Korean Journal of Pathology最新文献_第7页

An unusual case of pulmonary mucous gland adenoma with fibromyxoid stroma and cartilage islands in 68-year-old woman. 68岁女性肺黏液腺腺瘤合并纤维黏液样间质及软骨岛的罕见病例。

Korean Journal of Pathology Pub Date : 2014-04-01 Epub Date: 2014-04-28 DOI: 10.4132/KoreanJPathol.2014.48.2.167

Boram Lee, In Ho Choi, Joungho Han, Kyung Soo Lee, Young Mog Shim

{"title":"An unusual case of pulmonary mucous gland adenoma with fibromyxoid stroma and cartilage islands in 68-year-old woman.","authors":"Boram Lee, In Ho Choi, Joungho Han, Kyung Soo Lee, Young Mog Shim","doi":"10.4132/KoreanJPathol.2014.48.2.167","DOIUrl":"https://doi.org/10.4132/KoreanJPathol.2014.48.2.167","url":null,"abstract":"Pulmonary mucous gland adenoma (MGA) is an uncommon, benign tumor that histologically resembles the mucus-secreting component of the tracheobronchial gland. The majority of such tumors arise within the main, lobar or segmental bronchi, but peripheral lesions have been reported.1 The exact incidence rate cannot be determined, but its rarity can be presumed considering that the ten cases reported by England and Hochholzer2 is the largest available data set. Four cases of MGA were reported in Korea,1,3 and our case is the second presenting in the peripheral lung.1 MGA comprises many mucin-filled cystic spaces lined by bland columnar or flattened mucus-secreting cells. Though MGA usually has bands of spindle-rich stroma and may be hyalinized, multiple cartilage islands are an extraordinary finding. To the best of our knowledge, there has been no case of MGA combined with hamartoma-like stroma. Herein, we report a case of bronchial MGA with fibromyxoid stroma and cartilage islands in a 68-year-old woman.","PeriodicalId":49936,"journal":{"name":"Korean Journal of Pathology","volume":"48 2","pages":"167-9"},"PeriodicalIF":0.0,"publicationDate":"2014-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4132/KoreanJPathol.2014.48.2.167","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32374549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

KRAS Mutation Detection in Non-small Cell Lung Cancer Using a Peptide Nucleic Acid-Mediated Polymerase Chain Reaction Clamping Method and Comparative Validation with Next-Generation Sequencing. 利用肽核酸介导的聚合酶链反应夹紧法检测非小细胞肺癌中的KRAS突变并与新一代测序进行比较验证。

Korean Journal of Pathology Pub Date : 2014-04-01 Epub Date: 2014-04-28 DOI: 10.4132/KoreanJPathol.2014.48.2.100

Boram Lee, Boin Lee, Gangmin Han, Mi Jung Kwon, Joungho Han, Yoon-La Choi

{"title":"KRAS Mutation Detection in Non-small Cell Lung Cancer Using a Peptide Nucleic Acid-Mediated Polymerase Chain Reaction Clamping Method and Comparative Validation with Next-Generation Sequencing.","authors":"Boram Lee, Boin Lee, Gangmin Han, Mi Jung Kwon, Joungho Han, Yoon-La Choi","doi":"10.4132/KoreanJPathol.2014.48.2.100","DOIUrl":"https://doi.org/10.4132/KoreanJPathol.2014.48.2.100","url":null,"abstract":"Background: KRAS is one of commonly mutated genetic \"drivers\" in non-small cell lung cancers (NSCLCs). Recent studies indicate that patients with KRAS-mutated tumors do not benefit from adjuvant chemotherapy, so there is now a focus on targeting KRAS-mutated NSCLCs. A feasible mutation detection method is required in order to accurately test for KRAS status.Methods: We compared direct Sanger sequencing and the peptide nucleic acid (PNA)-mediated polymerase chain reaction (PCR) clamping method in 134 NSCLCs and explored associations with clinicopathological factors. Next-generation sequencing (NGS) was used to validate the results of discordant cases. To increase the resolution of low-level somatic mutant molecules, PNA-mediated PCR clamping was used for mutant enrichment prior to NGS.Results: Twenty-one (15.7%) cases were found to have the KRAS mutations using direct sequencing, with two additional cases by the PNA-mediated PCR clamping method. The frequencies of KRAS mutant alleles were 2% and 4%, respectively, using conventional NGS, increasing up to 90% and 89%, using mutant-enriched NGS. The KRAS mutation occurs more frequently in the tumors of smokers (p=.012) and in stage IV tumors (p=.032).Conclusions: Direct sequencing can accurately detect mutations, but, it is not always possible to obtain a tumor sample with sufficient volume. The PNA-mediated PCR clamping can rapidly provide results with sufficient sensitivity.","PeriodicalId":49936,"journal":{"name":"Korean Journal of Pathology","volume":"48 2","pages":"100-7"},"PeriodicalIF":0.0,"publicationDate":"2014-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4132/KoreanJPathol.2014.48.2.100","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32372891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 20

IMP3, a Promising Prognostic Marker in Clear Cell Renal Cell Carcinoma. 透明细胞肾细胞癌中一种有希望的预后标记物——IMP3。

Korean Journal of Pathology Pub Date : 2014-04-01 Epub Date: 2014-04-28 DOI: 10.4132/KoreanJPathol.2014.48.2.108

Ji Young Park, Misun Choe, Yuna Kang, Sang Sook Lee

{"title":"IMP3, a Promising Prognostic Marker in Clear Cell Renal Cell Carcinoma.","authors":"Ji Young Park, Misun Choe, Yuna Kang, Sang Sook Lee","doi":"10.4132/KoreanJPathol.2014.48.2.108","DOIUrl":"https://doi.org/10.4132/KoreanJPathol.2014.48.2.108","url":null,"abstract":"Background: Insulin-like growth factor II mRNA-binding protein 3 (IMP3) has been reported as a prognostic biomarker in various cancers. To validate IMP3 as a prognostic biomarker in renal cell carcinoma (RCC), we investigated the expression of IMP3, p53, and Ki-67, and their associations with clinicopathologic outcomes.Methods: We studied 148 clear cell RCCs (CCRCCs) from patients who underwent radical nephrectomy. The expression levels of IMP3, p53, and Ki-67 were assessed by immunohistochemical staining and the clinical and pathologic parameters were retrospectively reviewed.Results: Twenty-nine percent of CCRCCs expressed IMP3. Forty-one percent of IMP3-immunopositive tumors developed metastases, while only 11.4% of IMP3-negative tumors developed metastases (p<.001). A Kaplan-Meier curve showed that patients with IMP3-immunopositive tumors had lower metastasis-free survival and cancer-specific survival than did those with IMP3-immunonegative tumors (p<.001 and p<.001, respectively). Expression of high Ki-67 proliferation index was also associated with a higher metastatic rate. In the multivariate Cox regression analysis, pT stage and IMP3-positivity were independently associated with disease-specific survival.Conclusions: IMP3 is an independent prognostic biomarker for patients with CCRCC to predict metastasis and poor outcome.","PeriodicalId":49936,"journal":{"name":"Korean Journal of Pathology","volume":"48 2","pages":"108-16"},"PeriodicalIF":0.0,"publicationDate":"2014-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4132/KoreanJPathol.2014.48.2.108","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32372892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Adenocarcinoma arising in gastric duplication cyst. 发生于胃重复囊肿的腺癌。

Korean Journal of Pathology Pub Date : 2014-04-01 Epub Date: 2014-04-28 DOI: 10.4132/KoreanJPathol.2014.48.2.159

Hyo Jeong Kang, Se Jin Jang, Young Soo Park

引用次数: 30

Characteristics of Cutaneous Lymphomas in Korea According to the New WHO-EORTC Classification: Report of a Nationwide Study. 根据新的WHO-EORTC分类，韩国皮肤淋巴瘤的特征:一项全国性研究报告。

Korean Journal of Pathology Pub Date : 2014-04-01 Epub Date: 2014-04-28 DOI: 10.4132/KoreanJPathol.2014.48.2.126

Jae Ho Han, Young-Hyeh Ko, Yun Kyung Kang, Wan-Seop Kim, Yoon Jung Kim, Insun Kim, Hyun-Jung Kim, Soo Kee Min, Chan-Kum Park, Chan-Sik Park, Bong-Kyung Shin, Woo Ick Yang, Young-Ha Oh, Jong Sil Lee, Juhie Lee, Tae Hui Lee, Hyekyung Lee, Ho Jung Lee, Yoon Kyung Jeon, Hee Jeong Cha, Yoo-Duk Choi, Chul Woo Kim

{"title":"Characteristics of Cutaneous Lymphomas in Korea According to the New WHO-EORTC Classification: Report of a Nationwide Study.","authors":"Jae Ho Han, Young-Hyeh Ko, Yun Kyung Kang, Wan-Seop Kim, Yoon Jung Kim, Insun Kim, Hyun-Jung Kim, Soo Kee Min, Chan-Kum Park, Chan-Sik Park, Bong-Kyung Shin, Woo Ick Yang, Young-Ha Oh, Jong Sil Lee, Juhie Lee, Tae Hui Lee, Hyekyung Lee, Ho Jung Lee, Yoon Kyung Jeon, Hee Jeong Cha, Yoo-Duk Choi, Chul Woo Kim","doi":"10.4132/KoreanJPathol.2014.48.2.126","DOIUrl":"https://doi.org/10.4132/KoreanJPathol.2014.48.2.126","url":null,"abstract":"Background: Previously, cutaneous lymphomas were classified according to either the European Organization for the Research and Treatment of Cancer (EORTC) or the World Health Organization (WHO) classification paradigms. The aim of this study was to determine the relative frequency of Korean cutaneous lymphoma according to the new WHO-EORTC classification system.Methods: A total of 517 patients were recruited during a recent 5 year-period (2006-2010) from 21 institutes and classified according to the WHO-EORTC criteria.Results: The patients included 298 males and 219 females, and the mean age at diagnosis was 49 years. The lesions preferentially affected the trunk area (40.2%). The most frequent subtypes in order of decreasing prevalence were mycosis fungoides (22.2%), peripheral T-cell lymphoma (17.2%), CD30+ T-cell lymphoproliferative disorder (13.7%), and extranodal natural killer/T (NK/T) cell lymphoma, nasal type (12.0%). Diffuse large B-cell lymphoma accounted for 11.2% of cases, half of which were secondary cutaneous involvement; other types of B-cell lymphoma accounted for less than 1% of cases.Conclusions: In comparison with data from Western countries, this study revealed relatively lower rates of mycosis fungoides and B-cell lymphoma in Korean patients, as well as higher rates of subcutaneous panniculitis-like T-cell lymphoma and NK/T cell lymphoma.","PeriodicalId":49936,"journal":{"name":"Korean Journal of Pathology","volume":"48 2","pages":"126-32"},"PeriodicalIF":0.0,"publicationDate":"2014-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4132/KoreanJPathol.2014.48.2.126","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32372894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 19

Esophageal squamous cell carcinoma in situ overlying leiomyoma mimicking invasive cancer: a brief case report. 食管鳞状细胞癌原位覆盖模仿浸润性癌的平滑肌瘤:一个简短的病例报告。

Korean Journal of Pathology Pub Date : 2014-04-01 Epub Date: 2014-04-28 DOI: 10.4132/KoreanJPathol.2014.48.2.162

Woo Jin Oh, Eun Jung Lee, Youn Soo Lee, Tae-Jung Kim

引用次数: 2

Pleural mesothelioma: an institutional experience of 66 cases. 胸膜间皮瘤66例临床分析。

Korean Journal of Pathology Pub Date : 2014-04-01 Epub Date: 2014-04-28 DOI: 10.4132/KoreanJPathol.2014.48.2.91

Soomin Ahn, In Ho Choi, Joungho Han, Jhingook Kim, Myung-Ju Ahn

{"title":"Pleural mesothelioma: an institutional experience of 66 cases.","authors":"Soomin Ahn, In Ho Choi, Joungho Han, Jhingook Kim, Myung-Ju Ahn","doi":"10.4132/KoreanJPathol.2014.48.2.91","DOIUrl":"https://doi.org/10.4132/KoreanJPathol.2014.48.2.91","url":null,"abstract":"Background: Malignant mesothelioma of the pleura is an aggressive tumor known to be associated with asbestos. Histological diagnosis of mesothelioma is challenging and is usually aided by immunohistochemical markers.Methods: During an 18-year period (1995-2012), 66 patients with pleural mesothelioma were diagnosed at the Samsung Medical Center in Seoul. We reviewed hematoxylin and eosin and immunohistochemical slides of pleural mesothelioma and evaluated their pathological and clinical features.Results: The male-to-female ratio was 1.75:1, and age of patients ranged from 28 to 80 years with an average age of 56.84 years. Twenty-two out of 66 patients underwent curative pneumonectomy. Follow-up data was available in 60 patients (90.9%), and 50 of them (83.3%) died from the disease. The average overall survival was 15.39 months. Histologically, the epithelioid type was the most common, followed by the sarcomatoid and the biphasic types. Epidemiologic information was not available in most cases, and only one patient was confirmed to have a history of asbestos exposure.Conclusions: Malignant mesothelioma of the pleura is a fatal tumor, and the therapeutic benefit of pneumonectomy remains unproven. The combination of calretinin, Wilms tumor 1, HMBE-1, and thyroid transcription factor-1 may provide high diagnostic accuracy in diagnosing mesothelioma.","PeriodicalId":49936,"journal":{"name":"Korean Journal of Pathology","volume":"48 2","pages":"91-9"},"PeriodicalIF":0.0,"publicationDate":"2014-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4132/KoreanJPathol.2014.48.2.91","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32372470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Incidence and malignancy rates of diagnoses in the bethesda system for reporting thyroid aspiration cytology: an institutional experience. bethesda系统中甲状腺吸入细胞学报告的发病率和恶性肿瘤诊断率:一个机构经验。

Korean Journal of Pathology Pub Date : 2014-04-01 Epub Date: 2014-04-28 DOI: 10.4132/KoreanJPathol.2014.48.2.133

Ji Hye Park, Sun Och Yoon, Eun Ju Son, Hye Min Kim, Ji Hae Nahm, SoonWon Hong

{"title":"Incidence and malignancy rates of diagnoses in the bethesda system for reporting thyroid aspiration cytology: an institutional experience.","authors":"Ji Hye Park, Sun Och Yoon, Eun Ju Son, Hye Min Kim, Ji Hae Nahm, SoonWon Hong","doi":"10.4132/KoreanJPathol.2014.48.2.133","DOIUrl":"https://doi.org/10.4132/KoreanJPathol.2014.48.2.133","url":null,"abstract":"Background: The Bethesda System for Reporting Thyroid Cytopathology (BSRTC) uses six diagnostic categories to standardize communication of thyroid fine-needle aspiration (FNA) interpretations between clinicians and cytopathologists. Since several studies have questioned the diagnostic accuracy of this system, we examined its accuracy in our hospital.Methods: We calculated the incidences and malignancy rates of each diagnostic category in the BSRTC for 1,730 FNAs that were interpreted by four cytopathologists in Gangnam Severance Hospital between October 1, 2011, and December 31, 2011.Results: The diagnostic incidences of categories I-VI were as follows: 13.3%, 40.6%, 9.1%, 0.4%, 19.3%, and 17.3%, respectively. Similarly, the malignancy rates of these categories were as follows: 35.3%, 5.6%, 69.0%, 50.0%, 98.7%, and 98.9%, respectively. In categories II, V, and VI, there were no statistically significant differences in the ranges of the malignancy rates among the four cytopathologists. However, there were significant differences in the ranges for categories I and III.Conclusions: Our findings suggest that institutions that use the BSRTC should regularly update their diagnostic criteria. We also propose that institutions issue an annual report of incidences and malignancy rates to help other clinicians improve the case management of patients with thyroid nodules.","PeriodicalId":49936,"journal":{"name":"Korean Journal of Pathology","volume":"48 2","pages":"133-9"},"PeriodicalIF":0.0,"publicationDate":"2014-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4132/KoreanJPathol.2014.48.2.133","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32372895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 51

Multifocal osteosarcoma of the skull: multiple primary or metastatic? A case report. 颅骨多灶性骨肉瘤:多发原发还是转移?一份病例报告。

Korean Journal of Pathology Pub Date : 2014-04-01 Epub Date: 2014-04-28 DOI: 10.4132/KoreanJPathol.2014.48.2.146

Hyuck Cho, Bong-Jin Park, Yong-Koo Park

引用次数: 7

Different Protein Expressions between Peripheral Ameloblastoma and Oral Basal Cell Carcinoma Occurred at the Same Mandibular Molar Area. 外周成釉细胞瘤与口腔基底细胞癌在同一下颌磨牙区蛋白表达的差异。

Korean Journal of Pathology Pub Date : 2014-04-01 Epub Date: 2014-04-28 DOI: 10.4132/KoreanJPathol.2014.48.2.151

Yeon Sook Kim, Suk Keun Lee

{"title":"Different Protein Expressions between Peripheral Ameloblastoma and Oral Basal Cell Carcinoma Occurred at the Same Mandibular Molar Area.","authors":"Yeon Sook Kim, Suk Keun Lee","doi":"10.4132/KoreanJPathol.2014.48.2.151","DOIUrl":"https://doi.org/10.4132/KoreanJPathol.2014.48.2.151","url":null,"abstract":"Peripheral ameloblastoma (PA) in gingiva is rare and often confused with oral basal cell carcinoma (OBCC). The tissues of one case of PA and one case of OBCC with the same mandibular molar area affected were compared via an immunohistochemical examination using 50 antisera. The PA and OBCC showed similar proliferation of basaloid epithelial strands, but toluidine blue staining revealed that the PA had pinkish juxta-epithelial myxoid tissue, whereas the OBCC was infiltrated by many mast cells. Immunohistochemical comparisons showed that the PA was strongly positive for ameloblastin, KL1, p63, carcinoembryonic antigen, focal adhesion kinase, and cathepsin K, and slightly positive for amelogenin, Krox-25, E-cadherin, and PTCH1, whereas the OBCC was not. On the other hand, the OBCC was strongly positive for EpCam, matrix metalloprotease (MMP)-1, α1-antitrypsin, cytokeratin-7, p53, survivin, pAKT1, transforming growth factor-β1, NRAS, TGase-1, and tumor nescrosis factor-α, and consistently positive for β-catenin, MMP-2, cathepsin G, TGase-2, SOS-1, sonic hedgehog, and the β-defensins-1, -2, -3, while the PA was not. These data suggest that the tumorigeneses of PA and OBCC differ, and that PAs undergo odontogenic differentiation and generate oncogenic signals for infiltrative growth and bone resorption, whereas OBCCs undergo basaloid epidermal differentiation as a result of growth factor/cytokine-related oncogenic signals. ","PeriodicalId":49936,"journal":{"name":"Korean Journal of Pathology","volume":"48 2","pages":"151-8"},"PeriodicalIF":0.0,"publicationDate":"2014-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4132/KoreanJPathol.2014.48.2.151","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32372898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11