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Journal of Veterinary Medical Science最新文献

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End-tidal concentration of sevoflurane for optimal surgical conditions in pregnant sheep: a pragmatic approach to a retrospective observational study. 七氟醚潮气末浓度为妊娠羊提供最佳手术条件：一项回顾性观察研究的实用方法。
IF 1.1 4区 农林科学
Journal of Veterinary Medical Science Pub Date : 2024-12-01 Epub Date: 2024-10-25 DOI: 10.1292/jvms.24-0354
Tom Bleeser, Simen Vergote, David Basurto, Ignacio Valenzuela, Luc Joyeux, Francesca Russo, Yada Kunpalin, Doaa Emam, Marc VAN DE Velde, Sarah Devroe, Jan Deprest, Steffen Rex
{"title":"End-tidal concentration of sevoflurane for optimal surgical conditions in pregnant sheep: a pragmatic approach to a retrospective observational study.","authors":"Tom Bleeser, Simen Vergote, David Basurto, Ignacio Valenzuela, Luc Joyeux, Francesca Russo, Yada Kunpalin, Doaa Emam, Marc VAN DE Velde, Sarah Devroe, Jan Deprest, Steffen Rex","doi":"10.1292/jvms.24-0354","DOIUrl":"10.1292/jvms.24-0354","url":null,"abstract":"<p><p>The aim of this pragmatic approach to retrospective observational study was to identify the end-tidal concentration of sevoflurane which was associated with optimal surgical conditions (i.e., absence of any movement, coughing and straining) in 127 pregnant sheep. Optimal surgical conditions were observed in 90% of the ewes with an end-tidal concentration of sevoflurane of 2.4 Vol-% [95% CI: 2.2; 2.8] during minimal-mild nociceptive stimuli (placement of arterial catheter, bladder catheter, shaving), with 4.4 Vol-% [95% CI: 4.0; 5.2] during maternal laparotomy and hysterotomy and with 4.4 Vol-% [95% CI: 3.9; 5.8] during subsequent manipulation of the uterus and fetal surgery.</p>","PeriodicalId":49959,"journal":{"name":"Journal of Veterinary Medical Science","volume":" ","pages":"1299-1302"},"PeriodicalIF":1.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11612238/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142512008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Campylobacter fetus isolates from both human patients and healthy cattle carry three distinct cytolethal distending toxin (cdt) gene clusters. 从人类患者和健康牛身上分离出的胎儿弯曲杆菌携带三种不同的细胞致死膨胀毒素（ctt）基因簇。
IF 1.1 4区 农林科学
Journal of Veterinary Medical Science Pub Date : 2024-12-01 Epub Date: 2024-10-28 DOI: 10.1292/jvms.24-0336
Wen Wen, Noritoshi Hatanaka, Srinuan Somroop, Sharda Prasad Awasthi, Atsushi Hinenoya, Shinji Yamasaki
{"title":"Campylobacter fetus isolates from both human patients and healthy cattle carry three distinct cytolethal distending toxin (cdt) gene clusters.","authors":"Wen Wen, Noritoshi Hatanaka, Srinuan Somroop, Sharda Prasad Awasthi, Atsushi Hinenoya, Shinji Yamasaki","doi":"10.1292/jvms.24-0336","DOIUrl":"10.1292/jvms.24-0336","url":null,"abstract":"<p><p>Campylobacter fetus is a zoonotic pathogen. Although the precise virulence mechanisms have not yet been fully elucidated, cytolethal distending toxin (CDT) is considered as one of the well-characterized virulence factors in Campylobacter. In silico analysis of the genome of C. fetus type strain ATCC27374<sup>T</sup> indicates that there are three cdt gene clusters, Cfcdt-I, Cfcdt-II and Cfcdt-III. However, it is not clear whether these clusters are ubiquitously present in C. fetus and their association with diseases in humans and animals. In this study, we have analyzed the distribution and nucleotide sequences of these cdt gene clusters in 137 C. fetus strains isolated from human patients and healthy cattle. MLST and PFGE were also applied to determine clonal relationship between C. fetus strains isolated from patients and cattle. We found all C. fetus strains carry three Cfcdt gene clusters by colony hybridization assay and the strains belonged to 38 different pulsotypes. Whole genome sequencing of 38 C. fetus strains was carried out to determine the entire cdt gene cluster sequences and their sequence type (ST). Among 38 strains, six STs were identified, and each cdt gene cluster showed high similarity (>99%). Interestingly, some of these Cfcdt genes are more similar to the cdt genes of other Campylobacter species than other Cfcdt gene types. Altogether, the results suggest that three Cfcdt gene clusters are highly conserved in C. fetus and the strains belonging to ST-6 may be more pathogenic to human.</p>","PeriodicalId":49959,"journal":{"name":"Journal of Veterinary Medical Science","volume":" ","pages":"1311-1318"},"PeriodicalIF":1.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11612251/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142512006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dogs with severe tracheal flattening exhibit lower degrees of left lateralization of the cervical esophagus. 气管严重扁平的狗狗颈部食管左侧化程度较低。
IF 1.1 4区 农林科学
Journal of Veterinary Medical Science Pub Date : 2024-12-01 Epub Date: 2024-10-25 DOI: 10.1292/jvms.24-0270
Kenji Teshima, Teppei Fujimoto, Naoko Shiozawa, Chieko Ishikawa, Yoshiki Yamaya
{"title":"Dogs with severe tracheal flattening exhibit lower degrees of left lateralization of the cervical esophagus.","authors":"Kenji Teshima, Teppei Fujimoto, Naoko Shiozawa, Chieko Ishikawa, Yoshiki Yamaya","doi":"10.1292/jvms.24-0270","DOIUrl":"10.1292/jvms.24-0270","url":null,"abstract":"<p><p>Herein, we investigated the positional relationship between the cervical esophagus and trachea using computed tomography (CT) images in dogs with tracheal flattening. From these CT images, the ratio of the tracheal diameters in the short (vertical) and long (horizontal) axes of the tracheal ring (S/L ratio) and the vertebra-trachea-esophagus (VTE) angle were measured at the point from the 3rd cervical (C3) to the 3rd thoracic vertebra (T3) levels. The VTE angle in dogs with tracheal flattening with an S/L ratio under 0.24 tended to be smaller than the angles at the level from C4 to T2 in dogs with an S/L ratio over 0.25. The positional relationship between the esophagus and trachea seems to be possibly related to tracheal cross-sectional shape.</p>","PeriodicalId":49959,"journal":{"name":"Journal of Veterinary Medical Science","volume":" ","pages":"1284-1288"},"PeriodicalIF":1.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11612253/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142512007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Establishment of new mouse model for allergic dermatitis showing severe fibrosis. 建立显示严重纤维化的过敏性皮炎新小鼠模型。
IF 1.1 4区 农林科学
Journal of Veterinary Medical Science Pub Date : 2024-12-01 Epub Date: 2024-10-24 DOI: 10.1292/jvms.24-0394
Yusuke Yamada, Kyoko Yoshizaki, Masashi Sakurai, Masahiro Morimoto
{"title":"Establishment of new mouse model for allergic dermatitis showing severe fibrosis.","authors":"Yusuke Yamada, Kyoko Yoshizaki, Masashi Sakurai, Masahiro Morimoto","doi":"10.1292/jvms.24-0394","DOIUrl":"10.1292/jvms.24-0394","url":null,"abstract":"<p><p>Allergic dermatitis (AD) is a skin disease characterized by a chronic inflammation caused by immune dysregulation. In the histopathology of patients with AD, there are several features, such as accumulation of eosinophils and mast cells, hyperkeratosis, and dermal fibrosis which are related to the exacerbation of AD. Mast cells and eosinophils are thought to be involved in fibrosis, but the details are unknown. Yama mouse is an inbred mouse showing genetically eosinophilia. If eosinophils have significant effect on fibrosis, it may be possible to establish a new AD model with severe fibrosis. In this study, AD was induced by applying dinitrofluorobenzene to mice auricle. Yama mice showed AD lesion with more severe dermal fibrosis with severe eosinophil infiltration than Balb/c and Nc/nga mice. The expression of transforming growth factor-β (TGF-β), a cytokine important for fibrosis, was not significantly different among Yama, Balb/c, and Nc/nga mice, while the expression of interleukin-4 (IL-4), which is also mediator of tissue fibrosis, was increased only in Yama mice. The results of this study showed that AD with more severe fibrosis could be induced in Yama mice than in Balb/c and Nc/nga mice. In Yama mice, it can be concluded that the severe fibrosis is TGF-β independent, and IL-4 would be the main mediator of severe fibrosis. This mouse model may be useful for elucidating the mechanism of fibrosis in chronic AD, and for conducting research leading to the development of new therapies.</p>","PeriodicalId":49959,"journal":{"name":"Journal of Veterinary Medical Science","volume":" ","pages":"1303-1310"},"PeriodicalIF":1.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11612250/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142512009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A clinical case of B-cell lymphoma in a Japanese Black cow with monoclonal proliferation of B-cells as revealed by polymerase chain reaction based on the immunoglobulin light chain gene. 基于免疫球蛋白轻链基因的聚合酶链反应揭示的日本黑牛 B 细胞淋巴瘤单克隆增殖临床病例。
IF 1.1 4区 农林科学
Journal of Veterinary Medical Science Pub Date : 2024-12-01 Epub Date: 2024-11-04 DOI: 10.1292/jvms.24-0320
Tatsuki Nagata, Toshiyuki Harada, Masaki Maezawa, James K Chambers, Kazuyuki Uchida, Hisashi Inokuma
{"title":"A clinical case of B-cell lymphoma in a Japanese Black cow with monoclonal proliferation of B-cells as revealed by polymerase chain reaction based on the immunoglobulin light chain gene.","authors":"Tatsuki Nagata, Toshiyuki Harada, Masaki Maezawa, James K Chambers, Kazuyuki Uchida, Hisashi Inokuma","doi":"10.1292/jvms.24-0320","DOIUrl":"10.1292/jvms.24-0320","url":null,"abstract":"<p><p>A 35-month-old Japanese Black cow was presented to a local veterinarian with a main complaint of premature labor. There was no swelling of lymph nodes on the body surface and no palpable mass on rectal examination. Although atypical lymphocytes were observed in the peripheral blood, no lymphocytosis was recorded. On Day 12, the cow developed hindlimb paresis and was euthanized. Necropsy revealed swelling of some lymph nodes, and white nodules in uterus and right atrial appendage. Histopathological examination revealed B-cell lymphoma. In clonality analysis of peripheral blood and tumor tissue, monoclonal proliferation was detected by PCR for immunoglobulin light chain (IgL) λ, suggesting neoplastic proliferation of B-cell. IgL-PCR is thought to be a possible tool for diagnosis of B-cell lymphoma.</p>","PeriodicalId":49959,"journal":{"name":"Journal of Veterinary Medical Science","volume":" ","pages":"1294-1298"},"PeriodicalIF":1.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11612244/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142574868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nodal T-cell lymphoma with eosinophilic infiltration and sclerosing fibroplasia in a cat with eosinophilia. 一只患有嗜酸性粒细胞增多症的猫患上了伴有嗜酸性粒细胞浸润和硬化性纤维增生的结节性 T 细胞淋巴瘤。
IF 1.1 4区 农林科学
Journal of Veterinary Medical Science Pub Date : 2024-12-01 Epub Date: 2024-10-22 DOI: 10.1292/jvms.24-0225
Tamami Suzuki, Jumpei Yamazaki, Kouta Yamaguchi, Keisuke Aoshima, Takashi Kimura
{"title":"Nodal T-cell lymphoma with eosinophilic infiltration and sclerosing fibroplasia in a cat with eosinophilia.","authors":"Tamami Suzuki, Jumpei Yamazaki, Kouta Yamaguchi, Keisuke Aoshima, Takashi Kimura","doi":"10.1292/jvms.24-0225","DOIUrl":"10.1292/jvms.24-0225","url":null,"abstract":"<p><p>An 8-year-old castrated male mixed-breed cat presented with an abdominal mass of unknown origin, accompanied by eosinophilia. Autopsy revealed mild-to-severe enlargement of lymph nodes throughout the body and multiple nodules in the lungs. Histopathologically, the lymph nodes showed severe fibroplasia and infiltration by a large number of eosinophils and fewer tumor cells, exhibiting large-sized lymphoid cell morphology. Metastatic lesions of tumor cells with eosinophilic infiltration and fibrosis were observed in the lungs, liver, kidneys, stomach, and intestines. Immunohistochemistry revealed that the tumor cells were positive for CD3 and negative for B cell and mast cell markers. Thus, T-cell lymphoma with eosinophilic infiltration and sclerosing fibroplasia was diagnosed.</p>","PeriodicalId":49959,"journal":{"name":"Journal of Veterinary Medical Science","volume":" ","pages":"1252-1255"},"PeriodicalIF":1.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11612247/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142512010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Attenuation of the neuropathogenic equine herpesvirus type 1 strain Ab4p in hamsters by a single amino acid mutation (D752N) in viral DNA polymerase ORF30. 病毒DNA聚合酶ORF30中的一个氨基酸突变（D752N）对仓鼠神经致病性马疱疹病毒1型毒株Ab4p的影响。
IF 1.1 4区 农林科学
Journal of Veterinary Medical Science Pub Date : 2024-12-01 Epub Date: 2024-10-09 DOI: 10.1292/jvms.24-0338
Fuka Nishimura, Noriko Fukushi, Hiroki Sakai, Hideto Fukushi
{"title":"Attenuation of the neuropathogenic equine herpesvirus type 1 strain Ab4p in hamsters by a single amino acid mutation (D752N) in viral DNA polymerase ORF30.","authors":"Fuka Nishimura, Noriko Fukushi, Hiroki Sakai, Hideto Fukushi","doi":"10.1292/jvms.24-0338","DOIUrl":"10.1292/jvms.24-0338","url":null,"abstract":"<p><p>Equine herpesvirus type 1 (EHV-1) causes abortion, respiratory infection, and neurological diseases (equine herpesvirus myeloencephalopathy) in horses. A single nucleotide polymorphism (SNP) associated with a single amino acid in the DNA polymerase gene (ORF30, in which D752 is neuropathogenic and N752 is non-neuropathogenic) of EHV-1 has been associated with neuropathogenicity in horses. We constructed an EHV-1 Ab4p ORF30 N752 mutant and a repair virus to examine the effect of a D752N mutation on the neuropathogenicity of the virus in Syrian hamsters. The N752 mutation did not affect viral growth in cultured cells but it did attenuate the neuropathogenicity of Ab4p in the hamsters. The results suggest that D752N is involved in neuropathogenicity not only in horses but also in hamsters.</p>","PeriodicalId":49959,"journal":{"name":"Journal of Veterinary Medical Science","volume":" ","pages":"1273-1278"},"PeriodicalIF":1.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11612248/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142394806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalence of pathogens and antimicrobial resistance of isolated Staphylococcus spp. in bovine mastitis milk in South Korea, 2018-2022. 2018-2022 年韩国牛乳腺炎牛奶中分离出的葡萄球菌的病原体流行率和抗菌药耐药性。
IF 1.1 4区 农林科学
Journal of Veterinary Medical Science Pub Date : 2024-12-01 Epub Date: 2024-10-11 DOI: 10.1292/jvms.24-0239
Hye Jeong Kang, Ju-Yeon You, Serim Hong, Jin-San Moon, Ha-Young Kim, Ji-Hye Choi, Jae-Myoung Kim, Young Ju Lee, Hyun-Mi Kang
{"title":"Prevalence of pathogens and antimicrobial resistance of isolated Staphylococcus spp. in bovine mastitis milk in South Korea, 2018-2022.","authors":"Hye Jeong Kang, Ju-Yeon You, Serim Hong, Jin-San Moon, Ha-Young Kim, Ji-Hye Choi, Jae-Myoung Kim, Young Ju Lee, Hyun-Mi Kang","doi":"10.1292/jvms.24-0239","DOIUrl":"10.1292/jvms.24-0239","url":null,"abstract":"<p><p>Staphylococcus spp. are one of the most predominant isolates in milk samples of dairy cows with mastitis worldwide. The aims of this study were to investigate the prevalence of bacterial pathogens in bovine mastitis milk samples in South Korea and the antimicrobial resistance profiles of staphylococcal isolates. In total, 1,245 strains were isolated from 1,260 mastitis quarter milk samples (with somatic cell counts ≥ 200,000 cells/mL) from 66 dairy farms between 2018 and 2022. The bacterial genus with the highest prevalence in bovine mastitis milk samples was Staphylococcus spp. (33.9%), followed by Streptococcus spp. (11.5%). S. aureus and non-aureus staphylococci (NAS) accounted for 11.0% and 89.0% of staphylococcal isolates, respectively. S. chromogenes was the most prevalent species among the 22 NAS species detected. S. aureus showed the highest resistance rates to penicillin (25.0%) and ampicillin (20.8%), whereas NAS showed the highest resistance rates to penicillin (18.3%), tetracycline (11.4%) and erythromycin (10.1%). Sixteen multidrug-resistant (MDR) isolates were only isolated from NAS, and the most commonly detected antimicrobial resistance gene in the 16 MDR isolates was mecA (75.0%), followed by tetK (62.5%), blaZ (50.0%), ermC (50.0%), and lnuA (43.8%). In conclusion, NAS were the most common isolates from mastitis milk in South Korea and MDR isolates carried a variety of antibiotic resistance genes. Our study suggests that continuous monitoring of the distribution and antimicrobial resistance in Staphylococcus spp., particularly NAS, is needed to improve the effectiveness of management and treatment strategies in dairy farms.</p>","PeriodicalId":49959,"journal":{"name":"Journal of Veterinary Medical Science","volume":" ","pages":"1219-1226"},"PeriodicalIF":1.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11612239/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142479252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Salinomycin induces apoptosis and potentiates the antitumor effect of doxorubicin against feline mammary tumor 2.5D organoids. 盐霉素诱导细胞凋亡并增强多柔比星对猫乳腺肿瘤2.5D器官组织的抗肿瘤作用。
IF 1.1 4区 农林科学
Journal of Veterinary Medical Science Pub Date : 2024-12-01 Epub Date: 2024-10-22 DOI: 10.1292/jvms.24-0344
Yishan Liu, Mohamed Elbadawy, Haru Yamamoto, Amira Augomaa, Yusuke Ishihara, Masahiro Kaneda, Tatsuya Usui, Kazuaki Sasaki
{"title":"Salinomycin induces apoptosis and potentiates the antitumor effect of doxorubicin against feline mammary tumor 2.5D organoids.","authors":"Yishan Liu, Mohamed Elbadawy, Haru Yamamoto, Amira Augomaa, Yusuke Ishihara, Masahiro Kaneda, Tatsuya Usui, Kazuaki Sasaki","doi":"10.1292/jvms.24-0344","DOIUrl":"10.1292/jvms.24-0344","url":null,"abstract":"<p><p>Feline mammary tumors (FMT) are the third most common form of neoplasm in cats. The prognosis of FMT is poor due to its high malignancy and metastatic potential. The outcomes of treatment using the common anticancer drug doxorubicin (DOX) are unsatisfactory, with resistance inevitably leading to treatment failure and disease recurrence. Salinomycin (SAL), an antibiotic, has been reported to exert anticancer effects on both human and canine mammary tumors. To recapitulate the genetic and molecular imprints of the original tumor sample, we generated four strains of patient-derived FMT 2.5D organoids (FMTO) to examine the anti-tumor potential of SAL. Our results revealed that SAL decreased cell viability in a dose-dependent manner. Treatment of FMTO with SAL-induced cell apoptosis, represented by an upregulation of P21, Caspase-8, and Caspase-9, and increased activity of Caspase-3/7. The combination of low-dose SAL with DOX (SD) potentiated the cytotoxicity of the latter in both DOX-resistant and DOX-sensitive strains, promoting cell apoptosis and cell-cycle arrest. In vivo, experiments using FMTO-derived xenografts engrafted into mice revealed decreased tumor growth following SAL administration. In conclusion, SAL showed anticancer activity against FMTO and potentiated the anticancer effect of DOX by inhibiting cell proliferation and inducing apoptosis and cell cycle arrest. These results suggest that SAL may represent a new adjuvant treatment option for patients with FMT.</p>","PeriodicalId":49959,"journal":{"name":"Journal of Veterinary Medical Science","volume":" ","pages":"1256-1264"},"PeriodicalIF":1.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11612252/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142512011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Elephant endotheliotropic herpesvirus gB-specific antibody levels in sera of Asian elephants (Elephas maximus) in Japanese zoos. 日本动物园亚洲象（Elephas maximus）血清中大象内皮细胞疱疹病毒 gB 特异性抗体水平。
IF 1.1 4区 农林科学
Journal of Veterinary Medical Science Pub Date : 2024-12-01 Epub Date: 2024-10-16 DOI: 10.1292/jvms.23-0503
Kazuya Takehana, Tabitha E Hoornweg, Willem Schaftenaar, Victor Pgm Rutten, Cornelis Am DE Haan, Keita Matsuno
{"title":"Elephant endotheliotropic herpesvirus gB-specific antibody levels in sera of Asian elephants (Elephas maximus) in Japanese zoos.","authors":"Kazuya Takehana, Tabitha E Hoornweg, Willem Schaftenaar, Victor Pgm Rutten, Cornelis Am DE Haan, Keita Matsuno","doi":"10.1292/jvms.23-0503","DOIUrl":"10.1292/jvms.23-0503","url":null,"abstract":"<p><p>Prevalence of elephant endotheliotropic herpesvirus (EEHV) infections in Asian elephants in Japan was assessed by determination of EEHV gB specific antibody levels. Among 28 healthy Asian (sub) adult elephants from 11 zoos, 27 animals exhibited intermediate to high antibody levels. Like elsewhere worldwide, this suggested exposure of Asian elephants in Japan to at least one EEHV (sub) species. Longitudinal observations of two elephants monitored from birth to 30-month of age showed consistent high antibody levels. Another juvenile showed antibody levels that decreased to undetectable levels prior to death at 13 months of age. This fatal case supports earlier reports that low antibody levels are a risk factor for development of EEHV hemorrhagic disease.</p>","PeriodicalId":49959,"journal":{"name":"Journal of Veterinary Medical Science","volume":" ","pages":"1279-1283"},"PeriodicalIF":1.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11612242/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142479249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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