Laryngoscope最新文献

{"title":"Effects of Elexacaftor/Tezacaftor/Ivacaftor on the Sinonasal Airspace in Cystic Fibrosis.","authors":"Michelle H Kim, Nathan A Luzum, Adam J Kimple, Anna C Zemke, Dennis Frank-Ito","doi":"10.1002/lary.70156","DOIUrl":"https://doi.org/10.1002/lary.70156","url":null,"abstract":"<p><strong>Objectives: </strong>People with Cystic Fibrosis (CF) experience significant sinonasal airway opacification, leading to chronic airway-related conditions. The triple combination therapy Elexacaftor/Tezacaftor/Ivacaftor (ETI) has emerged as a therapeutic option for CF. This study uses volumetric quantification technique to evaluate changes in CF sinonasal airway patency pre-ETI and post-ETI.</p><p><strong>Methods: </strong>Anatomically accurate person-specific three-dimensional sinonasal airspaces were reconstructed from radiographical images of 19 people (12 male, 7 female) with CF, pre-ETI and post-ETI. Sinonasal airspace surface area, volume, and surface-area-to-volume ratio were calculated pre-ETI and post-ETI. Pre-ETI and post-ETI sinonasal airspace changes in these computed parameters were corrected with changes in both Lund-Mackay and SNOT-22 scores.</p><p><strong>Results: </strong>Median (IQR) surface area and volume increased significantly from pre-ETI (Surface Area: 251.97 cm² (43.71); Volume: 44.86 cm³ (20.72)) to post-ETI (Surface Area: 295.77 cm² (31.34); Volume: 61.03 cm³ (14.21)), with respective p < 0.01 per computed parameter. Furthermore, median surface-area-to-volume ratio (IQR) was significantly different; pre-ETI: 0.053 cm^-1 (0.007); post-ETI: 0.052 cm^-1 (0.013); p = 0.04. Pre-ETI to post-ETI improvement changes in surface area and volume significantly correlated with corresponding changes in Lund-Mackay scores (Surface Area: R = -0.78, p < 0.01; Volume: R = -0.68, p < 0.01), but correlated weakly with corresponding changes in patient-reported SNOT-22 scores (Surface Area: R = -0.13, p = 0.62; Volume: R = -0.06, p = 0.82).</p><p><strong>Conclusion: </strong>People with CF treated with ETI exhibited a significant increase in sinonasal airway patency, as evidenced by volumetric quantification analysis of surface area and volume differences. These increases in both parameters showed strong significant correlations with Lund-Mackay scores; however, no such correlations were observed with SNOT-22 scores.</p><p><strong>Level of evidence: 4: </strong></p>","PeriodicalId":49921,"journal":{"name":"Laryngoscope","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145139140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"BMI, Sex as Predictors of Anterolateral Thigh Free Flap Thickness for Oropharyngeal Reconstructions.","authors":"Ibrahim M Ibrahim, Emily Clementi, Paul F Chisolm, Sagar Vasandani, Jonathan P Giurintano","doi":"10.1002/lary.70166","DOIUrl":"https://doi.org/10.1002/lary.70166","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the relationship between body mass index (BMI), sex, and anterolateral thigh free flap (ALTFF) thickness, and to determine their impact on the use of ALT and super-thin ALT (STALFF) flaps for oral and oropharyngeal reconstruction.</p><p><strong>Methods: </strong>Ninety-four patients who underwent ALTFF, super thin-ALTFF (ST-ALTFF), or radial forearm free flap (RFFF) reconstruction following resection of oral cavity and oropharyngeal squamous cell carcinoma were included. Preoperative PET/CT scans were analyzed to measure ALTFF thickness at three points along the thigh: the proximal fourth (Point A), midpoint (Point B), and distal fourth (Point C) of the line extending from the anterior superior iliac spine to the superior lateral surface of the patella. Statistical analyses included chi-squared, t-tests, ANOVA, and Pearson's correlation to assess associations between BMI, sex, and flap thickness.</p><p><strong>Results: </strong>Forty patients (42.5%) underwent ALTFF reconstruction, 18 had ST-ALTFF (19.1%), and 36 (38.3%) received RFFF. Pearson's correlation confirmed a strong positive relationship between BMI and flap thickness at all points (r > 0.62). Although BMI did not differ significantly between sexes (p = 0.066), females had significantly thicker flaps at all measured points (p < 0.0001).</p><p><strong>Conclusion: </strong>BMI and sex are reliable predictors of ALTFF thickness and influence flap selection. Integrating these factors into preoperative planning optimizes patient selection for free flap type choice, minimizing intraoperative modifications and improving reconstructive outcomes.</p><p><strong>Level of evidence: 4: </strong></p>","PeriodicalId":49921,"journal":{"name":"Laryngoscope","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145132347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"C-Reactive Protein Serum Values in Idiopathic and Autoimmune Subglottic Stenosis.","authors":"Andrew J Neevel, Fatemeh Ramazani, Julia Ford, Ora Gewurz-Singer, Norman D Hogikyan, Robert J Morrison, Robbi A Kupfer","doi":"10.1002/lary.70167","DOIUrl":"https://doi.org/10.1002/lary.70167","url":null,"abstract":"<p><strong>Objective (s): </strong>Idiopathic and granulomatosis with polyangiitis (GPA)-related subglottic stenosis (SGS) are considered distinct immune-mediated inflammatory disorders. Limited data exist on serum inflammatory markers, specifically C-Reactive Protein (CRP), for SGS diagnosis, differentiation, and prognostication. The study objective was the characterization of CRP levels in idiopathic (iSGS) and GPA-SGS to assess CRP's ability to distinguish SGS subtypes and predict SGS progression and recurrence.</p><p><strong>Methods: </strong>Retrospective review of patients with idiopathic or GPA-SGS from 2007 to 2024 at a single institution. Surgery-free interval (SFI) was calculated as the time between surgical interventions. Statistical analysis included independent t-tests, chi-squared, and univariate linear regression.</p><p><strong>Results: </strong>59 iSGS and 47 GPA-SGS patients were included. CRP was elevated in 36% of iSGS and 49% of GPA-SGS patients (0.0.6 mg/dL). Mean maximum CRP was 2.7 mg/dL lower in iSGS compared to anti-neutrophil cytoplasmic antibody (ANCA)-positive GPA-SGS (p = 0.035). The maximum CRP in iSGS was 3.6 mg/dL, while 10 (21%) GPA patients had CRPs greater than 3.6 mg/dL (max = 31 mg/dL). ANCA-negative GPA-SGS mean CRP was not significantly different than iSGS or ANCA-positive GPA-SGS. CRP and SFI did not correlate on univariate linear analysis.</p><p><strong>Conclusion: </strong>Mild elevation of CRP is common in SGS patients. High CRP levels are more frequent in GPA-SGS, potentially aiding clinical differentiation of etiologies. However, CRP at presentation does not appear to correlate with disease recurrence in iSGS or GPA-related SGS, limiting its value as a biomarker and prognostic tool.</p><p><strong>Level of evidence: 3: </strong></p>","PeriodicalId":49921,"journal":{"name":"Laryngoscope","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145132358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Variables Affecting Time to Airway Improvement After Endoscopic Management of Subglottic Stenosis.","authors":"Zane D Kaiser, Yasine Mirmozaffari, Robert A Buckmire, Rupali N Shah","doi":"10.1002/lary.70141","DOIUrl":"https://doi.org/10.1002/lary.70141","url":null,"abstract":"<p><strong>Objectives: </strong>To determine time to maximal airway improvement in subglottic stenosis (SGS) patients after endoscopic surgery, measured by peak flow meter (PFM). Secondarily, to evaluate whether patient demographics, intraoperative treatments, or adjunctive medications influenced time to or change in maximal recovery.</p><p><strong>Methods: </strong>We performed a retrospective and prospective analysis of 42 SGS patients undergoing endoscopic surgery at the UNC Voice Center. PFM measurements were taken once preoperatively and weekly for 6 months postoperatively. Patient demographics, comorbidities, diagnostic etiology, intraoperative treatments (steroid injection, Mitomycin C, none), and postoperative medications (oral steroids, antibiotics, none) were recorded. Primary outcomes included time to maximal postoperative PFM (tmPFM) and percent change in PFM (%∆PFM). Mann-Whitney U, Kruskal-Wallis, and linear regression were used to assess the influence of stratifying factors on outcomes.</p><p><strong>Results: </strong>Average %∆PFM and increase in PFM following surgery were 98% (SD 69) and 164 L/min (SD 67). Mean tmPFM was 32 days (SD 17). Older age significantly impacted %∆PFM (coefficient of 1.713, p = 0.03) but not tmPFM. No statistically significant differences were found for %∆PFM or tmPFM vs. diagnostic etiology, comorbidities, BMI, intraoperative treatment, and postoperative medications, but the analysis was underpowered for subgroup analysis.</p><p><strong>Conclusion: </strong>Time to maximal airway caliber following endoscopic airway surgery is not immediate; most patients reach maximal airflow between 18 and 39 days postoperatively, with an average 98% increase in PFM. Further study is needed to determine the impact of intraoperative medications (steroid injection and mitomycin C) and postoperative medications (steroids or antibiotics) on postoperative healing.</p><p><strong>Level of evidence: 3: </strong></p>","PeriodicalId":49921,"journal":{"name":"Laryngoscope","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145126388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and Toxicity Evaluation of Stem Cell-Based Vocal Fold Implant in Swine.","authors":"Desiree Delavary, Larissa Nicolas, Dipti Sajed, Yazeed Alhiyari, Jennifer Long","doi":"10.1002/lary.70144","DOIUrl":"https://doi.org/10.1002/lary.70144","url":null,"abstract":"<p><strong>Background/introduction: </strong>Prior to introduction in humans, new implant technology must be thoroughly assessed with preclinical animal trials. Cell-based or cell-derived therapies undergo FDA evaluation to be granted Investigational New Drug designation prior to human trials. While data required can vary across applications, standard safety and toxicity measures are valuable. We previously described a stem cell-based vocal fold implant for reconstruction of the vibratory vocal fold. This study describes a proposed set of implant release criteria and safety and toxicity evaluation following this implantation in Yucatan minipigs.</p><p><strong>Methods: </strong>Eight Yucatan minipigs underwent bilateral Cell-based Outer Vocal Fold Replacement (COVR) containing multipotent human adipose stem cells. Perioperative corticosteroids and antibiotics were administered, but no chronic immunosuppressive medications were given. As a control, three additional animals had vocal fold resection without COVR implant and underwent an identical medication regimen. The animals were monitored for 6 months, with interval blood draws to measure basic chemistry, hematologic, and liver function tests. Any adverse events were recorded.</p><p><strong>Results: </strong>Several animals demonstrated minor serologic findings outside of the defined normal range, but none demonstrated severe abnormalities. Adverse events included skin wound dehiscence in two animals and gastrointestinal symptoms accompanied by a temporary behavior change. All adverse events resolved following empiric treatment. Histologic examination demonstrated varying degrees of local immune response.</p><p><strong>Conclusions: </strong>Hematologic and metabolic safety monitoring has thus far demonstrated no serious toxicity after xenograft vocal fold implantation in immunocompetent swine. Adverse events related to surgical complications are reported.</p><p><strong>Level of evidence: </strong>N/A.</p>","PeriodicalId":49921,"journal":{"name":"Laryngoscope","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145126420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of a Molding Device for Congenital Auricular Deformities.","authors":"Xinyu Li, Yiyuan Li, Zhicheng Xu, Qun Zhang, Xia Chen, Ru-Hong Zhang, Feng Xu, Datao Li","doi":"10.1002/lary.70157","DOIUrl":"https://doi.org/10.1002/lary.70157","url":null,"abstract":"<p><strong>Objectives: </strong>The EarWell Infant Ear Molding Device provides non-surgical correction for congenital ear deformities, but parental satisfaction data remain limited. This study evaluates our experience treating 120 infants with the EarWell system and assesses parental satisfaction with outcomes.</p><p><strong>Method: </strong>We conducted a prospective case series of 120 infants treated with the EarWell device between January 2017 and January 2024. We collected demographic and clinical data, documented pre- and post-treatment ear conditions with photographs, and evaluated parental satisfaction via telephone interviews and questionnaires.</p><p><strong>Results: </strong>The study included 120 infants (181 ears) with an overall success rate of 87.3% post-treatment and 81.8% at long-term follow-up. Treatment was most effective when initiated within the first week of life (93.8% success) compared to 8-14 days (90.6%) and 15-28 days (79.7%). Ear deformations achieved higher correction rates (95.2%) than malformations (76.3%). Minor complications occurred in 18.8% of cases, primarily pressure ulcers (14.4%) and dermatitis (4.4%). Parental satisfaction was high, with 78.3% of parents reporting being satisfied or very satisfied with outcomes, correlating with objective clinical results.</p><p><strong>Conclusion: </strong>The EarWell Infant Ear Molding Device is an effective, safe, and parent-approved non-surgical intervention for congenital auricular deformities. Treatment is most successful when initiated within the first week of life and for ear deformations rather than malformations. Early intervention results in better outcomes and fewer complications. High parental satisfaction correlates with objective clinical improvements, supporting ear molding as a first-line treatment for congenital auricular deformities when applied during the optimal window of neonatal cartilage malleability.</p><p><strong>Level of evidence: 4: </strong></p>","PeriodicalId":49921,"journal":{"name":"Laryngoscope","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145126346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Topical Dexamethasone During Stapedotomy in Patients With Otosclerosis: A Randomized Clinical Trial.","authors":"Behrooz Amirzargar, Sepideh Zoafa, Melika Karimi, Saeed Mohammadi, Hamed Emami, Ali Kouhi, Saeed Golparvaran","doi":"10.1002/lary.70076","DOIUrl":"https://doi.org/10.1002/lary.70076","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the effect of topical dexamethasone on improving hearing outcomes and alleviating postoperative symptoms in patients diagnosed with otosclerosis who have undergone stapedotomy.</p><p><strong>Study design: </strong>Randomized, single-blinded clinical trial METHODS: Seventy patients diagnosed with otosclerosis were randomly divided into intervention and control groups and underwent stapedotomy with or without topical dexamethasone, respectively. Hearing outcomes and postoperative pain, vertigo, and tinnitus were compared.</p><p><strong>Results: </strong>The mean improvement in the air-bone gap (ABG) was 23.53 ± 8.70 dB in the intervention group and 18.95 ± 11.66 dB in the control group, with no statistically significant difference between the two groups (0.087). Speech Reception Threshold (SRT) and Word Recognition Score (WRS) improved more significantly in the dexamethasone group (p < 0.001 and p = 0.004, respectively). Postoperative tinnitus and vertigo were significantly lower in the dexamethasone group (p = 0.032 and p < 0.001, respectively).</p><p><strong>Conclusion: </strong>Applying dexamethasone during stapedotomy can reduce post-operative vertigo and tinnitus. Although hearing outcomes were better in the intervention group, there was no statistically significant difference in ABG improvement between the two groups.</p><p><strong>Level of evidence: 2: </strong></p>","PeriodicalId":49921,"journal":{"name":"Laryngoscope","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145126438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pediatric Tracheostomy Decannulation: Should the Use of Polysomnography Be Mandatory?","authors":"Ross O'Shea, Sukgi Choi","doi":"10.1002/lary.70152","DOIUrl":"https://doi.org/10.1002/lary.70152","url":null,"abstract":"","PeriodicalId":49921,"journal":{"name":"Laryngoscope","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145114942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Symptom Characteristics of Benign Vocal Fold Lesions May Reflect Different Mechanisms of Injury.","authors":"Mark Lee, Lucian Sulica","doi":"10.1002/lary.70146","DOIUrl":"https://doi.org/10.1002/lary.70146","url":null,"abstract":"<p><strong>Objectives/hypotheses: </strong>To compare symptom characteristics between benign vocal fold lesions for insight into pathophysiology.</p><p><strong>Study design: </strong>Cross-sectional study.</p><p><strong>Methods: </strong>Adults who were diagnosed with a benign vocal fold lesion between June 2023 and June 2024 were included. Symptom features including acuity, duration, and inciting event were noted, along with prior history of voice problems, gender, and occupational voice load. Patients with cysts, polyps, and midfold lesions (fibrous mass, pseudocyst, non-specific midfold mass) were compared to those with lesions known to be acute (edema, hemorrhage) and lesions known to be chronic (sulcus vergeture, sulcus vocalis, scar, Reinke's edema).</p><p><strong>Results: </strong>One hundred and fifty-one adults (44M:106F:1Other; mean age 39.1 ± 15.8 years) were included. Midfold lesions (49.3%) and cysts (53.3%) had similar rates of gradual onset to known chronic lesions (50.0%), whereas polyps (30.4%) and known acute lesions had lower rates (8.3%, Exact Test = 16.6, p = 0.002). Similarly, midfold masses (37.3%), cysts (13.3%), and known chronic lesions (42.9%) had lower associations with an inciting event compared to polyps (52.2%) and known acute lesions (87.5%, Exact Test = 26.8, p < 0.001). While not statistically significant (p = 0.054), cysts (46.7%), midfold lesions (57.3%), and known chronic lesions (78.6%) had a trend for more prior voice problems compared to polyps (30.4%) and known acute lesions (50.0%).</p><p><strong>Conclusions: </strong>These findings are consistent with models of phonotraumatic lesion development that suggest midfold lesions develop as a result of chronic cumulative damage, whereas polyps are more likely to develop acutely. Cysts may be structural lesions, as demonstrated by their lack of association with occupational voice use and chronic nature.</p><p><strong>Level of evidence: 4: </strong></p>","PeriodicalId":49921,"journal":{"name":"Laryngoscope","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145092992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stellate Ganglion Blockade for Acute Pain Management After Transoral Robotic Surgery.","authors":"Emily C Wong, Carlos X Castellanos, Tristan Grogan, Tsione Holly, John Patton, Benjamin Chu, Valeria Cárcamo-Cavazos, Andrea Poon, Parisa Partownavid, Siamak Rahman, Abie Mendelsohn","doi":"10.1002/lary.70151","DOIUrl":"https://doi.org/10.1002/lary.70151","url":null,"abstract":"<p><strong>Objectives: </strong>Pharyngeal surgical site pain is a significant concern following transoral robotic surgery (TORS). The use of stellate ganglion blockade (SGB) has been reported as a treatment adjunct for postoperative pain.</p><p><strong>Methods: </strong>Patients who underwent TORS and neck dissection for oropharyngeal carcinoma between November 2019 and May 2021 by a single surgeon (AHM) were included. Patients underwent either SGB via injection of bupivacaine or no SGB. Inpatient pain and total daily morphine milligram equivalent (MME) usage were calculated. A retrospective chart review was performed to identify time in the OR spent placing the SGB, length of hospitalization, and postoperative complications.</p><p><strong>Results: </strong>Seventy-three patients were included. Of these, 43 (58.9%) underwent SGB. On average, SGB placement of any kind added 13 min to OR time prior to surgical start time. Patients who underwent SGB had significantly lower average pain scores over the postoperative time course (mean difference 0.75, 95% CI: 0.09-1.41, p = 0.027) and lower opioid consumption over time (mean difference 16.37 MME, 95% CI: 6.98-25.77, p < 0.001) compared with those who did not undergo SGB.</p><p><strong>Conclusion: </strong>SGB resulted in less narcotic pain medication use in the immediate postoperative period, without affecting length of hospitalization or rate of adverse events. SGB is a safe and effective adjunct to multimodal therapy for pain control in the postoperative period following TORS for laryngopharyngeal head and neck cancer.</p><p><strong>Level of evidence: 3: </strong></p>","PeriodicalId":49921,"journal":{"name":"Laryngoscope","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145092990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}