Korean Journal of Pathology最新文献_第6页

Mesenchymal stromal cells promote tumor progression in fibrosarcoma and gastric cancer cells. 间充质间质细胞促进纤维肉瘤和胃癌细胞的肿瘤进展。

Korean Journal of Pathology Pub Date : 2014-06-01 Epub Date: 2014-06-26 DOI: 10.4132/KoreanJPathol.2014.48.3.217

Byunghoo Song, Bokyung Kim, Se-Ha Choi, Kyo Young Song, Yang-Guk Chung, Youn-Soo Lee, Gyeongsin Park

{"title":"Mesenchymal stromal cells promote tumor progression in fibrosarcoma and gastric cancer cells.","authors":"Byunghoo Song, Bokyung Kim, Se-Ha Choi, Kyo Young Song, Yang-Guk Chung, Youn-Soo Lee, Gyeongsin Park","doi":"10.4132/KoreanJPathol.2014.48.3.217","DOIUrl":"https://doi.org/10.4132/KoreanJPathol.2014.48.3.217","url":null,"abstract":"Background: Extensive evidence has accumulated regarding the role of mesenchymal stromal cells (MSCs) in tumor progression, but the exact effects and mechanisms underlying this role remain unclear. We investigated the effects of MSC-associated tumor progression in MSC-sarcoma models and a gastric cancer metastatic model.Methods: We conducted an in vitro growth kinetics assay and an in vivo tumor progression assay for sarcoma cells and gastric cancer cells in the presence or absence of MSCs.Results: MSC-cocultured human fibrosarcoma cells (HT1080) showed accelerated growth compared with HT1080 alone (79- vs 37-fold change, p<.050). For HT1080, human MSC-coinjected tumors showed significantly greater and highly infiltrative growth compared to those of HT1080 alone (p=.035). For mouse fibrosarcoma cells (WEHI164), mouse MSC-coinjected tumors had greater volume than those of WEHI164 alone (p=.141). For rat sarcoma cells (RR1022), rat MSC-coinjected tumors exhibited greater volume and infiltrative growth than those of RR1022 alone (p=.050). For human gastric cancer cells (5FU), tumors of 5FU alone were compact, nodular in shape, and expansile with good demarcation and no definite lung metastatic nodules, whereas tumors grown in the presence of human MSCs showed highly desmoplastic and infiltrative growth and multiple lung metastasis.Conclusions: We observed morphological evidence for MSC-associated tumor progression of fibrosarcomas and gastric cancer cells.","PeriodicalId":49936,"journal":{"name":"Korean Journal of Pathology","volume":"48 3","pages":"217-24"},"PeriodicalIF":0.0,"publicationDate":"2014-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4132/KoreanJPathol.2014.48.3.217","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32494203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Extrapulmonary lymphangioleiomyoma: clinicopathological analysis of 4 cases. 肺外淋巴管平滑肌瘤4例临床病理分析。

Korean Journal of Pathology Pub Date : 2014-06-01 Epub Date: 2014-06-26 DOI: 10.4132/KoreanJPathol.2014.48.3.188

Dae Hyun Song, In Ho Choi, Sang Yun Ha, Kang Min Han, Jae Jun Lee, Min Eui Hong, Yoon-La Choi, Kee-Taek Jang, Sang Yong Song, Chin A Yi, Joungho Han

{"title":"Extrapulmonary lymphangioleiomyoma: clinicopathological analysis of 4 cases.","authors":"Dae Hyun Song, In Ho Choi, Sang Yun Ha, Kang Min Han, Jae Jun Lee, Min Eui Hong, Yoon-La Choi, Kee-Taek Jang, Sang Yong Song, Chin A Yi, Joungho Han","doi":"10.4132/KoreanJPathol.2014.48.3.188","DOIUrl":"https://doi.org/10.4132/KoreanJPathol.2014.48.3.188","url":null,"abstract":"Background: Lymphangioleiomyomatosis (LAM) is a slowly progressive neoplastic disease that predominantly affects females. Usually, LAM affects the lung; it can also affect extrapulmonary sites, such as the mediastinum, the retroperitoneum, or the lymph nodes, although these locations are rare. A localized form of LAM can manifest as extrapulmonary lesions; this form is referred to as extrapulmonary lymphangioleiomyoma (E-LAM). Due to the rare occurrence of E-LAM and its variable, atypical location, E-LAM is often difficult to diagnose. Herein, we report the clinicopathological information from four E-LAM cases, and also review previous articles investigating this disease.Methods: Four patients with E-LAM were identified at the Samsung Medical Center (Seoul, Korea) from 1995 to 2012. All E-LAM lesions underwent surgical excision.Results: All patients were females within the age range of 43 to 47 years. Two patients had para-aortic retroperitoneal masses, while the other two patients had pelvic lesions; two out of the four patients also had accompanying pulmonary LAM. In addition, no patient displayed any evidence of tuberous sclerosis. Histologically, two patients exhibited nuclear atypism with cytologic degeneration.Conclusions: E-LAM should be considered in the differential diagnosis of patients presenting with pelvic or para-aortic masses. We also conclude that further clinical and pathological evaluation is needed in patients with E-LAM and nuclear atypism.","PeriodicalId":49936,"journal":{"name":"Korean Journal of Pathology","volume":"48 3","pages":"188-92"},"PeriodicalIF":0.0,"publicationDate":"2014-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4132/KoreanJPathol.2014.48.3.188","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32495281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Current Concepts and Occurrence of Epithelial Odontogenic Tumors: II. Calcifying Epithelial Odontogenic Tumor Versus Ghost Cell Odontogenic Tumors Derived from Calcifying Odontogenic Cyst. 上皮性牙源性肿瘤的概念和发生现状:2。钙化上皮性牙源性肿瘤与源自钙化牙源性囊肿的鬼细胞牙源性肿瘤。

Korean Journal of Pathology Pub Date : 2014-06-01 Epub Date: 2014-06-26 DOI: 10.4132/KoreanJPathol.2014.48.3.175

Suk Keun Lee, Yeon Sook Kim

{"title":"Current Concepts and Occurrence of Epithelial Odontogenic Tumors: II. Calcifying Epithelial Odontogenic Tumor Versus Ghost Cell Odontogenic Tumors Derived from Calcifying Odontogenic Cyst.","authors":"Suk Keun Lee, Yeon Sook Kim","doi":"10.4132/KoreanJPathol.2014.48.3.175","DOIUrl":"https://doi.org/10.4132/KoreanJPathol.2014.48.3.175","url":null,"abstract":"Calcifying epithelial odontogenic tumors (CEOTs) and ghost cell odontogenic tumors (GCOTs) are characteristic odontogenic origin epithelial tumors which produce calcifying materials from transformed epithelial tumor cells. CEOT is a benign odontogenic tumor composed of polygonal epithelial tumor cells that show retrogressive calcific changes, amyloid-like deposition, and clear cytoplasm. Differentially, GCOTs are a group of transient tumors characterized by ghost cell presence, which comprise calcifying cystic odontogenic tumor (CCOT), dentinogenic ghost cell tumor (DGCT), and ghost cell odontogenic carcinoma (GCOC), all derived from calcifying odontogenic cysts (COCs). There is considerable confusion about COCs and GCOTs terminology, but these lesions can be classified as COCs or GCOTs, based on their cystic or tumorous natures, respectively. GCOTs include ameloblastomatous tumors derived from dominant odontogenic cysts classified as CCOTs, ghost cell-rich tumors producing dentinoid materials as DGCTs, and the GCOT malignant counterpart, GCOCs. Many authors have reported CEOTs and GCOTs variably express keratins, β-catenin, BCL-2, BSP, RANKL, OPG, Notch1, Jagged1, TGF-β, SMADs, and other proteins. However, these heterogeneous lesions should be differentially diagnosed to allow for accurate tumor progression and prognosis prediction. ","PeriodicalId":49936,"journal":{"name":"Korean Journal of Pathology","volume":"48 3","pages":"175-87"},"PeriodicalIF":0.0,"publicationDate":"2014-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4132/KoreanJPathol.2014.48.3.175","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32495282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 40

Evaluation of Protein Expression in Housekeeping Genes across Multiple Tissues in Rats. 大鼠多组织中管家基因蛋白表达的评价。

Korean Journal of Pathology Pub Date : 2014-06-01 Epub Date: 2014-06-26 DOI: 10.4132/KoreanJPathol.2014.48.3.193

Hye Jeong Kim, Jong In Na, Byung Woo Min, Joo Young Na, Kyung Hwa Lee, Jae Hyuk Lee, Young Jik Lee, Hyung Seok Kim, Jong Tae Park

{"title":"Evaluation of Protein Expression in Housekeeping Genes across Multiple Tissues in Rats.","authors":"Hye Jeong Kim, Jong In Na, Byung Woo Min, Joo Young Na, Kyung Hwa Lee, Jae Hyuk Lee, Young Jik Lee, Hyung Seok Kim, Jong Tae Park","doi":"10.4132/KoreanJPathol.2014.48.3.193","DOIUrl":"https://doi.org/10.4132/KoreanJPathol.2014.48.3.193","url":null,"abstract":"Background: Housekeeping genes, which show constant protein expression patterns between different tissue types, are very important in molecular biological studies as an internal control for protein research.Methods: The protein expression profiles of seven housekeeping genes (HPRT1, PPIA, GYS1, TBP, YWHAZ, GAPDH and ACTB) in various rat tissues (cerebrum, cerebellum, cardiac ventricle and atrium, psoas muscle, femoral muscle, liver, spleen, kidney, and aorta) were analyzed by Western blot and compared by coefficient of variation (CV).Results: HPRT1 was stably expressed (CV≤10%) in six tissues (cerebrum, cerebellum, ventricle, femoral muscle, spleen, and kidney), PPIA was stably expressed in five tissues (cerebrum, cerebellum, ventricle, spleen and kidney), YWHAZ was stably expressed in three tissues (cerebrum, cerebellum, and kidney), and GAPDH was stably expressed in four tissues (cerebrum, ventricle, psoas muscle, and kidney). In comparison, GYS1, TBP, and ACTB were found to have CV values over 10% in all tissues. Of the seven genes examined, four (HPRT1, PPIA, YWHAZ, and GAPDH) were found to be stably expressed across multiple organs, with low CV values (≤10%).Conclusions: These results will provide fundamental information regarding internal controls for protein expression studies and can be used for analysis of postmortem protein degradation patterns in forensic medicine.","PeriodicalId":49936,"journal":{"name":"Korean Journal of Pathology","volume":"48 3","pages":"193-200"},"PeriodicalIF":0.0,"publicationDate":"2014-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4132/KoreanJPathol.2014.48.3.193","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32494200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 19

Expression of CD99 in Multiple Myeloma: A Clinicopathologic and Immunohistochemical Study of 170 Cases. CD99在多发性骨髓瘤中的表达:170例临床病理和免疫组织化学研究

Korean Journal of Pathology Pub Date : 2014-06-01 Epub Date: 2014-06-26 DOI: 10.4132/KoreanJPathol.2014.48.3.209

Su-Jin Shin, Hyangsin Lee, Geunyoung Jung, Minchan Gil, Hosub Park, Young Soo Park, Dok Hyun Yoon, Cheolwon Suh, Chan-Jeoung Park, Jooryung Huh, Chan-Sik Park

{"title":"Expression of CD99 in Multiple Myeloma: A Clinicopathologic and Immunohistochemical Study of 170 Cases.","authors":"Su-Jin Shin, Hyangsin Lee, Geunyoung Jung, Minchan Gil, Hosub Park, Young Soo Park, Dok Hyun Yoon, Cheolwon Suh, Chan-Jeoung Park, Jooryung Huh, Chan-Sik Park","doi":"10.4132/KoreanJPathol.2014.48.3.209","DOIUrl":"https://doi.org/10.4132/KoreanJPathol.2014.48.3.209","url":null,"abstract":"Background: Multiple myeloma (MM) is a heterogeneous and ultimately fatal disease. Risk stratification using prognostic biomarkers is crucial to individualize treatments. We sought to investigate the role of CD99, a transmembrane protein highly expressed in many hematopoietic cells including subpopulations of normal and neoplastic plasma cells, for MM risk stratification.Methods: CD99 expression was measured in paraffin samples of bone marrow and extramedullary biopsies of 170 patients with MM. Patients were divided into those with high score (moderately and strongly positive) and low score (negative and weakly positive), with all staining being cytoplasmic and/or membranous.Results: High anti-CD99 immunostaining was observed in 72 of 136 (52.9%) bone marrow biopsies and 24 of 87 (27.6%) extramedullary biopsies in MM. High CD99 expression of extramedullary specimens was associated with significantly longer overall survival (OS; p=.016). High CD99 expression of extramedullary specimens was also associated with better prognosis in the nonautologous stem cell transplantation group of MM patients (p=.044). In multivariate analysis, International Staging System stage was an independent prognostic factor, whereas CD99 expression was no longer statistically significant.Conclusions: Expression of CD99 in extramedullary specimens was correlated with longer OS, suggesting that CD99 may be a helpful immunohistochemical marker for risk stratification.","PeriodicalId":49936,"journal":{"name":"Korean Journal of Pathology","volume":"48 3","pages":"209-16"},"PeriodicalIF":0.0,"publicationDate":"2014-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4132/KoreanJPathol.2014.48.3.209","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32494202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Dedifferentiated solitary fibrous tumor of thoracic cavity. 胸腔去分化孤立性纤维性肿瘤。

Korean Journal of Pathology Pub Date : 2014-06-01 Epub Date: 2014-06-26 DOI: 10.4132/KoreanJPathol.2014.48.3.250

Jung Wook Yang, Dae Hyun Song, In Seok Jang, Gyung Hyuck Ko

引用次数: 4

Intracranial extracerebral glioneuronal heterotopia with adipose tissue and a glioependymal cyst: a case report and review of the literature. 颅内脑外胶质神经元异位伴脂肪组织及胶质室管膜囊肿:1例报告及文献复习。

Korean Journal of Pathology Pub Date : 2014-06-01 Epub Date: 2014-06-26 DOI: 10.4132/KoreanJPathol.2014.48.3.254

Hwa Jin Cho, Han Na Kim, Kyung Ju Kim, Kyu Sang Lee, Jae Kyung Myung, Seung-Ki Kim, Sung-Hye Park

{"title":"Intracranial extracerebral glioneuronal heterotopia with adipose tissue and a glioependymal cyst: a case report and review of the literature.","authors":"Hwa Jin Cho, Han Na Kim, Kyung Ju Kim, Kyu Sang Lee, Jae Kyung Myung, Seung-Ki Kim, Sung-Hye Park","doi":"10.4132/KoreanJPathol.2014.48.3.254","DOIUrl":"https://doi.org/10.4132/KoreanJPathol.2014.48.3.254","url":null,"abstract":"The presence of central nervous system (CNS) tissue outside the cranium is often referred to as \"heterotopia,\" although technically this should be termed \"ectopia,\" according to the dictionary definition. Glioneuronal heterotopia (GH) is a rare, mass-forming, malformative lesion. Ectopic glioneuronal tissue of the head and neck has been detected in the nasopharynx, oropharynx, tongue, palate, tonsils, soft tissue, eye, and orbit, and intracranial extracerebral glioneuronal heterotopia (IEGH) has also been reported, although less frequently.1,2 Since the first description of neuroglial heterotopia in the dorsal meninges of the cervical spinal cord by Wolbach in 1907,3 fewer than 20 cases of IEGH have been reported. Glioependymal cysts are rare, ependyma-lined, cystic lesions of the subarachnoid space, which have been referred to as epithelial or ependymal cysts. Histopathologically, they are lined with ependymal cells abutted on the glial layer and are commonly detected in the posterior fossa. The origin of glioependymal cysts of the posterior fossa is not clear, but these cysts may represent neuroglial heterotopia, persistent Blake's pouch (diverticulum of the roof of the fourth ventricle), or remnants of a tela chorioidea. We report here a case of IEGH that was predominantly composed of cerebellar tissue with some fat tissue and a large glioependymal cyst, and was initially misdiagnosed as a teratoma with a glioependymal cyst.","PeriodicalId":49936,"journal":{"name":"Korean Journal of Pathology","volume":"48 3","pages":"254-7"},"PeriodicalIF":0.0,"publicationDate":"2014-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4132/KoreanJPathol.2014.48.3.254","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32495696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Classic papillary thyroid carcinoma with tall cell features and tall cell variant have similar clinicopathologic features. 典型甲状腺乳头状癌具有高细胞特征和高细胞变异具有相似的临床病理特征。

Korean Journal of Pathology Pub Date : 2014-06-01 Epub Date: 2014-06-26 DOI: 10.4132/KoreanJPathol.2014.48.3.201

Woo Jin Oh, Young Sub Lee, Uiju Cho, Ja Seong Bae, Sohee Lee, Min Hee Kim, Dong Jun Lim, Gyeong Sin Park, Youn Soo Lee, Chan Kwon Jung

{"title":"Classic papillary thyroid carcinoma with tall cell features and tall cell variant have similar clinicopathologic features.","authors":"Woo Jin Oh, Young Sub Lee, Uiju Cho, Ja Seong Bae, Sohee Lee, Min Hee Kim, Dong Jun Lim, Gyeong Sin Park, Youn Soo Lee, Chan Kwon Jung","doi":"10.4132/KoreanJPathol.2014.48.3.201","DOIUrl":"https://doi.org/10.4132/KoreanJPathol.2014.48.3.201","url":null,"abstract":"Background: The tall cell variant of papillary thyroid carcinoma (TCVPTC) is more aggressive than classic papillary thyroid carcinoma (PTC), but the percentage of tall cells needed to diagnose TCVPTC remains controversial. In addition, little is known about the clinicopathologic features of classic PTC with tall cell features (TCF).Methods: We retrospectively selected and reviewed the clinicopathologic features and presence of the BRAF mutation in 203 cases of classic PTC, 149 cases of classic PTC with TCF, and 95 cases of TCVPTCs, which were defined as PTCs having <10%, 10-50%, and ≥50% tall cells, respectively.Results: TCVPTCs and classic PTCs with TCF did not vary significantly in clinicopathologic characteristics such as pathologic (p) T stage, extrathyroidal extension, pN stage, lateral lymph node metastasis, or BRAF mutations; however, these features differed significantly in TCVPTCs and classic PTCs with TCF in comparison to classic PTCs. Similar results were obtained in a subanalysis of patients with microcarcinomas (≤1.0 cm in size).Conclusions: Classic PTCs with TCF showed a similar BRAF mutation rate and clinicopathologic features to TCVPTCs, but more aggressive characteristics than classic PTCs.","PeriodicalId":49936,"journal":{"name":"Korean Journal of Pathology","volume":"48 3","pages":"201-8"},"PeriodicalIF":0.0,"publicationDate":"2014-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4132/KoreanJPathol.2014.48.3.201","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32494201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 34

A case of metastatic angiosarcoma diagnosed by liquid-based preparation: peculiar cytoplasmic changes. 液基制备诊断转移性血管肉瘤1例:特殊的细胞质改变。

Korean Journal of Pathology Pub Date : 2014-06-01 Epub Date: 2014-06-26 DOI: 10.4132/KoreanJPathol.2014.48.3.241

Min Jung Jung, Young Ok Kim

引用次数: 5

Current concepts in primary effusion lymphoma and other effusion-based lymphomas. 原发性积液性淋巴瘤和其他积液性淋巴瘤的最新概念。

Korean Journal of Pathology Pub Date : 2014-04-01 Epub Date: 2014-04-28 DOI: 10.4132/KoreanJPathol.2014.48.2.81

Yoonjung Kim, Chan Jeong Park, Jin Roh, Jooryung Huh

{"title":"Current concepts in primary effusion lymphoma and other effusion-based lymphomas.","authors":"Yoonjung Kim, Chan Jeong Park, Jin Roh, Jooryung Huh","doi":"10.4132/KoreanJPathol.2014.48.2.81","DOIUrl":"https://doi.org/10.4132/KoreanJPathol.2014.48.2.81","url":null,"abstract":"Primary effusion lymphoma (PEL) is a human herpes virus 8 (HHV8)-positive large B-cell neoplasm that presents as an effusion with no detectable tumor in individuals with human immunodeficiency virus infection or other immune deficiencies. PEL is an aggressive neoplasm with a poor prognosis. PEL cells show diverse morphologies, ranging from immunoblastic or plasmablastic to anaplastic. The immunophenotype of PEL is distinct, but its lineage can be misdiagnosed if not assessed thoroughly. PEL cells usually express CD45, lack B- and T-cell-associated antigens, and characteristically express lymphocyte activation antigens and plasma cell-associated antigens. Diagnosis of PEL often requires the demonstration of a B-cell genotype. HHV8 must be detected in cells to diagnose PEL. In most cases, PEL cells also harbor the Epstein-Barr virus (EBV) genome. Similar conditions associated with HHV8 but not effusion-based are called \"extracavitary PELs.\" PELs should be differentiated from HHV8-negative, EBV-positive, body cavity-based lymphomas in patients with long-standing chronic inflammation; the latter can occur in tuberculous pleuritis, artificial pneumothorax, chronic liver disease and various other conditions. Despite their morphological similarity, these various lymphomas require different therapeutic strategies and have different prognostic implications. Correct diagnosis is essential to manage and predict the outcome of patients with PEL and related disorders. ","PeriodicalId":49936,"journal":{"name":"Korean Journal of Pathology","volume":"48 2","pages":"81-90"},"PeriodicalIF":0.0,"publicationDate":"2014-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4132/KoreanJPathol.2014.48.2.81","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32372469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 35