Laryngoscope最新文献

Quality of Life Outcomes in Vestibular Schwannoma: A Prospective Analysis of Treatment Modalities.

IF 2.2 3区医学

Laryngoscope Pub Date : 2025-02-27 DOI: 10.1002/lary.32080

A Hotchkies, E Heward, A Wadeson, C Heal, S R Freeman, S A Rutherford, A T King, O Pathmanaban, J Halliday, G Whitfield, C McBain, R J Colaco, T Campbell, S J Goh, S K W Lloyd

{"title":"Quality of Life Outcomes in Vestibular Schwannoma: A Prospective Analysis of Treatment Modalities.","authors":"A Hotchkies, E Heward, A Wadeson, C Heal, S R Freeman, S A Rutherford, A T King, O Pathmanaban, J Halliday, G Whitfield, C McBain, R J Colaco, T Campbell, S J Goh, S K W Lloyd","doi":"10.1002/lary.32080","DOIUrl":"https://doi.org/10.1002/lary.32080","url":null,"abstract":"Objective: Management options for vestibular schwannoma include microsurgery (MS), stereotactic radiosurgery (SRS), and watch, wait, and rescan (WWR). This study aimed to evaluate changes in patient and disease-specific quality of life (QoL) outcomes over time, comparing each treatment modality in a matched cohort.Methods: A prospective cohort study recruited adult patients with sporadic vestibular schwannomas ≤ 3 cm in size undergoing treatment between January 2012 and April 2022 in a single tertiary referral center. Questionnaires were completed at diagnosis and ≥ 12 months posttreatment to assess patient-reported changes in QoL (Hearing, Dizziness, Tinnitus Handicap Inventories; Penn Acoustic Neuroma QoL questionnaire (PANQOL) and the Short Form-36 QoL questionnaire (SF-36)).Results: In total, 124 patients returned completed questionnaires (MS: 42, SRS: 42, WWR 40). The SRS group had a clinically significant deterioration in their hearing scores posttreatment (p = 0.002). Dizziness scores worsened in the MS and WWR groups posttreatment; this did not reach clinical significance. Hearing deterioration was identified in the WWR group over time using the PANQOL domain (p = 0.012). The SF-36 questionnaire showed a significant deterioration in physical functioning, role limitations, and component summary for SRS patients posttreatment (p = 0.0018, p = 0.0032, p = 0.0308). No other significant differences were seen in disease-specific or general QoL domains when comparing treatment strategies.Conclusion: Outcomes in similar disease-specific domains were not consistent across questionnaires. All three treatment modalities appear to result in comparable long-term disease-specific QoL outcomes. These findings will enable evidence-based patient counseling to inform decision-making.Level of evidence: 3: ","PeriodicalId":49921,"journal":{"name":"Laryngoscope","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143517157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}