Laryngoscope最新文献

{"title":"In Reference to Is Topical Tranexamic Acid Effective in Treating Epistaxis?","authors":"Abdullah AlDaihani","doi":"10.1002/lary.32143","DOIUrl":"https://doi.org/10.1002/lary.32143","url":null,"abstract":"","PeriodicalId":49921,"journal":{"name":"Laryngoscope","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143765596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Response to: Is Topical Tranexamic Acid Effective in Treating Epistaxis?","authors":"Kelti M Munroe, Leigh J Sowerby, Christopher J Chin","doi":"10.1002/lary.32144","DOIUrl":"https://doi.org/10.1002/lary.32144","url":null,"abstract":"","PeriodicalId":49921,"journal":{"name":"Laryngoscope","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143765597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preventing Hearing Loss in Children Receiving Cisplatin: A Systematic Review and Meta-Analysis.","authors":"Ethan M Kallenberger, Erin E Briggs, Shaun A Nguyen, Peter R Dixon, Allyson V Drawdy, Robert F Labadie, Ted A Meyer, David R White","doi":"10.1002/lary.32158","DOIUrl":"https://doi.org/10.1002/lary.32158","url":null,"abstract":"<p><strong>Objective: </strong>Cisplatin-induced hearing loss leads to significant neurologic, social, and behavioral impairment in children. The goal of this study is to characterize options available to prevent cisplatin-induced hearing loss and to identify gaps in the literature.</p><p><strong>Data sources: </strong>CINAHL, Cochrane Library, PubMed, Scopus.</p><p><strong>Review methods: </strong>Literature was searched between 1990 and 2024. Studies evaluating interventions to prevent hearing loss in children receiving cisplatin were included. Audiometric data including pure tone threshold, pure tone average, and incidence of hearing loss were extracted from included studies.</p><p><strong>Results: </strong>Six studies (N = 760) pertaining to cisplatin-induced hearing loss in children were included. This includes four randomized control trials (N = 652), one nonrandomized control trial (N = 97) and one prospective cohort study (N = 11). The studies examined sodium thiosulfate or amifostine, both given intravenously. The relative risk of hearing loss between intervention and control groups was 0.78 (95% CI 0.71-0.85). The proportion of patients in the treatment group categorized as grade zero on the Brock ototoxicity grading scale was significantly higher (p < 0.0001) than in the control group (36.3% vs. 15.5%). The change in pure tone average after chemotherapy was significantly higher in the control group compared to the intervention group (5.2 vs. -1.2 dB, 95% CI 5.53-7.25).</p><p><strong>Conclusions: </strong>These results show mild success in reducing the incidence of hearing loss in children undergoing chemotherapy with cisplatin. However, the literature is limited, and further investigation is warranted.</p>","PeriodicalId":49921,"journal":{"name":"Laryngoscope","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143755577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artifact Reduction 3.0 T MRI in Cochlear Implantation Recipient With Diametrically Bipolar Magnets.","authors":"Xiaoqing Cen, Meng Wang, Chunxiang Zhou, Huiwen Zhuang, Jincangjian Sun, Qin Xiong, Kaitian Chen, Guanxia Xiong","doi":"10.1002/lary.32114","DOIUrl":"https://doi.org/10.1002/lary.32114","url":null,"abstract":"<p><strong>Objectives: </strong>This study aims to explore the clinical results of the MAVRIC-SL sequence in 3.0 Tesla (T) magnetic resonance imaging (MRI) examination of cochlear implant recipients with diametrically bipolar magnets.</p><p><strong>Study design: </strong>Retrospective study.</p><p><strong>Methods: </strong>Six consecutive patients implanted with diametrically bipolar magnets received a 3.0 T MRI for necessary reexaminations. The artifact volumes (cm³) and maximum artifact areas (cm²) were measured before and after applying the MAVRIC-SL. Adverse events, including discomfort or pain (measured using VAS), skin temperatures, and magnet displacement, were also recorded.</p><p><strong>Results: </strong>All enrolled patients completed the MRI scans. Significant reductions in artifact volumes and maximum areas were observed with the MAVRIC-SL sequence compared to others (p < 0.05 to < 0.01). Targeted disease regions, as well as the inner ear anatomy, were clearly revealed with MAVRIC-SL. One patient (aged 12) reported pain (VAS score: 8) during the scan, while others (aged 10-36) did not experience discomfort. Neither displacement nor tilt of the internal magnet was seen.</p><p><strong>Conclusion: </strong>The MAVRIC-SL sequence represents a feasible and safe solution for 3 T MRI in cochlear implanters with diametrically bipolar magnets, providing a new option to meet clinical needs.</p><p><strong>Level of evidence: 4: </strong></p>","PeriodicalId":49921,"journal":{"name":"Laryngoscope","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143755563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Sleep Deprivation on the Vestibulo-Ocular Reflex and Vestibular Adaptation in Healthcare Night-Shift Workers.","authors":"Nir Livneh, Hadas Ben-Rubi Shimron, Idit Tessler, Noa Rozendorn, Shibli Alsleibi, Amit Wolfovitz, Yoav Gimmon","doi":"10.1002/lary.32160","DOIUrl":"https://doi.org/10.1002/lary.32160","url":null,"abstract":"<p><strong>Objective: </strong>This study investigates the impact of sleep deprivation on the vestibulo-ocular reflex (VOR) in healthcare night-shift workers, focusing on basic VOR function and its adaptation during head movements with varying target distances.</p><p><strong>Methods: </strong>A prospective study was conducted with 14 night-shift healthcare workers, with a final analysis of 11 participants. Testing occurred under two conditions: After normal sleep and after a night shift. VOR gain was measured using the video head impulse test (vHIT) system for both active and passive head movements and for near and far targets. Participants also completed the computerized Dynamic Visual Acuity (c-DVA) test to assess gaze stability and a self-reported vigilance questionnaire.</p><p><strong>Results: </strong>Participants experienced significantly shorter sleep durations and reported lower vigilance levels on the post-night shift. VOR gain was notably reduced (7.5%) only during passive head movements toward a far target after a night shift. Other vestibular functions, such as distance modulation and other measurements including active head impulses, near-target tests, and c-DVA scores, showed no significant differences between normal sleep and sleep-deprived states.</p><p><strong>Conclusion: </strong>Sleep deprivation in healthcare night-shift workers demonstrated a complex effect on VOR, with significant impairment in only one specific condition (passive-far). Most other VOR functions, including adaptation to target distance, were maintained. This resilience may indicate an adaptive mechanism within the vestibular system under chronic sleep-deprived conditions, warranting further research into the underlying protective processes.</p><p><strong>Level of evidence: 3: </strong></p>","PeriodicalId":49921,"journal":{"name":"Laryngoscope","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143755579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving Measurement Efficiency of the Voice Handicap Index-10 With Item Response Theory.","authors":"Elliana Kirsh DeVore, Thomas L Carroll, Maria Edelen, Clark Rosen, Jennifer J Shin","doi":"10.1002/lary.32161","DOIUrl":"https://doi.org/10.1002/lary.32161","url":null,"abstract":"<p><strong>Objectives: </strong>To assess: (1) the Voice Handicap-10 (VHI) instrument with item response theory (IRT) and determine which items convey the most information, (2) the extent to which voice handicap can be measured with a subset of items for efficient information intake, and (3) whether a proposed shorter scale has differing discriminatory ability for key diagnoses made by fellowship-trained laryngologists, as compared to the 10-item instrument.</p><p><strong>Methods: </strong>Prospectively collected data from 3640 patients who completed the VHI-10 questionnaire during evaluation at a tertiary care otolaryngology clinic were utilized. IRT analysis provided discrimination and location parameters associated with each item. Residual item correlations were also assessed to assess redundant information. Based on these results, two 5-item subsets were further evaluated using item information function curves. Areas under receiver-operator characteristic curves (ROC-AUC) were also calculated to evaluate the discriminatory ability for findings from videolaryngoscopy/stroboscopy.</p><p><strong>Results: </strong>Item discrimination parameter estimates ranged from 1.55 to 4.68, with higher values indicating more information. Residual item correlations were determined within item pairs, and location parameters were calculated. Based on these data, potential 5-item subsets were proposed, which preserved the capacity to reflect underlying voice handicap assessment. ROC-AUC analyses suggested no significant difference between the 5-item subset and 10-item instrument with regard to their ability to discriminate whether findings such as vocal fold paralysis were present.</p><p><strong>Conclusions: </strong>IRT data distinguished items for a proposed 5-item subset of the 10-item instrument, with the goal of reflecting the latent trait without significant loss of discrimination and precision.</p><p><strong>Level of evidence: </strong>Level 2-Prospective validation study with reference standard.</p>","PeriodicalId":49921,"journal":{"name":"Laryngoscope","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143755576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation of the VFSS Esophageal Screen to High-Resolution Esophageal Manometry.","authors":"Tyler W Crosby, Joseph Lebowitz, Stamatela Balou, Uche C Ezeh, Abraham Khan, Rita Knotts, Shreya Chablaney, Paul E Kwak, Milan R Amin","doi":"10.1002/lary.32157","DOIUrl":"https://doi.org/10.1002/lary.32157","url":null,"abstract":"<p><strong>Objective: </strong>The videofluoroscopic swallow study (VFSS) is an evaluation of the anatomy and physiology of swallowing, and often includes a screening evaluation of the esophagus. How the esophageal screen translates to esophageal pathology remains unknown. The purpose of this study was to determine if abnormal esophageal clearance (EC) on VFSS correlates with esophageal function on high-resolution esophageal manometry (HREM).</p><p><strong>Materials and methods: </strong>This is a retrospective review of 115 adult patients who underwent both VFSS with esophageal screen and HRM. EC on VFSS was scored with the modified barium swallow impairment profile (MBSImP) component 17. Motility was characterized using HRM metrics according to the Chicago Classification Version 4.0 (CCv4.0). Predictive metrics were calculated for the esophageal screen.</p><p><strong>Results: </strong>An EC score o greater than or equal to 1 had a sensitivity of 66%, specificity of 57%, PPV of 52%, NPV of 70%, and OR of 2.55 (p = 0.027). EC weakly correlated with incomplete bolus clearance (rho = 0.331, p = 0.0004) and did not correlate with bolus transit time (rho = 0.17, p = 0.105).</p><p><strong>Conclusions: </strong>The esophageal screen as characterized by the MBSImP is not an effective predictor of esophageal function on HREM as defined by the CCv4.0. Future work may focus on a defining a standardized VFSS protocol for the esophageal screen and potentially a more nuanced assessment of esophageal findings on VFSS that may enhance the sensitivity of the modality to motility disorders.</p><p><strong>Level of evidence: 3: </strong></p>","PeriodicalId":49921,"journal":{"name":"Laryngoscope","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143743877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Account of Roman Surgical Treatments for Ozena: Historical Review.","authors":"Perry Hammond, Rebecca R Benefiel, Kent Lam","doi":"10.1002/lary.32096","DOIUrl":"https://doi.org/10.1002/lary.32096","url":null,"abstract":"<p><strong>Objective: </strong>To analyze a first-century Roman account of surgery for ozena-a tetrad of nasal crusting, ulceration, bony involvement, and foul odor-with a focus on historical context, etymology, and surgical management.</p><p><strong>Data sources: </strong>This historical review draws from the authors' translation of De Medicina. Primary sources detailing Roman surgical instruments from the House of the Surgeon in Pompeii, as well as secondary sources of surgical techniques, were utilized.</p><p><strong>Review methods: </strong>An in-depth review of Celsus' descriptions of surgical techniques for ozena was conducted using independent translation and exegetical analysis of primary sources. Archaeological findings were investigated to correlate surgical tools with the interventions described.</p><p><strong>Results: </strong>Proto-Indo-European and Classical interpretations of ozena revealed a unifying feature of malodor and a simultaneous relationship to nasal ulceration and suppurative lesions. Celsus detailed two procedures for ozena: closed cauterization using a heated probe and an open technique involving dissection, direct cauterization, and structural repair. These align with ancient Roman understanding of wound care and caustic applications. Three surgical instruments were identified for these procedures based on archaeological finds from the House of the Surgeon in Pompeii and other collections.</p><p><strong>Conclusion: </strong>Celsus' ancient structural interventions for ozena demonstrate an advanced understanding of anatomy and a mastery of instrumentation. This study underscores the importance of the historical contextualization of ancient medical practices, providing a foundation for the treatments of nasal pathology still in use today.</p><p><strong>Levels of evidence: </strong>Not applicable.</p>","PeriodicalId":49921,"journal":{"name":"Laryngoscope","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143743819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased Neck Visual Fixation in Children With Tracheostomies: An Eye-Tracking Study.","authors":"Dorsa Mavedatnia, Justin Levinsky, Siyu Miao, Meera Chopra, Rachel Lim, Meghan Tepsich, Evan J Propst, Nikolaus E Wolter, Jennifer M Siu","doi":"10.1002/lary.32132","DOIUrl":"https://doi.org/10.1002/lary.32132","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study is to objectively quantify the attentional distraction effect of a tracheostomy on visual attention and gaze using eye-tracking technology.</p><p><strong>Methods: </strong>This was a cross-sectional observational study. An eye-tracking device was used to capture eye movements of participants over 5 years of age who were shown 20 images of children with and without tracheostomies. The primary outcome was the number and duration of fixations on different mapped regions of the head and neck, including the central triangle (CT) and peripheral triangle (PT) of the face, and the anterior neck. Facial recall recognition was also assessed and compared across groups.</p><p><strong>Results: </strong>A total of 160 participants were recruited (57% female, median age 18 years, range 6-54 years). The greatest amount of time was spent viewing the CT of both children with and without tracheostomies. Participants viewed the necks of children with tracheotomies 3.7 times more frequently, spent eight times longer viewing the neck, and were more likely to incorrectly recall children with tracheotomies compared with the control group (3.33 vs. 0.85 fixations, p < 0.001; 0.15 vs. 1.12 ms, p < 0.0001; p < 0.001).</p><p><strong>Conclusion: </strong>Viewers who are looking at children with tracheostomies redirect their attention from the face toward the neck and spend a longer duration of time viewing the necks of children with tracheostomies compared to those without. Viewers are also more likely to incorrectly recall the faces of children with tracheostomies. These findings highlight a possible explanation for why social interactions may be different for children with tracheostomies beyond their underlying medical and communication problems.</p><p><strong>Level of evidence: 3: </strong></p>","PeriodicalId":49921,"journal":{"name":"Laryngoscope","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143743977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Olfaction, Eating Preference, and Quality of Life in Cystic Fibrosis Chronic Rhinosinusitis.","authors":"Christine M Liu, Jakob L Fischer, Michelle J Lee, Jess C Mace, Adam J Kimple, Karolin Markarian, Jeremiah A Alt, Todd E Bodner, Naweed I Chowdhury, Sei Y Chung, Patricia H Eshaghian, Yuqing A Gao, Anne E Getz, Peter H Hwang, Ashoke Khanwalkar, Jivianne T Lee, Douglas A Li, Meghan Norris, Jayakar V Nayak, Jonathan B Overdevest, Cameran Owens, Zara M Patel, Lindsay E Pappas, Katie Poch, Rodney J Schlosser, Kristine A Smith, Timothy L Smith, Zachary M Soler, Jeffrey D Suh, Grant A Turner, Marilene B Wang, Jennifer L Taylor-Cousar, Milene T Saavedra, Daniel M Beswick","doi":"10.1002/lary.32155","DOIUrl":"https://doi.org/10.1002/lary.32155","url":null,"abstract":"<p><strong>Objectives: </strong>Olfactory dysfunction (OD) is common among people with cystic fibrosis (PwCF) and chronic rhinosinusitis (CRS). OD is associated with impaired quality of life (QOL) and dietary alterations in certain non-CF populations. This study explored relationships between OD, QOL, and modulator use in PwCF.</p><p><strong>Methods: </strong>This is a cross-sectional analysis of an ongoing multicenter, prospective study (2019-2023) investigating PwCF with comorbid CRS. Participants completed the 40-Question Smell Identification Test (SIT-40), 22-question SinoNasal Outcome Test-(SNOT-22), Questionnaire of Olfactory Disorders (QOD-NS), and Cystic Fibrosis Questionnaire-Revised (CFQ-R). Clinical and sinus CT data were collected. After stratification by SIT-40 score, data was analyzed by chi-square, Kruskal-Wallis, Spearman correlation, and logistic regression to identify factors associated with OD.</p><p><strong>Results: </strong>Of 59 participants, those with anosmia (n = 12) had worse eating-related QOL (CFQ-R eating) compared to individuals with normosmia (n = 16) and hyposmia (n = 31). Participants with anosmia had worse sinus CT scores than those with hyposmia. Although PwCF treated with highly effective modulator therapy (HEMT; n = 30) had better CT scores vs. non-HEMT individuals (n = 23), rates of OD in both groups were comparable. Higher SNOT-22 total scores were associated with increased odds of hyposmia or anosmia. In an eating-related QOD-NS subscore, those with worse CFQ-R eating had 2.38 times higher odds of having OD. Each point decrease in CFQ-R eating domain score was associated with 10% increased odds of OD.</p><p><strong>Conclusion: </strong>In PwCF, OD was associated with increased CRS severity, impaired olfactory QOL, and decreased CFQ-R eating. There were no differences in SIT-40 or QOD-NS scores based on HEMT status.</p><p><strong>Level of evidence: 3: </strong></p><p><strong>Trial registration: </strong>NCT04469439.</p>","PeriodicalId":49921,"journal":{"name":"Laryngoscope","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143743922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}