Journal of Veterinary Medical Science最新文献_第5页

Assessment of motor deterioration in a cynomolgus macaque with neuronal ceroid lipofuscinosis type 2 disease using two behavioral analyses. 用两种行为分析评估患有2型神经性脑蜡样脂褐质病的食蟹猴的运动退化

IF 1.1 4区农林科学

Journal of Veterinary Medical Science Pub Date : 2025-09-18 DOI: 10.1292/jvms.25-0314

Yoshiko Munesue, Fumiko Ono, Naohide Ageyama, Ken-Ichi Yagami, Kazuhiro Ishii, Akira Tamaoka, Yasuhiro Yasutomi, Nobuhiro Shimozawa

引用次数: 0

Potential inhibitory effect of Shigyakusan on gallstone formation in a mice model of cholesterol gallstone disease. 石屋散对胆固醇型胆结石病小鼠模型胆石形成的潜在抑制作用。

IF 1.1 4区农林科学

Journal of Veterinary Medical Science Pub Date : 2025-09-18 DOI: 10.1292/jvms.25-0296

Go Utsunomiya, Yuta Shinohara, Haruki Kurihara, Yishan Liu, Yusuke Ishihara, Minami Kobayashi, Mohamed Elbadawy, Amira Abugomaa, Tatsuya Usui, Kazuaki Sasaki

{"title":"Potential inhibitory effect of Shigyakusan on gallstone formation in a mice model of cholesterol gallstone disease.","authors":"Go Utsunomiya, Yuta Shinohara, Haruki Kurihara, Yishan Liu, Yusuke Ishihara, Minami Kobayashi, Mohamed Elbadawy, Amira Abugomaa, Tatsuya Usui, Kazuaki Sasaki","doi":"10.1292/jvms.25-0296","DOIUrl":"https://doi.org/10.1292/jvms.25-0296","url":null,"abstract":"Cholesterol gallstones (CGs) are formed in the biliary system due to cholesterol supersaturation in the bile and delayed bile excretion. The current treatments for CGs involve potentially severe complications, and novel therapeutic approaches are still required. Shigyakusan is a traditional Chinese medicine used for treating CG disease (CGD), but there are no reports on the action or efficacy of Shigyakusan in CGD. The present study was conducted to clarify the inhibitive effects of Shigyakusan on CGD. Mice were fed a normal or lithogenic diet for 8 weeks (to create a mouse model of CGD) and simultaneously treated with vehicle or Shigyakusan. Organs were removed after blood sampling to examine CG formation and perform pathological evaluations. Genetic analysis of the liver, gallbladder, and ileum tissues was also conducted. CGD was induced by feeding mice with a lithogenic diet. Specifically, gallstones were detected, and serum T-CHO and LDL-C were significantly elevated. Administration of Shigyakusan to CGD mice reduced the development of CGs and lowered the serum T-CHO and LDL-C levels. Additionally, Shigyakusan administration increased ABCG5/G8 and ABCB4 mRNA expression in the liver, AQP5 expression in the gallbladder, and ABCG5 expression in the ileum of CGD mice. Shigyakusan administration diminished the synthesis of CGs in mice by lowering serum cholesterol and improving bile flow. The results show that Shigyakusan may be a beneficial option for CGD treatment and prevention.","PeriodicalId":49959,"journal":{"name":"Journal of Veterinary Medical Science","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145088060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inverted papilloma with Civatte/colloid body-like eosinophilic structures, accumulated with Keratins 14-, 6a-, 5-, and 4-like proteins in an oriental turtle dove (Streptopelia orientalis). 在东方斑鸠（Streptopelia orientalis）中，具有Civatte/胶体体样嗜酸性粒细胞结构的倒置乳头状瘤，积聚了角蛋白14-、6a-、5-和4-样蛋白。

IF 1.1 4区农林科学

Journal of Veterinary Medical Science Pub Date : 2025-09-18 DOI: 10.1292/jvms.25-0182

Tatsu Kuriki, Bai Yadan, Nanami Watanabe, Yuri Ebizuka, Mai Hirata, Mio Takimoto, Mengyuan Luo, Mai Todoroki, Mio Kobayashi, Natsumi Kobayashi, Susumu Iwaide, Tomoaki Murakami, Tetsuhito Kigata, Yoshiyuki Itoh, Ma Suzanneth G Lola, Makoto Shibutani, Toshinori Yoshida

{"title":"Inverted papilloma with Civatte/colloid body-like eosinophilic structures, accumulated with Keratins 14-, 6a-, 5-, and 4-like proteins in an oriental turtle dove (Streptopelia orientalis).","authors":"Tatsu Kuriki, Bai Yadan, Nanami Watanabe, Yuri Ebizuka, Mai Hirata, Mio Takimoto, Mengyuan Luo, Mai Todoroki, Mio Kobayashi, Natsumi Kobayashi, Susumu Iwaide, Tomoaki Murakami, Tetsuhito Kigata, Yoshiyuki Itoh, Ma Suzanneth G Lola, Makoto Shibutani, Toshinori Yoshida","doi":"10.1292/jvms.25-0182","DOIUrl":"https://doi.org/10.1292/jvms.25-0182","url":null,"abstract":"Cutaneous inverted papilloma is rarely reported in avian species. In this study, an oriental turtle dove presented with subcutaneous masses in the neck, thorax, and leg. Histopathological examination revealed an inverted proliferation of basaloid squamous epithelial cells in a cord-like, lobulated growth pattern containing Civatte/colloid body-like structures, which extend into the abundant stroma with melanosis. Proteomic analysis of formalin-fixed paraffin-embedded tissues identified Keratins 14- and 5-like proteins, with lower levels of Keratins 6A-, and 4-like proteins. Immunohistochemistry confirmed strong reactivity of Keratin 14 in the basal layers of the tumor. This case of cutaneous inverted papilloma was distinguished by unique Civatte/colloid body-like structures and the accumulation of several keratins.","PeriodicalId":49959,"journal":{"name":"Journal of Veterinary Medical Science","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145087926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pathogenicity and host range of avian influenza viruses: molecular determinants and virological perspectives. 禽流感病毒的致病性和宿主范围：分子决定因素和病毒学观点。

IF 1.1 4区农林科学

Journal of Veterinary Medical Science Pub Date : 2025-09-16 DOI: 10.1292/jvms.25-0313

Toshihiro Ito

{"title":"Pathogenicity and host range of avian influenza viruses: molecular determinants and virological perspectives.","authors":"Toshihiro Ito","doi":"10.1292/jvms.25-0313","DOIUrl":"https://doi.org/10.1292/jvms.25-0313","url":null,"abstract":"The pathogenicity of avian influenza virus (AIV) is governed primarily by the hemagglutinin (HA) glycoprotein. Highly pathogenic avian influenza viruses contain a highly cleavable HA molecule susceptible to ubiquitous host proteases, such as furin, resulting in severe systemic infections. In contrast, low-pathogenic avian influenza viruses have HAs that require activation by trypsin-like proteases, restricted to specific organs, causing localized and mild infections. We generated highly pathogenic virus variants by serially passaging low-pathogenic waterfowl isolates that originally replicated poorly in domestic poultry. The increased pathogenicity was correlated with a shift from a low-pathogenic to a highly pathogenic motif in the HA cleavage site. These findings suggest that benign viruses maintained in wild waterfowl in nature have the potential to become highly pathogenic variants during circulation and adaptation in chickens. Moreover, the host specificity of AIV is also primarily determined by the HA glycoprotein. AIVs usually replicate less efficiently in humans, whereas human influenza viruses replicate poorly in birds. This host restriction largely reflects differences in receptor-binding specificity of the HA protein. Most AIVs preferentially bind to sialic acid receptors with α2,3-linked galactose (SAα2,3Gal), while human viruses prefer the SAα2,6Gal linkage. Interestingly, both receptor types are expressed in the respiratory epithelium of pigs. Swine serve as \"mixing vessels\" that facilitate the reassortment of viruses between avian and human strains. These results provide a molecular basis for the key mechanisms underlying the emergence of novel influenza viruses with pandemic potential in humans.","PeriodicalId":49959,"journal":{"name":"Journal of Veterinary Medical Science","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145076386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence, antimicrobial susceptibility, and virulence profiles of fluoroquinolone-resistant Escherichia coli isolated from companion animals in Sapporo, Japan. 日本札幌从伴侣动物中分离出的氟喹诺酮类耐药大肠杆菌的流行、耐药性和毒力谱

IF 1.1 4区农林科学

Journal of Veterinary Medical Science Pub Date : 2025-09-16 DOI: 10.1292/jvms.25-0251

Aiko Maeda, Toyotaka Sato, Jirachaya Toyting-Hiraishi, Akio Suzuki, Yuuji Hoshino, Shingo Torigoe, Keiichiro Sakakibara, Satoshi Tamai, Tooru Tachibana, Motohiro Horiuchi

{"title":"Prevalence, antimicrobial susceptibility, and virulence profiles of fluoroquinolone-resistant Escherichia coli isolated from companion animals in Sapporo, Japan.","authors":"Aiko Maeda, Toyotaka Sato, Jirachaya Toyting-Hiraishi, Akio Suzuki, Yuuji Hoshino, Shingo Torigoe, Keiichiro Sakakibara, Satoshi Tamai, Tooru Tachibana, Motohiro Horiuchi","doi":"10.1292/jvms.25-0251","DOIUrl":"https://doi.org/10.1292/jvms.25-0251","url":null,"abstract":"Antimicrobial resistance in Escherichia coli is a growing concern in both human and veterinary medicine. Although fluoroquinolone-resistant (FQ-R) E. coli has been reported in companion animals, no integrated analysis incorporating antimicrobial susceptibility, clonality, resistance genes, and virulence factors (VFs) to assess human health risks has been conducted in Japan. This study aimed to characterize FQ-R E. coli isolates from companion animals in Sapporo, Japan by identifying antimicrobial susceptibility, clonality, resistance genes, and VFs. Among 106 animals sampled, 33.0% carried FQ-R E. coli. Among 104 FQ-R E. coli isolates, 58 isolates (55.8%) were identified as ST131. Whole-genome sequencing of 35 representative FQ-R E. coli isolates, including 20 ST131 isolates, showed that the ST131 isolates were distributed among five clades/sub-clades (C1-nM27, C1-M27, A, C2 and Unclassified), indicating increased clade diversity compared to previous years. ST1193, another international high-risk clone, was also detected. All isolates harbored mutations of quinolone resistance-determining regions in gyrA and parC, and 51.4% carried blaCTX-M genes, including blaCTX-M-27 and blaCTX-M-14. Most isolates remained susceptible to aminoglycosides and cefmetazole, although the latter is not approved for veterinary use in Japan. Additionally, 72 VFs were identified, and eight were shared by all isolates, suggesting potential risk to human health. Our findings indicate that companion animals share certain E. coli lineages including ST131 and ST1193 with humans. Prudent antimicrobial use and routine hygiene practices are essential to limit the transmission. Further studies incorporating human and environmental isolates are needed to better understand the transmission dynamics of FQ-R E. coli within communities.","PeriodicalId":49959,"journal":{"name":"Journal of Veterinary Medical Science","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145076483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

First outbreak of lumpy skin disease in Japan, 2024. 2024年，日本首次爆发结节性皮肤病。

IF 1.1 4区农林科学

Journal of Veterinary Medical Science Pub Date : 2025-09-16 DOI: 10.1292/jvms.25-0290

Mizuki Watanabe, Mitsutaka Ikezawa, Tomoya Kitamura, Hiroaki Shirafuji, Naoki Yoshida, Tatsuya Nishi, Rie Kawaguchi, Takehiro Kokuho, Kentaro Masujin, Katsuhiko Fukai, Kazuki Morioka

引用次数: 0

First report of systemic round cell tumor, suspected lymphoma, in a wild Amami rabbit (Pentalagus furnessi) from Tokunoshima Island. 德野岛野生天美兔（Pentalagus furnessi）首次报道系统性圆细胞瘤，疑似淋巴瘤。

IF 1.1 4区农林科学

Journal of Veterinary Medical Science Pub Date : 2025-09-16 DOI: 10.1292/jvms.25-0184

Rui Kato, Masami Yamamoto, Sayoko Hiruma, Keiko Ito, Hiroshi Aoki, Makoto Haritani, Hisashi Yoshimura

引用次数: 0

Acute toxicity of local anesthetics used for humans and other animals in the larvae of marine crustacean, red-clawed crab Chiromantes haematocheir. 用于人类和其他动物的局部麻醉剂对海洋甲壳类红爪蟹（Chiromantes haematocheir）幼虫的急性毒性。

IF 1.1 4区农林科学

Journal of Veterinary Medical Science Pub Date : 2025-09-11 DOI: 10.1292/jvms.25-0273

Atsushi Nishikawa, Keito Tsunoda, Kaito Hatano, Yoshiaki Tabuchi, Tetsushi Hirano, Riku Izumi, Shion Oshima, Yukihiro Furusawa, Akihiro Sakatoku, Ajai K Srivastav, Masato Honda, Hajime Matsubara, Shouzo Ogiso, Marin Takasu, Chun-Sang Hong, Jun Hirayama, Atsuhiko Hattori, Nobuo Suzuki

{"title":"Acute toxicity of local anesthetics used for humans and other animals in the larvae of marine crustacean, red-clawed crab Chiromantes haematocheir.","authors":"Atsushi Nishikawa, Keito Tsunoda, Kaito Hatano, Yoshiaki Tabuchi, Tetsushi Hirano, Riku Izumi, Shion Oshima, Yukihiro Furusawa, Akihiro Sakatoku, Ajai K Srivastav, Masato Honda, Hajime Matsubara, Shouzo Ogiso, Marin Takasu, Chun-Sang Hong, Jun Hirayama, Atsuhiko Hattori, Nobuo Suzuki","doi":"10.1292/jvms.25-0273","DOIUrl":"https://doi.org/10.1292/jvms.25-0273","url":null,"abstract":"Local anesthetics such as lidocaine have been used in humans and other animals to perform surgical procedures, therapeutics, and experiments. Lidocaine discarded into the environment through industrial waste, human and animal excretion, and household waste has been detected in the aquatic environment. For example, lidocaine in rivers, lakes, and influent and effluent water has been detected at wastewater treatment plants (7 ng/L-2.06 μg/L), suggesting that this chemical substance influences aquatic animals. However, the toxic effects of lidocaine on marine organisms have not been investigated. This study examined the acute toxicity of local anesthetics (lidocaine and dibucaine) on the marine zoea larvae of red-clawed crabs, which feature a life cycle in which adults live on land and larvae live in the sea. Survival analysis of zoea larvae revealed that dibucaine was more toxic than lidocaine. The 50% effective concentrations (EC50s) for lidocaine and dibucaine were 1.64 × 10-3 and 4.63 × 10-5 M, respectively, after 24 hr of exposure. Next, RNA sequencing was performed using the EC50 of each drug. Both local anesthetics were highly toxic to the kidneys, in addition to their effects on the heart, nerves, and liver. These local anesthetics were also found to affect melatonin metabolism and possibly decrease melatonin levels in zoea larvae. To the best of our knowledge, no prior study conducted a comprehensive analysis of the effects of local anesthetics on aquatic larvae, illustrating the need to focus on the toxicity of these drugs in aquatic animals.","PeriodicalId":49959,"journal":{"name":"Journal of Veterinary Medical Science","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145034127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An exploratory study on the effects of dermal suctioning prior to underwater treadmill exercise on post-exercise oxidative stress in healthy dogs. 水下跑步机运动前皮肤抽吸对健康犬运动后氧化应激影响的探索性研究。

IF 1.1 4区农林科学

Journal of Veterinary Medical Science Pub Date : 2025-09-11 DOI: 10.1292/jvms.25-0233

Takuma Miyata, Saya Kawai, Seri Seki, Hiroki Shibutani, Tomonari Shibutani, Katsumi Ishioka

{"title":"An exploratory study on the effects of dermal suctioning prior to underwater treadmill exercise on post-exercise oxidative stress in healthy dogs.","authors":"Takuma Miyata, Saya Kawai, Seri Seki, Hiroki Shibutani, Tomonari Shibutani, Katsumi Ishioka","doi":"10.1292/jvms.25-0233","DOIUrl":"https://doi.org/10.1292/jvms.25-0233","url":null,"abstract":"Oxidative stress has attracted attention as an indicator of exercise load. Minimizing the impact on the body is essential during underwater treadmill exercise. Here, we conducted an exploratory study of the effects of dermal suction, which has been reported to improve blood flow in healthy dogs, prior to underwater treadmill exercise. Five healthy beagles (two neutered males and three spayed females) underwent dermal suctioning with Medicell for PETS over the entire body for 30 min. Underwater treadmill exercise was performed (water temperature: 32-33°C, water level: hip joint, load: 1.5 km/hr for 20 min). Blood samples were collected immediately before; immediately after; and 1 hr, 1 day, and 3 days after the underwater treadmill exercise; the diacron-reactive oxygen metabolites (d-ROMs), indicating the oxidation level, and biological antioxidant potential (BAP), indicating antioxidant capacity, were measured to determine the BAP/d-ROM ratio as the potential antioxidant capacity. The results showed that dermal suction significantly decreased d-ROMs 3 days after underwater treadmill exercise, and the BAP/d-ROM ratio was significantly higher immediately after exercise and 1 and 3 days after dermal suctioning. The parasympathetic nervous system is activated by dermal suctioning, resulting in muscle relaxation and mild psychological change. This study showed that dermal suction tended to decrease oxidative stress after exercise. Future studies should consider effects on the nervous system and exercise intensity indices and should be conducted in larger canine cohorts.","PeriodicalId":49959,"journal":{"name":"Journal of Veterinary Medical Science","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145034191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Porcine reproductive and respiratory syndrome virus type 1 and type 2 co-infection in a Japanese swine herd. 日本猪群猪繁殖与呼吸综合征病毒1型和2型合并感染。

IF 1.1 4区农林科学

Journal of Veterinary Medical Science Pub Date : 2025-09-08 DOI: 10.1292/jvms.25-0279

Osamu Taira, Akira Fujiwara, Ryosuke Takai, Nobuyuki Tsutsumi, Katsuaki Sugiura

引用次数: 0