Journal of Veterinary Medical Science最新文献

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Transvenous embolization of patent ductus arteriosus in 16 dogs using the Amplatzer Vascular Plug II device: description of a modified technique and complications. 使用 Amplatzer Vascular Plug II 装置对 16 只狗的动脉导管未闭进行经静脉栓塞治疗:改良技术及并发症描述。
IF 1.1 4区 农林科学
Journal of Veterinary Medical Science Pub Date : 2024-10-01 Epub Date: 2024-09-02 DOI: 10.1292/jvms.23-0445
Antoine Dubès, Jean-Benoît Thambo, Virginie Loyer, Pierre Menaut
{"title":"Transvenous embolization of patent ductus arteriosus in 16 dogs using the Amplatzer Vascular Plug II device: description of a modified technique and complications.","authors":"Antoine Dubès, Jean-Benoît Thambo, Virginie Loyer, Pierre Menaut","doi":"10.1292/jvms.23-0445","DOIUrl":"10.1292/jvms.23-0445","url":null,"abstract":"<p><p>Patent ductus arteriosus (PDA) is a deadly congenital disease in dogs if left untreated. Occlusion of the defect is the treatment of choice and can be achieved by surgical ligation or interventional closure. In this retrospective study of 16 dogs, an alternative to the classically used canine device which is placed by an arterial route is described. The Amplatzer Vascular Plug II<sup>®</sup> (AVPII) can be deployed by a transvenous approach, using a modified and simplified technique using a single catheter to perform angiography and device delivery. This allows the percutaneous treatment of smaller dogs <3 kg and the concomitant treatment of pulmonic stenosis if present. Successful and complete closure was achieved in all dogs with a mean device/ampulla diameter ratio of 1.28 and a mean device/ostium ratio of 3.6. Embolization into the pulmonary artery was observed in one dog where the device/ampulla diameter ratio was <1.1 and device/ostium ratio was <2.1. In conclusion, our study confirms that PDA transvenous closure using the AVPII appears to be a viable alternative to transarterial closure, allowing the treatment of smaller dogs and a fully percutaneous approach. Care should be taken in patients with very large ducti where undersizing might result in device embolization.</p>","PeriodicalId":49959,"journal":{"name":"Journal of Veterinary Medical Science","volume":" ","pages":"1089-1095"},"PeriodicalIF":1.1,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11442394/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142114177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Investigation of the mutations in the genes involved in Janus kinase/signal transducer and activator of transcription pathway in canine large cell gastrointestinal lymphoma. 犬大细胞胃肠道淋巴瘤中 Janus 激酶/信号转导和转录激活通路相关基因突变的研究。
IF 1.1 4区 农林科学
Journal of Veterinary Medical Science Pub Date : 2024-10-01 Epub Date: 2024-08-13 DOI: 10.1292/jvms.24-0096
Takumi Tsuruta, Naoki Matsumura, Keijiro Mizukami, Yuko Goto-Koshino, Tomomi Aoi, Ryoko Yamada, Itsuma Nagao, Megumi Sakamoto, Taisuke Nakagawa, Ray Fukuoka, Aki Ohmi, James K Chambers, Kazuyuki Uchida, Yukihide Momozawa, Hirotaka Tomiyasu
{"title":"Investigation of the mutations in the genes involved in Janus kinase/signal transducer and activator of transcription pathway in canine large cell gastrointestinal lymphoma.","authors":"Takumi Tsuruta, Naoki Matsumura, Keijiro Mizukami, Yuko Goto-Koshino, Tomomi Aoi, Ryoko Yamada, Itsuma Nagao, Megumi Sakamoto, Taisuke Nakagawa, Ray Fukuoka, Aki Ohmi, James K Chambers, Kazuyuki Uchida, Yukihide Momozawa, Hirotaka Tomiyasu","doi":"10.1292/jvms.24-0096","DOIUrl":"10.1292/jvms.24-0096","url":null,"abstract":"<p><p>Canine gastrointestinal lymphoma is known to be of T-cell origin in most cases, but the molecular biological aberrations have not been clarified. In human intestinal T-cell lymphoma, the mutations in the genes associated with Janus kinase/signal transducer and activator of transcription (JAK-STAT) pathway have been frequently observed. In this study, the gene mutations were investigated in 31 dogs with large cell gastrointestinal lymphoma (LCGIL) by focusing on the genes involved in JAK-STAT pathway. Next-generation sequencing analysis to examine the mutations in STAT3, STAT5B, and JAK1 genes throughout the exon regions revealed the mutations in STAT3 gene in two dogs and JAK1 gene in one dog. In conclusion, this study could not indicate the associations of gene mutations in JAK-STAT pathway with LCGIL in most canine cases.</p>","PeriodicalId":49959,"journal":{"name":"Journal of Veterinary Medical Science","volume":" ","pages":"1052-1055"},"PeriodicalIF":1.1,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11442398/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141972155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Aquaporin 3 is expressed in the basaloid cells of canine sebaceous glands. Aquaporin 3 在犬皮脂腺的基底细胞中表达。
IF 1.1 4区 农林科学
Journal of Veterinary Medical Science Pub Date : 2024-10-01 Epub Date: 2024-08-15 DOI: 10.1292/jvms.24-0188
Hiroko Sonoda, Yoshiki Taniguchi, Naruki Fujimoto, Yoshiki Higashijima, Toshiyuki Matsuzaki, Takuya Hirai, Teruo Itoh, Kazuyuki Uchida, Masahiro Ikeda
{"title":"Aquaporin 3 is expressed in the basaloid cells of canine sebaceous glands.","authors":"Hiroko Sonoda, Yoshiki Taniguchi, Naruki Fujimoto, Yoshiki Higashijima, Toshiyuki Matsuzaki, Takuya Hirai, Teruo Itoh, Kazuyuki Uchida, Masahiro Ikeda","doi":"10.1292/jvms.24-0188","DOIUrl":"10.1292/jvms.24-0188","url":null,"abstract":"<p><p>The role of aquaporin proteins (AQPs) in tumor biology has attracted attention over the past 20 years. However, the expression profiles of AQPs in canine sebaceous gland tumors remain obscure. This study was performed to clarify the expression of AQP1, 3, 5, the most studied AQPs in tumor biology, in sebaceous adenoma and sebaceous epithelioma. Among these AQPs, only AQP3 was expressed in normal tissue and both tumor types and located to only undifferentiated sebocytes (basaloid cells). A cellular proliferation marker, Ki-67, was detected only in the area including basaloid cells in both tumor types. These findings suggest that AQP3 is useful for clarifying the origin of sebaceous gland tumors, and that AQP3 may be related to sebaceous gland development.</p>","PeriodicalId":49959,"journal":{"name":"Journal of Veterinary Medical Science","volume":" ","pages":"1063-1067"},"PeriodicalIF":1.1,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11442393/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141983731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A probable cluster of premature birth and stillbirth caused by Leptospira interrogans serogroup Hebdomadis in an integrated swine farm in Nagasaki Prefecture, Japan. 日本长崎县一家综合养猪场可能发生由钩端螺旋体血清群 Hebdomadis 引起的早产和死胎群。
IF 1.1 4区 农林科学
Journal of Veterinary Medical Science Pub Date : 2024-10-01 Epub Date: 2024-08-07 DOI: 10.1292/jvms.24-0215
Yoshimi Terayama, Masashi Maeda, Yusuke Hata, Youhei Kawasaki, Nobuo Koizumi
{"title":"A probable cluster of premature birth and stillbirth caused by Leptospira interrogans serogroup Hebdomadis in an integrated swine farm in Nagasaki Prefecture, Japan.","authors":"Yoshimi Terayama, Masashi Maeda, Yusuke Hata, Youhei Kawasaki, Nobuo Koizumi","doi":"10.1292/jvms.24-0215","DOIUrl":"10.1292/jvms.24-0215","url":null,"abstract":"<p><p>In an integrated swine farm with 135 sows in Nagasaki Prefecture, premature births and stillbirths were observed in six sows in June and July 2023, and their etiology was investigated. Leptospiral flaB gene was detected in the kidney of one stillborn fetus and the placenta of its sow by nested PCR. Multilocus sequence typing revealed that the infecting strain was Leptospira interrogans ST118. In addition, leptospiral antigens were detected in lesions of the above tissues by immunohistochemical staining. The examined sow and several other sows in the farm had antibodies against serogroup Hebdomadis. These results suggested that L. interrogans serogroup Hebdomadis ST118 was the causative agent of premature births and stillbirths that occurred in this farm.</p>","PeriodicalId":49959,"journal":{"name":"Journal of Veterinary Medical Science","volume":" ","pages":"1040-1044"},"PeriodicalIF":1.1,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11442401/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141903377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bovine respiratory syncytial virus enhances the attachment of Trueperella pyogenes to cells. 牛呼吸道合胞病毒可增强化脓性真菌对细胞的附着。
IF 1.1 4区 农林科学
Journal of Veterinary Medical Science Pub Date : 2024-10-01 Epub Date: 2024-08-08 DOI: 10.1292/jvms.24-0068
Satomi Yamamoto, Shiori Okumura, Risa Kobayashi, Yosuke Maeda, Fumiaki Takahashi, Taishi Tanabe
{"title":"Bovine respiratory syncytial virus enhances the attachment of Trueperella pyogenes to cells.","authors":"Satomi Yamamoto, Shiori Okumura, Risa Kobayashi, Yosuke Maeda, Fumiaki Takahashi, Taishi Tanabe","doi":"10.1292/jvms.24-0068","DOIUrl":"10.1292/jvms.24-0068","url":null,"abstract":"<p><p>In cattle, bovine respiratory syncytial virus (BRSV) is associated with secondary bacterial infections; however, the mechanisms of the interaction between BRSV and bacteria are unclear. Trueperella pyogenes (T. pyogenes) causes pneumonia in cattle and is involved in secondary infections following viral infections. In this study, we evaluated the effect of BRSV infection on the adhesion of T. pyogenes to BRSV-infected cells. BRSV infection significantly enhanced the adhesion of T. pyogenes to cells in a multiplicity of infection- and time-dependent manner. The BRSV-mediated change in the adhesion of T. pyogenes was widely observed in various cell types and bacterial strains. The results from the gentamicin protection assay showed that BRSV infection did not affect the intracellular invasion ability of T. pyogenes. Furthermore, adhesion assays conducted using BRSV G protein-expressing cells and anti-BRSV G antibodies revealed that the increased adhesion of T. pyogenes to cells was mediated by the G protein of BRSV. In addition, immunofluorescence assay revealed the colocalization of BRSV G protein and T. pyogenes. Thus, BRSV infection can potentially lead to bovine respiratory disease complex by promoting the adhesion of T. pyogenes to the infected cells.</p>","PeriodicalId":49959,"journal":{"name":"Journal of Veterinary Medical Science","volume":" ","pages":"1068-1075"},"PeriodicalIF":1.1,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11442402/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141903378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association between highly pathogenic avian influenza outbreaks and weather conditions in Japan. 日本高致病性禽流感爆发与天气条件之间的关系。
IF 1.1 4区 农林科学
Journal of Veterinary Medical Science Pub Date : 2024-10-01 Epub Date: 2024-08-16 DOI: 10.1292/jvms.23-0521
Yuri Fujimoto, Takeshi Haga
{"title":"Association between highly pathogenic avian influenza outbreaks and weather conditions in Japan.","authors":"Yuri Fujimoto, Takeshi Haga","doi":"10.1292/jvms.23-0521","DOIUrl":"10.1292/jvms.23-0521","url":null,"abstract":"<p><p>Highly pathogenic avian influenza (HPAI) poses a significant threat to animal and public health, with outbreaks occurring globally. HPAI poses significant challenges due to its high mortality rate and public health concerns, with outbreaks spreading globally since the emergence of the H5N1 virus in 2003. In Japan, HPAI outbreaks have been particularly prevalent during autumn and winter seasons, with the 2022-2023 winter experiencing the most severe outbreak to date. However, limited research has directly examined the association between HPAI outbreaks and weather conditions in Japan. Here we show that specific weather conditions are associated with an increased risk of HPAI outbreaks on poultry farms in Japan. By analyzing databases of HPAI cases and meteorological data from 2020-2023, we found that higher average air temperatures two to three weeks prior, lower average wind speeds four weeks prior, and longer sunlight hours two and four weeks prior to outbreaks were significantly associated with increased risk of HPAI outbreaks in Japan. These results suggest that weather may influence environmental survival and transmission of the virus, as well as patterns of wild bird movement that could seed new outbreaks. These findings enhance our understanding of the factors influencing HPAI transmission dynamics and highlight the importance of integrating weather forecasts into disease surveillance and prevention strategies.</p>","PeriodicalId":49959,"journal":{"name":"Journal of Veterinary Medical Science","volume":" ","pages":"1045-1051"},"PeriodicalIF":1.1,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11442392/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142001157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reference intervals for urinary metanephrines to creatinine ratios in dogs in Japan. 日本犬尿液中甲氧基肾上腺素与肌酐比率的参考区间。
IF 1.1 4区 农林科学
Journal of Veterinary Medical Science Pub Date : 2024-10-01 Epub Date: 2024-09-03 DOI: 10.1292/jvms.24-0163
Noriyuki Nagata, Yoshinori Ikenaka, Hiryu Sawamura, Noboru Sasaki, Mitsuyoshi Takiguchi
{"title":"Reference intervals for urinary metanephrines to creatinine ratios in dogs in Japan.","authors":"Noriyuki Nagata, Yoshinori Ikenaka, Hiryu Sawamura, Noboru Sasaki, Mitsuyoshi Takiguchi","doi":"10.1292/jvms.24-0163","DOIUrl":"10.1292/jvms.24-0163","url":null,"abstract":"<p><p>The urinary normetanephrine to creatinine ratio (uNMN/Cr) and urinary metanephrine to creatinine ratio (uMN/Cr) are commonly evaluated for the diagnosis of pheochromocytomas (PCC) in dogs. This study aimed to establish reference intervals for uNMN/Cr and uMN/Cr in 56 healthy dogs in Japan and to investigate the effect of urine collection methods on these measurements in 15 non-PCC dogs. The upper limits of reference intervals for uNMN/Cr and uMN/Cr were 124.4 nmol/mmol (90% confidence interval [CI] 107.7-137.0) and 121.1 nmol/mmol (90% CI 102.8-145.1), respectively. Both uNMN/Cr and uMN/Cr were significantly higher when urine was collected in the hospital compared to at home. Several factors, including the method of urine collection, should be considered when utilizing these reference intervals.</p>","PeriodicalId":49959,"journal":{"name":"Journal of Veterinary Medical Science","volume":" ","pages":"1096-1099"},"PeriodicalIF":1.1,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11442400/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142134288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Successful emergency surgery for accidental ingestion of multiple neodymium magnets in an Argentine tegu (Salvator merianae). 阿根廷虎皮鹦鹉(Salvator merianae)误食多块钕磁铁,成功进行了紧急手术。
IF 1.1 4区 农林科学
Journal of Veterinary Medical Science Pub Date : 2024-10-01 Epub Date: 2024-09-10 DOI: 10.1292/jvms.24-0189
Kengo Ueda, Akiko Ueda, Kiyokazu Ozaki
{"title":"Successful emergency surgery for accidental ingestion of multiple neodymium magnets in an Argentine tegu (Salvator merianae).","authors":"Kengo Ueda, Akiko Ueda, Kiyokazu Ozaki","doi":"10.1292/jvms.24-0189","DOIUrl":"10.1292/jvms.24-0189","url":null,"abstract":"<p><p>A large Argentine tegu (Salvator merianae) presented with anorexia. Initial radiographs revealed a metallic foreign body in the stomach. The tegu vomited and became inactive two days later. A follow-up radiograph revealed the persistence of the foreign body in the same region. The foreign body was identified as a cluster of multiple magnets resembling neodymium magnets reported missing by the owner. An emergent laparotomy was performed due to gastrointestinal perforations caused by the multiple magnets. The surgical intervention revealed perforations in the walls of the stomach and small intestine and progressing acute peritonitis. Three magnets were extracted from the abdominal cavity and the tegu showed recovery. At 200 days postoperatively, the tegu continued to demonstrate good appetite and energy levels.</p>","PeriodicalId":49959,"journal":{"name":"Journal of Veterinary Medical Science","volume":" ","pages":"1105-1109"},"PeriodicalIF":1.1,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11442395/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142299678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Availability and issues of 3D-printed skull models for veterinary anatomy laboratories from students' perspective before and during the COVID-19 pandemic. 在 COVID-19 大流行之前和期间,从学生角度看兽医解剖实验室 3D 打印头骨模型的可用性和问题。
IF 1.1 4区 农林科学
Journal of Veterinary Medical Science Pub Date : 2024-10-01 Epub Date: 2024-08-27 DOI: 10.1292/jvms.24-0021
Motoharu Sakaue, Motoharu Oishi, Aisa Ozawa, Atsushi Tsukamoto, Hideki Kayanuma, Nobutsune Ichihara
{"title":"Availability and issues of 3D-printed skull models for veterinary anatomy laboratories from students' perspective before and during the COVID-19 pandemic.","authors":"Motoharu Sakaue, Motoharu Oishi, Aisa Ozawa, Atsushi Tsukamoto, Hideki Kayanuma, Nobutsune Ichihara","doi":"10.1292/jvms.24-0021","DOIUrl":"10.1292/jvms.24-0021","url":null,"abstract":"<p><p>Three-dimensional (3D)-printed models of bones are a convenient and durable alternative to real bone specimens, and they have been used in anatomy laboratories. It is necessary to identify the precise advantages of 3D-printed models from all perspectives; not only the improvement in students' knowledge of anatomy but also the students' assessment of such models. Here, students of veterinary medicine and animal science evaluated the reproducibility and effectiveness of 3D-printed models as a learning tool by completing our questionnaires, with a focus on their understanding of the skull-morphological differences among dog breeds. With the COVID-19 pandemic having obliged veterinary universities to provide courses online, we also investigated how the pandemic affected the students' evaluation of the 3D-printed models. The questionnaire results revealed that the animal science students were satisfied with the reproducibility of the 3D-printed models, but the veterinary students were not (they preferred to use real specimens). The skull differences were well understood by both types of students, indicating that 3D-printed models are effective for learning about rare skeletal specimens. The veterinary students who experienced the COVID-19 pandemic tended to choose real specimens more often than those who did not have this experience. Our results suggest that the use of 3D-printed models as an introduction and the use of real specimens in anatomy laboratory courses can be adequate for veterinary students. Together our findings suggest ways to improve the educational performance of 3D-printed models for veterinary students who need to understand the anatomy of many species.</p>","PeriodicalId":49959,"journal":{"name":"Journal of Veterinary Medical Science","volume":" ","pages":"1081-1088"},"PeriodicalIF":1.1,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11442399/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142094105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diversity of genes encoding immune-related GTPase B2 protein, an inherited element responsible for resistance against virulent Toxoplasma gondii strains, among wild Mus musculus in local area of Japan. 编码免疫相关 GTPase B2 蛋白的基因的多样性,该蛋白是日本当地野生麝类对毒性弓形虫菌株具有抵抗力的遗传因子。
IF 1.1 4区 农林科学
Journal of Veterinary Medical Science Pub Date : 2024-10-01 Epub Date: 2024-08-16 DOI: 10.1292/jvms.24-0059
Nikolai D Shamaev, Tatiana Batanova, Yuki Iwatake, Junji Moribe, Hisako Kyan, Tatsunori Masatani, Yuko Kitamura, Keisuke Nakagawa, Taizo Saito, Yasuhiro Takashima
{"title":"Diversity of genes encoding immune-related GTPase B2 protein, an inherited element responsible for resistance against virulent Toxoplasma gondii strains, among wild Mus musculus in local area of Japan.","authors":"Nikolai D Shamaev, Tatiana Batanova, Yuki Iwatake, Junji Moribe, Hisako Kyan, Tatsunori Masatani, Yuko Kitamura, Keisuke Nakagawa, Taizo Saito, Yasuhiro Takashima","doi":"10.1292/jvms.24-0059","DOIUrl":"10.1292/jvms.24-0059","url":null,"abstract":"<p><p>The major genetic group of Toxoplasma gondii, known as type I, generally displays high lethality in laboratory Mus musculus (mouse) strains, with few exceptions. However, because rodents are the primary reservoir hosts for T. gondii, if this characteristic manifests in the wild, type I strains would be extinct. Therefore, we hypothesized that populations of wild rodents capable of harboring type I T. gondii asymptomatically exist globally and are not limited to a few localized areas, as previously thought. The strength of mouse resistance to T. gondii is known to depend on the affinity of the mouse-expressed immunity-related GTPases B2 (IRGB2) protein for the T. gondii-expressed rphoptry protein 5B (ROP5B) protein. Therefore, the Irgb2 gene sequences of 12 individuals mice captured at two animal farms in Gifu Prefecture, and on an island in Okinawa Prefecture, Japan were determined, and subjected to a molecular phylogenetic analysis together with those of various mouse strains worldwide. The Irgb2 gene of M. musculus individuals captured on one farm and one island showed diverse sequences. The sequences from two individual mice captured in an animal farm formed a single clade with a wild mouse derived CAST/EiJ strain, known for its exceptional resistance to type I T. gondii lethality. These results suggest that M. musuculus individuals resistant to the Type I T. gondii strain may be present in Japan, in addition to the previously known populations in South Asia, Thailand and India.</p>","PeriodicalId":49959,"journal":{"name":"Journal of Veterinary Medical Science","volume":" ","pages":"1056-1062"},"PeriodicalIF":1.1,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11442403/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142001158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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