Korean Journal of Pathology最新文献

{"title":"Combined squamous cell carcinoma and follicular carcinoma of the thyroid.","authors":"Da Hye Son, Jong-Lyel Roh, Kyung-Ja Cho","doi":"10.4132/KoreanJPathol.2014.48.6.418","DOIUrl":"https://doi.org/10.4132/KoreanJPathol.2014.48.6.418","url":null,"abstract":"Primary squamous cell carcinoma of the thyroid (PSCCT) is a malignant epithelial tumor, composed entirely of cells with squamous differentiation and accounting for fewer than 1% of all malignancies of the thyroid gland [1]. Because squamous cells are absent from the normal thyroid gland, the etiology of PSCCT remains unclear. Hypotheses include the differentiation of squamous cells derived from embryonic remnants of epithelial cells in the gland, squamous metaplastic changes in response to inflammatory diseases such as thyroiditis, and malignant neoplasms, such as papillary, follicular, or anaplastic carcinoma [2]. Occasionally, PSCCT arises from other thyroid diseases such as Hashimoto’s thyroiditis, tall cell variant papillary carcinoma, follicular carcinoma, and anaplastic carcinoma [3,4]. We describe a patient with the combination of a well-differentiated squamous cell carcinoma and follicular carcinoma of the thyroid. To our knowledge, this is the third report of a patient with primary squamous cell carcinoma plus follicular carcinoma of the thyroid in the English language literature [2,5].","PeriodicalId":49936,"journal":{"name":"Korean Journal of Pathology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4132/KoreanJPathol.2014.48.6.418","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32976456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of epithelioid blue nevus.","authors":"Chung Hun Lee, Hye Sook Min, Eon Sub Park, Kye Yong Song","doi":"10.4132/KoreanJPathol.2014.48.6.434","DOIUrl":"https://doi.org/10.4132/KoreanJPathol.2014.48.6.434","url":null,"abstract":"Although epithelioid blue nevus (EBN) is a rare variant of blue nevus that was first reported in patients with Carney complex, which encompasses cardiac and cutaneous myxomas, spotty skin pigmentation, endocrine overactivity, and psammomatous melanotic schwannomas [1], it has been also documented in the absence of such clinical features [2]. Histological characteristics of EBN are variably pigmented, large epithelioid melanocytes with vesicular nuclei and prominent eosinophilic nucleoli and a small number of melanophages that are sometimes associated with a few pigmented, spindle, and dendritic cells [3]. EBN is a diagnostically challenging entity because of its rarity and histological overlap with other pigmented melanocytic lesions, such as cellular blue nevus, malignant blue nevus, and the so-called animal-type malignant melanoma. Because it is very uncommon and no cases have been recorded in the Korean literature, this Korean case is reported.","PeriodicalId":49936,"journal":{"name":"Korean Journal of Pathology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4132/KoreanJPathol.2014.48.6.434","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32976460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peritoneal Carcinosarcoma and Ovarian Papillary Serous Carcinoma Are the Same Origin: Analysis of TP53 Mutation and Microsatellite Suggests a Monoclonal Origin.","authors":"Chang Gok Woo, Dae Shik Suh, Joo Young Kim, Chang Ohk Sung, Jene Choi, Kyu-Rae Kim","doi":"10.4132/KoreanJPathol.2014.48.6.449","DOIUrl":"https://doi.org/10.4132/KoreanJPathol.2014.48.6.449","url":null,"abstract":"Carcinosarcoma is an aggressive malignant neoplasm of the female genital tract that is biphasic and composed of carcinomatous and sarcomatous components. It was previously considered as a subtype of uterine sarcoma but is currently regarded as a type of metaplastic carcinoma. 1 Here, we report a case in which a carcinosarcoma forming a discrete mass in the peritoneal cavity was diagnosed concurrently with smaller bilateral ovarian masses showing unequivocal histologic features of high-grade serous carcinoma. Although there seems to be a close relationship between the two tumors in this case, firm evidence for the histopathologic determination of the primary site is lacking because primary carcinosarcomas have been described in many extragenital organs, including the peritoneum, in the literature. We demonstrated two tumors with different histologic findings at distant tumor locations but with a common origin in their pathogenetic mechanism, as suggested by their similar immunohistochemical overexpression of p53 protein and identical pattern TP53 mutation and microsatellites (the reference panel, the Bethesda markers) by molecular analysis.","PeriodicalId":49936,"journal":{"name":"Korean Journal of Pathology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4132/KoreanJPathol.2014.48.6.449","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32976464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hybrid granular cell tumor/perineurioma.","authors":"Sung Sun Kim, Yoo Duk Choi, Jae Hyuk Lee, Chan Choi, Chang Soo Park","doi":"10.4132/KoreanJPathol.2014.48.6.409","DOIUrl":"https://doi.org/10.4132/KoreanJPathol.2014.48.6.409","url":null,"abstract":"Hybrid peripheral nerve sheath tumors (PNSTs), which show hybrid features of more than one cell type normally found in a peripheral nerve sheath, are recently recognized clinical entities. Various composite tumors have been reported; however, granular cell tumor/perineurioma is a rare combination [1-4]. Since perineurial cells may be found in other types of PNSTs, it is important to determine if those are reactive, remnantal, or true neoplastic when a perineurial component of the PNST is identified. Main differential diagnoses include granular perineurioma and granular cell tumor with reactive perineurial cell hyperplasia, which show a lack of immunopositivity for S-100 in the granular cells and prominent perineurial cell proliferation throughout the tumor, respectively.","PeriodicalId":49936,"journal":{"name":"Korean Journal of Pathology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4132/KoreanJPathol.2014.48.6.409","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32976454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Indolent CD56-Positive Clonal T-Cell Lymphoproliferative Disease of the Stomach Mimicking Lymphomatoid Gastropathy.","authors":"Mineui Hong, Won Seog Kim, Young Hyeh Ko","doi":"10.4132/KoreanJPathol.2014.48.6.430","DOIUrl":"https://doi.org/10.4132/KoreanJPathol.2014.48.6.430","url":null,"abstract":"Natural killer (NK)- or T-cell lymphomas of the gastrointestinal (GI) tract are uncommon, accounting for less than 10% of all malignant lymphomas arising in the GI tract [1]. According to the third national survey by the Hematopathology Study Group of the Korean Society of Pathologists, peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS), is the most common type, followed by extranodal NK/T-cell lymphoma, nasaltype (ENKL). Enteropathy-associated T-cell lymphoma (EATL) is rare [1]. Malignant lymphoma of T and NK lineage is an aggressive disease with poor prognosis [2]. Recently, two indolent forms of mature T- or NK-cell lymphoproliferative diseases (LPD) of the GI tract have drawn the attention of pathologists. One is indolent NK cell proliferative lesion of the stomach and intestine reported under the name of lymphomatoid gastropathy [3] or NK-cell enteropathy [4]. The lesion is often self-limited, even when left untreated. Histological findings have been described as dense infiltration of lymphoid cells with mild to moderate atypia and peculiar eosinophilic cytoplasmic granules [3]. Frequently, there are lymphoepithelial lesion-like changes with or without necrosis. All cases published previously have been positive for both cytoplasmic CD3 and CD56 and negative for CD4 and CD8. T-cell receptor (TCR) gene rearrangement is polyclonal [3-5], and unlike ENKL, infiltrating cells were negative for Epstein-Barr virus (EBV). The other form of indolent T- or NK-cell LPD of the GI tract is a clonal T-cell proliferative disease involving the oral cavity, esophagus, stomach, small intestine, and colon [6]. The lesion shows a superficial and nondestructive lymphoid infiltrate that occasionally extends into the muscularis mucosae and submucosa. Infiltrating cells are small T-cells, which are CD4+ or CD8+ or uncommonly CD4–/CD8–phenotype [6-9]. CD56 and EBV-encoded RNA (EBER) are negative, and TCR gene rearrangement has been monoclonal in all cases reported so far. Unlike indolent NK-cell proliferative lesions, indolent T-cell LPD does not spontaneously regress, but is persistent without progression [6,9]. These two indolent entities can be easily mistaken as aggressive T- or NK-cell lymphoma; therefore, recognition of these entities is important to avoid unnecessary aggressive chemotherapy. Herein we report, to our knowledge, the first Korean case of indolent T-cell LPD of the stomach with expression of CD56.","PeriodicalId":49936,"journal":{"name":"Korean Journal of Pathology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4132/KoreanJPathol.2014.48.6.430","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32976459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A rare case of mesothelioma showing micropapillary and small cell differentiation with aggressive behavior.","authors":"Yoon Jin Cha, Binnari Kim, Joungho Han, Chin A Yi, Jae Ill Zo","doi":"10.4132/KoreanJPathol.2014.48.6.466","DOIUrl":"https://doi.org/10.4132/KoreanJPathol.2014.48.6.466","url":null,"abstract":"Pleural mesothelioma is a rare neoplasm and roughly 70% are the epithelioid type, which is characterized by proliferation of epithelioid tumor cells with a tubulopapillary growth pattern [1]. There have been few reports of mesothelioma having a micropapillary pattern [2] and a small cell component [3]. To the best of our knowledge, there has been no previously reported case containing both micropapillary and small cell components. Herein, we report a rare case of mesothelioma with micropapillary component and small cell differentiation exhibiting aggressive behavior in a 59-year-old woman.","PeriodicalId":49936,"journal":{"name":"Korean Journal of Pathology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4132/KoreanJPathol.2014.48.6.466","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32974879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lymphoepithelioma-like Carcinoma of the Renal Pelvis: A Case Report and Review of the Literature.","authors":"Hyein Ahn, Jongmin Sim, Hyunsung Kim, Kijong Yi, Hulin Han, Yumin Chung, Abdul Rehman, Seung Sam Paik","doi":"10.4132/KoreanJPathol.2014.48.6.458","DOIUrl":"https://doi.org/10.4132/KoreanJPathol.2014.48.6.458","url":null,"abstract":"Lymphoepithelioma is an undifferentiated epithelial tumor primarily described in the nasopharynx and characterized by syncytial nests of malignant epithelial cells with a prominent reactive lymphoid infiltrate [1]. A carcinoma that shows similar histological features but arises outside the nasopharynx is called lymphoepithelioma-like carcinoma (LELC). LELC has been described in a variety of organs including salivary glands, thymus, lungs, stomach, skin, uterine cervix, breast, prostate, and the urinary tract [2]. The renal pelvis is an extremely rare site for this tumor. To the best of our knowledge, only eight cases have been reported in the English literature and one case has been reported in the Korean literature [1-8]. We recently experienced a case of LELC arising in the right renal pelvis in a 65-year-old woman.","PeriodicalId":49936,"journal":{"name":"Korean Journal of Pathology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4132/KoreanJPathol.2014.48.6.458","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32974877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Digital papillary carcinoma.","authors":"Sharon Lim, Inju Cho, Mi Ja Lee","doi":"10.4132/KoreanJPathol.2014.48.6.438","DOIUrl":"https://doi.org/10.4132/KoreanJPathol.2014.48.6.438","url":null,"abstract":"Digital papillary carcinoma (DPC) is a rare, slow growing, malignant tumor with eccrine differentiation that occurs predominantly in digits. This tumor was originally classified as a benign neoplasm; aggressive digital papillary adenoma (ADPA) was first described by Helwig in 1979 [1]. In 1987, Kao et al. [2] classified ADPA and aggressive digital papillary adenocarcinoma (ADPAca) based on differences in histologic findings. However, a recent retrospective study revealed that neither histologic nor clinical characteristics were predictive of recurrence or metastasis [3]. Therefore, the designations “ADPA” or “ADPAca” should be reevaluated because lesions with benign histologic features have both recurred and metastasized [3]. In the 2006 World Health Organization (WHO) classification, ADPA or ADPAca were grouped under a single entity of DPC without any benign counterpart [4]. We report a case of DPC on the third finger that lasted for 20 years, but increased in size and became extremely painful in the past 7 months. After a complete excision, no recurrence or metastasis was found for two and a half years. A brief review of the literature is presented.","PeriodicalId":49936,"journal":{"name":"Korean Journal of Pathology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4132/KoreanJPathol.2014.48.6.438","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32976461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of mixed adenoneuroendocrine carcinoma of the common bile duct: initially diagnosed as cholangiocarcinoma.","authors":"Soon Wook Lee, In Seok Lee, Yu Kyung Cho, Jae Myung Park, Sang Woo Kim, Myung-Gyu Choi, Kyu Yong Choi, Myung Ah Lee, Tae Ho Hong, Young Kyoung You, Eun-Sun Jung","doi":"10.4132/KoreanJPathol.2014.48.6.445","DOIUrl":"https://doi.org/10.4132/KoreanJPathol.2014.48.6.445","url":null,"abstract":"Neuroendocrine tumors (NETs) are mostly found in the gastrointestinal tract and the pancreas. The World Health Organization (WHO) classification (2010) has been widely used to categorize NETs [1]. In the digestive system, NETs including those found within the bile ducts, are classed as NET G1 (carcinoid, mitotic count of 20 per 10 HPF and/or >20% Ki-67 index), and mixed adenoneuroendocrine carcinoma (MANEC) [1]. NETs arising from the bile duct are rare, accounting for only 1.8% of gastroenteropancreatic NETs [2]. MANECs of the common bile ducts (CBDs) are extremely rare, and only a few cases have been reported thus far [3-5]. \u0000 \u0000In this study, we report a case of MANEC arising from the mid CBD.","PeriodicalId":49936,"journal":{"name":"Korean Journal of Pathology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4132/KoreanJPathol.2014.48.6.445","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32976463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Myoepithelial carcinoma of soft tissue: a case report and review of the literature.","authors":"Chang Hwan Choi, Young Chae Chu, Lucia Kim, Suk Jin Choi, In Suh Park, Jee Young Han, Joon Mee Kim","doi":"10.4132/KoreanJPathol.2014.48.6.413","DOIUrl":"https://doi.org/10.4132/KoreanJPathol.2014.48.6.413","url":null,"abstract":"Myoepithelial carcinoma of soft tissue is extremely rare although its counterpart of the salivary gland is relatively common and well-known with similar morphology. The histogenesis of myoepithelial carcinoma of soft tissue is still unknown. In fact, the tumor may present with myoepithelial differentiation but not originate from myoepithelial cells [1]. The tumor cells are heterogeneous in terms of cell type and architecture. The tumor cells may be epithelioid, spindled, clear, or plasmacytoid. The growth pattern varies and can be solid sheets, reticular, or trabecular architecture without ductal differentiation [2]. Myoepithelial carcinoma usually shows cytologic atypia, mitotic activity, infiltrative growth, or tumor necrosis [2]. Only few studies have been reported because of the rarity of myoepithelial carcinoma of soft tissue [1-4]. Consequently the clinical and pathologic characterization has been limited. Also, the limitation of definite diagnostic criteria and prognostic parameters makes the diagnosis and management of myoepithelial carcinoma of soft tissue difficult. Here we report the first case of myoepithelial carcinoma of soft tissue in Korea.","PeriodicalId":49936,"journal":{"name":"Korean Journal of Pathology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4132/KoreanJPathol.2014.48.6.413","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32976455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}