Laryngoscope最新文献

{"title":"Optimizing Microtia Results in Alloplastic Ear Reconstruction.","authors":"Marta Kulich, Beth A Osterbauer, Gabriel Arom, Amit Kochhar, Gabriel Gomez","doi":"10.1002/lary.70174","DOIUrl":"https://doi.org/10.1002/lary.70174","url":null,"abstract":"<p><strong>Objective: </strong>To analyze which patient and surgeon factors impacted aesthetic outcomes in alloplastic microtia reconstruction.</p><p><strong>Methods: </strong>Retrospective cohort study was conducted of a single microtia team at an academic tertiary care children's hospital. Consecutive patients who underwent porous polyethylene (PPE) microtia reconstruction between October 2020 and September 2023 were retrospectively included in the study. Data including demographics, height, and weight, microtia grade, complications, and surgeon experience was collected. Reviewers (otolaryngology residents) blinded to surgical details provided an aesthetic score for each postoperative ear photograph through a web-based survey.</p><p><strong>Results: </strong>Fifty-one subjects undergoing primary microtia reconstruction were included: mean age was 9.5 years (range 4-18 years), and 24 (47%) were female. Post-operative photographs were taken an average of 23 weeks following surgery (range 8-42 weeks). Younger age was correlated with better aesthetic outcomes (coef. -0.8, p = 0.02). In a linear regression model controlling for age and sex, both BMI z-score > 1.0 (-6.6, p = 0.004) and need for revision surgery (-9.6, p = 0.003) were significantly associated with lower mean cosmetic scores. Mean aesthetic scores increased with surgical experience, but the trend was not statistically significant.</p><p><strong>Conclusion: </strong>Certain patient characteristics such as younger age, normal BMI, and uncompromised wound healing were strongly associated with improved aesthetic results in alloplastic microtia reconstruction. Increasing surgeon experience may contribute to improved aesthetic outcomes. These findings can be used to counsel families and help predict results after alloplastic microtia reconstruction.</p><p><strong>Level of evidence: 3: </strong></p>","PeriodicalId":49921,"journal":{"name":"Laryngoscope","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145276550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of a De-Escalated Post-Operative Cochlear Implant Programming Protocol.","authors":"Leena Asfour, Michelle Coppola, Samantha Espinal, Meredith A Holcomb","doi":"10.1002/lary.70172","DOIUrl":"https://doi.org/10.1002/lary.70172","url":null,"abstract":"<p><strong>Objective: </strong>Cochlear implantation often requires frequent post-operative programming visits which can disrupt daily life, impose financial burdens, and delay access for new cochlear implant (CI) candidates. This study evaluated the feasibility of a de-escalated schedule of four programming appointments within the first year after surgery.</p><p><strong>Methods: </strong>A retrospective review was completed for 236 patients aged 0-100 years who received CI from July 2022 to December 2023. Explants, reimplants and second CI within the study window were excluded. Collected data included demographics, schedule adherence, additional visit reason, and Consonant-Nucleus-Consonant (CNC) word scores for adults.</p><p><strong>Results: </strong>A total of 201 CI recipients (mean age 46.9 years; 72.6% adults) met inclusion criteria. Most were male (53%), White (88%), Non-Hispanic (54.7%), and privately insured (56.2%). Overall, 53% adhered to the 4-visit protocol, 35% required 1-2 additional visits, and 12% required 3-6. Among those requiring additional appointments (n = 95), 28.4% followed the prior protocol of up to 10+ visits. Adherence to the new streamlined protocol improved by 43% over the study period. On multivariate analysis, each additional year of age at surgery reduced the odds of adherence by 3.4% (p < 0.05). No statistical or clinical differences were observed in 12-month CNC scores between patients with ≤ 4 versus > 4 visits.</p><p><strong>Conclusions: </strong>A de-escalated post-CI programming schedule of four visits in the first year is feasible and does not compromise adult speech perception outcomes. Older patients may require closer follow-up. Successful implementation may require time for workflows and provider adoption.</p><p><strong>Level of evidence: 3: </strong></p>","PeriodicalId":49921,"journal":{"name":"Laryngoscope","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145276448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incorporating HTA and VR Simulation to Teach Trainees in Endoscopic Endonasal Skull Base Approaches.","authors":"Shireen Samargandy, David Ahmadian, Jason Zhang, David Biffar, Michael B Avery, Christopher Le, Eugene Chang","doi":"10.1002/lary.70188","DOIUrl":"https://doi.org/10.1002/lary.70188","url":null,"abstract":"<p><p>This study introduces a novel educational framework for endoscopic endonasal skull base surgery that integrates hierarchical task analysis (HTA) and systematic human error reduction and prediction approach (SHERPA) into an immersive virtual reality (VR) simulator. The platform deconstructs complex procedures into structured steps, identifies potential errors, and embeds decision-making prompts to enhance both technical skill and situational awareness. This structured, error-aware VR approach offers a transformative advancement in surgical training, providing a safe, repeatable, and clinically relevant learning environment.</p>","PeriodicalId":49921,"journal":{"name":"Laryngoscope","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145276423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine Learning to Predict Extranodal Extension in Head and Neck Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis.","authors":"Arshbir Aulakh, Masih Sarafan, Amardeep S Sekhon, Khanh Linh Tran, Ameen Amanian, Farahna Sabiq, Cornelius Kürten, Eitan Prisman","doi":"10.1002/lary.70194","DOIUrl":"https://doi.org/10.1002/lary.70194","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the clinical utility of machine learning algorithms (MLAs) in diagnosing extra-nodal extension (ENE) using CT imaging in HNSCC.</p><p><strong>Data sources: </strong>A comprehensive literature search was conducted on MEDLINE (Ovid), EMBASE, Cochrane, Scopus, and Web of Science, from January 1, 2000, to February 12, 2025.</p><p><strong>Review methods: </strong>Two independent reviewers selected studies reporting the diagnostic accuracy of MLAs in detecting ENE in patients with HNSCC. The review followed PRISMA guidelines. Meta-analysis was performed using MedCalc (23.0.2), with pooled estimates of the area under the curve (AUC) and corresponding 95% confidence intervals (CI) calculated. The Checklist for Artificial Intelligence in Medical Imaging (CLAIM) was used to analyze the methodological quality of the included studies.</p><p><strong>Results: </strong>Of 57 articles retrieved, six met inclusion criteria, encompassing 2870 lymph nodes from 1407 patients. MLAs achieved a pooled AUC of 0.92 (95% CI [0.915, 0.923], p < 0.001; fixed-effects) and 0.91 (95% CI [0.882, 0.929], p < 0.001; random-effects), outperforming radiologists who had pooled AUCs of 0.65 (95% CI [0.645-0.654], p < 0.001; fixed-effects) and 0.65 (95% CI [0.591-0.708], p < 0.001; random-effects). Furthermore, MLA achieved a sensitivity ranging from 66.9% to 91.2%, compared to 24% to 96.0% by radiologists. The specificity and accuracy of MLA ranged from 72% to 96.2% and 66% to 92.2%, respectively, compared to that of radiologists, which ranged from 43.0% to 96.0% and 51.5% to 88.6%, respectively.</p><p><strong>Conclusion: </strong>MLAs demonstrate superior diagnostic performance in predicting ENE in HNSCC and may serve as a valuable adjunct to radiologists in clinical practice.</p><p><strong>Level of evidence: 1: </strong></p>","PeriodicalId":49921,"journal":{"name":"Laryngoscope","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145276432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polyphenolic Activation of Basophils Explains Alcohol Hypersensitivity in AERD.","authors":"Spencer C Payne, William Eschenbacher, Ryan Stepp, Larry Borish","doi":"10.1002/lary.70183","DOIUrl":"https://doi.org/10.1002/lary.70183","url":null,"abstract":"<p><strong>Objective: </strong>Alcohol hypersensitivity (AH), an exacerbation of respiratory symptoms in response to alcohol consumption, is common in aspirin-exacerbated respiratory disease (AERD) and other forms of chronic rhinosinusitis (CRS). The mechanism of this is unknown. This study investigates the ability of polyphenolic compounds in alcoholic beverages to activate innate immune cells as a means of explaining AH in AERD.</p><p><strong>Methods: </strong>Data were collected from 478 consecutive adults presenting to a tertiary care sinonasal clinic in whom the presence of AH and their CRS phenotype was determined. A subset of these individuals was invited to provide whole blood samples on which the effects of ethanol, red wine extract (RWE), and individual polyphenolic compounds were explored. Granulocyte activation was quantified by flow cytometry as upregulation of CD63 during the Basophil Activation Test (BAT). Additionally, secretion of lipid metabolites was measured by enzyme immunoassays (EIAs).</p><p><strong>Results: </strong>Twelve patients with CRSwNP were compared to age and sex-matched healthy controls. A dose-dependent stimulation of basophil degranulation was noted with RWE and epigallocatechin (p < 0.05). No activation was noted in healthy controls or subjects to ethanol. Catechin demonstrated a dose-dependent, but only near-significant difference (p = 0.07) in basophil degranulation compared to controls.</p><p><strong>Conclusions: </strong>Polyphenolic compounds, and not ethanol, can trigger the activation and degranulation of eosinophils and basophils, and this may explain the sensitivity to alcoholic beverages seen in patients with AERD and CRSwNP.</p><p><strong>Level of evidence: </strong>NA.</p>","PeriodicalId":49921,"journal":{"name":"Laryngoscope","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145253422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors Affecting Audiometric and Speech Perception Outcomes in Hybrid Cochlear Implant Recipients.","authors":"Paul N Reinhart, Aaron J Parkinson, Camille C Dunn, Bruce J Gantz","doi":"10.1002/lary.70195","DOIUrl":"https://doi.org/10.1002/lary.70195","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the long-term audiometric and speech perception outcomes in Hybrid cochlear implant recipients meeting hybrid or electric-acoustic stimulation (EAS) indications, and to identify factors, including age, sex, and duration of hearing loss, that may contribute to outcome variability. Additionally, the study evaluates the impact of EAS on speech perception.</p><p><strong>Methods: </strong>Data from two clinical trials and retrospective data from the University of Iowa were combined for a total dataset of 150 Cochlear Nucleus Hybrid L24 (Cochlear Ltd., Sydney, Australia) cochlear implant recipients. Audiometric outcomes, as quantified by low-frequency pure-tone average (LFPTA; 125-500 Hz), and speech perception outcomes, including unilateral and bilateral CNC words in quiet and AzBio +5 dB SNR sentences in noise, were assessed preoperatively and postoperatively up to 5 years postactivation.</p><p><strong>Results: </strong>Functional low-frequency acoustic hearing (LFPTA < 80 dB HL) was preserved in 72.9% of Hybrid L24 recipients up to 5 years postactivation, with audiometric changes stabilizing around 1 year. Significant improvements were observed in speech perception both in quiet and in noise. Age at implantation was a significant predictor of both audiometric and speech outcomes, with younger recipients demonstrating greater speech-in-noise improvements and a greater likelihood of maintaining functionally aidable hearing. EAS users demonstrated superior speech outcomes compared to electric-only users.</p><p><strong>Conclusion: </strong>Cochlear implantation for EAS candidates provides long-term preservation of acoustic hearing and improved speech perception outcomes, particularly in younger recipients. These findings support the use of hybrid/EAS cochlear implantation in candidates with low-frequency hearing and highlight the benefit of EAS in enhancing speech understanding.</p><p><strong>Level of evidence: </strong>3 Trial Registration: Relevant studies were registered on ClinicalTrials.gov under trial registration numbers NCT00678899 (pivotal study group), NCT02379273 (continuation of pivotal study group), and NCT02379819 (post-approval study group).</p>","PeriodicalId":49921,"journal":{"name":"Laryngoscope","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145253470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of Self-Administered Olfactory Assessments Novel Olfactory Sorting Task (NOST) and Odor Dilution Sorting (ODS) in a Community-Based Population.","authors":"Tiana M Saak, Renjie Zhang, Matthew D A Spence, Davangere P Devanand, Jeffrey N Motter, Jonathan B Overdevest","doi":"10.1002/lary.70190","DOIUrl":"https://doi.org/10.1002/lary.70190","url":null,"abstract":"<p><strong>Objectives: </strong>Olfactory evaluation beyond conventional domain testing may inform how olfactory impairment presents among the general population. Recently reported assessments based on odor matching (NOST) and intensity sorting (ODS) may provide additional insight into olfactory function. Characterizing performance of these simple and self-administered tasks among a community-based population offers a valuable benchmark for subsequent evaluation in aging and cognition-impaired cohorts.</p><p><strong>Methods: </strong>Seventy community-based individuals completed Sniffin' Sticks TDI testing, NOST, and ODS. NOST is an odor matching task among twelve pairs of odorants, and ODS is an odor intensity scaling task. Scores were compared to TDI using Spearman correlations and Wilcoxon signed-rank tests.</p><p><strong>Results: </strong>NOST median score was 6 (IQR: 4, 9) while ODS was 0.80 (0.70, 0.85). NOST correlated with TDI (r; [confidence interval]: 0.640, [0.47, 0.76]), threshold (0.342; [0.11, 0.54]), discrimination (0.556; [0.36, 0.70]), and identification (0.297, [0.06, 0.50]), but not with ODS. Participants performed significantly better on the ODS-Eugenol trial than on the ODS-PEA trial, with median scores of 0.90 (IQR: 0.80, 1.0) and 0.70 (0.50, 0.80), respectively (p < 0.001).</p><p><strong>Conclusions: </strong>NOST correlates strongly with odor discrimination in this community-based population, while ODS shows no significant correlations with any TDI subdomains. The lack of several strong correlations on either assessment with overall TDI suggests these assessments may evaluate domains of smell and cognition not previously captured by standalone TDI testing. Continued validation of NOST and ODS across a broad population with ranging olfactory and cognitive statuses is needed to fully characterize the utility of these well-tolerated, self-administered olfactory tests.</p><p><strong>Level of evidence: 2: </strong></p>","PeriodicalId":49921,"journal":{"name":"Laryngoscope","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145253478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of Mental Fatigue in Individuals With Tinnitus.","authors":"Özlem Icoz, Eser Sendesen","doi":"10.1002/lary.70198","DOIUrl":"https://doi.org/10.1002/lary.70198","url":null,"abstract":"<p><strong>Objective: </strong>Mental fatigue is a common but understudied symptom in individuals with tinnitus. This study aimed to examine the relationship between tinnitus-related distress, anxiety symptoms, and mental fatigue.</p><p><strong>Methods: </strong>A total of 119 participants (52 with tinnitus, 67 healthy controls) were included. All participants completed the Mental Fatigue Scale (MFS) and Generalized Anxiety Disorder-7 (GAD-7). The tinnitus group also completed the Tinnitus Handicap Inventory (THI), Visual Analog Scales (VAS), and psychoacoustic assessments (pitch matching, loudness level, minimum masking level). Group comparisons and correlation analyses were conducted.</p><p><strong>Results: </strong>MFS scores were significantly higher in the tinnitus group than in controls (11.74 ± 5.51 vs. 8.13 ± 4.34, p = 0.015, d = 0.45). A moderate positive correlation was found between mental fatigue and anxiety symptoms (r = 0.44, p = 0.001). Within the tinnitus group, mental fatigue was weakly associated with THI and VAS attention deficit scores (r = 0.31, p = 0.022 and r = 0.30, p = 0.033, respectively), though these did not survive correction for multiple comparisons, nor with tinnitus loudness, masking levels, sleep disturbance, or hearing loss.</p><p><strong>Conclusion: </strong>Mental fatigue in tinnitus appears more closely related to psychological and attentional factors than to auditory variables. Routine screening for fatigue and cognitive complaints may support more comprehensive tinnitus management and improve patient outcomes.</p><p><strong>Level of evidence: 3: </strong></p>","PeriodicalId":49921,"journal":{"name":"Laryngoscope","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145253409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prolonged Treatment Gaps and Recurrence Patterns in Recurrent Respiratory Papillomatosis.","authors":"Sarah Gao, Raymond J So, Ronit Malka, Lee M Akst, Alexander T Hillel, Kevin M Motz, Simon R Best","doi":"10.1002/lary.70175","DOIUrl":"https://doi.org/10.1002/lary.70175","url":null,"abstract":"<p><strong>Objectives: </strong>Recurrent respiratory papillomatosis (RRP) is characterized by an irregular disease course, with recurrences after long periods of remission. New immunologic strategies are under investigation that aim to eliminate the chronic HPV infection. We evaluated recurrence patterns in RRP patients and sought to identify variables associated with prolonged remission periods.</p><p><strong>Methods: </strong>Charts of all RRP patients seen since 2003 at our institution were reviewed. Surgical history and disease status in treatment-free intervals were evaluated. Patient and disease characteristics were compared using chi-squared and Fisher's exact tests in an exploratory analysis.</p><p><strong>Results: </strong>Of 312 RRP patients, 71 (22.8%) experienced a treatment gap (TG) of at least 4 years between treatment and recurrence, with 43 (13.8%) having a TG over 10 years. TG patients did not differ from the remaining cohort in sex, juvenile/adult onset, or other clinical characteristics. To control for the possibility that TG patients resembled the entire cohort because of untreated occult disease, a subset was identified with prolonged (≥ 4 years) definitive remission. Compared to this remission group, TG patients were more likely to undergo surgery rather than office procedures before the gap in treatment (100% vs. 71.4% p = 0.003) and less likely to have supraglottic disease (17.5% vs. 57.1% p = 0.012). Other patient characteristics showed no significant differences.</p><p><strong>Conclusion: </strong>A substantial portion of RRP patients experience recurrence after prolonged treatment-free intervals, and this cohort cannot be easily predicted from available clinical characteristics. This highlights the need for effective immunologic strategies to eliminate the causative chronic infection.</p><p><strong>Level of evidence: 3: </strong></p>","PeriodicalId":49921,"journal":{"name":"Laryngoscope","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145240455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the Role of the CoPE in Relation to Established Laryngology PROMs.","authors":"Camryn R Marshall, James J Lappin, Tyler W Crosby, Steve D Stockton, Yue Ma, VyVy N Young, Clark A Rosen","doi":"10.1002/lary.70163","DOIUrl":"https://doi.org/10.1002/lary.70163","url":null,"abstract":"<p><strong>Objectives: </strong>Laryngology patient-reported outcome measures (PROMs) quantify symptoms related to voice, swallowing, and/or breathing. Vocal Cord Paralysis Experience (CoPE) is a PROM developed to evaluate disabilities associated with unilateral vocal fold paralysis (UVFP). The relationship between disease-specific and general symptom-based PROMs has not been previously studied in Laryngology. Correlations between CoPE and established Laryngology PROMs [e.g., Voice Handicap Index-10 (VHI-10), Eating Assessment Tool-10 (EAT-10), Dyspnea Index (DI)] assessed the role and added benefit of CoPE.</p><p><strong>Methods: </strong>Patients with UVFP at a tertiary Laryngology clinic completed CoPE, VHI-10, EAT-10, and DI during routine visits. Comparisons across PROMs were performed.</p><p><strong>Results: </strong>One hundred and eight unique data collection epochs were obtained from 80 patients (34 men, 46 women), mean age of 62.6 years. Mean scores were 43.4 ± 22 for CoPE, 21.2 ± 10.2 for VHI-10, 9.2 ± 8.5 for EAT-10, and 10.5 ± 9.9 for DI. Comparison of CoPE score to other Laryngology PROMS demonstrated statistically significant, positive correlations: CoPE versus VHI-10 (R = 0.596, p = 0.000), CoPE versus DI (R = 0.424, p = 0.000), and CoPE versus EAT-10 (R = 0.447, p = 0.000). CoPE subscale scores similarly demonstrated statistically significant, positive correlations: CoPE voice subscale versus VHI-10 (R = 0.641, p = 0.000) and CoPE swallowing subscale versus EAT-10 (R = 0.603, p = 0.000).</p><p><strong>Conclusion: </strong>PROMs are critical for assessing UVFP-related functional impairments. CoPE does not appear to capture unique aspects of the UVFP experience not already covered by VHI-10, DI, and EAT-10. Furthermore, these commonly used Laryngology PROMs have broad utility across many pathologic conditions and can be implemented prior to diagnosis, offering psychometric advantages. Clinicians and researchers can confidently employ commonly used Laryngology PROMs or CoPE to report UVFP results.</p><p><strong>Level of evidence: 3: </strong></p>","PeriodicalId":49921,"journal":{"name":"Laryngoscope","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145240329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}