Chisato Akita, Hinako Harada, Hiroki Kubota, Yuji Sunden","doi":"10.1292/jvms.25-0292","DOIUrl":"10.1292/jvms.25-0292","url":null,"abstract":"<p><p>A 13-year-old female Persian cat with a heart murmur presented with dyspnea. Thoracic radiography revealed pleural effusion and dilation of peripheral pulmonary vessels. Echocardiography showed significant enlargement of the right atrium and ventricle and left atrial appendage; an atrial septal defect (ASD) near the atrioventricular valves; and a septum-like structure below the left atrial appendage. Left-to-right shunting through the ASD was noted, with a pulmonary-to-systemic flow ratio of 2.72. The cat was diagnosed with incomplete atrioventricular septal defect (IAVSD) and supravalvular mitral stenosis (SVMS) and subsequently medically managed for 7 months before death. Necropsy confirmed IAVSD with a mitral valve cleft and SVMS. To our knowledge, this is the longest reported survival in a cat with both anomalies.</p>","PeriodicalId":49959,"journal":{"name":"Journal of Veterinary Medical Science","volume":" ","pages":"1199-1203"},"PeriodicalIF":1.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12508600/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144994090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Isolation of vapA-positive Rhodococcus equi from soil and fecal samples in Mongolia. 蒙古国土壤和粪便样品中分离出vapa阳性马红球菌。
IF 1.1 4区 农林科学
Journal of Veterinary Medical Science Pub Date : 2025-10-01 Epub Date: 2025-08-04 DOI: 10.1292/jvms.25-0267
Otgontuya Ganbaatar, Sumiya Ganzorig, Erdene-Ochir Tseren-Ochir, Yasunori Suzuki, Shinji Takai
{"title":"Isolation of vapA-positive Rhodococcus equi from soil and fecal samples in Mongolia.","authors":"Otgontuya Ganbaatar, Sumiya Ganzorig, Erdene-Ochir Tseren-Ochir, Yasunori Suzuki, Shinji Takai","doi":"10.1292/jvms.25-0267","DOIUrl":"10.1292/jvms.25-0267","url":null,"abstract":"<p><p>In 2024, 90 soil samples and 11 fecal samples were collected from nine Mongolian provinces. Using NANAT selective agar, R. equi was successfully isolated from 23 soil samples (25.6%) across five provinces and from three fecal samples (27.3%) collected in two provinces. A total of 122 isolates were identified as R. equi via choE-targeted polymerase chain reaction (PCR) and subsequently screened for virulence-associated genes (vapA, vapB, and vapN) by PCR. Of these, 17 isolates tested positive for the vapA gene, while the remaining 105 isolates were negative for both vapB and vapN. Plasmid profiling of the vapA-positive isolates revealed the presence of an 85-kb type I virulence plasmid, which is common in isolates from Europe and North America. This is the first documented detection of vapA-positive R. equi in Mongolia.</p>","PeriodicalId":49959,"journal":{"name":"Journal of Veterinary Medical Science","volume":" ","pages":"1112-1115"},"PeriodicalIF":1.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12508559/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144776767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Improved method for elimination of bovine viral diarrhea virus from contaminated cell lines using virus inhibitor DB772. 用病毒抑制剂DB772对牛病毒性腹泻病毒进行了改进。
IF 1.1 4区 农林科学
Journal of Veterinary Medical Science Pub Date : 2025-10-01 Epub Date: 2025-08-01 DOI: 10.1292/jvms.25-0109
Asami Nishimori, Shinya Iwasaki, Kiyohiko Andoh, Yuichi Matsuura
{"title":"Improved method for elimination of bovine viral diarrhea virus from contaminated cell lines using virus inhibitor DB772.","authors":"Asami Nishimori, Shinya Iwasaki, Kiyohiko Andoh, Yuichi Matsuura","doi":"10.1292/jvms.25-0109","DOIUrl":"10.1292/jvms.25-0109","url":null,"abstract":"<p><p>Contamination of cell lines with bovine viral diarrhea virus (BVDV) derived from fetal bovine serum (FBS) is a major obstacle in cell biology experiments. Although the selection of BVDV-free FBS and constant viral checking are important to prevent the viral contamination of cells, they have been ineffective in the past contamination of several cell lines available from cell banks. Recently, a novel method to eliminate BVDV from one contaminated cell line, LFBK-α<sub>v</sub>β<sub>6</sub> cells, using BVDV inhibitor DB772 was reported. To confirm the reproducibility and possibility of practical use of this method in other cell lines, we attempted BVDV elimination using DB772 from five contaminated cell lines: BL3.1, EBTr, A26, FLK-BLV, and CC81. Treatment with DB772 significantly decreased viral genome counts in all BVDV-contaminated cells; however, cytotoxicity-like growth suppression was observed, in contrast to previously reported findings. Moreover, continuous cell passages in the presence of DB772, conducted in imitation of a previous study, resulted in the failure of elimination with rebound of viral genomes after several cell passages. Hence, we modified the method to combine limiting dilution of cultured cells with drug treatment and finally succeeded in BVDV elimination in four of the 5 cell lines, except for EBTr cells, which exhibited strong suppression of cell proliferation after DB772 treatment. Taken together, our findings will help to solve the problem of BVDV contamination in cell lines.</p>","PeriodicalId":49959,"journal":{"name":"Journal of Veterinary Medical Science","volume":" ","pages":"1149-1157"},"PeriodicalIF":1.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12508568/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144776766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of a multiplex real-time PCR assay for bovine immunodeficiency virus and bovine leukemia virus and its application to a large-Scale survey in Kyushu, Japan. 牛免疫缺陷病毒和牛白血病病毒多重实时PCR检测方法的建立及其在日本九州大规模调查中的应用。
IF 1.1 4区 农林科学
Journal of Veterinary Medical Science Pub Date : 2025-10-01 Epub Date: 2025-08-19 DOI: 10.1292/jvms.25-0278
Mari Yamamoto, Tomohiro Okagawa, Satoru Konnai, Hirohisa Mekata
{"title":"Development of a multiplex real-time PCR assay for bovine immunodeficiency virus and bovine leukemia virus and its application to a large-Scale survey in Kyushu, Japan.","authors":"Mari Yamamoto, Tomohiro Okagawa, Satoru Konnai, Hirohisa Mekata","doi":"10.1292/jvms.25-0278","DOIUrl":"10.1292/jvms.25-0278","url":null,"abstract":"<p><p>Bovine immunodeficiency virus (BIV) and bovine leukemia virus (BLV) are retroviruses infecting cattle, with BLV being a known cause of enzootic bovine leukosis. In contrast, BIV is considered non-pathogenic and has been less studied, despite its relevance to animal lentiviral evolution. This study aimed to develop and validate a multiplex real-time PCR assay for simultaneous detection of BIV proviral DNA and quantification of BLV proviral load. Novel primers and probes targeting the BIV pol gene were designed. The assay demonstrated a detection limit of 10 copies per reaction with a probability of 83%, comparable to conventional nested PCR. Importantly, the addition of BIV primers and probes did not interfere with the accurate quantification of BLV. Furthermore, BIV detection was unaffected even in samples with high BLV proviral loads, confirming the assay's robustness for simultaneous detection. The validated assay was applied to a molecular epidemiological survey of 6,051 cattle in the Kyushu region of Japan, conducted between 2021 and 2025. No BIV proviral DNA was detected in any sample, indicating a low prevalence of BIV in this population. This multiplex PCR assay provides a sensitive, efficient, and labor-saving tool for integrated surveillance of retroviral infections in cattle. Furthermore, it offers a valuable platform for future studies on the epidemiology and ecological role of BIV in bovine populations.</p>","PeriodicalId":49959,"journal":{"name":"Journal of Veterinary Medical Science","volume":" ","pages":"1164-1169"},"PeriodicalIF":1.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12508560/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144976720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Detection of avian haemosporidian parasite DNA from potential vector arthropods distributed in the endangered bird conservation facility at Sado Island of Japan. 日本佐渡岛濒危鸟类保护设施潜在病媒节肢动物中禽带孢子虫寄生虫DNA的检测。
IF 1.1 4区 农林科学
Journal of Veterinary Medical Science Pub Date : 2025-10-01 Epub Date: 2025-08-25 DOI: 10.1292/jvms.25-0276
Hayato Sugasawa, Saori Yoshioka, Youta Sasaki, Nodoka Sadoshima, Yuki Kaneko, Hideaki Abe, Yusuke Echigoya, Madoka Ichikawa-Seki, Yukita Sato
{"title":"Detection of avian haemosporidian parasite DNA from potential vector arthropods distributed in the endangered bird conservation facility at Sado Island of Japan.","authors":"Hayato Sugasawa, Saori Yoshioka, Youta Sasaki, Nodoka Sadoshima, Yuki Kaneko, Hideaki Abe, Yusuke Echigoya, Madoka Ichikawa-Seki, Yukita Sato","doi":"10.1292/jvms.25-0276","DOIUrl":"10.1292/jvms.25-0276","url":null,"abstract":"<p><p>Avian haemosporidian parasites cause high pathogenicity and lethal infections to non-native or introduced birds. Crested ibis (Nipponia nippon) resulted extinct in Japan but the Chinese population was introduced to Japan. Understanding the prevalence of pathogens of rare species is important for their conservation but it is often difficult to investigate them due to the limitation of the access. We collected parasite vector insects in 2022 and 2023 around the crested ibis conservation center in Sado Island. Among collected 214 mosquitoes and 585 biting midges, three Haemoproteus genetic lineages were detected from four Culicoides biting midges for the first time. Our findings suggested that the transmission of Haemoproteus could occur between biting midges and wild birds including crested ibis.</p>","PeriodicalId":49959,"journal":{"name":"Journal of Veterinary Medical Science","volume":" ","pages":"1170-1175"},"PeriodicalIF":1.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12508571/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144976669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Solitary phospholipase C β2-positive cells in the vomeronasal organs of Korean roe deer (Capreolus pygargus). 韩国鹿犁鼻器官中孤立的磷脂酶C β2阳性细胞。
IF 1.1 4区 农林科学
Journal of Veterinary Medical Science Pub Date : 2025-10-01 Epub Date: 2025-09-03 DOI: 10.1292/jvms.24-0534
Jeongtae Kim, Kyungsook Jung, Irene Ortiz-Leal, Pablo Sanchez-Quinteiro, Meejung Ahn, Taekyun Shin
{"title":"Solitary phospholipase C β2-positive cells in the vomeronasal organs of Korean roe deer (Capreolus pygargus).","authors":"Jeongtae Kim, Kyungsook Jung, Irene Ortiz-Leal, Pablo Sanchez-Quinteiro, Meejung Ahn, Taekyun Shin","doi":"10.1292/jvms.24-0534","DOIUrl":"10.1292/jvms.24-0534","url":null,"abstract":"<p><p>Little is known about the vomeronasal organ (VNO), which is associated with social behaviors through pheromone detection in mammals, particularly ungulates. We investigated the distribution of phospholipase C beta 2 (PLCβ2), a marker of solitary chemosensory cells (SCCs), in the VNO of the Korean roe deer (Capreolus pygargus). PLCβ2-positive cells were detected in both the sensory and non-sensory epithelium of the VNO, and resembled the bipolar cells. PLCβ2-positive cells colocalized with choline acetyltransferase, and Lens culinaris agglutinin. Furthermore, PLCβ2-positive cells were surrounded with trigeminal nerve fibers with calcitonin gene-related peptide (CGRP)-positive immunoreaction. The results indicate that the VNO of the Korean roe deer exhibits a distinct distribution of SCCs, which may be involved in detecting risk factors such as harmful substances.</p>","PeriodicalId":49959,"journal":{"name":"Journal of Veterinary Medical Science","volume":" ","pages":"1176-1179"},"PeriodicalIF":1.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12508590/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144994268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reverse genetics study disclaims the role of African swine fever virus gene I196L in the pathogenesis in pigs. 反向遗传学研究否定了非洲猪瘟病毒基因I196L在猪发病中的作用。
IF 1.1 4区 农林科学
Journal of Veterinary Medical Science Pub Date : 2025-10-01 DOI: 10.1292/jvms.25-0245
Ayumi Yoshimoto, Tomoya Kitamura, Mitsutaka Ikezawa, Takehiro Kokuho, Kentaro Masujin
{"title":"Reverse genetics study disclaims the role of African swine fever virus gene I196L in the pathogenesis in pigs.","authors":"Ayumi Yoshimoto, Tomoya Kitamura, Mitsutaka Ikezawa, Takehiro Kokuho, Kentaro Masujin","doi":"10.1292/jvms.25-0245","DOIUrl":"https://doi.org/10.1292/jvms.25-0245","url":null,"abstract":"<p><p>The African swine fever virus (ASFV) genome encodes over 170 genes, but only a small number have been investigated for their roles in disease progression. Understanding the genetic and biological functions of these lesser-known genes accelerates the specification of open reading frames involved in pathogenesis in host animals and the development of ASF vaccines. In this study, we deleted the I196L gene of the highly virulent parental strain AQS-C-1-22 to generate the ASFV mutant AQSΔI196L. In vitro, AQSΔI196L replicated similarly to the parental virus in immortalized porcine kidney macrophage cultures. Pigs intramuscularly inoculated with 10² median tissue culture infectious dose (TCID<sub>50</sub>) AQSΔI196L developed similar clinical signs and consequences (e.g., high fever, anorexia, and death) as infections with the parental strain. However, viremia in AQSΔI196L-inoculated pigs was slightly reduced compared with pigs inoculated with the parental strain. These findings suggest that the I196L gene does not significantly affect the pathogenicity of the virus in pigs.</p>","PeriodicalId":49959,"journal":{"name":"Journal of Veterinary Medical Science","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145208247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pure red cell aplasia and amegakaryocytic thrombocytopenia in a cat. 猫的纯红细胞发育不全和无核细胞血小板减少症。
IF 1.1 4区 农林科学
Journal of Veterinary Medical Science Pub Date : 2025-10-01 Epub Date: 2025-08-04 DOI: 10.1292/jvms.24-0514
Akihisa Suwa
{"title":"Pure red cell aplasia and amegakaryocytic thrombocytopenia in a cat.","authors":"Akihisa Suwa","doi":"10.1292/jvms.24-0514","DOIUrl":"10.1292/jvms.24-0514","url":null,"abstract":"<p><p>A 14-year-old, castrated male mixed-breed cat presented with weight loss and rhinitis for several months and was referred due to anemia and thrombocytopenia. A complete blood cell count (CBC) revealed severe non-regenerative anemia (hematocrit (HCT), 9.7%) and thrombocytopenia (0 /μL). Serology was positive for feline immunodeficiency virus (FIV) antibodies. Bone marrow aspiration showed moderate myeloid hyperplasia, severe erythroid hypoplasia, and megakaryocytic hypoplasia. The cat was diagnosed with pure red cell aplasia (PRCA) and amegakaryocytic thrombocytopenia (AMT) and treated with corticosteroids, leading to recovery. On day 242, bone marrow aspirates showed erythroid and megakaryocytic cell production. By day 600, both diseases had not recurred without medication. This is the documented case of concurrent PRCA and AMT in an FIV-infected cat.</p>","PeriodicalId":49959,"journal":{"name":"Journal of Veterinary Medical Science","volume":" ","pages":"1116-1121"},"PeriodicalIF":1.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12508578/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144776768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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