四种抗组胺药与奥洛他定对健康纯种马的疗效比较。

IF 1.1 4区农林科学 Q3 VETERINARY SCIENCES

Journal of Veterinary Medical Science Pub Date : 2025-02-04 Epub Date: 2025-01-14 DOI:10.1292/jvms.24-0412

Yasuhiko Ikeda, Taisuke Kuroda, Hiroshi Mita, Norihisa Tamura, Minoru Ohta

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引用次数: 0

摘要

我们比较了四种新型抗组胺药与治疗马变态反应性疾病的奥洛他定的抗组胺效果。6匹健康的纯种马口服剂量为奥洛他定（50毫克）、左西替利嗪（50毫克）、bilastine（200毫克）、rupatadine（100毫克）和地氯雷他定（50毫克），每隔100 - 2周。通过皮内注射组胺对大鼠的轮面积测定，并与阳性对照和阴性对照比较抑制率。奥洛他定的最大轮抑制率（平均±SD）为85.3%±7.7%，显著高于比拉斯汀（51.1%±11.8%）、鲁帕他定（55.3%±6.6%）和地氯雷他定（59.8%±6.4%），但低于左西替利嗪（85.4%±8.0%）。预计左西替利嗪对马有很高的抗组胺作用。

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Comparing the effectiveness of four antihistamines with olopatadine in healthy Thoroughbred horses.

We compared the antihistamine effect of four new antihistamines with olopatadine, which is used to treat equine allergic diseases. Six healthy Thoroughbred horses received oral doses of olopatadine (50 mg), levocetirizine (50 mg), bilastine (200 mg), rupatadine (100 mg), and desloratadine (50 mg) at >2-week intervals. The effects were investigated by measurement of the wheal area induced by histamine intradermal injection, and inhibition rate was compared with positive and negative controls. The maximum wheal inhibition rate (mean ± SD) of olopatadine (85.3% ± 7.7%) was significantly higher than those of bilastine (51.1% ± 11.8%), rupatadine (55.3% ± 6.6%), and desloratadine (59.8% ± 6.4%), but not levocetirizine (85.4% ± 8.0%). Levocetirizine is expected to have a high antihistamine effect on horses.

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来源期刊

Journal of Veterinary Medical Science 农林科学-兽医学

CiteScore

2.30

自引率

8.30%

发文量

230

审稿时长

9-18 weeks

期刊介绍： JVMS is a peer-reviewed journal and publishes a variety of papers on veterinary science from basic research to applied science and clinical research. JVMS is published monthly and consists of twelve issues per year. Papers are from the areas of anatomy, physiology, pharmacology, toxicology, pathology, immunology, microbiology, virology, parasitology, internal medicine, surgery, clinical pathology, theriogenology, avian disease, public health, ethology, and laboratory animal science. Although JVMS has played a role in publishing the scientific achievements of Japanese researchers and clinicians for many years, it now also accepts papers submitted from all over the world.