Laryngoscope最新文献_第7页

Major Human Leukocyte Antigen Expression in Respiratory Papillomatosis Clinical Specimens. 呼吸道乳头状瘤临床标本中主要白细胞抗原的表达。

IF 2.2 3区医学

Laryngoscope Pub Date : 2025-03-13 DOI: 10.1002/lary.32121

Yvette Robbins, Wiem Lassoued, Ke Bai, Angel Huynh, Scott M Norberg, Clint T Allen

{"title":"Major Human Leukocyte Antigen Expression in Respiratory Papillomatosis Clinical Specimens.","authors":"Yvette Robbins, Wiem Lassoued, Ke Bai, Angel Huynh, Scott M Norberg, Clint T Allen","doi":"10.1002/lary.32121","DOIUrl":"https://doi.org/10.1002/lary.32121","url":null,"abstract":"Objectives: Prior studies have reported low or absent major HLA class I expression on respiratory papilloma cells, conflicting with the recent clinical success of immunotherapy designed to activate HPV-specific T cells in patients with recurrent respiratory papillomatosis (RRP). We aimed to determine major human leukocyte antigen (HLA) class I expression on respiratory papilloma cells in untreated RRP clinical specimens using contemporary techniques.Methods: Formalin-fixed, paraffin-embedded RRP sections were subjected to signal-amplified multispectral immunofluorescence using the OPAL system to determine major and minor HLA class I expression, and digitally scanned slides were analyzed using digital pathology software. Positive and negative controls were used to optimize primary antibody conditions.Results: All samples harbored major HLA class I expression on varying proportions of papilloma cells. Considering all samples, major HLA class I expression was observed on the majority (74%) of papilloma cells. Nearly all (98%) papilloma infiltrating immune cells were positive for major HLA class I expression, serving as an internal control for each stained sample. Major HLA class I negative papilloma cells were enriched in the apical, suprabasal layers compared to the basal layers of the papillomatous epithelium, suggesting an association with the epithelial cell differentiation state. Fewer papilloma cells inconsistently expressed the minor HLA class I HLA-E across the basal and suprabasal epithelial layers.Conclusion: Papilloma cells express major HLA class I molecules. Using contemporary immunofluorescent techniques with signal amplification that likely provide improved sensitivity, these results clarify the major HLA class I expression status on papilloma cells in clinical specimens.Level of evidence: N/A.","PeriodicalId":49921,"journal":{"name":"Laryngoscope","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143617665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Is Cognitive Behavioral Therapy Effective for Tinnitus? 认知行为疗法对耳鸣有效吗？

IF 2.2 3区医学

Laryngoscope Pub Date : 2025-03-13 DOI: 10.1002/lary.32105

Elizabeth Bader, Elizabeth Dinces, Howard S Moskowitz, Joshua J Sturm

引用次数: 0

What Is the Current Management of Osteoradionecrosis of the Temporal Bone Following Head and Neck Cancer Radiotherapy? 目前头颈部肿瘤放疗后颞骨放射性坏死的处理方法是什么？

IF 2.2 3区医学

Laryngoscope Pub Date : 2025-03-11 DOI: 10.1002/lary.32111

Shravani Pathak, Richard V Smith

引用次数: 0

Suicidal Ideation and Behaviors in Adults With Tinnitus: A Systematic Review and Meta-Analysis. 成人耳鸣患者的自杀意念和行为：系统回顾和荟萃分析。

IF 2.2 3区医学

Laryngoscope Pub Date : 2025-03-11 DOI: 10.1002/lary.32118

Lauren R McCray, Megan K Scharner, Shaun A Nguyen, Habib G Rizk, Ted A Meyer, Robert F Labadie, Thomas W Uhde, Peter R Dixon

{"title":"Suicidal Ideation and Behaviors in Adults With Tinnitus: A Systematic Review and Meta-Analysis.","authors":"Lauren R McCray, Megan K Scharner, Shaun A Nguyen, Habib G Rizk, Ted A Meyer, Robert F Labadie, Thomas W Uhde, Peter R Dixon","doi":"10.1002/lary.32118","DOIUrl":"https://doi.org/10.1002/lary.32118","url":null,"abstract":"Objective: To assess relations between tinnitus and suicidality, measured by suicidal ideation and suicide attempts.Data sources: CINAHL, Cochrane Library, PubMed, PsycINFO, and SCOPUS databases were searched from inception through June 14, 2024.Review methods: Observational studies related to suicidality in tinnitus patients at least 18 years old were included. Case reports and studies on objective or pulsatile tinnitus were excluded. Two authors extracted data, and disagreements were resolved with a third party if needed. The risk of bias was assessed according to the Risk Of Bias In Non-randomized Studies of Exposure for cohort studies and the Joanna Briggs Institute critical appraisal checklist for cross-sectional studies. Random effects meta-analyses (single means, proportions, and relative risks (RR)) were used for primary analysis.Results: Nine studies (n = 912,013) pertaining to suicidality and tinnitus in an adult population were included. The tinnitus group experienced a significantly higher prevalence of suicidal ideation (19.5% [95% CI: 12.9%-27.1%] versus 9.9% [95% CI: 7.1%-13.2%]) and suicide attempts (1.9% [95% CI: 0.1%-5.7%] versus 0.9% [95% CI: 0.0%-3.9%]) than the control population (p < 0.0001). The tinnitus group had a significantly (p < 0.001) higher risk of suicidal ideation (RR = 2.1, 95% CI: 1.6-2.8) and suicide attempts (RR = 1.8, 95% CI: 1.3-2.4) than the control group.Conclusion: Nearly one in five people with tinnitus will experience suicidal ideation, and nearly 2% will attempt suicide. Thus, otolaryngologists should be mindful of the increased risk of suicidality in patients with tinnitus.","PeriodicalId":49921,"journal":{"name":"Laryngoscope","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143598167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Need for Postoperative Chest X-Ray After Placement of Hypoglossal Nerve Stimulator. 舌下神经刺激器置入后胸部x线透视的必要性。

IF 2.2 3区医学

Laryngoscope Pub Date : 2025-03-10 DOI: 10.1002/lary.32103

Jacob Beiriger, Nicole Molin, Jared Robinson, Kalena Liu, Erin Creighton, Chihun Han, Dylan Bertoni, Maurits Boon, Colin Huntley

{"title":"The Need for Postoperative Chest X-Ray After Placement of Hypoglossal Nerve Stimulator.","authors":"Jacob Beiriger, Nicole Molin, Jared Robinson, Kalena Liu, Erin Creighton, Chihun Han, Dylan Bertoni, Maurits Boon, Colin Huntley","doi":"10.1002/lary.32103","DOIUrl":"https://doi.org/10.1002/lary.32103","url":null,"abstract":"Objective: Hypoglossal nerve stimulation (HGNS) is a surgical treatment for obstructive sleep apnea (OSA) in patients intolerant to CPAP. Current practice often involves chest x-ray (CXR) in the postanesthesia care unit (PACU), though the incidence of pulmonary complications is low. This study evaluates the necessity of immediate postoperative CXR after HGNS placement.Methods: We conducted a retrospective chart review of 361 patients who underwent unilateral HGNS placement from 2014 to 2021 at a single institution. Surgeries were performed by two high-volume sleep surgeons. Data collected included demographics, preoperative sleep study results, postoperative CXR findings, and subsequent management. Logistic regression calculated odds ratios (ORs) for the association between abnormal CXR findings and patient characteristics, with mean differences and 95% confidence intervals (CIs) for continuous variables.Results: Abnormal CXR findings occurred in five patients (1.4%), including two pneumothoraxes (0.6%) and three pulmonary edemas (0.8%). Patients with abnormal CXR findings had increased odds of reporting respiratory symptoms in the PACU compared to those without (OR: 3.8, 95% CI: 1.1-13.2, p < 0.001) and required extended postoperative stays. All patients with pulmonary edema had respiratory symptoms before CXR confirmation. No significant demographic or clinical differences were found between patients with normal and abnormal CXR findings.Conclusion: This study confirms the low incidence of pulmonary complications following HGNS placement by high-volume surgeons. Immediate CXR may not be necessary in asymptomatic patients. However, routine postoperative imaging in the recovery period is warranted to document hardware placement.Level of evidence: 4: ","PeriodicalId":49921,"journal":{"name":"Laryngoscope","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparing Tinnitus Suppression in Asymmetric Hearing Loss and Single-Sided Deafness: Cochlear Versus Bone Conduction Implants. 不对称听力损失和单侧耳聋的耳鸣抑制比较：人工耳蜗与骨传导植入。

IF 2.2 3区医学

Laryngoscope Pub Date : 2025-03-10 DOI: 10.1002/lary.32090

Jae Sang Han, Min Chae Jeon, Chan Mi Lee, Gianfranco C Velasco, So Young Park, Shi Nae Park

{"title":"Comparing Tinnitus Suppression in Asymmetric Hearing Loss and Single-Sided Deafness: Cochlear Versus Bone Conduction Implants.","authors":"Jae Sang Han, Min Chae Jeon, Chan Mi Lee, Gianfranco C Velasco, So Young Park, Shi Nae Park","doi":"10.1002/lary.32090","DOIUrl":"https://doi.org/10.1002/lary.32090","url":null,"abstract":"Objectives: Implantable hearing devices, such as cochlear implants (CI) and bone conduction implants (BCI), are options for hearing rehabilitation in patients with asymmetric hearing loss (AHL) and single-sided deafness (SSD). This study aimed to compare the effects of CI and BCI on tinnitus in AHL/SSD patients with tinnitus.Methods: This retrospective study enrolled adult AHL/SSD patients with significant tinnitus who underwent CI or BCI placement between 2017 and 2023. Clinical characteristics, preoperative and postoperative audiologic test results, and tinnitus questionnaires (tinnitus handicap inventory, THI; visual analog scale, VAS) were collected and analyzed.Results: Of 33 AHL/SSD patients with significant tinnitus (THI ≥ 18), 16 received CI and 17 BCI. In the CI group, all four VAS scores (loudness, awareness, annoyance, and effect on life) and THI scores significantly improved. In the BCI group, annoyance and effect on life categories of VAS and THI scores significantly improved, while VAS loudness and awareness remained similar. Linear mixed model analysis showed that the decrease in VAS loudness, awareness, and annoyance scores was significantly greater in the CI group compared to the BCI group. The CI group showed a significantly higher tinnitus cure rate (62.5.0%) compared with the BCI group (11.8%) at 6-months postoperative.Conclusion: Both CI and BCI effectively improved tinnitus in AHL/SSD patients with tinnitus. However, CI is considered the first-line therapeutic option for tinnitus due to its stronger effect on tinnitus suppression as well as the higher cure rate in SSD/AHL patients with tinnitus.Level of evidence: 3: ","PeriodicalId":49921,"journal":{"name":"Laryngoscope","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nasopharyngeal Augmentation for Velopharyngeal Insufficiency Treatment in Wind Instrument Players. 鼻咽隆术治疗管乐器演奏者腭咽功能不全。

IF 2.2 3区医学

Laryngoscope Pub Date : 2025-03-10 DOI: 10.1002/lary.32100

Calabria DeFazio, Lily Stevenson, Phillip Song

引用次数: 0

Rare Hypopharyngeal Polyp Presenting Without Dysphagia: A Case Report. 罕见下咽息肉无吞咽困难1例。

IF 2.2 3区医学

Laryngoscope Pub Date : 2025-03-10 DOI: 10.1002/lary.32110

Tiffany Win, Komal Hombal, Melissa Mortensen-Welch

{"title":"Rare Hypopharyngeal Polyp Presenting Without Dysphagia: A Case Report.","authors":"Tiffany Win, Komal Hombal, Melissa Mortensen-Welch","doi":"10.1002/lary.32110","DOIUrl":"https://doi.org/10.1002/lary.32110","url":null,"abstract":"Fibrovascular polyps (FVPs) of the hypopharynx are exceedingly rare benign tumors. This case showcases an incidental finding of a fibrovascular hypopharyngeal polyp discovered during a flexible laryngoscopy secondary to ear pain in a 72-year-old male. The patient reported no associated dysphagia, voice changes, dyspnea, or globus sensation. Imaging studies, including a CT neck scan, MRI, and videofluoroscopic swallow study, revealed a 1.2 × 1.3 × 1.4 cm solid polyp attached to the hypopharynx without extending into the esophagus. The patient underwent a successful endoscopic excision of the pharyngeal polyp with a partial pharyngectomy. The biopsy of the specimen showed squamous mucosa with stromal degeneration, consistent with a benign polyp. This case report describes a rare asymptomatic hypopharyngeal FVP, notable for its small size and lack of typical symptoms like dysphagia. It emphasizes the importance of early identification through a multimodal approach and careful surgical management to prevent potential complications, as complete surgical excision is curative. While dysphagia is the common symptom of FVPs, this case demonstrates that FVPs can present without it, highlighting the need for FVPs to remain in the differential diagnosis, even when found incidentally.","PeriodicalId":49921,"journal":{"name":"Laryngoscope","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dental Prosthetic Rehabilitation in Mandibular Reconstruction: Optimizing Timing and Patient Selection. 下颌骨重建中牙体修复康复：优化时机和患者选择。

IF 2.2 3区医学

Laryngoscope Pub Date : 2025-03-06 DOI: 10.1002/lary.32084

Amanda J Bastien, Jay Lee, Steven Kupferman, Avi Donitza, Aria Davodi, Luv Amin, Missael Vasquez, Leila Musavi, Harsh Patel, Michelle Chen, Evan Walgama, Zachary S Zumsteg, Allen S Ho, Jon Mallen-St Clair

{"title":"Dental Prosthetic Rehabilitation in Mandibular Reconstruction: Optimizing Timing and Patient Selection.","authors":"Amanda J Bastien, Jay Lee, Steven Kupferman, Avi Donitza, Aria Davodi, Luv Amin, Missael Vasquez, Leila Musavi, Harsh Patel, Michelle Chen, Evan Walgama, Zachary S Zumsteg, Allen S Ho, Jon Mallen-St Clair","doi":"10.1002/lary.32084","DOIUrl":"https://doi.org/10.1002/lary.32084","url":null,"abstract":"Background: Dental prosthetic rehabilitation (DPR) plays a critical role in restoring function and quality of life following mandibular reconstruction. This study examines the rate of patients undergoing dental implants and DPR after reconstruction of a segmental jaw defect with a fibula free flap reconstruction. We identify factors associated with successful dental implants and DPR in this patient population.Methods: Retrospective review examining the rate of dental implants and DPR in fibula free flaps at a tertiary academic hospital.Results: Of the 67 patients, 34 did not undergo dental implants at the time of reconstruction, 33 underwent primary dental implants, with 19 of these patients undergoing implants alone with a plan for later prosthesis and 14 (20.9%) getting immediate implants with provisional prosthesis-referred to as jaw in a day (JIAD). Implants were placed with a success rate of 89.3% for implants alone and 94.0% for JIAD patients. None of the 34 patients who did not receive dental implants at the time of reconstruction later underwent dental implants or DPR. In contrast, of those who underwent dental implants without the placement of a provisional prosthesis, 63.2% (12/19) successfully obtained a final prosthesis. In patients who underwent JIAD, 92.8% (13/14) went on to get a final dental prosthesis.Conclusion: Our study demonstrates that immediate placement of dental implants with or without a tissue-borne prosthesis during mandibular reconstruction can be performed with a high rate of success. Furthermore, our data suggest that immediate placement of a dental prosthesis is the most efficient method of achieving dental rehabilitation.Level of evidence: 3: ","PeriodicalId":49921,"journal":{"name":"Laryngoscope","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143574560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Factors Influencing Nasal Irrigation Efficacy in Infants: An Exploratory 3D Model Study. 影响婴儿鼻冲洗效果的因素：一项探索性三维模型研究。

IF 2.2 3区医学

Laryngoscope Pub Date : 2025-03-06 DOI: 10.1002/lary.32107

Pierre Cnockaert, Emma Trehoux, Jeremy Patarin, Lydia Esteban Enjuto, Nicolas Audag, William Poncin

{"title":"Factors Influencing Nasal Irrigation Efficacy in Infants: An Exploratory 3D Model Study.","authors":"Pierre Cnockaert, Emma Trehoux, Jeremy Patarin, Lydia Esteban Enjuto, Nicolas Audag, William Poncin","doi":"10.1002/lary.32107","DOIUrl":"https://doi.org/10.1002/lary.32107","url":null,"abstract":"Background: Nasal irrigation is widely practiced in infants, but its execution varies greatly. Although a consensus on how to perform this procedure has been published, supporting experimental evidence is lacking. In vitro investigations using anatomical models are a promising first step toward clinical research. Quantitative, exploratory data on pediatric nasal irrigation, obtained from a pragmatic irrigation setup, are needed.Methods: A previously validated upper airway model of a 10-month-old infant was used and filled with mucus-mimicking hydrogel at two different concentrations. The upper airway clearance efficacy (UAC%) of nasal irrigation (i.e., the extent of airway clearance) was tested by varying different parameters: head position and the nostril selected for irrigation (side-lying via the supra- or infra-lateral nostril, or sitting), irrigation pattern (unilateral or bilateral irrigation), irrigation volume (5, 10, 15, or 20 mL), and hydrogel concentration (1 or 1.5%).Results: Increasing nasal irrigation volume significantly improved UAC% with each 5 mL increment: mean (SD) UAC% was 75.10 (8.06), 84.00 (7.79), 89.94 (5.86), and 93.15 (4.63) % for 5, 10, 15, and 20 mL/nostril, respectively. Performing unilateral nasal irrigation through the supra-lateral nostril led to a greater UAC% compared to infra-lateral nostril irrigation (mean UAC% (SD) was 83.02 (7.32) and 75.30 (9.29) %, respectively; p < 0.001). The other parameters did not significantly impact the UAC%.Conclusion: The irrigation volume and the nostril selected for unilateral nasal irrigation significantly impacted upper airway clearance during in vitro nasal irrigation. Future studies should investigate whether large irrigation volumes improve clinical outcomes in infants.Level of evidence: NA, in vitro study.","PeriodicalId":49921,"journal":{"name":"Laryngoscope","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143568291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0