Korean Journal of Pathology最新文献_第8页

Simultaneous Occurrence of Ductal Carcinoma In Situ within Juvenile Fibroadenoma in Both Breasts: A Brief Case Report. 双侧乳房幼年纤维腺瘤中同时存在乳腺导管原位癌：简要病例报告。

Korean Journal of Pathology Pub Date : 2014-04-01 Epub Date: 2014-04-28 DOI: 10.4132/KoreanJPathol.2014.48.2.164

Mi Jung Kwon, Hye-Rim Park, Jinwon Seo, Dong Hoon Kim, Kyoonsoon Jung, Young Ah Lim, Lee Su Kim, Hoonsik Bae, In Ae Park, Soo Kee Min

引用次数: 0

Fine Needle Aspiration Cytology of Warthin-like Papillary Thyroid Carcinoma: A Brief Case Report. 甲状腺wartin样乳头状癌细针抽吸细胞学1例。

Korean Journal of Pathology Pub Date : 2014-04-01 Epub Date: 2014-04-28 DOI: 10.4132/KoreanJPathol.2014.48.2.170

Yosep Chong, Sungwook Suh, Tae-Jung Kim, Eun Jung Lee

{"title":"Fine Needle Aspiration Cytology of Warthin-like Papillary Thyroid Carcinoma: A Brief Case Report.","authors":"Yosep Chong, Sungwook Suh, Tae-Jung Kim, Eun Jung Lee","doi":"10.4132/KoreanJPathol.2014.48.2.170","DOIUrl":"https://doi.org/10.4132/KoreanJPathol.2014.48.2.170","url":null,"abstract":"The Warthin-like variant of papillary thyroid carcinoma (WL-PTC) was first introduced by Apel et al.1 in 1995 as an extremely rare subtype of papillary thyroid carcinoma (PTC) that is characterized by papillary architecture, lined by Hurthle cells, with classical cytologic features of PTC cells, and a heavy lymphocytic stroma of the papillary core. WL-PTC is now classified in the World Health Organization terminology as a special subtype of an oncocytic variant of PTC.2 Its histopathological features have been relatively well documented in cases that followed the first 13 that were described by Apel et al.1,2 However, the cytologic features of WL-PTC in fine needle aspiration cytology (FNAC) are described rather poorly and by only a few authors.3,4,5,6 Although Kim et al.7 have documented the cytologic features of an oncocytic variant of PTC in a Korean patient, FNAC of WL-PTC has not been reported in Korea. \u0000 \u0000FNAC is being used widely for initial diagnosis of thyroid lesions for a treatment plan decision. The first cytological picture of WL-PTC highly resembles that of benign lymphocyterich thyroid lesions such as Hashimoto's thyroiditis. Therefore, knowledge about key points in the differential cytological diagnosis is essential for an accurate diagnosis and appropriate treatment. Here, we present WL-PTC with FNAC for the first time in Korea in a teaching case involving liquid-based cytology (LBC) preparation in a 31-year-old woman.","PeriodicalId":49936,"journal":{"name":"Korean Journal of Pathology","volume":"48 2","pages":"170-3"},"PeriodicalIF":0.0,"publicationDate":"2014-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4132/KoreanJPathol.2014.48.2.170","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32374550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Tumor sprouting in papillary thyroid carcinoma is correlated with lymph node metastasis and recurrence. 甲状腺乳头状癌的肿瘤萌芽与淋巴结转移和复发有关。

Korean Journal of Pathology Pub Date : 2014-04-01 Epub Date: 2014-04-28 DOI: 10.4132/KoreanJPathol.2014.48.2.117

Eunjung Lee, Wonkyung Jung, Jeong-Soo Woo, Jae Bok Lee, Bong Kyung Shin, Han Kyeom Kim, Aeree Kim, Baek-Hui Kim

{"title":"Tumor sprouting in papillary thyroid carcinoma is correlated with lymph node metastasis and recurrence.","authors":"Eunjung Lee, Wonkyung Jung, Jeong-Soo Woo, Jae Bok Lee, Bong Kyung Shin, Han Kyeom Kim, Aeree Kim, Baek-Hui Kim","doi":"10.4132/KoreanJPathol.2014.48.2.117","DOIUrl":"https://doi.org/10.4132/KoreanJPathol.2014.48.2.117","url":null,"abstract":"Background: Identification of poor prognostic factors in papillary thyroid carcinoma (PTC) patients is important for the patients' care and follow-up. We can sometimes see small tumor clusters without desmoplasia and no evidence of lymphatic emboli around the main tumor mass of PTC. We termed this form of tumor clustering, 'tumor sprouting,' and determined whether these tumors correlate with lymphovascular invasion, lymph node metastasis, and recurrence.Methods: We analyzed a total of 204 cases of papillary thyroid macrocarcinoma. Number, size and distance from the main tumor of the tumor sprouting were observed and analyzed with clinicopathologic characteristics.Results: Tumor sprouting was observed in 101 patients. Presence of tumor sprouting was significantly associated with positive resection margin (p=.002), lymphovascular invasion (p=.001), lymph node metastasis (p<.001), and recurrence (p=.004). Univariate analysis of recurrence-free survival revealed that tumor multiplicity (p=.037), positive resection margin (p=.007), lymphovascular invasion (p=.004), lymph node metastasis (p<.001), and tumor sprouting (p=.004) were poor prognostic factors. In multivariate analysis, positive resection margin was an independent poor prognostic factor of recurrence.Conclusions: In conclusion, tumor sprouting is significantly correlated with lymph node metastasis and recurrence. Evaluation of tumor sprouting in PTC patients could be helpful in predicting tumor recurrence or lymph node metastasis.","PeriodicalId":49936,"journal":{"name":"Korean Journal of Pathology","volume":"48 2","pages":"117-25"},"PeriodicalIF":0.0,"publicationDate":"2014-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4132/KoreanJPathol.2014.48.2.117","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32372893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Follicular Dendritic Cell Sarcoma of the Inflammatory Pseudotumor-like Variant Presenting as a Colonic Polyp. 炎性假肿瘤样变异的滤泡树突状细胞肉瘤表现为结肠息肉。

Korean Journal of Pathology Pub Date : 2014-04-01 Epub Date: 2014-04-28 DOI: 10.4132/KoreanJPathol.2014.48.2.140

Shien-Tung Pan, Chih-Yuan Cheng, Nie-Sue Lee, Peir-In Liang, Shih-Sung Chuang

{"title":"Follicular Dendritic Cell Sarcoma of the Inflammatory Pseudotumor-like Variant Presenting as a Colonic Polyp.","authors":"Shien-Tung Pan, Chih-Yuan Cheng, Nie-Sue Lee, Peir-In Liang, Shih-Sung Chuang","doi":"10.4132/KoreanJPathol.2014.48.2.140","DOIUrl":"https://doi.org/10.4132/KoreanJPathol.2014.48.2.140","url":null,"abstract":"Follicular dendritic cell (FDC) sarcoma is rare and is classified either as conventional type or inflammatory pseudotumor (IPT)-like variant. Extranodal presentation is uncommon and nearly all gastrointestinal FDC tumors are of the conventional type. IPT-like variant tumors occur almost exclusively in the liver and spleen and are consistently associated with Epstein-Barr virus (EBV). Here we report the case of a 78-year-old woman with an IPT-like FDC sarcoma presenting as a pedunculated colonic polyp. Histologically, scanty atypical ovoid to spindle cells were mixed with a background of florid lymphoplasmacytic infiltrate, which led to an initial misdiagnosis of pseudolymphoma. These atypical cells expressed CD21, CD23, CD35, and D2-40, and were positive for EBV by in situ hybridization, confirming the diagnosis. The patient was free of disease five months after polypectomy without adjuvant therapy. Although extremely rare, the differential diagnosis for colonic polyp should include FDC sarcoma to avoid an erroneous diagnosis. A review of the 24 cases of IPT-like FDC sarcoma reported in the literature reveal that this tumor occurs predominantly in females with a predilection for liver and spleen, and has a strong association with EBV. ","PeriodicalId":49936,"journal":{"name":"Korean Journal of Pathology","volume":"48 2","pages":"140-5"},"PeriodicalIF":0.0,"publicationDate":"2014-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4132/KoreanJPathol.2014.48.2.140","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32372896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 36

Distribution of Human Papillomavirus 52 and 58 Genotypes, and Their Expression of p16 and p53 in Cervical Neoplasia. 人乳头瘤病毒52、58基因型在宫颈肿瘤组织中的分布及p16、p53的表达

Korean Journal of Pathology Pub Date : 2014-02-01 Epub Date: 2014-02-25 DOI: 10.4132/KoreanJPathol.2014.48.1.24

Tae Eun Kim, Hwal Woong Kim, Kyung Eun Lee

{"title":"Distribution of Human Papillomavirus 52 and 58 Genotypes, and Their Expression of p16 and p53 in Cervical Neoplasia.","authors":"Tae Eun Kim, Hwal Woong Kim, Kyung Eun Lee","doi":"10.4132/KoreanJPathol.2014.48.1.24","DOIUrl":"https://doi.org/10.4132/KoreanJPathol.2014.48.1.24","url":null,"abstract":"Background: This study investigates the prevalence of human papillomavirus (HPV) 52 and 58 genotypes among women residing in Busan, and the expression of p16 and p53 proteins in cervical neoplasia with HPV 52 and 58 infections.Methods: A total of three hundred fifteen cases were analyzed using the HPV DNA chip test for HPV genotypes, and of these, we retrospectively examined p16 and p53 expression in 62 cases of cervical tissues infected with HPV 52 and 58 using immunohistochemistry.Results: HPV 52 and 58 genotypes were identified in 62 (54.9%) out of 113 high-risk, HPV-infected cases. Of the cases examined, there were 19 single HPV 52 infections (16.8%), 23 single HPV 58 infections (20.4%), 4 multiple HPV 52 infections (3.5%), and 16 multiple HPV-58 infections (14.2%). Immunoreactivity of p16 and p53 was observed in 41 (66.1%) and 23 (37.1%) of the 62 cases of cervical neoplasia infected with HPV 52 and 58 genotypes, respectively.Conclusions: This study demonstrates a high prevalence of HPV 52 and 58 genotypes, in addition to HPV 16, among high-risk strains of cervical neoplasia in Korea. These findings suggest that development of more vaccines would be beneficial for the prevention of the various HPV genotypes.","PeriodicalId":49936,"journal":{"name":"Korean Journal of Pathology","volume":"48 1","pages":"24-9"},"PeriodicalIF":0.0,"publicationDate":"2014-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4132/KoreanJPathol.2014.48.1.24","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32174105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Uncommon and rare human papillomavirus genotypes relating to cervical carcinomas. 与宫颈癌有关的不常见和罕见人类乳头瘤病毒基因型。

Korean Journal of Pathology Pub Date : 2014-02-01 Epub Date: 2014-02-25 DOI: 10.4132/KoreanJPathol.2014.48.1.43

Na Rae Kim, Myunghee Kang, Soon Pyo Lee, Hyunchul Kim, Jungsuk An, Dong Hae Chung, Seung Yeon Ha, Hyun Yee Cho

{"title":"Uncommon and rare human papillomavirus genotypes relating to cervical carcinomas.","authors":"Na Rae Kim, Myunghee Kang, Soon Pyo Lee, Hyunchul Kim, Jungsuk An, Dong Hae Chung, Seung Yeon Ha, Hyun Yee Cho","doi":"10.4132/KoreanJPathol.2014.48.1.43","DOIUrl":"10.4132/KoreanJPathol.2014.48.1.43","url":null,"abstract":"Background: Human papillomavirus (HPV) is an oncogenic virus in cervical cancer and most invasive carcinomas (ICs) are caused by HPV16 and 18. However, the roles and contributions of other uncommon and rare genotypes remain uncertain.Methods: HPV genotypes were retrospectively assessed using an HPV DNA chip that can specify up to 32 HPV genotypes. We arbitrarily regarded genotypes accounting for less than 6% of the total as uncommon and rare genotypes.Results: A total of 3,164 HPV-positive cases were enrolled. In groups 2A, 2B, 3, and unclassified HPV genotypes, 2.4% of cases with uncommon HPV genotypes (68, 26, 34, 53, 66, 69, 70, 73, 40, 42, 43, 44, 54, 55, 61, 62, 6, and 11) showed high grade squamous intraepithelial lesions and ICs. There were no HPV32- and 57-infected cases.Conclusions: We found that the uncommon and rare HPV genotypes may provide incremental etiologic contributions in cervical carcinogenesis, especially HPV68, 70, and 53. Further studies on these uncommon and rare HPV genotypes will be of importance in establishing the significance of genotypes in different regions, especially in planning a strategy for further vaccine development as well as follow-up on the effectiveness of the currently used vaccines.","PeriodicalId":49936,"journal":{"name":"Korean Journal of Pathology","volume":"48 1","pages":"43-9"},"PeriodicalIF":0.0,"publicationDate":"2014-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/5f/1d/kjpathol-48-43.PMC3950234.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32174559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of fixation and storage of human tissue samples on nucleic Acid preservation. 人体组织标本固定和保存对核酸保存的影响。

Korean Journal of Pathology Pub Date : 2014-02-01 Epub Date: 2014-02-25 DOI: 10.4132/KoreanJPathol.2014.48.1.36

Soo Kyung Nam, Joon Im, Yoonjin Kwak, Nayoung Han, Kyung Han Nam, An Na Seo, Hye Seung Lee

{"title":"Effects of fixation and storage of human tissue samples on nucleic Acid preservation.","authors":"Soo Kyung Nam, Joon Im, Yoonjin Kwak, Nayoung Han, Kyung Han Nam, An Na Seo, Hye Seung Lee","doi":"10.4132/KoreanJPathol.2014.48.1.36","DOIUrl":"https://doi.org/10.4132/KoreanJPathol.2014.48.1.36","url":null,"abstract":"Background: Because of recent advances in the molecular diagnosis of cancer patients, tissue quality has become more important in daily practice.Methods: To evaluate the effects of fixative, duration of fixation, decalcification, and storage periods on nucleic acid integrity, DNA and RNA were extracted from gastrointestinal cancer tissue. The yield and purity were analyzed, and polymerase chain reaction (PCR) for glyceraldehyde 3-phosphate dehydrogenase (GAPDH; 60 bp), β-actin (148 bp), and human growth hormone (hGH; 434 bp) and real-time reverse transcription-PCR for β-actin (97 bp) were performed.Results: All formalin-fixed paraffin-embedded (FFPE) and methacarn-fixed paraffin-embedded (MFPE) samples tested positive for GAPDH and β-actin by PCR. hGH was successfully detected in all MFPE samples, but in only 46.7% of the FFPE samples. Prolonged formalin fixation resulted in fewer GAPDH and β-actin PCR products, and amplification of hGH was not successful. The PCR and reverse transcription-PCR results were significantly affected by the duration of decalcification. The yield, purity, and integrity of mRNA progressively decreased with increased storage periods of paraffin blocks.Conclusions: Fixation and storage should therefore be standardized in order to improve the quality of molecular pathologic diagnosis.","PeriodicalId":49936,"journal":{"name":"Korean Journal of Pathology","volume":"48 1","pages":"36-42"},"PeriodicalIF":0.0,"publicationDate":"2014-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4132/KoreanJPathol.2014.48.1.36","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32174558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 37

Malignant fat-forming solitary fibrous tumor of the thigh. 恶性脂肪形成孤立的纤维瘤的大腿。

Korean Journal of Pathology Pub Date : 2014-02-01 Epub Date: 2014-02-25 DOI: 10.4132/KoreanJPathol.2014.48.1.69

Sang Jae Noh, Kyu Yun Jang

引用次数: 1

Altered Expression of PTEN and Its Major Regulator MicroRNA-21 in Pulmonary Neuroendocrine Tumors. PTEN及其主要调控因子MicroRNA-21在肺神经内分泌肿瘤中的表达改变

Korean Journal of Pathology Pub Date : 2014-02-01 Epub Date: 2014-02-25 DOI: 10.4132/KoreanJPathol.2014.48.1.17

Hyoun Wook Lee, Seung Yeon Ha, Mee Sook Roh

{"title":"Altered Expression of PTEN and Its Major Regulator MicroRNA-21 in Pulmonary Neuroendocrine Tumors.","authors":"Hyoun Wook Lee, Seung Yeon Ha, Mee Sook Roh","doi":"10.4132/KoreanJPathol.2014.48.1.17","DOIUrl":"https://doi.org/10.4132/KoreanJPathol.2014.48.1.17","url":null,"abstract":"Background: Phosphatase and tensin homolog on chromosome ten (PTEN) is one of the most frequently inactivated tumor suppressors in various tumor types. MicroRNA-21 (miR-21) may affect tumor progression by post-transcriptional repression of expression of tumor suppressors, such as PTEN. This study was conducted to evaluate the significance of PTEN expression in pulmonary neuroendocrine (NE) tumors and to analyze the relationship between PTEN and miR-21 expressions.Methods: Expressions of PTEN and miR-21 were investigated by immunohistochemistry and real time reverse transcription-polymerase chain reaction, respectively, in 75 resected pulmonary NE tumors (23 typical carcinoids [TCs], nine atypical carcinoids [ACs], 22 large cell NE carcinomas [LCNECs], and 21 small cell lung carcinomas [SCLCs]).Results: Loss of PTEN expression was observed in four of 23 TCs (17.4%), four of nine ACs (44.4%), 16 of 22 LCNECs (72.7%) and nine of 21 SCLCs (42.9%) (p=.025). The expression level of miR-21 was significantly higher in high-grade NE carcinomas than in carcinoid tumors (p<.001). PTEN expression was inversely correlated with miR-21 expression (p<.001).Conclusions: This study suggests that aberrant expression of PTEN in relation to miR-21 may represent an important step in the development and progression of pulmonary NE tumors.","PeriodicalId":49936,"journal":{"name":"Korean Journal of Pathology","volume":"48 1","pages":"17-23"},"PeriodicalIF":0.0,"publicationDate":"2014-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4132/KoreanJPathol.2014.48.1.17","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32174104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

A rare case of pulmonary papillary adenoma in old aged woman: a brief case report. 老年妇女肺乳头状腺瘤1例报告。

Korean Journal of Pathology Pub Date : 2014-02-01 Epub Date: 2014-02-25 DOI: 10.4132/KoreanJPathol.2014.48.1.66

In Ho Choi, Joungho Han, Jung Won Moon, Yong Soo Choi, Kyung-Jong Lee

引用次数: 8