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Identification of signaling pathways induced by porcine parvovirus in porcine kidney-15 cells based on weighted correlation network analysis. 基于加权相关网络分析鉴定猪副猪嗜血杆菌在猪肾-15细胞中诱导的信号通路
IF 1.1 4区 农林科学
Journal of Veterinary Medical Science Pub Date : 2024-12-01 Epub Date: 2024-10-16 DOI: 10.1292/jvms.24-0082
Tingting Lu, Xia Ma, Xinghui Song, Li Zhao
{"title":"Identification of signaling pathways induced by porcine parvovirus in porcine kidney-15 cells based on weighted correlation network analysis.","authors":"Tingting Lu, Xia Ma, Xinghui Song, Li Zhao","doi":"10.1292/jvms.24-0082","DOIUrl":"10.1292/jvms.24-0082","url":null,"abstract":"<p><p>Porcine parvovirus (PPV) is an important trigger of reproductive issues in pigs. Infection of the porcine kidney-15 (PK-15) cells with PPV induces cell death and inflammation. To explore the impact of PPV infection on gene expression in PK-15 cells and to identify the associated signaling pathways, we performed weighted correlation network analysis (WGCNA) on both PPV-infected and uninfected cells. We identified the blue and brown modules, with the blue module demonstrating decreased gene expression and the brown module showing increased gene expression at 48 hr post-PPV induction. Gene Ontology (GO) analysis revealed that genes in the blue module were predominantly associated with cellular components, while those in the brown module were enriched in biological processes, including the immunological response to PPV infection. The Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis of the modules indicated that the \"Cytokine-cytokine receptor interaction\" was linked to PPV. Furthermore, we screened 124 target genes involved in more than 100 pathways that interact with C-X-C motif chemokine ligand 8 (CXCL8), which plays an essential role in regulating numerous biological processes. The signaling pathways we identified facilitate a comprehensive examination of the mechanisms of interactions initiated by PPV infection.</p>","PeriodicalId":49959,"journal":{"name":"Journal of Veterinary Medical Science","volume":" ","pages":"1265-1272"},"PeriodicalIF":1.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11612249/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142479250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antimicrobial resistance of Salmonella isolates from cattle and horses with salmonellosis in Hokkaido, Japan. 日本北海道牛马沙门氏菌病沙门氏菌分离物的抗菌药耐药性。
IF 1.1 4区 农林科学
Journal of Veterinary Medical Science Pub Date : 2024-12-01 Epub Date: 2024-10-16 DOI: 10.1292/jvms.24-0236
Yoshimasa Sasaki, Shotaro Suzuki, Nobuyuki Kusaba, Nahid Rahman, Chihiro Aikawa, Masashi Okamura
{"title":"Antimicrobial resistance of Salmonella isolates from cattle and horses with salmonellosis in Hokkaido, Japan.","authors":"Yoshimasa Sasaki, Shotaro Suzuki, Nobuyuki Kusaba, Nahid Rahman, Chihiro Aikawa, Masashi Okamura","doi":"10.1292/jvms.24-0236","DOIUrl":"10.1292/jvms.24-0236","url":null,"abstract":"<p><p>In recent years, reported cases of salmonellosis in cattle and horses in Hokkaido, Japan, have increased. To optimize antimicrobial therapy, we assessed the antimicrobial susceptibility of Salmonella isolates from these animals. Among 112 bovine isolates, high resistance rates were observed for streptomycin (92.0%), ampicillin (88.4%), and tetracycline (79.5%), while resistance rates for kanamycin (8.9%), ciprofloxacin (1.8%), gentamicin (0.0%), and colistin (0.0%) were low. Additionally, 18.8% of the bovine isolates were resistant to cefotaxime, and all of these cefotaxime-resistant isolates carried bla<sub>CMY-2</sub>. Among 16 equine isolates, no resistance was observed to cefazolin, cefotaxime, gentamicin, nalidixic acid, ciprofloxacin, colistin, or chloramphenicol. Gentamicin and kanamycin are recommended as the first-line treatment for salmonellosis in cattle, with fluoroquinolones as the second choice.</p>","PeriodicalId":49959,"journal":{"name":"Journal of Veterinary Medical Science","volume":" ","pages":"1227-1232"},"PeriodicalIF":1.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11612240/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142479248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Histopathological and immunohistochemical examination of the brains of rabid dogs in the Philippines. 菲律宾狂犬脑部的组织病理学和免疫组化检查。
IF 1.1 4区 农林科学
Journal of Veterinary Medical Science Pub Date : 2024-12-01 Epub Date: 2024-10-08 DOI: 10.1292/jvms.24-0249
Boonkanit Markbordee, Alpha Grace B Cabic, Nuttipa Iamohbhars, Nozomi Shiwa-Sudo, Kazunori Kimitsuki, Mark Joseph M Espino, Leilanie B Nacion, Daria Llenarresas Manalo, Satoshi Inoue, Chun-Ho Park
{"title":"Histopathological and immunohistochemical examination of the brains of rabid dogs in the Philippines.","authors":"Boonkanit Markbordee, Alpha Grace B Cabic, Nuttipa Iamohbhars, Nozomi Shiwa-Sudo, Kazunori Kimitsuki, Mark Joseph M Espino, Leilanie B Nacion, Daria Llenarresas Manalo, Satoshi Inoue, Chun-Ho Park","doi":"10.1292/jvms.24-0249","DOIUrl":"10.1292/jvms.24-0249","url":null,"abstract":"<p><p>Dogs are the primary transmitters of the rabies virus in the Philippines; however, to the best of our knowledge, no published studies have examined its detailed neuropathology. The present study analyzed the neuropathology in the cerebrum, hippocampus, thalamus, and brainstem of 70 rabid dogs with confirmed rabies infection in the Philippines. Histopathologically, inclusion bodies (Negri bodies) were detected in the hippocampus (87.14%), cerebrum (70%), and thalamus (2.86%) of the dogs. The inclusion bodies in the cytoplasm of the hippocampal and cerebral cortical pyramidal cells were large and round to oval in shape. Whereas the inclusion bodies in the neurons of the thalamus and brainstem were small, fine, and granular. In contrast to the high prevalence of inclusion bodies in the hippocampus and cerebrum, perivascular cuffing and glial nodules were more prominent in the thalamus and brainstem. Immunohistochemically using the anti-phosphoprotein (anti-P), the sensitivity of viral antigen detection was 100% in the hippocampus, thalamus, and brainstem and 97.14% in the cerebrum. Our findings confirmed that observing the inclusion bodies in the hippocampus and cerebral cortex by histopathology could facilitate rabies diagnosis in the dogs in the Philippines, and furthermore, using immunohistochemistry on the brainstem could also be useful to detect rabies virus antigens with high sensitivity.</p>","PeriodicalId":49959,"journal":{"name":"Journal of Veterinary Medical Science","volume":" ","pages":"1243-1251"},"PeriodicalIF":1.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11612245/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142394807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The utility of Ocimum basilicum, Perilla frutescens, and Mentha spicata essential oils to control larvae and engorged female Rhipicephalus sanguineus ticks on dogs. 罗勒草（Ocimum basilicum）、紫苏（Perilla frutescens）和薄荷（Mentha spicata）精油在控制狗身上的幼虫和充血的雌性 Rhipicephalus sanguineus 蜱虫方面的效用。
IF 1.1 4区 农林科学
Journal of Veterinary Medical Science Pub Date : 2024-12-01 Epub Date: 2024-10-08 DOI: 10.1292/jvms.24-0288
Nguyen Van Vui, Nguyen Thuy Linh, Nguyen Thi Kim Quyen, Kim Nang, Ho Van Viet
{"title":"The utility of Ocimum basilicum, Perilla frutescens, and Mentha spicata essential oils to control larvae and engorged female Rhipicephalus sanguineus ticks on dogs.","authors":"Nguyen Van Vui, Nguyen Thuy Linh, Nguyen Thi Kim Quyen, Kim Nang, Ho Van Viet","doi":"10.1292/jvms.24-0288","DOIUrl":"10.1292/jvms.24-0288","url":null,"abstract":"<p><p>The study evaluated the larvicidal and reproductive effects of essential oils from Ocimum basilicum, Perilla frutescens, and Mentha spicata on engorged female Rhipicephalus sanguineus ticks. Adult immersion and larval packet assays were used to evaluate their larvicidal efficacy and impact on tick reproductive abilities. For tick larvae, Perilla frutescens essential oil had the highest 50% lethal dose of 1.89 mg/mL, followed by Ocimum basilicum at 1.58 mg/mL, and Mentha spicata at 1.07 mg/mL. Regarding adult ticks, although Mentha spicata essential oil had the lowest reduced oviposition value, it showed the highest product efficacy. Overall, all tested essential oils effectively killed tick larvae and influenced the reproductive capacity of engorged female ticks, with Mentha spicata essential oil being the most potent.</p>","PeriodicalId":49959,"journal":{"name":"Journal of Veterinary Medical Science","volume":" ","pages":"1237-1242"},"PeriodicalIF":1.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11612241/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142394809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Situational syncope caused by vomiting in a cat. 猫咪呕吐引起的情况性晕厥。
IF 1.1 4区 农林科学
Journal of Veterinary Medical Science Pub Date : 2024-12-01 Epub Date: 2024-10-17 DOI: 10.1292/jvms.24-0058
Daiki Hirao, Ryohei Kato, Keisuke Sakaguchi, Takahiro Ohmori, Shohei Morita, Hiroshi Hasegawa, Aritada Yoshimura, Ryuji Fukushima
{"title":"Situational syncope caused by vomiting in a cat.","authors":"Daiki Hirao, Ryohei Kato, Keisuke Sakaguchi, Takahiro Ohmori, Shohei Morita, Hiroshi Hasegawa, Aritada Yoshimura, Ryuji Fukushima","doi":"10.1292/jvms.24-0058","DOIUrl":"10.1292/jvms.24-0058","url":null,"abstract":"<p><p>A 14-year-old spayed female mixed-breed cat weighing 3.4 kg was admitted to the Tokyo University of Agriculture and Technology Animal Medical Center for syncope after vomiting. Echocardiography, electrocardiography, and thoracic radiography revealed no abnormalities. Holter electrocardiography showed a paroxysmal high-grade atrioventricular block coinciding with the vomiting. Based on these findings, the cat was diagnosed as having situational syncope with paroxysmal high-grade atrioventricular block triggered by vomiting, which improved with antiemetic treatment alone. The cat subsequently died of chronic kidney disease approximately 3 years and 4 months after the initial diagnosis. This is the first reported case of situational syncope triggered by vomiting in a cat.</p>","PeriodicalId":49959,"journal":{"name":"Journal of Veterinary Medical Science","volume":" ","pages":"1233-1236"},"PeriodicalIF":1.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11612246/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142479253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A clinical case of enzootic bovine leukosis in a Holstein cow with minor clonality of B-cell in the peripheral blood. 一例荷斯坦奶牛感染牛白血病的临床病例，其外周血中的 B 细胞有轻微克隆现象。
IF 1.1 4区 农林科学
Journal of Veterinary Medical Science Pub Date : 2024-12-01 Epub Date: 2024-11-04 DOI: 10.1292/jvms.24-0298
Masaki Maezawa, Misato Kikuzawa, Asahi Takiguchi, Ryo Saito, James K Chambers, Kazuyuki Uchida, Hisashi Inokuma
{"title":"A clinical case of enzootic bovine leukosis in a Holstein cow with minor clonality of B-cell in the peripheral blood.","authors":"Masaki Maezawa, Misato Kikuzawa, Asahi Takiguchi, Ryo Saito, James K Chambers, Kazuyuki Uchida, Hisashi Inokuma","doi":"10.1292/jvms.24-0298","DOIUrl":"10.1292/jvms.24-0298","url":null,"abstract":"<p><p>A 4-year 9-month-old Holstein-Friesian dairy cow presented with anorexia. On physical examination, swelling of superficial lymph nodes, pelvic masses, and prolonged urination posture after urinating a small amount were noted. Hematological examination revealed no lymphocytosis. The bovine leukemia virus proviral load was relatively high. At necropsy, enlarged lymph nodes, a large mass in the pelvic cavity, and mass lesions in several organs were observed. Histopathological examination revealed the proliferation of neoplastic lymphocytes, which were immune-positive for CD79α and negative for CD3. B-cell clonality test indicated the presence of monoclonality in the urine, masses, and lymph nodes and minor clonality in the peripheral blood. These findings led to a diagnosis of EBL with minor clonality of B-cell in the peripheral blood.</p>","PeriodicalId":49959,"journal":{"name":"Journal of Veterinary Medical Science","volume":" ","pages":"1289-1293"},"PeriodicalIF":1.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11612243/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142575201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
End-tidal concentration of sevoflurane for optimal surgical conditions in pregnant sheep: a pragmatic approach to a retrospective observational study. 七氟醚潮气末浓度为妊娠羊提供最佳手术条件：一项回顾性观察研究的实用方法。
IF 1.1 4区 农林科学
Journal of Veterinary Medical Science Pub Date : 2024-12-01 Epub Date: 2024-10-25 DOI: 10.1292/jvms.24-0354
Tom Bleeser, Simen Vergote, David Basurto, Ignacio Valenzuela, Luc Joyeux, Francesca Russo, Yada Kunpalin, Doaa Emam, Marc VAN DE Velde, Sarah Devroe, Jan Deprest, Steffen Rex
{"title":"End-tidal concentration of sevoflurane for optimal surgical conditions in pregnant sheep: a pragmatic approach to a retrospective observational study.","authors":"Tom Bleeser, Simen Vergote, David Basurto, Ignacio Valenzuela, Luc Joyeux, Francesca Russo, Yada Kunpalin, Doaa Emam, Marc VAN DE Velde, Sarah Devroe, Jan Deprest, Steffen Rex","doi":"10.1292/jvms.24-0354","DOIUrl":"10.1292/jvms.24-0354","url":null,"abstract":"<p><p>The aim of this pragmatic approach to retrospective observational study was to identify the end-tidal concentration of sevoflurane which was associated with optimal surgical conditions (i.e., absence of any movement, coughing and straining) in 127 pregnant sheep. Optimal surgical conditions were observed in 90% of the ewes with an end-tidal concentration of sevoflurane of 2.4 Vol-% [95% CI: 2.2; 2.8] during minimal-mild nociceptive stimuli (placement of arterial catheter, bladder catheter, shaving), with 4.4 Vol-% [95% CI: 4.0; 5.2] during maternal laparotomy and hysterotomy and with 4.4 Vol-% [95% CI: 3.9; 5.8] during subsequent manipulation of the uterus and fetal surgery.</p>","PeriodicalId":49959,"journal":{"name":"Journal of Veterinary Medical Science","volume":" ","pages":"1299-1302"},"PeriodicalIF":1.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11612238/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142512008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Campylobacter fetus isolates from both human patients and healthy cattle carry three distinct cytolethal distending toxin (cdt) gene clusters. 从人类患者和健康牛身上分离出的胎儿弯曲杆菌携带三种不同的细胞致死膨胀毒素（ctt）基因簇。
IF 1.1 4区 农林科学
Journal of Veterinary Medical Science Pub Date : 2024-12-01 Epub Date: 2024-10-28 DOI: 10.1292/jvms.24-0336
Wen Wen, Noritoshi Hatanaka, Srinuan Somroop, Sharda Prasad Awasthi, Atsushi Hinenoya, Shinji Yamasaki
{"title":"Campylobacter fetus isolates from both human patients and healthy cattle carry three distinct cytolethal distending toxin (cdt) gene clusters.","authors":"Wen Wen, Noritoshi Hatanaka, Srinuan Somroop, Sharda Prasad Awasthi, Atsushi Hinenoya, Shinji Yamasaki","doi":"10.1292/jvms.24-0336","DOIUrl":"10.1292/jvms.24-0336","url":null,"abstract":"<p><p>Campylobacter fetus is a zoonotic pathogen. Although the precise virulence mechanisms have not yet been fully elucidated, cytolethal distending toxin (CDT) is considered as one of the well-characterized virulence factors in Campylobacter. In silico analysis of the genome of C. fetus type strain ATCC27374<sup>T</sup> indicates that there are three cdt gene clusters, Cfcdt-I, Cfcdt-II and Cfcdt-III. However, it is not clear whether these clusters are ubiquitously present in C. fetus and their association with diseases in humans and animals. In this study, we have analyzed the distribution and nucleotide sequences of these cdt gene clusters in 137 C. fetus strains isolated from human patients and healthy cattle. MLST and PFGE were also applied to determine clonal relationship between C. fetus strains isolated from patients and cattle. We found all C. fetus strains carry three Cfcdt gene clusters by colony hybridization assay and the strains belonged to 38 different pulsotypes. Whole genome sequencing of 38 C. fetus strains was carried out to determine the entire cdt gene cluster sequences and their sequence type (ST). Among 38 strains, six STs were identified, and each cdt gene cluster showed high similarity (>99%). Interestingly, some of these Cfcdt genes are more similar to the cdt genes of other Campylobacter species than other Cfcdt gene types. Altogether, the results suggest that three Cfcdt gene clusters are highly conserved in C. fetus and the strains belonging to ST-6 may be more pathogenic to human.</p>","PeriodicalId":49959,"journal":{"name":"Journal of Veterinary Medical Science","volume":" ","pages":"1311-1318"},"PeriodicalIF":1.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11612251/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142512006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dogs with severe tracheal flattening exhibit lower degrees of left lateralization of the cervical esophagus. 气管严重扁平的狗狗颈部食管左侧化程度较低。
IF 1.1 4区 农林科学
Journal of Veterinary Medical Science Pub Date : 2024-12-01 Epub Date: 2024-10-25 DOI: 10.1292/jvms.24-0270
Kenji Teshima, Teppei Fujimoto, Naoko Shiozawa, Chieko Ishikawa, Yoshiki Yamaya
{"title":"Dogs with severe tracheal flattening exhibit lower degrees of left lateralization of the cervical esophagus.","authors":"Kenji Teshima, Teppei Fujimoto, Naoko Shiozawa, Chieko Ishikawa, Yoshiki Yamaya","doi":"10.1292/jvms.24-0270","DOIUrl":"10.1292/jvms.24-0270","url":null,"abstract":"<p><p>Herein, we investigated the positional relationship between the cervical esophagus and trachea using computed tomography (CT) images in dogs with tracheal flattening. From these CT images, the ratio of the tracheal diameters in the short (vertical) and long (horizontal) axes of the tracheal ring (S/L ratio) and the vertebra-trachea-esophagus (VTE) angle were measured at the point from the 3rd cervical (C3) to the 3rd thoracic vertebra (T3) levels. The VTE angle in dogs with tracheal flattening with an S/L ratio under 0.24 tended to be smaller than the angles at the level from C4 to T2 in dogs with an S/L ratio over 0.25. The positional relationship between the esophagus and trachea seems to be possibly related to tracheal cross-sectional shape.</p>","PeriodicalId":49959,"journal":{"name":"Journal of Veterinary Medical Science","volume":" ","pages":"1284-1288"},"PeriodicalIF":1.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11612253/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142512007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Establishment of new mouse model for allergic dermatitis showing severe fibrosis. 建立显示严重纤维化的过敏性皮炎新小鼠模型。
IF 1.1 4区 农林科学
Journal of Veterinary Medical Science Pub Date : 2024-12-01 Epub Date: 2024-10-24 DOI: 10.1292/jvms.24-0394
Yusuke Yamada, Kyoko Yoshizaki, Masashi Sakurai, Masahiro Morimoto
{"title":"Establishment of new mouse model for allergic dermatitis showing severe fibrosis.","authors":"Yusuke Yamada, Kyoko Yoshizaki, Masashi Sakurai, Masahiro Morimoto","doi":"10.1292/jvms.24-0394","DOIUrl":"10.1292/jvms.24-0394","url":null,"abstract":"<p><p>Allergic dermatitis (AD) is a skin disease characterized by a chronic inflammation caused by immune dysregulation. In the histopathology of patients with AD, there are several features, such as accumulation of eosinophils and mast cells, hyperkeratosis, and dermal fibrosis which are related to the exacerbation of AD. Mast cells and eosinophils are thought to be involved in fibrosis, but the details are unknown. Yama mouse is an inbred mouse showing genetically eosinophilia. If eosinophils have significant effect on fibrosis, it may be possible to establish a new AD model with severe fibrosis. In this study, AD was induced by applying dinitrofluorobenzene to mice auricle. Yama mice showed AD lesion with more severe dermal fibrosis with severe eosinophil infiltration than Balb/c and Nc/nga mice. The expression of transforming growth factor-β (TGF-β), a cytokine important for fibrosis, was not significantly different among Yama, Balb/c, and Nc/nga mice, while the expression of interleukin-4 (IL-4), which is also mediator of tissue fibrosis, was increased only in Yama mice. The results of this study showed that AD with more severe fibrosis could be induced in Yama mice than in Balb/c and Nc/nga mice. In Yama mice, it can be concluded that the severe fibrosis is TGF-β independent, and IL-4 would be the main mediator of severe fibrosis. This mouse model may be useful for elucidating the mechanism of fibrosis in chronic AD, and for conducting research leading to the development of new therapies.</p>","PeriodicalId":49959,"journal":{"name":"Journal of Veterinary Medical Science","volume":" ","pages":"1303-1310"},"PeriodicalIF":1.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11612250/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142512009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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