Korean Journal of Pathology最新文献

{"title":"Micropapillary mucinous adenocarcinoma of the lung: a brief case report.","authors":"In Ho Choi, Boin Lee, Joungho Han, Chin A Yi, Yong Soo Choi, Jin Seok Ahn","doi":"10.4132/KoreanJPathol.2013.47.6.603","DOIUrl":"https://doi.org/10.4132/KoreanJPathol.2013.47.6.603","url":null,"abstract":"In 2011, the International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society (IASLC/ATS/ERS) classification added micropapillary predomi nant adenocarcinoma of the lung as a new histologic subtype and reclassified the former mucinous bronchioloalveolar carcino ma (BAC) as a variant of invasive mucinous adenocarcinoma. 1 Recent studies regarding epidermal growth factor receptor (EGFR) and K-ras mutations in lung cancer demonstrated that BAC with a lepidic or hobnail growth pattern is more typically associated with EGFR mutation, while mucinous differentiation is more common in cases with K-ras mutation. 2-4 However, these studies were based on the 2004 World Health Organization (WHO) classification, and there had been a few reports on the micropapillary pattern of this disease and its correlation with EGFR and K-ras mutations. 4,5 According to the report of the IASLC, 1 micropapillary predominant adenocarcinoma is known to be related to K-ras (33%), EGFR (20%), and BRAF (20%) mutations. Hypothesizing that micropapillary predominant adenocarcinoma with mucinous differentiation may be correlated with K-ras mutation, we performed a histological review of a case of micropapillary mucinous adenocarcinoma with associated K-ras mutation.","PeriodicalId":49936,"journal":{"name":"Korean Journal of Pathology","volume":"47 6","pages":"603-5"},"PeriodicalIF":0.0,"publicationDate":"2013-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4132/KoreanJPathol.2013.47.6.603","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32028644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Myxoid solitary fibrous tumor of the central nervous system.","authors":"Haeri Han, Sangjeong Ahn, Won Hwangbo, Yang Seok Chae","doi":"10.4132/KoreanJPathol.2013.47.6.505","DOIUrl":"https://doi.org/10.4132/KoreanJPathol.2013.47.6.505","url":null,"abstract":"Solitary fibrous tumors (SFTs) most commonly occur in the pleura, but may also occur in the central nervous system (CNS). Among the numerous cases of CNS SFT that have been reported, totaling to more than 220 cases, the myxoid SFT of the CNS has been the least recognized and most misleading subtype.1 Differential diagnosis from chordoid or myxo-chordoid meningioma, myxoid peripheral nerve sheath tumor, metastatic or primary low-grade fibromyxoid sarcoma, primary intracranial myxoma, and metastatic tumor from a cardiac primary tumor is therefore necessary. Here, we present a case of a myxoid SFT located in the tentorium cerebelli. A 45-year-old woman presented with headache, general weakness, and impaired vision. A magnetic resonance imaging scan revealed a lunulating, contoured, enhancing mass measuring 7.0×6.0×2.0 cm with hemorrhagic foci, located in the right posterior parietal and temporooccipital convexities. Under the diagnosis of meningioma, open craniotomy, right parietotemporooccipital, and subtotal tumor removal was performed. \u0000 \u0000Upon observation, many firm, rubbery, and bosselated tumor fragments, tan-white in color, were identified. The cut surface was relatively homogeneous, with a whitish fibrotic appearance and softer areas of gelatinous myxoid change, approximately 50%. Necrotic areas were not observed. Microscopic examination revealed a predominantly hypocellular area in the myxoid stroma, intervening with foci of a morphologically typical, densely cellular SFT with spindle cells and collagenous stroma (Fig. 1). In the hypocellular and myxoid areas, a proliferation of cytologically bland spindled cells was randomly arranged in a loose myxoid matrix, forming interconnecting strands, and resulting in degeneration. The neoplastic cells had oval to elongated nuclei, with evenly distributed chromatin, inconspicuous nucleoli, and scant pale cytoplasm. Immunohistochemically, the tumor cells showed a strong expression of CD34, vimentin, Bcl2 and CD99, but were negative for epithelial membrane antigen (EMA), pan-cytokeratin, and glial fibrillary acidic protein (GFAP). The Ki-67 labeling index was lower than 4%. On the basis of these findings, the final diagnosis was myxoid SFT. \u0000 \u0000 \u0000 \u0000Fig. 1 \u0000 \u0000Histologic findings. Myxoid stroma with focal ropy collagen in a rich vascularized tumor (A), moderately cellular area exhibiting spindle cells and collagenous stroma (B), and strong immunoreactivity for CD34 (C). \u0000 \u0000 \u0000 \u0000Myxoid SFT of the CNS is an extremely rare tumor and differential diagnosis may be difficult to achieve owing to confusion with several other myxoid spindle cell neoplasms. Indeed, myxoid SFT of the CNS must be differentiated from chordoid or myxo-chordoid meningioma, myxoid peripheral nerve sheath tumor, metastatic or primary low-grade fibromyxoid sarcoma, primary intracranial myxoma, meningeal hemangiopericytoma and metastatic tumor from a cardiac primary. \u0000 \u0000Immunohistochemistry has proven to be a useful tool in attaining an accu","PeriodicalId":49936,"journal":{"name":"Korean Journal of Pathology","volume":"47 6","pages":"505-6"},"PeriodicalIF":0.0,"publicationDate":"2013-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4132/KoreanJPathol.2013.47.6.505","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32027553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microtubule-Associated Protein Tau, α-Tubulin and βIII-Tubulin Expression in Breast Cancer.","authors":"Soyoung Im,&nbsp;Changyoung Yoo,&nbsp;Ji-Han Jung,&nbsp;Ye-Won Jeon,&nbsp;Young Jin Suh,&nbsp;Youn Soo Lee,&nbsp;Hyun Joo Choi","doi":"10.4132/KoreanJPathol.2013.47.6.534","DOIUrl":"https://doi.org/10.4132/KoreanJPathol.2013.47.6.534","url":null,"abstract":"<p><strong>Background: </strong>The microtubule-associated protein Tau binds to both inner and outer surfaces of microtubules, leading to tubulin assembly and microtubule stabilization. The aim of this study was to evaluate the significance of Tau, α-tubulin, and βIII-tubulin expression in breast carcinoma and to assess their relationships with disease progression in the context of taxane treatment.</p><p><strong>Methods: </strong>Immunohistochemical expressions of Tau, α-tubulin, and βIII-tubulin were assessed in 183 breast cancer cases. Expression was correlated with clinicopathologic parameters, disease progression and overall survival.</p><p><strong>Results: </strong>Tau expression was correlated with lymph node metastasis and estrogen receptor (ER) positivity (p=.003 and p<.001, respectively). Loss of α-tubulin was significantly correlated with distant metastasis (p=.034). Loss of βIII-tubulin was correlated with lymph node metastasis and ER positivity (p=.004 and p<.001, respectively). In taxane-treated cases, Tau expression and loss of α-tubulin and βIII-tubulin expression were related to disease progression (p=.001, p=.028, and p=.030, respectively). Tau expression was associated with a worse survival rate in taxane-treated patients (p=.049).</p><p><strong>Conclusions: </strong>Tau expression and loss of α-tubulin and βIII-tubulin expression were correlated with aggressive behavior in taxane-treated breast cancer. Further evaluation of Tau, α-tubulin and βIII-tubulin may be useful in predicting clinical behavior and seeking therapeutic measures in taxane-based chemotherapy for breast cancer.</p>","PeriodicalId":49936,"journal":{"name":"Korean Journal of Pathology","volume":"47 6","pages":"534-40"},"PeriodicalIF":0.0,"publicationDate":"2013-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4132/KoreanJPathol.2013.47.6.534","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32027557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunohistochemical classification of primary and secondary glioblastomas.","authors":"Kyu Sang Lee,&nbsp;Gheeyoung Choe,&nbsp;Kyung Han Nam,&nbsp;An Na Seo,&nbsp;Sumi Yun,&nbsp;Kyung Ju Kim,&nbsp;Hwa Jin Cho,&nbsp;Sung Hye Park","doi":"10.4132/KoreanJPathol.2013.47.6.541","DOIUrl":"https://doi.org/10.4132/KoreanJPathol.2013.47.6.541","url":null,"abstract":"<p><strong>Background: </strong>Glioblastomas may develop de novo (primary glioblastomas, P-GBLs) or through progression from lower-grade astrocytomas (secondary glioblastomas, S-GBLs). The aim of this study was to compare the immunohistochemical classification of glioblastomas with clinically determined P-GBLs and S-GBLs to identify the best combination of antibodies for immunohistochemical classification.</p><p><strong>Methods: </strong>We evaluated the immunohistochemical expression of epidermal growth factor receptor (EGFR), p53, and isocitrate dehydrogenase 1 (IDH-1) in 150 glioblastoma cases.</p><p><strong>Results: </strong>According to clinical history, the glioblastomas analyzed in this study consisted of 146 P-GBLs and 4 S-GBLs. Immunohistochemical expression of EGFR, p53, and IDH-1 was observed in 62.6%, 49.3%, and 11.1%, respectively. Immunohistochemical profiles of EGFR(+)/p53(-), IDH-1(-)/EGFR(+)/p53(-), and EGFR(-)/p53(+) were noted in 41.3%, 40.2%, and 28.7%, respectively. Expression of IDH-1 and EGFR(-)/p53(+) was positively correlated with young age. The typical immunohistochemical features of S-GBLs comprised IDH-1(+)/EGFR(-)/p53(+), and were noted in 3.6% of clinically P-GBLs. The combination of IDH-1(-) or EGFR(+) was the best set of immunohistochemical stains for identifying P-GBLs, whereas the combination of IDH-1(+) and EGFR(-) was best for identifying S-GBLs.</p><p><strong>Conclusions: </strong>We recommend a combination of IDH-1 and EGFR for immunohistochemical classification of glioblastomas. We expect our results to be useful for determining treatment strategies for glioblastoma patients.</p>","PeriodicalId":49936,"journal":{"name":"Korean Journal of Pathology","volume":"47 6","pages":"541-8"},"PeriodicalIF":0.0,"publicationDate":"2013-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4132/KoreanJPathol.2013.47.6.541","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32027558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endogenous gastric-resident mesenchymal stem cells contribute to formation of cancer stroma and progression of gastric cancer.","authors":"Eun-Kyung Kim,&nbsp;Hye-Jung Kim,&nbsp;Young-Il Yang,&nbsp;Jong Tae Kim,&nbsp;Min-Young Choi,&nbsp;Chang Soo Choi,&nbsp;Kwang-Hee Kim,&nbsp;Jeong-Han Lee,&nbsp;Won-Hee Jang,&nbsp;Soon-Ho Cheong","doi":"10.4132/KoreanJPathol.2013.47.6.507","DOIUrl":"https://doi.org/10.4132/KoreanJPathol.2013.47.6.507","url":null,"abstract":"<p><strong>Background: </strong>Carcinoma-associated fibroblasts (CAFs) contribute to carcinogenesis and cancer progression, although their origin and role remain unclear. We recently identified and investigated the in situ identity and implications of gastric submucosa-resident mesenchymal stem cells (GS-MSCs) in the progression of gastric carcinogenesis.</p><p><strong>Methods: </strong>We isolated GS-MSCs from gastric submucosa using hydrogel-supported organ culture and defined their identity. Isolated cells were assessed in vitro by immunophenotype and mesengenic multipotency. Reciprocal interactions between GS-MSCs and gastric cancer cells were evaluated. To determine the role of GS-MSCs, xenografts were constructed of gastric cancer cells admixed with or without GS-MSCs.</p><p><strong>Results: </strong>Isolated cells fulfilled MSCs requirements in regard to plastic adherence, stromal cell immunophenotype, and multipotency. We demonstrated a paracrine loop that gastric cancer cells enhanced the migration, proliferation, and differentiation of GS-MSCs; additionally, GS-MSCs promoted the proliferation of gastric cancer cell in vitro. Xenograft experiments showed that GS-MSCs significantly promoted cancer growth and angiogenesis. GS-MSCs that integrated into gastric cancer became not only CAFs but also rarely endothelial cells which contributed to the formation of cellular and vascular cancer stroma.</p><p><strong>Conclusions: </strong>Endogenous GS-MSCs play an important role in gastric cancer progression.</p>","PeriodicalId":49936,"journal":{"name":"Korean Journal of Pathology","volume":"47 6","pages":"507-18"},"PeriodicalIF":0.0,"publicationDate":"2013-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4132/KoreanJPathol.2013.47.6.507","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32027554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diffuse Large B-Cell Lymphoma Arising in Warthin's Tumor: Case Study and Review of the Literature.","authors":"Güliz Ozkök,&nbsp;Funda Taşlı,&nbsp;Nazan Ozsan,&nbsp;Rafet Oztürk,&nbsp;Hakan Postacı","doi":"10.4132/KoreanJPathol.2013.47.6.579","DOIUrl":"https://doi.org/10.4132/KoreanJPathol.2013.47.6.579","url":null,"abstract":"<p><p>Warthin's tumor is the second most common type of salivary gland tumor. Microscopically, Warthin's tumor displays a proliferative epithelial component and lymphoid stroma. Carcinomas arising from the epithelial component are well known, but malignant transformations of the lymphoid stroma are rare. When they do occur, they are most commonly B-cell type non-Hodgkin lymphomas. A 60-year-old male patient underwent surgical resection of a parotid mass. After superficial parotidectomy, microscopic examination indicated that the tumor was of epithelial components with basaloid and oncocytic columns of cells neighboring lymphoid components. In addition to the lymphoid follicles with distinct germinal centers, there were large, bizarre and extremely atypical neoplastic cells seen in the lymphoid component. Large neoplastic cells were diffusely CD20 and CD30 positive. The patient was diagnosed with \"Warthin's tumor and diffuse large B-cell lymphoma with expression of CD30.\" The histopathologic and clinical features are discussed along with a review of the literature. </p>","PeriodicalId":49936,"journal":{"name":"Korean Journal of Pathology","volume":"47 6","pages":"579-82"},"PeriodicalIF":0.0,"publicationDate":"2013-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4132/KoreanJPathol.2013.47.6.579","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32028638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Accuracy of Cerebrospinal Fluid (CSF) Cytology in Metastatic Tumors: An Analysis of Consecutive CSF Samples.","authors":"Yoon Sung Bae,&nbsp;June-Won Cheong,&nbsp;Won Seok Chang,&nbsp;Sewha Kim,&nbsp;Eun Ji Oh,&nbsp;Se Hoon Kim","doi":"10.4132/KoreanJPathol.2013.47.6.563","DOIUrl":"https://doi.org/10.4132/KoreanJPathol.2013.47.6.563","url":null,"abstract":"<p><strong>Background: </strong>Cerebrospinal fluid (CSF) examination can be used to verify the presence of primary malignancies as well as cases of central nervous system (CNS) metastasis. Because of its importance, there have been several studies concerning the sensitivity of CSF cytology. To determine the practical use and reproducibility of diagnoses based on CSF cytology, we evaluated this test by analyzing cytology results from consecutive CSF samples.</p><p><strong>Methods: </strong>Between July 2010 and June 2013, 385 CSF cytology samples from 42 patients were collected. The samples were gathered using a ventricular catheter and reservoir. CSF cytology of all patients was examined more than two times with immunocytochemistry for cytokeratin.</p><p><strong>Results: </strong>Primary neoplastic sites and histologic types of patients' metastatic cancer were diverse. The overall sensitivity for detecting malignancy was 41.3%. Even within short-term intervals, diagnoses frequently changed.</p><p><strong>Conclusions: </strong>Our results were inconsistent, with low sensitivity, when compared to the results of previous studies. However, CSF evaluation can still provide valuable diagnostic and prognostic information because adjuvant treatments are now routinely performed in patients with CNS metastasis. Negative CSF cytology results should not be ignored, and continuous CSF follow-up is essential for following the clinical course of patients with metastatic cancer involving the CNS.</p>","PeriodicalId":49936,"journal":{"name":"Korean Journal of Pathology","volume":"47 6","pages":"563-8"},"PeriodicalIF":0.0,"publicationDate":"2013-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4132/KoreanJPathol.2013.47.6.563","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32028635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cystic benign phyllodes tumor in the inguinal region.","authors":"Jai Hyang Go","doi":"10.4132/KoreanJPathol.2013.47.6.583","DOIUrl":"https://doi.org/10.4132/KoreanJPathol.2013.47.6.583","url":null,"abstract":"<p><p>The present lesion was the first reported case of a benign intracystic phyllodes tumor in the inguinal region. We report the case of a 51-year-old female patient who presented with an inguinal mass. A clinical diagnosis of malignant lymphoma was considered in this case. The resected tumor was well-circumscribed and showed numerous papillary nodular protrusions into a central cystic cavity (3.5×2.5 cm). The microscopic findings showed hyperplastic epithelium-lined cysts with leaf-like intraluminal epithelium-lined bland stromal projections. The epithelial cell linings were strongly positive for estrogen and progesterone receptors. </p>","PeriodicalId":49936,"journal":{"name":"Korean Journal of Pathology","volume":"47 6","pages":"583-6"},"PeriodicalIF":0.0,"publicationDate":"2013-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4132/KoreanJPathol.2013.47.6.583","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32028639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mediastinal thymolipoma with striated myoid cells: report of a peculiar case.","authors":"Young Keum Kim,&nbsp;Nari Shin,&nbsp;Won Young Park,&nbsp;Do Youn Park,&nbsp;Gi Young Huh,&nbsp;Chang Hun Lee","doi":"10.4132/KoreanJPathol.2013.47.6.596","DOIUrl":"https://doi.org/10.4132/KoreanJPathol.2013.47.6.596","url":null,"abstract":"Thymolipoma is a rare anterior mediastinal tumor composed of mature adipose tissue and benign thymic tissue, and is a benign neoplasm for which complete surgical excision is curative.1 Literature has reported that the thymic parenchyma of thymolipoma exceptionally contain myoid cells that are immunoreactive for desmin, muscle-specific actin and myoglobin.2,3 Herein, we describe a very rare case of thymolipoma with myoid cells. To the best of our knowledge, this is the sixth case of thymolipoma containing striated myoid cells in the English literature since 1972.","PeriodicalId":49936,"journal":{"name":"Korean Journal of Pathology","volume":"47 6","pages":"596-8"},"PeriodicalIF":0.0,"publicationDate":"2013-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4132/KoreanJPathol.2013.47.6.596","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32028642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Renal histologic parameters influencing postoperative renal function in renal cell carcinoma patients.","authors":"Myoung Ju Koh, Beom Jin Lim, Kyu Hun Choi, Yon Hee Kim, Hyeon Joo Jeong","doi":"10.4132/KoreanJPathol.2013.47.6.557","DOIUrl":"10.4132/KoreanJPathol.2013.47.6.557","url":null,"abstract":"<p><strong>Background: </strong>Pre-existing non-neoplastic renal diseases or lesions may influence patient renal function after tumor removal. However, its description is often neglected or omitted in pathologic reports. To determine the incidence and clinical significance of non-neoplastic lesions, we retrospectively examined renal tissues obtained during 85 radical nephrectomies for renal cell carcinoma.</p><p><strong>Methods: </strong>One paraffin-embedded tissue block from each case containing a sufficient amount of non-tumorous renal parenchyma was cut and processed with hematoxylin and eosin and periodic acid-Schiff methods. Non-neoplastic lesions of each histological compartment were semi-quantitatively and quantitatively evaluated.</p><p><strong>Results: </strong>Among the various histologic lesions found, tubular atrophy, arterial intimal thickening, and glomerulosclerosis were the most common (94.1%, 91.8%, and 88.2%, respectively). Glomerulosclerosis correlated with estimated glomerular filtration rate at the time of surgery, as well as at 1- and 5-years post-surgery (p=.0071), but tubulointerstitial fibrosis or arterial fibrous intimal thickening did not. Post-hoc analysis revealed that glomerulosclerosis of more than 20% predicted post-operative renal function. However, its significance disappeared when gender and age were considered.</p><p><strong>Conclusions: </strong>In conclusion, non-neoplastic lesions, especially with regard to glomerulosclerosis percentage, should be described in pathology reports to provide additional information on renal function decline.</p>","PeriodicalId":49936,"journal":{"name":"Korean Journal of Pathology","volume":"47 6","pages":"557-62"},"PeriodicalIF":0.0,"publicationDate":"2013-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c0/6c/kjpathol-47-557.PMC3887158.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32027560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}