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The expression of serotonin receptors in the gastrointestinal tract of healthy and fat necrosis-affected Japanese Black cattle. 5 -羟色胺受体在健康和肥胖坏死性日本黑牛胃肠道中的表达。
IF 1.1 4区 农林科学
Journal of Veterinary Medical Science Pub Date : 2026-08-31 DOI: 10.1292/jvms.26-0268
Nilla Sari Ngadi, Hiroko Sonoda, Mizuho Uematsu, Masahiro Yasuda, Shoichi Wakitani, Yoshiki Higashijima, Masahiro Ikeda
{"title":"The expression of serotonin receptors in the gastrointestinal tract of healthy and fat necrosis-affected Japanese Black cattle.","authors":"Nilla Sari Ngadi, Hiroko Sonoda, Mizuho Uematsu, Masahiro Yasuda, Shoichi Wakitani, Yoshiki Higashijima, Masahiro Ikeda","doi":"10.1292/jvms.26-0268","DOIUrl":"https://doi.org/10.1292/jvms.26-0268","url":null,"abstract":"<p><p>Serotonin (5-HT) regulates gastrointestinal (GI) motility by activating various 5-HT receptor (5-HTR) subtypes. However, the expression and distribution of 5-HTR subtypes in the GI tract of Japanese Black cattle under both healthy and diseased conditions remain largely unknown. This study examined the expression of seven-transmembrane 5-HTR subtypes in healthy and fat necrosis (FN)-affected Japanese Black cattle. We found clear expression of 5-HT<sub>1B</sub>R, 5-HT<sub>2B</sub>R, 5-HT<sub>4</sub>R, and 5-HT<sub>7</sub>R mRNAs in the GI tract, in both young and adult groups. Expression of 5-HT<sub>4</sub>R and 5-HT<sub>7</sub>R was higher at most sites in adult cattle than in young cattle. The highest 5-HT<sub>4</sub>R expression was observed in the colon of adult cattle. Given the availability of antibodies and use of 5-HT<sub>4</sub>R agonists in therapy, we further examined the localization of 5-HT<sub>4</sub>R. We detected 5-HT<sub>4</sub>R mRNA and protein in neurons of the myenteric and submucosal plexuses. In FN-affected cattle, expression of 5-HT<sub>1B</sub>R, 5-HT<sub>2B</sub>R, and 5-HT<sub>7</sub>R mRNAs tended to decrease in the GI tract, while 5-HT<sub>4</sub>R mRNA remained unchanged, in comparison with healthy adult cattle. Our results show that 5-HT<sub>1B</sub>R, 5-HT<sub>2B</sub>R, 5-HT<sub>4</sub>R, and 5-HT<sub>7</sub>R mRNAs are obviously expressed in the GI tracts of Japanese Black cattle. Because 5-HT<sub>4</sub>R mRNA expression did not differ between healthy and FN-affected cattle, 5-HT<sub>4</sub>R agonists may offer therapeutic benefits for both groups, suggesting potential for clinical application in Japanese Black cattle.</p>","PeriodicalId":49959,"journal":{"name":"Journal of Veterinary Medical Science","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148860662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Incidence of emesis induced by low-dose intravenous medetomidine administration in dogs: a retrospective study of 155 cases. 155例犬静脉小剂量美托咪定致呕吐发生率的回顾性研究。
IF 1.1 4区 农林科学
Journal of Veterinary Medical Science Pub Date : 2026-08-28 DOI: 10.1292/jvms.25-0479
Teppei Kanda, Yusuke Ohashi, Mai Ohta, Kanna Saeki, Kosuke Kobayashi, Natsuki Akashi, Ryohei Yoshitake, Kanako Tsuji, Junpei Hanayama, Yuki Shimizu
{"title":"Incidence of emesis induced by low-dose intravenous medetomidine administration in dogs: a retrospective study of 155 cases.","authors":"Teppei Kanda, Yusuke Ohashi, Mai Ohta, Kanna Saeki, Kosuke Kobayashi, Natsuki Akashi, Ryohei Yoshitake, Kanako Tsuji, Junpei Hanayama, Yuki Shimizu","doi":"10.1292/jvms.25-0479","DOIUrl":"https://doi.org/10.1292/jvms.25-0479","url":null,"abstract":"<p><p>This study aimed to determine the incidence of emesis in dogs receiving a low dose of intravenous medetomidine. Anesthetic records of dogs that received ≤3 µg/kg medetomidine intravenously before anesthesia induction were retrospectively reviewed. Data included demographics, doses, and the presence of emesis, retching, sialorrhea, or lip licking. A total of 155 cases met the criteria. The administered dose of medetomidine was 3.0 (0.5-3.0) µg/kg (median [range]). Emesis occurred in 3 of 155 dogs (1.9%), while retching, sialorrhea, and lip licking occurred in two, two, and five dogs, respectively. The incidence of emesis observed in dogs receiving low-dose (≤3 µg/kg) intravenous medetomidine was lower than that reported in studies using higher doses.</p>","PeriodicalId":49959,"journal":{"name":"Journal of Veterinary Medical Science","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148860654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intraocular carcinosarcoma with osteosarcomatous component arising from iridociliary adenocarcinoma in a dog. 犬虹膜睫状体腺癌伴骨肉瘤成分的眼内癌肉瘤。
IF 1.1 4区 农林科学
Journal of Veterinary Medical Science Pub Date : 2026-08-28 DOI: 10.1292/jvms.26-0295
Miyuu Kakimoto, Kotoko Fukuyo, Chisa Miura, Yuto Sano
{"title":"Intraocular carcinosarcoma with osteosarcomatous component arising from iridociliary adenocarcinoma in a dog.","authors":"Miyuu Kakimoto, Kotoko Fukuyo, Chisa Miura, Yuto Sano","doi":"10.1292/jvms.26-0295","DOIUrl":"https://doi.org/10.1292/jvms.26-0295","url":null,"abstract":"<p><p>A 9-year-old neutered male Labrador Retriever presented with increased intraocular pressure in the left eye and underwent enucleation for a suspected intraocular tumor. Grossly, a white to greyish-white solid mass occupied the anterior segment and was partially contiguous with the lens. Histologically, the tumor exhibited biphasic proliferation of epithelial and mesenchymal components. The mesenchymal component showed osteoid formation, and transitional features were observed between the two components. Based on histological and immunohistochemical findings, the tumor was diagnosed as a carcinosarcoma composed of an iridociliary adenocarcinoma component and an osteosarcomatous component. This is the first report of carcinosarcoma in the canine eye, expanding the understanding of the morphological diversity and histogenetic characteristics of canine iridociliary tumors.</p>","PeriodicalId":49959,"journal":{"name":"Journal of Veterinary Medical Science","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148860708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Remarkable similarity between domestic cat hepatitis B virus strains identified in stray cats and outbreak-associated strains from a cat shelter in Okinawa, Japan. 在流浪猫身上发现的家猫乙型肝炎病毒毒株与在日本冲绳一家猫收容所发现的与疫情相关的毒株之间存在显著的相似性。
IF 1.1 4区 农林科学
Journal of Veterinary Medical Science Pub Date : 2026-08-28 DOI: 10.1292/jvms.26-0218
Yuika Y Houri, Nanami X Kato, Yukinobu Adachi, Miki X Kawano, Haruka Dosaka, Takuya Hirai, Naoyuki Fuke, Yasuyuki Kaneko, Akatsuki Saito
{"title":"Remarkable similarity between domestic cat hepatitis B virus strains identified in stray cats and outbreak-associated strains from a cat shelter in Okinawa, Japan.","authors":"Yuika Y Houri, Nanami X Kato, Yukinobu Adachi, Miki X Kawano, Haruka Dosaka, Takuya Hirai, Naoyuki Fuke, Yasuyuki Kaneko, Akatsuki Saito","doi":"10.1292/jvms.26-0218","DOIUrl":"https://doi.org/10.1292/jvms.26-0218","url":null,"abstract":"<p><p>We recently identified a domestic cat hepatitis B virus (DCHBV) outbreak at a cat shelter in Okinawa, Japan. Viral genome sequencing showed that this particular strain was highly conserved and distinct from previously reported Japanese strains, suggesting that a single strain had spread within the shelter. However, the origin of this strain remained unclear. DCHBV strains were also identified in two stray cats in central Okinawa. The outbreak strain shared 99.4-99.8% and 99.5-99.8% nucleotide identity with the strain from stray cat #1 and #2, respectively, indicating a close genetic relationship among all DCHBV strains identified in Okinawa. Our findings highlight the importance of screening stray cats for DCHBV before admission to shelters to help prevent outbreaks.</p>","PeriodicalId":49959,"journal":{"name":"Journal of Veterinary Medical Science","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148860652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Histological and proteomic characterization of hyaline material in two dogs with hyalinizing pancreatic adenocarcinoma. 两只透明化胰腺腺癌犬透明物质的组织学和蛋白质组学特征。
IF 1.1 4区 农林科学
Journal of Veterinary Medical Science Pub Date : 2026-08-27 DOI: 10.1292/jvms.26-0303
Niki Sedghi Masoud, Susumu Iwaide, Natsumi Kobayashi, Kenta Owaku, Yoshiyuki Itoh, Tomoyuki Harada, Tomoyuki Shibahara, Tomoaki Murakami
{"title":"Histological and proteomic characterization of hyaline material in two dogs with hyalinizing pancreatic adenocarcinoma.","authors":"Niki Sedghi Masoud, Susumu Iwaide, Natsumi Kobayashi, Kenta Owaku, Yoshiyuki Itoh, Tomoyuki Harada, Tomoyuki Shibahara, Tomoaki Murakami","doi":"10.1292/jvms.26-0303","DOIUrl":"https://doi.org/10.1292/jvms.26-0303","url":null,"abstract":"<p><p>Hyalinizing pancreatic adenocarcinoma is a rare subtype of exocrine pancreatic carcinoma in dogs, characterized by abundant extracellular hyaline material within the tumor. In this study, we investigated two canine cases exhibiting this distinctive hyalinizing morphology using histological, proteomic, immunohistochemical, ultrastructural, and molecular approaches. Histological examination revealed amyloid-like eosinophilic hyaline deposits; however, these deposits lacked diagnostic features of amyloid, as confirmed by Congo red and thioflavin S staining and transmission electron microscopy. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) identified bile salt-activated lipase (BAL) as the predominant component of the hyaline deposits. Immunohistochemistry confirmed strong anti-BAL immunoreactivity in the deposits. In addition to BAL, amyloid-associated proteins, including clusterin, vitronectin, apolipoprotein E, and apolipoprotein A-I, were detected. Together with the negative Congo red and thioflavin S staining and ultrastructural findings, these results support that the hyaline deposits are BAL-rich, non-amyloid extracellular deposits. Some deposits also contained collagen, indicating biochemical heterogeneity of the hyaline material. RT-qPCR analysis suggested higher CEL, and lower GRP94 expression in hyalinizing pancreatic adenocarcinomas than in non-hyalinizing pancreatic carcinomas. These observations raise a hypothesis that excessive BAL production, together with reduced GRP94-mediated chaperone support, may contribute to extracellular accumulation of aggregated BAL. Collectively, this study identifies BAL as the predominant component of hyaline deposits in canine hyalinizing pancreatic adenocarcinoma based on LC-MS/MS analysis and highlights a non-amyloid protein aggregation process associated with this tumor subtype.</p>","PeriodicalId":49959,"journal":{"name":"Journal of Veterinary Medical Science","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148834315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Activity patterns of small- and medium-sized mammals inside and outside a sanitation control zone on a pig farm. 猪场卫生控制区内和区外中小型哺乳动物的活动模式
IF 1.1 4区 农林科学
Journal of Veterinary Medical Science Pub Date : 2026-08-26 DOI: 10.1292/jvms.26-0335
Takashi Ikeda, Tomoya Shichijo, Daishi Higashide, Akitaka Omori, Masatsugu Suzuki
{"title":"Activity patterns of small- and medium-sized mammals inside and outside a sanitation control zone on a pig farm.","authors":"Takashi Ikeda, Tomoya Shichijo, Daishi Higashide, Akitaka Omori, Masatsugu Suzuki","doi":"10.1292/jvms.26-0335","DOIUrl":"https://doi.org/10.1292/jvms.26-0335","url":null,"abstract":"<p><p>The intensification of livestock production has increased vulnerability to pathogen transmission, highlighting the importance of farm biosecurity. Using camera-trap data, we assessed the activity patterns of humans and small- and medium-sized mammals inside and outside a sanitary control zone (SCZ) on a pig farm in Japan. Most wildlife intrusions into the SCZ occurred during nighttime, reflecting the predominantly nocturnal activity of the assessed mammals, with little difference between activity patterns inside and outside the SCZ. In contrast, feral cats remained active within the SCZ during daytime and nighttime. These findings suggest that nighttime represents a high-risk period for wildlife intrusion and highlight the importance of strengthening physical barriers and implementing integrated wildlife and farm management.</p>","PeriodicalId":49959,"journal":{"name":"Journal of Veterinary Medical Science","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148834248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Copper toxicosis in 3 Japanese Black cattle with chronic cholangiohepatitis. 3头日本黑牛慢性胆管肝炎铜中毒的研究。
IF 1.1 4区 农林科学
Journal of Veterinary Medical Science Pub Date : 2026-08-19 DOI: 10.1292/jvms.26-0184
Yuki Tsukamoto, Kenichi Watanabe, Rintaro Kinoshita, Natsuko Fukumoto, Hisashi Inokuma, Yoshiyasu Kobayashi
{"title":"Copper toxicosis in 3 Japanese Black cattle with chronic cholangiohepatitis.","authors":"Yuki Tsukamoto, Kenichi Watanabe, Rintaro Kinoshita, Natsuko Fukumoto, Hisashi Inokuma, Yoshiyasu Kobayashi","doi":"10.1292/jvms.26-0184","DOIUrl":"https://doi.org/10.1292/jvms.26-0184","url":null,"abstract":"<p><p>Three Japanese Black cattle raised in different farms died suddenly with severe jaundice and hemoglobinuria. Gross examination revealed diffuse hepatic discoloration and highly viscous bile in the gallbladder. Histologically, the livers showed chronic cholangiohepatitis with hepatocellular vacuolation, bile plugs, interlobular bile duct hyperplasia, and periportal fibrosis. Alcian blue-periodic acid-Schiff staining showed acidic mucin in the bile ducts. Rhodanine staining and metallothionein immunohistochemistry demonstrated copper accumulation mildly in hepatocytes and mainly in Kupffer cells, and hepatic copper concentrations were markedly elevated (901-1,766 ppm). No histological evidence of infectious etiology was identified. Although these findings resembled dietary copper toxicosis, sporadic occurrence and severe cholangiohepatitis suggested that impaired biliary copper excretion may have played a role in the pathogenesis.</p>","PeriodicalId":49959,"journal":{"name":"Journal of Veterinary Medical Science","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148800852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hematological and biochemical reference intervals for two-humped camels (Camelus bactrianus) in Mongolia with effects of age/physiological class and season. 蒙古双峰骆驼（Camelus bactrianus）血液学和生化参考区间与年龄/生理类别和季节的影响
IF 1.1 4区 农林科学
Journal of Veterinary Medical Science Pub Date : 2026-08-17 DOI: 10.1292/jvms.26-0087
Tsognemekh Bolormaa, Badrakh Sandagdorj, Sedkhuu Burenjargal, Nyamsuren Ochirkhuu, Sambalkhundev Gerelt-Od, Batsaikhan Chantsal, Motohiro Horiuchi, Purevdorj Nyam-Osor
{"title":"Hematological and biochemical reference intervals for two-humped camels (Camelus bactrianus) in Mongolia with effects of age/physiological class and season.","authors":"Tsognemekh Bolormaa, Badrakh Sandagdorj, Sedkhuu Burenjargal, Nyamsuren Ochirkhuu, Sambalkhundev Gerelt-Od, Batsaikhan Chantsal, Motohiro Horiuchi, Purevdorj Nyam-Osor","doi":"10.1292/jvms.26-0087","DOIUrl":"https://doi.org/10.1292/jvms.26-0087","url":null,"abstract":"<p><p>Reference intervals (RIs) are essential for interpreting laboratory results. We established hematological and serum biochemical RIs for apparently healthy Mongolian Bactrian camels and evaluated age/physiological class and seasonal effects. Samples were collected from yearlings, subadults, adult castrated males, and lactating adult females in spring and autumn. Following CLSI EP28-A3c and ASVCP guidelines, 95% RIs were estimated by parametric, nonparametric, or robust methods according to sample size and distribution. Age/physiological class influenced multiple analytes, while season explained greater variation in several erythroid indices, total protein, and glucose. Season-specific RIs are therefore provided for analytes with substantial seasonal effects. These locally derived RIs support clinical interpretation and herd health monitoring under Mongolian pastoral conditions.</p>","PeriodicalId":49959,"journal":{"name":"Journal of Veterinary Medical Science","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148763679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A dog with suspected hypothalamic hypoadrenocorticism classified by corticotropin-releasing hormone (CRH) testing. 用促肾上腺皮质激素释放激素（CRH）测试对疑似下丘脑肾上腺皮质功能低下的狗进行分类。
IF 1.1 4区 农林科学
Journal of Veterinary Medical Science Pub Date : 2026-08-17 DOI: 10.1292/jvms.26-0056
Takumi Komiya, Hitomi Oda, Ran Akiyama, Akihiro Mori
{"title":"A dog with suspected hypothalamic hypoadrenocorticism classified by corticotropin-releasing hormone (CRH) testing.","authors":"Takumi Komiya, Hitomi Oda, Ran Akiyama, Akihiro Mori","doi":"10.1292/jvms.26-0056","DOIUrl":"https://doi.org/10.1292/jvms.26-0056","url":null,"abstract":"<p><p>A 7-year-old intact male toy poodle presented with abdominal distension, polydipsia, and polyuria. Abdominal ultrasonography revealed bilateral adrenal atrophy, and adrenocorticotropic hormone (ACTH) stimulation testing showed persistently low cortisol concentrations with concurrent low endogenous ACTH, indicating central hypoadrenocorticism. To localize dysfunction within the hypothalamic-pituitary-adrenal axis, a corticotropin-releasing hormone (CRH) stimulation test was performed. Endogenous ACTH increased markedly after CRH administration, whereas cortisol remained undetectable, demonstrating preserved pituitary responsiveness and supporting a diagnosis of hypothalamic hypoadrenocorticism. Treatment of hypoadrenocorticism with prednisolone alone resulted in long-term clinical stabilization without electrolyte abnormalities for over one year. To our knowledge, this is the first canine report classifying suspected hypothalamic hypoadrenocorticism using CRH stimulation testing.</p>","PeriodicalId":49959,"journal":{"name":"Journal of Veterinary Medical Science","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148765627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Spatial epidemiology and socio-economics of bovine brucellosis in selected districts of the Northern Province of Sri Lanka. 斯里兰卡北部省选定地区牛布鲁氏菌病的空间流行病学和社会经济学。
IF 1.1 4区 农林科学
Journal of Veterinary Medical Science Pub Date : 2026-08-01 Epub Date: 2026-06-04 DOI: 10.1292/jvms.26-0249
Yoshiharu Sugino, Sivagurunathan Vaseeharan, Kasthuri Arachchige Chandrika Ha Kothalawala, Madalagama Appuhamilage Roshan Priyantha, Palika Fernando, Shyamali DE Alwis, Renuka Gowrithilagan, Kohei Makita
{"title":"Spatial epidemiology and socio-economics of bovine brucellosis in selected districts of the Northern Province of Sri Lanka.","authors":"Yoshiharu Sugino, Sivagurunathan Vaseeharan, Kasthuri Arachchige Chandrika Ha Kothalawala, Madalagama Appuhamilage Roshan Priyantha, Palika Fernando, Shyamali DE Alwis, Renuka Gowrithilagan, Kohei Makita","doi":"10.1292/jvms.26-0249","DOIUrl":"10.1292/jvms.26-0249","url":null,"abstract":"<p><p>This study was conducted to characterize the spatial epidemiology and socio-economics of bovine brucellosis on dairy farms in the Kilinochchi and Mullaitivu Districts of Northern Province, Sri Lanka. A cross-sectional study involving bulk milk sampling and interviews using a structured questionnaire was conducted at 214 dairy farms. Milk samples were tested for Brucella antibodies using an indirect enzyme-linked immunosorbent assay. Global spatial clustering statistics and SaTScan were also performed. The association between milk sero-positivity and socio-economic variables was evaluated using univariable analysis. Multi-variable spatial risk factor analysis was conducted using the integrated nested Laplace approximation selecting principal components (PCs) of land use and socio-economic and ecological variables with P<0.2 in the univariable analyses as explanatory variables. The crude and true herd-level prevalence was estimated at 12.1% (26/214; 95% confidence interval [CI]: 8.4-17.2%), and 11.2% (95% CI: 7.3% to 16.3%), respectively. The Cuzick and Edward's k-nearest neighbor test found significant clustering at 8, 10, and 11 nearest neighbors; however, no local cluster was suggested by SaTScan. In the final multivariable model, the PC representing agricultural land as positive loading and forest land as negative was positively associated with brucellosis sero-positivity, whereas barn cleaning was negatively associated, suggesting good farm hygiene is important for preventing bovine brucellosis.</p>","PeriodicalId":49959,"journal":{"name":"Journal of Veterinary Medical Science","volume":" ","pages":"1122-1133"},"PeriodicalIF":1.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13500395/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148158911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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