Journal of Veterinary Medical Science最新文献_第4页

Clinical evaluation of plasma D-dimer concentrations as a marker for thromboembolism in cattle with inflammation. 血浆d -二聚体浓度作为炎症牛血栓栓塞标志物的临床评价。

IF 1.1 4区农林科学

Journal of Veterinary Medical Science Pub Date : 2026-10-03 Epub Date: 2026-07-20 DOI: 10.1292/jvms.26-0230

Saki Ohkubo, Masaki Maezawa, Ken-Ichi Watanabe, Yoshiyasu Kobayashi, Hisashi Inokuma

引用次数: 0

A case of feline aspergillosis with central nervous system involvement: clinical utility of cerebrospinal fluid PCR testing. 猫曲霉病累及中枢神经系统一例：脑脊液PCR检测的临床应用。

IF 1.1 4区农林科学

Journal of Veterinary Medical Science Pub Date : 2026-10-03 Epub Date: 2026-08-10 DOI: 10.1292/jvms.26-0216

Takamasa Aoyama, Mako Sonoda, Eiichi Kanai, Naoyuki Aihara, Hinako Suzuki, Takuma Shibuya, Takayuki Mineshige, Yuichiro Kanesashi, Hidetaka Nishida

引用次数: 0

Three consecutive cases of rhinocerebral mucormycosis in calves caused by Lichtheimia ramosa infection on a beef cattle farm. 某肉牛养殖场致犊牛鼻脑毛霉病连续3例。

IF 1.1 4区农林科学

Journal of Veterinary Medical Science Pub Date : 2026-10-03 Epub Date: 2026-08-13 DOI: 10.1292/jvms.26-0147

Chisato Kazama, Chieko Kato, Kyoko Kawauchi, Mitsuru Ito, Yasuko Hanafusa, Osamu Mikami

引用次数: 0

Sedative effects of administration through the nares of dexmedetomidine, midazolam, and butorphanol in cockatiels (Nymphicus hollandicus): a preliminary crossover study. 右美托咪定、咪达唑仑和丁托啡诺经鼻腔给药对荷兰凤尾鹦鹉的镇静作用：初步交叉研究。

IF 1.1 4区农林科学

Journal of Veterinary Medical Science Pub Date : 2026-10-03 Epub Date: 2026-07-30 DOI: 10.1292/jvms.26-0111

Sakura Isayama, Mizuki Tanahashi, Seiko Doi, Hitomi Fuchigami, Yukiko Sassa-O'Brien, Satoshi Takashima, Sanae Shibata

{"title":"Sedative effects of administration through the nares of dexmedetomidine, midazolam, and butorphanol in cockatiels (Nymphicus hollandicus): a preliminary crossover study.","authors":"Sakura Isayama, Mizuki Tanahashi, Seiko Doi, Hitomi Fuchigami, Yukiko Sassa-O'Brien, Satoshi Takashima, Sanae Shibata","doi":"10.1292/jvms.26-0111","DOIUrl":"10.1292/jvms.26-0111","url":null,"abstract":"This study evaluated the efficacy and safety of a sedation protocol through the nares combining dexmedetomidine with midazolam and butorphanol in cockatiels. Six adults were enrolled in a randomized, 4 treatment, 4 period crossover trial comparing a control regimen (midazolam 3 mg/kg and butorphanol 3 mg/kg) with three combinations including dexmedetomidine at 0.04, 0.06, or 0.08 mg/kg, administered through the nares. The volume of all treatments was standardized to the volume of the highest dose of dexmedetomidine administered (2 mL/kg) with sterile saline solution. Sedation scores, respiratory rate, heart rate, and cloacal temperature were recorded for 10 min after drug administration and during 15 min of manual restraint, followed by flumazenil and atipamezole via the nares for reversal. All birds completed all treatments; mild sneezing occurred but no clinically relevant respiratory complications were observed. Medium and high dose dexmedetomidine produced higher sedation scores and lower respiratory rate, heart rate, and body temperature during restraint than the control regimen, whereas the control group showed increased respiratory rate, suggesting insufficient suppression of restraint induced stress. In all groups, sedation and physiological variables returned to near baseline values within 15 min after reversal, and no serious adverse events occurred. These findings indicate that administration through the nares dexmedetomidine at 0.06 or 0.08 mg/kg combined with midazolam and butorphanol provides deeper, more stable, and reversible sedation and improved control of stress responses in cockatiels and may represent a clinically useful protocol in this species.","PeriodicalId":49959,"journal":{"name":"Journal of Veterinary Medical Science","volume":" ","pages":"1523-1530"},"PeriodicalIF":1.1,"publicationDate":"2026-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148622414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Marimastat attenuates local tissue damage induced by Indonesian Trimeresurus insularis and Calloselasma rhodostoma venoms in a mouse skin model. 海绵体可减轻印度尼西亚岛Trimeresurus insularis和Calloselasma rhodostoma毒液对小鼠皮肤模型的局部组织损伤。

IF 1.1 4区农林科学

Journal of Veterinary Medical Science Pub Date : 2026-10-03 Epub Date: 2026-08-17 DOI: 10.1292/jvms.26-0256

Fajar Sofyantoro, Benadya Aprilia Susanto, Fitriana Damayanti, Ghea Navali Wihatma, Muhamad Rusdi Ahmad Rusmili, Muhammad Kadzim Al Habsyi, Mutiara Puri Pradani, Anindya Sisilia Syarif, Riska Nur Aisiyah, Alda Zaenida Nurul Raizma, Muhammad Ahyf Mutawakkil, Imran Sadewo, Ardaning Nuriliani, Tri Rini Nuringtyas, Donan Satria Yudha, Slamet Raharjo, Yekti Asih Purwestri

{"title":"Marimastat attenuates local tissue damage induced by Indonesian Trimeresurus insularis and Calloselasma rhodostoma venoms in a mouse skin model.","authors":"Fajar Sofyantoro, Benadya Aprilia Susanto, Fitriana Damayanti, Ghea Navali Wihatma, Muhamad Rusdi Ahmad Rusmili, Muhammad Kadzim Al Habsyi, Mutiara Puri Pradani, Anindya Sisilia Syarif, Riska Nur Aisiyah, Alda Zaenida Nurul Raizma, Muhammad Ahyf Mutawakkil, Imran Sadewo, Ardaning Nuriliani, Tri Rini Nuringtyas, Donan Satria Yudha, Slamet Raharjo, Yekti Asih Purwestri","doi":"10.1292/jvms.26-0256","DOIUrl":"10.1292/jvms.26-0256","url":null,"abstract":"Snakebite-induced local tissue damage remains a challenge in snakebite envenoming management because venom toxins rapidly disrupt vascular and extracellular matrix integrity at the bite site. This study evaluated the inhibitory effect of marimastat, an inhibitor of zinc-dependent metalloproteinases, against local tissue damage induced by Indonesian Trimeresurus insularis and Calloselasma rhodostoma venoms in a mouse skin model. The minimum hemorrhagic dose (MHD) of C. rhodostoma venom was determined in BALB/c mice and estimated to be 7.07 µg, while the MHD of T. insularis was adopted from a previous study. Mice received intradermal injections of venom at 2× MHD, either alone or pre-incubated with marimastat at venom:marimastat ratios of 1:1, 1:5, and 1:10 based on MHD equivalents. Macroscopic hemorrhage and histopathological changes, including erythrocyte extravasation, inflammatory cell infiltration, and collagen degradation, were assessed three hours after injection. Both venoms induced marked hemorrhagic lesions and tissue damage. Marimastat reduced venom-induced hemorrhage in both models, with near-complete inhibition in the T. insularis 1:10 group and complete inhibition in the C. rhodostoma 1:10 group. Marimastat also decreased erythrocyte extravasation, inflammatory infiltration, and collagen degradation, indicating preservation of microvascular and dermal matrix integrity. These findings support the central role of snake venom metalloproteinases in local viperid tissue damage and highlight marimastat as a promising adjunctive treatment for reducing venom-induced skin injury.","PeriodicalId":49959,"journal":{"name":"Journal of Veterinary Medical Science","volume":" ","pages":"1625-1635"},"PeriodicalIF":1.1,"publicationDate":"2026-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148763710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antemortem magnetic resonance imaging examination of an intracardiac bony mass in a cynomolgus monkey (Macaca fascicularis). 食蟹猴（Macaca Macaca fascularis）心脏内骨团的死前磁共振成像检查。

IF 1.1 4区农林科学

Journal of Veterinary Medical Science Pub Date : 2026-10-03 Epub Date: 2026-08-17 DOI: 10.1292/jvms.26-0046

Yasuyo Ito Fujishiro, Shunya Nakayama, Ibuki Yoneda, Yuki Mega, Tadashi Sankai, Yasuhiro Yasutomi, Naohide Ageyama, Hiroshi Koie

引用次数: 0

Extended-spectrum beta-lactamase-producing Escherichia coli and methicillin-resistant staphylococci originating from dog and cat urine in Japan, 2017-2024: annual proportions and prefecture-level distributions of submitted isolates. 2017-2024年日本犬猫尿产β -内酰胺酶广谱大肠杆菌和耐甲氧西林葡萄球菌：提交分离株的年度比例和地级市分布

IF 1.1 4区农林科学

Journal of Veterinary Medical Science Pub Date : 2026-10-02 DOI: 10.1292/jvms.25-0357

Yuzo Tsuyuki, Kae Torii, Kakeru Izumi, Takashi Takahashi

引用次数: 0

Morphological and immunohistochemical analysis of unilateral testicular hypoplasia in an XY calf: correlation with the timing of bovine hypospadias. XY型小牛单侧睾丸发育不全的形态学和免疫组织化学分析：与牛尿道下裂发生时间的相关性。

IF 1.1 4区农林科学

Journal of Veterinary Medical Science Pub Date : 2026-10-01 DOI: 10.1292/jvms.26-0245

Tatsuki Kajimoto, Keiko Sakai, Chie Kuroki, Kumi Kobayashi, Yoshiakira Kanai, Ayaka Yanagida, Ryuji Hiramatsu

{"title":"Morphological and immunohistochemical analysis of unilateral testicular hypoplasia in an XY calf: correlation with the timing of bovine hypospadias.","authors":"Tatsuki Kajimoto, Keiko Sakai, Chie Kuroki, Kumi Kobayashi, Yoshiakira Kanai, Ayaka Yanagida, Ryuji Hiramatsu","doi":"10.1292/jvms.26-0245","DOIUrl":"https://doi.org/10.1292/jvms.26-0245","url":null,"abstract":"Hypospadias is a common disorder of sex development (DSD), resulting from the impaired formation of the penile urethra. In mammals, penile urethral development depends on androgens secreted during a limited time window immediately after the onset of testis development. In this study, we performed morphological and immunohistochemical analyses of a 15-day-old genetically XY Holstein calf with perineal hypospadias to characterize a unique phenotype providing critical insights into its pathogenic mechanisms. Although the penis and prostate were grossly developed, the penile urethra was not formed. Furthermore, the right testis presented as a streak gonad attached to the dorsal abdominal wall and was covered by a fibrous membrane. Extensive fatty infiltration and a lack of interstitial Leydig cells were observed throughout the testis; however, a few testicular cords containing GATA4/SOX9-positive Sertoli cells and VASA-positive germ cells were identified. In contrast, the left testis was morphologically normal, but exhibited increased expression of the androgen-biosynthetic enzyme P450C17, suggesting compensatory up-regulation of androgen production. These findings suggest that a transient androgen deficiency, caused by developmental arrest of the right testis after testicular cord formation, led to the failure of penile urethral formation. This case provides clinical evidence that the precise timing of unilateral testicular impairment is a critical determinant of the hypospadias phenotype in cattle.","PeriodicalId":49959,"journal":{"name":"Journal of Veterinary Medical Science","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149117663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Infectious foot-and-mouth disease virus was isolated from meat product illegally brought into Japan and confiscated during quarantine inspection. 从非法进入日本的肉制品中分离出传染性口蹄疫病毒，并在检疫过程中被没收。

IF 1.1 4区农林科学

Journal of Veterinary Medical Science Pub Date : 2026-10-01 DOI: 10.1292/jvms.26-0359

Rie Kawaguchi, Nene Odawara, Tatsuya Nishi, Katsuhiko Fukai, Megumi Kusakari, Masahiro Asaoka, Kazuki Morioka

{"title":"Infectious foot-and-mouth disease virus was isolated from meat product illegally brought into Japan and confiscated during quarantine inspection.","authors":"Rie Kawaguchi, Nene Odawara, Tatsuya Nishi, Katsuhiko Fukai, Megumi Kusakari, Masahiro Asaoka, Kazuki Morioka","doi":"10.1292/jvms.26-0359","DOIUrl":"https://doi.org/10.1292/jvms.26-0359","url":null,"abstract":"In recent years, the emergence of foot-and-mouth disease virus (FMDV) in previously unaffected regions has become a serious concern. Although the routes of incursion remain unclear, transportation of contaminated products is a major risk factor. Here, we report the first isolation of infectious FMDV from illegally brought animal product confiscated by the Animal Quarantine Service of Japan. Among the animal products prohibited from being imported into Japan, the FMDV gene was detected in two types of meat products, goat meat and sausages, which were confiscated from passenger luggage and international parcel from China, respectively. Infectious FMDV was isolated from only one of the products, epithelial tissues of goat hoof, despite the absence of apparent vesicular lesions. The isolate belonged to the Ind-2001e lineage within the ME-SA topotype of serotype O (O/ME-SA), which has spread widely across Central, Southeast, and East Asia. Whole-genome sequencing demonstrated close genetic relationships with isolates from Myanmar and Indonesia. In the other product, the sausages, FMDV gene belonging to the O/ME-SA/PanAsia lineage was detected, which has not been officially reported since 2023. Although the details of the materials were unclear, this detection may suggest that a greater number and variety of viruses are circulating silently in the field. These results provide evidence for cryptic yet critical FMDV transboundary movements and animal products without gross vesicular lesions can serve as routes for FMDV transmission. This highlights the crucial role of animal quarantine measures in preventing FMDV incursion.","PeriodicalId":49959,"journal":{"name":"Journal of Veterinary Medical Science","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149117650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Age distribution and regression-associated immunophenotypic features in canine cutaneous histiocytoma. 犬皮肤组织细胞瘤的年龄分布和退行性免疫表型特征。

IF 1.1 4区农林科学

Journal of Veterinary Medical Science Pub Date : 2026-10-01 DOI: 10.1292/jvms.26-0189

Ya-Mei Chen, Zong-Wei Liao, Ching-Liang Kuo, Chien-Chun Kuo, Wei-Hsiang Huang

{"title":"Age distribution and regression-associated immunophenotypic features in canine cutaneous histiocytoma.","authors":"Ya-Mei Chen, Zong-Wei Liao, Ching-Liang Kuo, Chien-Chun Kuo, Wei-Hsiang Huang","doi":"10.1292/jvms.26-0189","DOIUrl":"https://doi.org/10.1292/jvms.26-0189","url":null,"abstract":"Canine cutaneous histiocytoma (CCH) is a benign tumor characterized by spontaneous immune-mediated regression. Although common in young dogs, it also occurs in older animals. This retrospective study evaluated histologic and immunohistochemical features of CCH across age groups, focusing on mitotic count, lymphocytic infiltration grade, major histocompatibility complex II (MHC-II) expression score and pattern, and CD206 expression. Cases were divided using an a priori 4-year cutoff based on reported age distributions. Immunohistochemistry was performed for CD3, MHC-II, and CD206, with MHC-II expression categorized by score and pattern (membranous versus cytoplasmic). Thirty-eight cases were included, and the age range was 0.75-14 years (median, 7 years). MHC-II score differed significantly between age groups (P=0.0118), whereas mitotic count, lymphocytic infiltration grade, CD206 score, and MHC-II pattern did not. Age showed a weak negative correlation with MHC-II score (r=-0.3299, P=0.0431). However, multivariable logistic regression demonstrated that age was not independently associated with the membranous MHC-II pattern after adjustment for lymphocytic infiltration grade (OR=1.20, 95% CI 0.99-1.50). In contrast, higher lymphocytic infiltration was associated with membranous MHC-II expression (OR=9.87, 95% CI 1.96-77.54). These findings suggest that, in this cohort, regression-associated MHC-II localization was more closely related to lymphocytic infiltration grade than to age. In conclusion, CCH in older dogs showed largely comparable histologic and immunophenotypic features to those in younger dogs, although age-related differences in MHC-II expression score should be interpreted cautiously.","PeriodicalId":49959,"journal":{"name":"Journal of Veterinary Medical Science","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149117630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0