Korean Journal of Pathology最新文献_第2页

A Case of Type II Enteropathy-Associated T-Cell Lymphoma with Epstein-Barr Virus Positivity. II型肠病相关t细胞淋巴瘤伴eb病毒阳性1例。

Korean Journal of Pathology Pub Date : 2014-12-01 Epub Date: 2014-12-31 DOI: 10.4132/KoreanJPathol.2014.48.6.426

Min Jeong Song, Chan Sik Park, Hee Sang Hwang, Cheol Won Suh, Dok Hyun Yoon, Jooryung Huh

{"title":"A Case of Type II Enteropathy-Associated T-Cell Lymphoma with Epstein-Barr Virus Positivity.","authors":"Min Jeong Song, Chan Sik Park, Hee Sang Hwang, Cheol Won Suh, Dok Hyun Yoon, Jooryung Huh","doi":"10.4132/KoreanJPathol.2014.48.6.426","DOIUrl":"https://doi.org/10.4132/KoreanJPathol.2014.48.6.426","url":null,"abstract":"Enteropathy-associated T-cell lymphoma (EATL) is defined as an intestinal lymphoma of intraepithelial T lymphocytes. EATL is further classified into two distinct types: type I (classical) EATL, which comprises 80%–90% of all cases; and type II EATL, a monomorphic variant of the disease. Type I EATL occurs at a higher frequency in northern Europe, where celiac disease is more common, and is characterized by the presence of large tumor cells with a CD3+CD4–CD8–CD56– immunophonotype [1]. Conversely, type II EATL, originally described as CD56+ intestinal lymphoma, consists of monomorphic small- to medium-sized tumor cells, typically with a CD3+CD4–CD8+CD56+ immunophenotype, with weak or no association with celiac disease [1,2]. Recently, a number of reports have defined type II EATL as a distinct T-cell neoplasm predominant in patients of Asian ethnicity with no history of enteropathy or Epstein-Barr virus (EBV) association. In addition, type II EATL is characterized by frequent expression of gamma-delta T-cell receptors (γδ TCR). EBV-positive cases were suggested to represent extranodal natural killer (NK)/T-cell lymphoma rather than type II EATL. Whether EBV-positive cases with similar morphology and phenotype should be included in the definition of EATL and whether a proportion of these cases are γδ T-cell lymphomas remain debatable. Herein, we report a case of T-cell lymphoma of the jejunum with a CD3+CD4–CD8+CD56–betaF1+ phenotype, rearranged γ TCR genes, and diffuse EBV-encoded RNA (EBER) positivity.","PeriodicalId":49936,"journal":{"name":"Korean Journal of Pathology","volume":"48 6","pages":"426-9"},"PeriodicalIF":0.0,"publicationDate":"2014-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4132/KoreanJPathol.2014.48.6.426","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32976458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Periductal stromal tumor of breast: a case report and a review of literature. 乳腺导管周围间质瘤1例报告并文献复习。

Korean Journal of Pathology Pub Date : 2014-12-01 Epub Date: 2014-12-31 DOI: 10.4132/KoreanJPathol.2014.48.6.442

Salma L Abbasi, Kate McNamara, Mohammed S Absar, Alison Darlington, Francene Clucas, Sami Titi

{"title":"Periductal stromal tumor of breast: a case report and a review of literature.","authors":"Salma L Abbasi, Kate McNamara, Mohammed S Absar, Alison Darlington, Francene Clucas, Sami Titi","doi":"10.4132/KoreanJPathol.2014.48.6.442","DOIUrl":"https://doi.org/10.4132/KoreanJPathol.2014.48.6.442","url":null,"abstract":"Periductal stromal tumor (PDST) is a rare biphasic tumor of the breast that exhibits low-grade malignancy and intermediate behavior. It is characterized by proliferation of atypical spindle cells surrounding benign mammary ducts and infiltrating adjacent adipose tissue. PDST is distinguished from phyllodes tumor by its lack of leaf-like architecture; however, it is still unclear whether PDST is a separate entity or a certain spectrum of phyllodes tumor [1,2]. Its therapeutic management is based on wide surgical excision with tumor-free margins. \u0000 \u0000We report the case of a 20-year-old female who presented with a lump in her left breast with clinical features mimicking fibroadenoma. Excisional biopsy was performed because the mass gradually enlarged and became painful. On histological examination a biphasic tumor composed of benign epithelial ducts surrounded by proliferation of spindle cells with dense hyperchromatic nuclei and mild-to-moderate atypia was found. Stromal overgrowth, variable stromal cellularity and myxoid background were evident. A diagnosis of PDST was established after extensive sampling and immunohistochemical analysis. Our patient was treated with surgical resection and has been recurrence-free for more than 38 months.","PeriodicalId":49936,"journal":{"name":"Korean Journal of Pathology","volume":"48 6","pages":"442-4"},"PeriodicalIF":0.0,"publicationDate":"2014-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4132/KoreanJPathol.2014.48.6.442","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32976462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Malignant perivascular epithelioid cell tumor of the uterus with lung metastasis. 子宫恶性血管周围上皮样细胞瘤伴肺转移。

Korean Journal of Pathology Pub Date : 2014-12-01 Epub Date: 2014-12-31 DOI: 10.4132/KoreanJPathol.2014.48.6.454

Jeong Bae Kang, Jin Won Seo, Young-Han Park, Pong Rheem Jang

引用次数: 5

Supratentorial hemangioblastoma with unusual features. 具有不寻常特征的幕上血管母细胞瘤。

Korean Journal of Pathology Pub Date : 2014-12-01 Epub Date: 2014-12-31 DOI: 10.4132/KoreanJPathol.2014.48.6.462

Yooju Shin, Seokhwi Kim, Hyun-Woo Lee, Heejin Bang, Yeon-Lim Suh

{"title":"Supratentorial hemangioblastoma with unusual features.","authors":"Yooju Shin, Seokhwi Kim, Hyun-Woo Lee, Heejin Bang, Yeon-Lim Suh","doi":"10.4132/KoreanJPathol.2014.48.6.462","DOIUrl":"https://doi.org/10.4132/KoreanJPathol.2014.48.6.462","url":null,"abstract":"Hemangioblastomas of the central nervous system (CNS) are benign tumors that most commonly occur in the cerebellum, followed by the brainstem and spinal cord [1]. Supratentorial location is extremely rare [2]. CNS hemangioblastomas can occur sporadically or in association with von Hippel-Lindau disease [2]. Histologically, the tumors are composed of two main components: large and vacuolated stromal cells and numerous thinwalled vessels. Due to the characteristic lipid-containing cytoplasm and foci of pleomorphic nuclei, the differential diagnosis of hemangioblastoma from some other malignant tumors, such as clear cell renal cell carcinoma (RCC), adrenal cortical carcinoma and paraganglioma, remains challenging, especially in cellular variants. Hyaline globules can be found in many different tumors and benign tissues [3], including CNS hemangioblastomas, and they contribute to the diagnostic difficulty. Herein, we report a case of sporadic supratentorial hemangioblastoma with unusual features and discuss the differential diagnosis of CNS hemangioblastoma.","PeriodicalId":49936,"journal":{"name":"Korean Journal of Pathology","volume":"48 6","pages":"462-5"},"PeriodicalIF":0.0,"publicationDate":"2014-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4132/KoreanJPathol.2014.48.6.462","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32974878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Primary leiomyosarcoma of adrenal gland with tissue eosinophilic infiltration. 原发性肾上腺平滑肌肉瘤伴嗜酸性细胞浸润。

Korean Journal of Pathology Pub Date : 2014-12-01 Epub Date: 2014-12-31 DOI: 10.4132/KoreanJPathol.2014.48.6.423

Seungkoo Lee, Gail Domecq C Tanawit, Rolando A Lopez, Jaime T Zamuco, Betsy Grace G Cheng, Menandro V Siozon

引用次数: 12

Preparation of compact agarose cell blocks from the residues of liquid-based cytology samples. 从液基细胞学样品的残留物中制备致密琼脂糖细胞块。

Korean Journal of Pathology Pub Date : 2014-10-01 Epub Date: 2014-10-27 DOI: 10.4132/KoreanJPathol.2014.48.5.351

Suk Jin Choi, Yeon Il Choi, Lucia Kim, In Suh Park, Jee Young Han, Joon Mee Kim, Young Chae Chu

{"title":"Preparation of compact agarose cell blocks from the residues of liquid-based cytology samples.","authors":"Suk Jin Choi, Yeon Il Choi, Lucia Kim, In Suh Park, Jee Young Han, Joon Mee Kim, Young Chae Chu","doi":"10.4132/KoreanJPathol.2014.48.5.351","DOIUrl":"https://doi.org/10.4132/KoreanJPathol.2014.48.5.351","url":null,"abstract":"Background: Inevitable loss of diagnostic material should be minimized during cell block preparation. We introduce a modified agarose cell block technique that enables the synthesis of compact cell blocks by using the entirety of a cell pellet without the loss of diagnostic material during cell block preparations. The feasibility of this technique is illustrated by high-throughput immunocytochemistry using high-density cell block microarray (CMA).Methods: The cell pellets of Sure- Path residues were pre-embedded in ultra-low gelling temperature agarose gel and re-embedded in standard agarose gel. They were fixed, processed, and embedded in paraffin using the same method as tissue sample processing. The resulting agarose cell blocks were trimmed and represented on a CMA for high-throughput analysis using immunocytochemical staining.Results: The SurePath residues were effectively and entirely incorporated into compact agarose cell buttons and embedded in paraffin. Sections of the agarose cell blocks revealed cellularities that correlated well with corresponding SurePath smears and had immunocytochemical features that were sufficient for diagnosis of difficult cases.Conclusions: This agarose-based compact cell block technique enables preparation of high-quality cell blocks by using up the residual SurePath samples without loss of diagnostic material during cell block preparation.","PeriodicalId":49936,"journal":{"name":"Korean Journal of Pathology","volume":"48 5","pages":"351-60"},"PeriodicalIF":0.0,"publicationDate":"2014-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4132/KoreanJPathol.2014.48.5.351","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32788822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 21

One Case of a BRCA1 Germ Line Mutation Ovarian Carcinoma Patient Based on Abnormal Immunohistochemistry Finding. 基于异常免疫组化发现的BRCA1种系突变卵巢癌1例

Korean Journal of Pathology Pub Date : 2014-10-01 Epub Date: 2014-10-27 DOI: 10.4132/KoreanJPathol.2014.48.5.379

Hyun Joo Kim, Jung Min Park, Hyoun Wook Lee, Eun Hee Lee, Min Kyu Kim

{"title":"One Case of a BRCA1 Germ Line Mutation Ovarian Carcinoma Patient Based on Abnormal Immunohistochemistry Finding.","authors":"Hyun Joo Kim, Jung Min Park, Hyoun Wook Lee, Eun Hee Lee, Min Kyu Kim","doi":"10.4132/KoreanJPathol.2014.48.5.379","DOIUrl":"https://doi.org/10.4132/KoreanJPathol.2014.48.5.379","url":null,"abstract":"Ovarian cancer is one of the most lethal gynecological cancers in the Western world. In 2012, approximately 2,000 new patients and 980 mortalities due to ovarian cancer were reported in Korea. Due to the lack of efficient diagnostic methods for early detection and rapid progression to advanced stages, patients with ovarian cancer have poor survival rates. As hereditary ovarian cancers tend to present as higher grade disease in younger patients, screening for hereditary ovarian cancer is important for decreasing prevalence and improving patient survival. BRCA1 and BRCA2 are mismatch repair genes accounting for 85% of hereditary breast and epithelial ovarian cancers. 1 They are located on chromosomes 17q21 (22 exons, 80-kb DNA) and 13q12-13 (26 exons, 70-kb DNA), 2,3 respectively. Other mismatch repair genes also contribute to carcinogenesis. 4 The average lifetime risk of developing breast and ovarian cancers in women with a BRCA1 mutation are 65% and 39%, respectively, and the corresponding estimates for BRCA2 are 45% and 11%, respectively. 5 Three methods are commonly used to man","PeriodicalId":49936,"journal":{"name":"Korean Journal of Pathology","volume":"48 5","pages":"379-81"},"PeriodicalIF":0.0,"publicationDate":"2014-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4132/KoreanJPathol.2014.48.5.379","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32788827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alveolar soft part sarcoma of the uterine cervix: a case report and review of the literature. 子宫颈腺泡软组织肉瘤：病例报告和文献综述。

Korean Journal of Pathology Pub Date : 2014-10-01 Epub Date: 2014-10-27 DOI: 10.4132/KoreanJPathol.2014.48.5.361

Hyun Ju Lee

引用次数: 0

Nodular fasciitis of the parotid gland, masquerading as pleomorphic adenoma. 腮腺结节性筋膜炎，伪装为多形性腺瘤。

Korean Journal of Pathology Pub Date : 2014-10-01 Epub Date: 2014-10-27 DOI: 10.4132/KoreanJPathol.2014.48.5.366

Chung Su Hwang, Chang Hun Lee, Ahrong Kim, Nari Shin, Won Young Park, Min Gyoung Park, Do Youn Park

引用次数: 6

Cytokeratin-positive gastrointestinal stromal tumor of biphasic morphology: a case report. 细胞角蛋白阳性双相胃肠道间质瘤1例。

Korean Journal of Pathology Pub Date : 2014-10-01 Epub Date: 2014-10-27 DOI: 10.4132/KoreanJPathol.2014.48.5.375

Sung Sun Kim, Yoo Duk Choi, Jae Hyuk Lee, Chan Choi

引用次数: 3