Laryngoscope最新文献_第7页

Vocal Fold Scar Treatment via Controlled Dexamethasone Delivery With a Light-Activatable Implant. 用可光激活植入物控制地塞米松给药治疗声带瘢痕。

IF 2 3区医学

Laryngoscope Pub Date : 2025-09-18 DOI: 10.1002/lary.70149

Denzel Ryan D Cruz, Nour Awad, Avery Zheng, Alexander Karabachev, Charles Farbos de Luzan, Yoonjee C Park, Gregory R Dion

{"title":"Vocal Fold Scar Treatment via Controlled Dexamethasone Delivery With a Light-Activatable Implant.","authors":"Denzel Ryan D Cruz, Nour Awad, Avery Zheng, Alexander Karabachev, Charles Farbos de Luzan, Yoonjee C Park, Gregory R Dion","doi":"10.1002/lary.70149","DOIUrl":"10.1002/lary.70149","url":null,"abstract":"Objective: Intralesional steroid injections for vocal fold (VF) scarring are rapidly cleared, limiting their effectiveness. This study evaluates the efficacy of a light-activatable dexamethasone implant compared to a single steroid injection for VF scar healing.Methods: Ten rabbits underwent endoscopic VF injury and were treated with either a dexamethasone injection or a light-activatable implant; injured-only and no-injury VFs served as controls. On days 0 and 21, VF implants were irradiated with a near-infrared pulsed laser for 1 min. Larynges were harvested after 42 days. High-speed video (> 10 kHz) of excised larynges captured VF vibrations for kymographic analysis. Normal force, structural stiffness, and displacement were measured. Data were analyzed with appropriate statistical tests.Results: Compared to injury-only VFs, implant-treated VFs demonstrated significantly reduced normal force and stiffness (5.28 ± 0.77 mN vs. 2.34 ± 0.66 mN, p < 0.0001; 17.74 ± 2.45 mN/mm vs. 6.80 ± 1.32 mN/mm, p < 0.0001), and increased displacement at 1.96 mN (0.14 ± 0.02 mm vs. 0.29 ± 0.05 mm, p < 0.0001) along the injury zone. Implant-treated VFs exhibited larger amplitude ratios and improved tissue architecture than untreated scars. No differences in quantitative measures were observed between implant-treated and injection-treated groups.Conclusion: A light-activatable dexamethasone implant improved VF biomechanics, vibratory behavior, and histological outcomes in a rabbit injury model comparable to a single steroid injection. This novel approach shows promise for delivering controlled, repeatable therapy to VF scars.","PeriodicalId":49921,"journal":{"name":"Laryngoscope","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145082072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Functionality of Pituitary Tumors Impacts Sinonasal Quality of Life Before and After Endoscopic Surgery. 垂体肿瘤功能对鼻内镜手术前后鼻窦生活质量的影响。

IF 2 3区医学

Laryngoscope Pub Date : 2025-09-17 DOI: 10.1002/lary.70116

Yossawee Wongworawut, Peter H Hwang, Jayakar V Nayak, Robert Dodd, Juan C Fernandez-Miranda, Zara M Patel

{"title":"Functionality of Pituitary Tumors Impacts Sinonasal Quality of Life Before and After Endoscopic Surgery.","authors":"Yossawee Wongworawut, Peter H Hwang, Jayakar V Nayak, Robert Dodd, Juan C Fernandez-Miranda, Zara M Patel","doi":"10.1002/lary.70116","DOIUrl":"https://doi.org/10.1002/lary.70116","url":null,"abstract":"Objectives: Local effects of pituitary hormones in the sinonasal region are not well characterized. We sought to examine sinonasal quality of life outcomes in functional and non-functional pituitary tumors after endoscopic skull base surgery.Study design: Retrospective Medical Record Review.Methods: Three hundred four patients who received endoscopic resection of a pituitary tumor at a tertiary skull base center reviewed. This population was divided into non-functional and functional groups. Surgical outcomes and pre and postoperative quality of life scores were examined.Results: Preoperative total SNOT 22 scores were not different overall between the two groups, but the rhinologic and extra-nasal rhinologic subdomain scores in the functional group were higher than in the non-functional group (3.57 ± 3.95 vs. 2.58 ± 3.64, and 1.48 ± 2.2 vs. 0.92 ± 1.75 respectively) (p = 0.04 and 0.02). Change from baseline in overall postoperative SNOT 22 score was significantly greater in the functional group at 6 weeks post-operation (6.75 ± 17.51 vs. 1.4 ± 16.83 respectively) (p = 0.03). Time to normalization on nasal endoscopy was longer in the functional group compared to the non-functional group (p = 0.02).Conclusion: Corticotrophic and somatotrophic tumors affect quality of life both pre- and post-operation. Patients with functional tumors took longer to reach full healing and normalization of the sinus cavity. These findings can be used to counsel patients about different expectations during the immediate postoperative healing period, but also to reassure them that regardless of tumor functionality, they will be able to reach a good quality of life after endoscopic skull base surgery.Level of evidence: 3: ","PeriodicalId":49921,"journal":{"name":"Laryngoscope","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145076139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Is Ankyloglossia Correlated With Pediatric Sleep Disordered Breathing? A Systematic Review. 小儿睡眠呼吸障碍与强直性咬合症有关吗？系统评价。

IF 2 3区医学

Laryngoscope Pub Date : 2025-09-17 DOI: 10.1002/lary.70134

Nainika Venugopal, Josh Neposlan, Andrew Bysice, Sami Khoury, Edward Madou, Raymond Lee, Julie E Strychowsky, Aaron St-Laurent, Claire M Lawlor, M Elise Graham

{"title":"Is Ankyloglossia Correlated With Pediatric Sleep Disordered Breathing? A Systematic Review.","authors":"Nainika Venugopal, Josh Neposlan, Andrew Bysice, Sami Khoury, Edward Madou, Raymond Lee, Julie E Strychowsky, Aaron St-Laurent, Claire M Lawlor, M Elise Graham","doi":"10.1002/lary.70134","DOIUrl":"https://doi.org/10.1002/lary.70134","url":null,"abstract":"Objectives: Sleep disordered breathing (SDB) affects 2%-11% of children, predisposing them to neurobehavioral and developmental consequences. Ankyloglossia has been proposed as a risk factor for SDB, and frenotomy as a treatment for SDB in children with ankyloglossia. With increasing ankyloglossia diagnoses, it is critical to evaluate the evidence for a linkage between SDB and ankyloglossia.Data sources: EMBASE, Web of Science, Medline, CINAHL, CCRCT, and SCOPUS were searched from inception to February 13, 2025. Publications assessing the relationship between ankyloglossia and SDB in non-syndromic children ages 0 to 18 years were included. Eight studies involving 1171 patients met inclusion criteria.Review methods: Two reviewers independently screened abstracts and full texts for inclusion. Strength of clinical data was graded according to the Cochrane Risk of Bias Assessment and modified Newcastle-Ottawa Scale.Results: There is mixed evidence of a relationship between ankyloglossia and pediatric SDB. The lack of standardized diagnostic criteria for ankyloglossia and the use of surveys instead of validated clinical assessment tools to assess SDB limit the generalizability of findings. There is also insufficient data to conclude that frenotomy is indicated in managing SDB in children with ankyloglossia. While two interventional studies report a positive association, their results have limited validity and generalizability.Conclusion: There is an unclear relationship between ankyloglossia and pediatric SDB and insufficient evidence to determine if frenotomy is indicated as a treatment for SDB in children with ankyloglossia. Higher quality studies with standardized functional measures of ankyloglossia and validated assessment of SDB are needed.Level of evidence: N/A.","PeriodicalId":49921,"journal":{"name":"Laryngoscope","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145076144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unveiling Immune Responses in the Trachea Following Scaffold Implantation in a Mouse Model. 揭示小鼠气管支架植入后的免疫反应。

IF 2 3区医学

Laryngoscope Pub Date : 2025-09-17 DOI: 10.1002/lary.70139

Jeon Seong, Hye Jeong Lee, Haeyoon Chung, Ji Suk Choi, Joo-Young Park, Seong Keun Kwon

{"title":"Unveiling Immune Responses in the Trachea Following Scaffold Implantation in a Mouse Model.","authors":"Jeon Seong, Hye Jeong Lee, Haeyoon Chung, Ji Suk Choi, Joo-Young Park, Seong Keun Kwon","doi":"10.1002/lary.70139","DOIUrl":"https://doi.org/10.1002/lary.70139","url":null,"abstract":"Objectives: Tracheal stenosis with long lesions poses a challenge for surgical treatment, requiring a bioengineering approach. However, synthetic tracheal scaffolds often fail due to the host immune response against the implant. Nonetheless, the key immune cells in the tracheal environment and their interactions against scaffolds remain poorly understood. In this study, we examined the tracheal immune cell compositions and their dynamics in response to the scaffold implantation.Methods: We used C57BL/6 mice to develop a model for identifying immune cells. For the scaffold implantation, a circumferential tracheal defect was made, and a poly(ε-caprolactone) (PCL) scaffold was orthotopically implanted. Tracheal cells were isolated using an enzyme digestion protocol, and immune cells and their subsets were identified by flow cytometry on days 1 and 7 post-implantation.Results: A circumferential tracheal defect was successfully created in mice, followed by the implantation of a PCL scaffold. Viable immune cells were consistently isolated from the trachea. Diverse populations of innate and adaptive immune cells were recovered, with CD3-B220-myeloid cells constituting the predominant population in normal mouse trachea. Importantly, implantation of the PCL scaffold severely disrupted local immune homeostasis, inducing a strong CD8α- T cell response, reaching approximately 65% of total immune cells on postoperative day 1.Conclusion: We present findings on immune responses in the trachea, highlighting the immune cells involved in maintaining homeostasis and their disruption following scaffold implantation. These insights could support the development of targeted immunomodulation strategies, thereby improving the integration and clinical application of biomaterials in tracheal reconstruction.Level of evidence: NA.","PeriodicalId":49921,"journal":{"name":"Laryngoscope","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145076408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cochlear Implantation and Facial Nerve Stimulation: Clinical and Anatomic Correlations. 人工耳蜗植入与面神经刺激：临床与解剖的相关性。

IF 2 3区医学

Laryngoscope Pub Date : 2025-09-17 DOI: 10.1002/lary.70143

Karin Hallin, Sumit Agrawal, Hanif M Ladak, Helge Rask-Andersen, Hao Li

{"title":"Cochlear Implantation and Facial Nerve Stimulation: Clinical and Anatomic Correlations.","authors":"Karin Hallin, Sumit Agrawal, Hanif M Ladak, Helge Rask-Andersen, Hao Li","doi":"10.1002/lary.70143","DOIUrl":"https://doi.org/10.1002/lary.70143","url":null,"abstract":"Objectives: One rare complication of cochlear implantation (CI) is facial nerve stimulation (FNS). The aim of the study was to analyze the location and insertion depths for electrode contacts causing FNS. The anatomical variance of the human facial nerve canal (FNC) was explored to elucidate the mechanisms underlying FNS.Methods: Data were collected from adults that had received a CI from a single tertiary care center. Medical records from 307 patients were retrospectively reviewed. The Uppsala human temporal bone library was leveraged to analyze anatomical structures relevant to FNS. Micro-computed tomography (CT) images of temporal bones (n = 246) were used for three-dimensional (3D) analyses after rendering. Data from synchrotron radiation phase-contrast imaging (SR-PCI) of 83 human temporal bones were analyzed.Results: Nineteen (5.8%) patients experienced FNS. No statistical difference in FNS rates between lateral wall (LW) and peri modiolar (PM) electrodes was found (p > 0.05). Electrode contacts with an angular insertion depth from 250° to 340° were associated with FNS. Analyses of the macerated temporal bones and corrosion casts showed that the average distance between the cochlea and the FNC was 0.3 mm and the closest position of the FNC varied from 253° to 304°.Conclusion: The labyrinthine segment of the FN is in close proximity to the cochlea and can be affected by dehiscence. Typically, the bony partition between the FNC and the cochlea is thicker than the modiolar wall and provides insulation against electrical stimulation from nearby CI electrodes. FNS may occur from both LW and PM electrodes.Level of evidence: 3: ","PeriodicalId":49921,"journal":{"name":"Laryngoscope","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145076162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictive Efficacy of CAPE-V, pVHI, and CVA in Detecting Vocal Fold Pathology in Children. CAPE-V、pVHI和CVA检测儿童声带病理的预测效果。

IF 2 3区医学

Laryngoscope Pub Date : 2025-09-16 DOI: 10.1002/lary.70132

Nicholas A Rossi, Brenda Shen, Amy S Puckett, Brad W deSilva, Gregory J Wiet

{"title":"Predictive Efficacy of CAPE-V, pVHI, and CVA in Detecting Vocal Fold Pathology in Children.","authors":"Nicholas A Rossi, Brenda Shen, Amy S Puckett, Brad W deSilva, Gregory J Wiet","doi":"10.1002/lary.70132","DOIUrl":"https://doi.org/10.1002/lary.70132","url":null,"abstract":"Objectives: To evaluate the diagnostic accuracy of the Consensus Auditory-Perceptual Evaluation of Voice (CAPE-V), Pediatric Voice Handicap Index (pVHI), and computer-assisted voice analysis (CVA) against flexible fiberoptic laryngoscopy in a pediatric cohort.Methods: A retrospective cohort of 116 children (4-18 years) underwent same-day CAPE-V, pVHI, CVA (Visipitch), and flexible fiberoptic laryngoscopy at a tertiary pediatric voice clinic. Encounters were classified as dysphonia evaluation versus vocal fold surveillance, and age was grouped as preschool (≤ 5 years) versus school-aged (> 5 years). Diagnostic performance was assessed with receiver operating characteristic (ROC) curves, area under the curve (AUC), and optimal cutpoints by the Youden index. Multivariable logistic regression-adjusted for age category and encounter type-modeled odds of abnormal endoscopic findings.Results: CAPE-V demonstrated the highest individual accuracy (AUC 0.827; p = 0.0034). Combined use of CAPE-V, pVHI, and CVA yielded superior discrimination (AUC 0.846; sensitivity 0.886; specificity 0.771; positive predictive value 0.886; negative predictive value 0.771). Dysphonia encounters had lower odds of abnormal findings compared to vocal fold surveillance (OR 0.09; 95% CI 0.02-0.36). School-aged children had lower odds of pathology than preschoolers (OR 0.18; 95% CI 0.03-0.09). Peak sensitivity occurred at Age 7; the probability of abnormal findings declined with increasing age.Conclusion: CAPE-V is a robust single-test predictor of pediatric vocal fold pathology, and integration with pVHI and CVA enhances diagnostic accuracy. A tiered, age-tailored screening algorithm beginning with CAPE-V may optimize referral pathways and improve early detection of vocal fold pathology while preserving laryngoscopy as the diagnostic standard.Level of evidence: Level 3 (retrospective cohort study).","PeriodicalId":49921,"journal":{"name":"Laryngoscope","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145071034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of an Observational Versus Surgical Approach for Pediatric Post-Tonsillectomy Hemorrhage. 观察与手术治疗小儿扁桃体切除术后出血的比较分析。

IF 2 3区医学

Laryngoscope Pub Date : 2025-09-16 DOI: 10.1002/lary.70140

Joshua Verhagen, Elle Nuttall, Samuel Floren, Daniel Traverzo, Tony Kille

{"title":"Analysis of an Observational Versus Surgical Approach for Pediatric Post-Tonsillectomy Hemorrhage.","authors":"Joshua Verhagen, Elle Nuttall, Samuel Floren, Daniel Traverzo, Tony Kille","doi":"10.1002/lary.70140","DOIUrl":"https://doi.org/10.1002/lary.70140","url":null,"abstract":"Objectives: Post-tonsillectomy hemorrhage (PTH) is a common complication in pediatric patients, yet management strategies vary due to limited outcome data. Historically, all patients at our institution with postoperative bleeding or visible clot were taken to the OR. In 2018, a new protocol was introduced in which patients with a visible clot but no active bleeding were managed conservatively. This study evaluates the efficacy and revisit outcomes of this observational approach versus immediate surgical intervention.Methods: A retrospective cohort study was conducted at a tertiary center over two 3-year periods. Pediatric patients (< 18 years) presenting to the ED (emergency department) with PTH were categorized into pre-protocol (n = 86, surgical) and post-protocol (n = 134, observational) cohorts. Outcomes included revisit rates, surgical intervention rates, and hospital length of stay. Statistical analysis was performed using two-sample t tests and Fisher's exact tests.Results: The post-protocol cohort had a higher proportion of patients presenting with PTH (3.86% vs. 5.88%, p = 0.0018), but fewer underwent surgery (54.65% vs. 26.87%, p < 0.0001). No significant differences were found in repeat visits leading to surgery or multiple surgical interventions. More patients with a visible clot avoided surgery post-protocol (3.49% vs. 29.85%, p < 0.0001). However, the average hospital stay was longer (9.25 vs. 13.13 h, p = 0.0774).Conclusion: An observational approach for pediatric PTH patients with clot-only presentation significantly reduced the need for surgical intervention. This strategy may minimize unnecessary procedures and improve care quality.Level of evidence: 3: ","PeriodicalId":49921,"journal":{"name":"Laryngoscope","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145071055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel Biomolecule-Infused Gelatin Injectable for Treatment of Recurrent Laryngeal Nerve Injury. 新型生物分子注入明胶治疗喉返神经损伤。

IF 2 3区医学

Laryngoscope Pub Date : 2025-09-15 DOI: 10.1002/lary.32459

Ananya Tadikonda, Sunjay Anekal, Lena W Chen, Gabriel Sobczak, Troy Wesson, Carmilya Jackson, Marisa A Egan, Julie C Liu, Patrick R Finnegan, Stacey Halum

{"title":"Novel Biomolecule-Infused Gelatin Injectable for Treatment of Recurrent Laryngeal Nerve Injury.","authors":"Ananya Tadikonda, Sunjay Anekal, Lena W Chen, Gabriel Sobczak, Troy Wesson, Carmilya Jackson, Marisa A Egan, Julie C Liu, Patrick R Finnegan, Stacey Halum","doi":"10.1002/lary.32459","DOIUrl":"https://doi.org/10.1002/lary.32459","url":null,"abstract":"Objective: Unilateral vocal fold paralysis (UVFP) due to recurrent laryngeal nerve injury (RLN) is a major cause of voice disorders. We have recently identified three biomolecules (agrin, acetylcholine, and neuregulin) with the potential to promote reinnervation after RLN injury. This study aimed to determine if a gelatin injectable with the reinnervating biomolecules will induce site-specific amplification of neurotrophic factor release and reinnervation after RLN injury in unilateral vocal fold paralysis.Methods: C57BL/6 mice underwent RLN transection with the following treatment allocations: saline control (N = 16), biomolecule cocktail only (N = 16), and biomolecule-infused gelatin (N = 16). All injectables were delivered into the denervated thyroarytenoid muscle. Assessment of glottic function was determined via laryngeal electromyography (L-EMG) and stimulated video laryngoscopy post-RLN transection on days 7 and 28. Histopathology analysis via immunohistochemistry (IHC) and genetic analysis via quantitative polymerase chain reaction (qPCR) were utilized to characterize reinnervation and gene expression changes within the harvested larynges.Results: Both biomolecule treatment groups had enhanced reinnervation of the adductor complex, as indicated by higher stimulated L-EMG area under the curve (p < 0.001), adduction during stimulation (p < 0.002), midline resting position (p < 0.002), and the presence of innervated neuromuscular junctions on IHC. qPCR results suggest both biomolecule treatments resulted in elevated neurotrophic and angiogenic factor expression from the injected muscle.Conclusions: Injectable biomolecule-infused gelatin may serve as a novel long-term therapeutic for glottic functional restoration by redirecting existing mechanisms of synkinesis via site-specific neurotrophic factor release.Level of evidence: N/A.","PeriodicalId":49921,"journal":{"name":"Laryngoscope","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145066278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Distinguishing Audiometric and Radiographic Features of Oval Window Atresia. 鉴别卵圆窗闭锁的听力学和影像学特征。

IF 2 3区医学

Laryngoscope Pub Date : 2025-09-15 DOI: 10.1002/lary.70133

Keelin Fallon, Amanda M Griffin, Caroline D Robson, Aaron K Remenschneider

{"title":"Distinguishing Audiometric and Radiographic Features of Oval Window Atresia.","authors":"Keelin Fallon, Amanda M Griffin, Caroline D Robson, Aaron K Remenschneider","doi":"10.1002/lary.70133","DOIUrl":"https://doi.org/10.1002/lary.70133","url":null,"abstract":"Objectives: Oval window atresia (OWA) is a rare otologic condition often associated with a maximal conductive hearing loss, and variable ossicular and facial nerve canal (FNC) anomalies, which have contributed to suboptimal middle ear surgical outcomes. No grading scheme exists to detail the spectrum of associated temporal bone anomalies in OWA; therefore, our objectives were to complete an audiometric and radiographic review to characterize audiometric patterns of hearing loss, and refine the classification system for OWA to determine suitability for middle ear surgery.Methods: A retrospective audiometric and radiographic review was conducted at a pediatric tertiary care institution. Patients with OWA identified on temporal bone computerized tomography (CT) scans obtained from 01/2010 to 06/2024 were included. Audiological, radiological, and patient factors were analyzed.Results: Thirty-one patients (48 ears) with OWA were identified. Across frequencies, the air-bone gap decreased significantly as frequency increased (ANOVA with pairwise comparisons, p < 0.001) due to a worsening of bone conduction thresholds and improvement in air conduction thresholds. The FNC was abnormal in 43/48 ears and was determined to overlay the oval window in 6 ears. Additional anomalies included inferiorly displaced, dehiscent, and duplicated canals. Ossicular anomalies were reported in 46/48 ears, and stapedial anomalies were most common.Conclusions: Our findings indicate OWA may manifest audiometrically with consistent and specific hearing loss characterized by a 60-80 dB ABG at lower frequencies that decreases above 2 kHz. CT findings of OWA show considerable variability. We propose a new classification system for OWA based on facial nerve position as this directly influences middle ear surgical feasibility.Level of evidence: 4: ","PeriodicalId":49921,"journal":{"name":"Laryngoscope","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145066216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Robotic Resection of Parapharyngeal Follicular Dendritic Cell Sarcoma With Castleman Disease. 机器人切除伴有Castleman病的咽旁滤泡树突状细胞肉瘤。

IF 2 3区医学

Laryngoscope Pub Date : 2025-09-15 DOI: 10.1002/lary.70130

Lily Huang, Aman M Patel, Timothy Chao, Ryan M Carey

引用次数: 0