Laryngoscope最新文献_第7页

Unique Application of the Jaw-in-a-Day Technique in a Case of Trauma.

IF 2.2 3区医学

Laryngoscope Pub Date : 2025-03-04 DOI: 10.1002/lary.32042

Alberto Nunez, Kaitlynne Y Pak, Steven Kupferman, Jay K Lee, Jon Mallen-St Clair

引用次数: 0

Real-World Insights Into cN3 Larynx and Hypopharynx Cancer: Treatment Modalities, Long-Term Outcomes, and Prognostic Factors.

IF 2.2 3区医学

Laryngoscope Pub Date : 2025-03-03 DOI: 10.1002/lary.32079

Yu-Jie Shen, Tian Wang, Chang-Ding He, Hong-Li Gong, Cheng-Zhi Xu, Huai-Dong Du, Lei Tao, Ming Zhang, Liang Zhou

{"title":"Real-World Insights Into cN3 Larynx and Hypopharynx Cancer: Treatment Modalities, Long-Term Outcomes, and Prognostic Factors.","authors":"Yu-Jie Shen, Tian Wang, Chang-Ding He, Hong-Li Gong, Cheng-Zhi Xu, Huai-Dong Du, Lei Tao, Ming Zhang, Liang Zhou","doi":"10.1002/lary.32079","DOIUrl":"https://doi.org/10.1002/lary.32079","url":null,"abstract":"Objectives: cN3 larynx and hypopharynx cancer is rare with a poor prognosis. This study evaluates treatment approaches, effectiveness, and prognosis for these patients in real-world settings. It aims to offer targeted and practical clinical guidance to enhance their treatment results and quality of life.Methods: This retrospective cohort study (2014-2021) included 192 cN3 larynx and hypopharynx cancer patients from Eye & ENT Hospital of Fudan University. We collected detailed information on demographics, tumor characteristics, and treatment outcomes. The study focused on overall survival (OS), cancer-specific survival (CSS), and disease-free survival (DFS), using Kaplan-Meier and Cox regression analyses for independent prognostic analysis.Results: This study encompassed 192 cN3 larynx and hypopharynx cancer patients, revealing a five-year overall survival rate of 40.60%. Treatment modalities analyzed included Surgery + CRT, ICT + Surgery + CRT, ICT + CRT, Surgery alone, and CRT alone. Patients receiving surgery followed by CRT demonstrated the most favorable prognosis (p < 0.0001) and the longest DFS (p < 0.0001), while those undergoing monotherapy had the poorest outcomes. Induction chemotherapy (ICT) achieved a 70% primary tumor response rate and a 48% neck lesion response rate, with patients showing a response to ICT exhibiting superior OS, CSS, and distant metastasis rate (DMR) (p < 0.05). Pathological type and primary tumor surgery were identified as independent prognostic factors for cN3 larynx and hypopharynx cancer.Conclusion: This study shows that combined treatments, especially surgery followed by chemoradiotherapy, improve survival and prognosis for cN3 larynx and hypopharynx cancer patients. It highlights the importance of tailored treatments and notes better outcomes for those responding to ICT.Level of evidence: 3: ","PeriodicalId":49921,"journal":{"name":"Laryngoscope","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143544287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Volume Outcome Relationships of Oropharyngeal Cancer Patients Undergoing Transoral Robotic Surgery.

IF 2.2 3区医学

Laryngoscope Pub Date : 2025-03-03 DOI: 10.1002/lary.32098

Aaron Tucker, Craig Allen Bollig

{"title":"Volume Outcome Relationships of Oropharyngeal Cancer Patients Undergoing Transoral Robotic Surgery.","authors":"Aaron Tucker, Craig Allen Bollig","doi":"10.1002/lary.32098","DOIUrl":"https://doi.org/10.1002/lary.32098","url":null,"abstract":"Objectives: We aim to demonstrate whether facility case volume is associated with (1) perioperative outcomes and (2) overall survival in patients with oropharyngeal cancer (OPC) undergoing transoral robotic surgery (TORS).Methods: This is a retrospective cohort analysis of adults with OPC who underwent TORS between 2010 and 2017 using the National Cancer Database. Patients were stratified into high, mid, and low-volume facility groups based on facility TORS volume percentiles. Perioperative variables included 30- and 90-day mortality and positive margin rates. Baseline clinicopathologic variables and perioperative outcomes were compared using univariate testing. Multivariable analyses were carried out with logistic regression. Overall survival was evaluated by the Kaplan-Meier method with log-rank test as well as multivariable Cox proportional hazards models. Adjusted odds ratios (aOR) and hazard ratios (aHR) with 95% confidence intervals (CI) were created.Results: 4294 patients were included. As facility volume increased, there were stepwise decreases in rates of positive margins, 30-day mortality, and 90-day mortality (p < 0.001, respectively). Low-and mid-volume facilities were associated with greater rates of 30- and 90-day mortality compared to high-volume facilities, adjusting for comorbidity and age. Mid- and high-volume facilities were independently associated with improved overall survival, adjusting for age, comorbidity, histologic type, and clinical T stage.Conclusion: Treatment at higher volume TORS facilities is associated with lower rates of perioperative mortality, lower positive margins, and improved long-term overall survival for patients with OPC.Level of evidence: N/A.","PeriodicalId":49921,"journal":{"name":"Laryngoscope","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143544296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In Reference to Step-By-Step Surgery for Diffuse Idiopathic Skeletal Hyperostosis (DISH) of the Cervical Spine.

IF 2.2 3区医学

Laryngoscope Pub Date : 2025-03-03 DOI: 10.1002/lary.32095

Ali Imran Ozmarasali, Gökhan Tüzemen

引用次数: 0

Spending and Utilization for Chronic Rhinosinusitis With Nasal Polyps Therapies Among Commercially Insured Beneficiaries. 商业保险受益人中慢性鼻炎伴鼻息肉治疗的支出和使用情况。

IF 2.2 3区医学

Laryngoscope Pub Date : 2025-03-03 DOI: 10.1002/lary.32063

Akash M Bhat, Rodney J Schlosser, Zachary M Soler, Vinay K Rathi

引用次数: 0

Validation of a Novel Adaptive Inner EAR Scale to Intelligently Quantify the Impact of Hearing Loss.

IF 2.2 3区医学

Laryngoscope Pub Date : 2025-03-03 DOI: 10.1002/lary.32087

Minjee Kim, Carleton Eduardo Corrales, Anthony A Prince, Anne Li, Maria Edelen, Bevan Yueh, Jennifer J Shin

{"title":"Validation of a Novel Adaptive Inner EAR Scale to Intelligently Quantify the Impact of Hearing Loss.","authors":"Minjee Kim, Carleton Eduardo Corrales, Anthony A Prince, Anne Li, Maria Edelen, Bevan Yueh, Jennifer J Shin","doi":"10.1002/lary.32087","DOIUrl":"https://doi.org/10.1002/lary.32087","url":null,"abstract":"Objectives: To develop and validate a novel adaptive version of the Inner EAR scale, which efficiently quantifies the patient-centered impact of hearing loss. Adaptive testing is a vetted, established means to provide targeted questions that assess each individual to achieve increased accuracy with less work for respondents.Methods: A prospective validation study was performed. The adaptive test was developed through factor analysis, item response theory assessments, and evaluation of internal consistency (n = 2200). Convergent and discriminant validity were measured in relation to standard static testing and measured audiometry (n = 513). Assessments of intra-rater reliability and responsiveness to change were also performed.Results: Factor analysis demonstrated that items reflected one domain (hearing ability). Internal consistency was strong (Cronbach alpha 0.91, 95% CI: > 0.89). Convergent validity was also demonstrated, with positive associations between adaptive scale scores and audiogram results (Spearman rho 0.30, 95% CI: 0.19-0.41), overall PROMIS physical health (Spearman rho 0.29, 95% CI: 0.17-0.40), social health scores, and global overview scores. Intra-rater reliability was also demonstrated (Cohen kappa 0.6, 95% CI: 0.5-0.7). Responsiveness to change and discriminant validity (an increase in adaptive test score of 10 was associated with 10.4-fold increase in odds of normal hearing) were also observed. The adaptive scale had comparable internal consistency, validity, and responsiveness to change, and higher intra-rater reliability than the standard static scale.Conclusions: This novel adaptive validated instrument is clinically applicable, internally consistent, reliable, responsive, aligns with audiometry, and has higher reliability than standard static testing.Level of evidence: 2 (diagnostic or monitoring test).","PeriodicalId":49921,"journal":{"name":"Laryngoscope","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143544292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quality of Life Outcomes in Vestibular Schwannoma: A Prospective Analysis of Treatment Modalities.

IF 2.2 3区医学

Laryngoscope Pub Date : 2025-02-27 DOI: 10.1002/lary.32080

A Hotchkies, E Heward, A Wadeson, C Heal, S R Freeman, S A Rutherford, A T King, O Pathmanaban, J Halliday, G Whitfield, C McBain, R J Colaco, T Campbell, S J Goh, S K W Lloyd

{"title":"Quality of Life Outcomes in Vestibular Schwannoma: A Prospective Analysis of Treatment Modalities.","authors":"A Hotchkies, E Heward, A Wadeson, C Heal, S R Freeman, S A Rutherford, A T King, O Pathmanaban, J Halliday, G Whitfield, C McBain, R J Colaco, T Campbell, S J Goh, S K W Lloyd","doi":"10.1002/lary.32080","DOIUrl":"https://doi.org/10.1002/lary.32080","url":null,"abstract":"Objective: Management options for vestibular schwannoma include microsurgery (MS), stereotactic radiosurgery (SRS), and watch, wait, and rescan (WWR). This study aimed to evaluate changes in patient and disease-specific quality of life (QoL) outcomes over time, comparing each treatment modality in a matched cohort.Methods: A prospective cohort study recruited adult patients with sporadic vestibular schwannomas ≤ 3 cm in size undergoing treatment between January 2012 and April 2022 in a single tertiary referral center. Questionnaires were completed at diagnosis and ≥ 12 months posttreatment to assess patient-reported changes in QoL (Hearing, Dizziness, Tinnitus Handicap Inventories; Penn Acoustic Neuroma QoL questionnaire (PANQOL) and the Short Form-36 QoL questionnaire (SF-36)).Results: In total, 124 patients returned completed questionnaires (MS: 42, SRS: 42, WWR 40). The SRS group had a clinically significant deterioration in their hearing scores posttreatment (p = 0.002). Dizziness scores worsened in the MS and WWR groups posttreatment; this did not reach clinical significance. Hearing deterioration was identified in the WWR group over time using the PANQOL domain (p = 0.012). The SF-36 questionnaire showed a significant deterioration in physical functioning, role limitations, and component summary for SRS patients posttreatment (p = 0.0018, p = 0.0032, p = 0.0308). No other significant differences were seen in disease-specific or general QoL domains when comparing treatment strategies.Conclusion: Outcomes in similar disease-specific domains were not consistent across questionnaires. All three treatment modalities appear to result in comparable long-term disease-specific QoL outcomes. These findings will enable evidence-based patient counseling to inform decision-making.Level of evidence: 3: ","PeriodicalId":49921,"journal":{"name":"Laryngoscope","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143517157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Embolized Middle Meningeal Artery as a Surgical Landmark in Infratemporal Fossa. 作为颞下窝手术标志的栓塞脑膜中动脉

IF 2.2 3区医学

Laryngoscope Pub Date : 2025-02-27 DOI: 10.1002/lary.32092

Sung-Min Park, Ja-Won Koo

引用次数: 0

In Reference to Effect of Rurality in Head and Neck Cancer: A Scoping Review.

IF 2.2 3区医学

Laryngoscope Pub Date : 2025-02-27 DOI: 10.1002/lary.32094

Nitin A Pagedar, Jason T Semprini, Whitney E Zahnd, Mary E Charlton, Amanda R Kahl, Aaron T Seaman

引用次数: 0

Concurrent Subepithelial Vocal Fold Infusion and Photoangiolysis for Vessel Coagulation in Vocal Fold Surgery.