Laryngoscope最新文献_第5页

In response to Attic Retraction Pockets: Classification System. 对阁楼收放口袋的回应：分类系统。

IF 2.2 3区医学

Laryngoscope Pub Date : 2025-03-21 DOI: 10.1002/lary.32154

Nilesh Mahajan

引用次数: 0

In Reference to Attic Retraction Pockets: Classification System. 论阁楼收放袋：分类系统。

IF 2.2 3区医学

Laryngoscope Pub Date : 2025-03-21 DOI: 10.1002/lary.32152

Meliksah Cakir, Fatih Ozdogan, Halil Erdem Ozel, Selahattin Genc

引用次数: 0

Does Dupilumab Improve Sinonasal Outcomes in AERD Patients? Dupilumab能改善AERD患者的鼻窦预后吗？

IF 2.2 3区医学

Laryngoscope Pub Date : 2025-03-21 DOI: 10.1002/lary.32099

Heli Majeethia, Zain Mehdi, Andrew P Lane, Masayoshi Takashima, Omar G Ahmed

引用次数: 0

Characterizing Adenoid Cystic Carcinoma of the Middle Ear-A Rare Entity. 中耳腺样囊性癌的特征--一种罕见实体。

IF 2.2 3区医学

Laryngoscope Pub Date : 2025-03-21 DOI: 10.1002/lary.32134

Masanari G Kato, Seilesh C Babu

{"title":"Characterizing Adenoid Cystic Carcinoma of the Middle Ear-A Rare Entity.","authors":"Masanari G Kato, Seilesh C Babu","doi":"10.1002/lary.32134","DOIUrl":"https://doi.org/10.1002/lary.32134","url":null,"abstract":"Objectives: To characterize patient demographics, tumor features, treatment patterns, and survival outcomes of adenoid cystic carcinoma of the middle ear.Methods: Retrospective review of the Surveillance, Epidemiology, and End Results Database of the National Cancer Institute for all cases of histopathologically confirmed adenoid cystic carcinoma of the middle ear as the primary location.Results: Twenty-one patients with adenoid cystic carcinoma of the middle ear were identified. Patients had a median age of 61 years (range 16-86) and were more commonly female (57.1%) and Caucasian (85.7%). Tumors had a median size of 11 mm (range 5-22) with disease involvement most frequently locally (70%), followed by distant (20%), then regional disease (10%). Most underwent upfront surgery (85.7%) compared to radiation therapy (14.3%). Surgery was often followed by radiation. Five- and ten-year disease-specific survival remained stable at 67.3%.Conclusion: Demographics of middle ear adenoid cystic carcinoma reflect that of other primary locations, with a predilection for middle-aged and female patients. Tumors more often present with local involvement, though distant metastasis is not uncommon. Surgery, followed by radiation, appears to be the favored treatment modality and generally portends a good prognosis, despite involvement of a complicated anatomic location. Further research is necessary to better characterize the disease and define its optimal management.Level of evidence: 4: ","PeriodicalId":49921,"journal":{"name":"Laryngoscope","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143674194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cytological Alterations of Benign Thyroid Nodules Following Radiofrequency Ablation. 射频消融术后良性甲状腺结节的细胞学变化

IF 2.2 3区医学

Laryngoscope Pub Date : 2025-03-21 DOI: 10.1002/lary.32130

Emad Kandil, Mohammad H Hussein, Kavin Sugumar, Milee Patel, Marika Russell, Gregory Randolph, Eman A Toraih

{"title":"Cytological Alterations of Benign Thyroid Nodules Following Radiofrequency Ablation.","authors":"Emad Kandil, Mohammad H Hussein, Kavin Sugumar, Milee Patel, Marika Russell, Gregory Randolph, Eman A Toraih","doi":"10.1002/lary.32130","DOIUrl":"https://doi.org/10.1002/lary.32130","url":null,"abstract":"Background: Radiofrequency ablation (RFA) has emerged as a minimally invasive treatment for benign thyroid nodules. However, concerns exist about potential cytological progression following RFA. This study investigated the incidence of progression from benign (Bethesda II) to indeterminate (Bethesda III-IV) cytology and evaluated RFA's long-term efficacy and safety.Methods: This prospective study included patients with benign thyroid nodules treated with RFA from July 2019 to December 2023. Pre- and post-ablation fine-needle aspiration (FNA) cytology results were analyzed. Treatment efficacy was assessed through nodular volume changes and thyroid function, while safety was evaluated through complication rates.Results: Among 312 benign thyroid nodules treated with RFA, post-ablation FNA showed 12 cases (3.84%) progressed to Bethesda III, all confirmed benign by Afirma Gene Sequencing Classifier. Three patients underwent surgical resection due to inadequate volume reduction, with histopathology confirming benign nature. RFA achieved sustained nodular volume reduction, with a median reduction rate of 88% at 60 months. The overall complication rate was 3.2%, with no major complications requiring hospitalization.Conclusions: RFA demonstrates low risk of cytological progression and high efficacy in treating benign thyroid nodules. The significant volume reduction and favorable safety profile support RFA as a viable surgical alternative in selected patients. Future studies with larger cohorts and longer follow-up are needed to validate these findings and identify treatment success predictors.Level of evidence: 3: ","PeriodicalId":49921,"journal":{"name":"Laryngoscope","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143674530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rapid Intrathecal Fluorescein Injection During Cerebrospinal Fluid Leak Repair Is Safe and Effective. 快速鞘内注射荧光素在脑脊液漏修补术中的安全性和有效性。

IF 2.2 3区医学

Laryngoscope Pub Date : 2025-03-20 DOI: 10.1002/lary.32135

Hussein Mackie, Jacob G Eide, Abdul Yassin-Kassab, Carl Wilson, Amrita Ray, Adam M Robin, Karam Asmaro, Jack P Rock, John R Craig

{"title":"Rapid Intrathecal Fluorescein Injection During Cerebrospinal Fluid Leak Repair Is Safe and Effective.","authors":"Hussein Mackie, Jacob G Eide, Abdul Yassin-Kassab, Carl Wilson, Amrita Ray, Adam M Robin, Karam Asmaro, Jack P Rock, John R Craig","doi":"10.1002/lary.32135","DOIUrl":"https://doi.org/10.1002/lary.32135","url":null,"abstract":"Objective: Intrathecal fluorescein (IF) is effective for localizing nasal cerebrospinal fluid (CSF) leaks along the skull base during endoscopic exploration, with largest studies reporting sensitivities ranging from 66%-93%. Due to reports of intraoperative and postoperative neurologic complications such as seizures and paralysis, surgeons often dilute the fluorescein and inject it intrathecally slowly over a variable amount of time. However, no study has assessed whether rapid IF administration causes the aforementioned risks or whether it affects its accuracy in identifying CSF leaks intraoperatively.Methods: A prospective study was conducted from 2015 to 2024, where all patients undergoing endoscopic exploration and/or repair of CSF rhinorrhea had 0.1 mL of 10% fluorescein (10 mg) mixed with 3-5 mL of patients' CSF injected rapidly via the lumbar drain over a few seconds.Results: Of the 82 included patients, the mean age was 53.8 ± 15.2 years, and 84% were female. Sixty-nine patients underwent successful endoscopic CSF leak repairs, and 13 had negative endoscopic explorations. Rapid IF injection was 80% sensitive (20% false negative rate) and 100% specific for identifying CSF leaks, and it caused no seizures, paralysis, or other neurologic complications.Conclusion: Compared to prior reports of slow low-dose IF injection for CSF leak localization, rapid IF injection yielded similar efficacy (80% sensitivity) with no IF-related complications. Rapid IF injection was safe and effective but should be corroborated by future studies.Level of evidence: 4: ","PeriodicalId":49921,"journal":{"name":"Laryngoscope","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143665204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cost Savings Analysis for Otolaryngologic Medications Using Direct-to-Consumer Models. 使用直接面向消费者模型的耳鼻喉科药物的成本节约分析。

IF 2.2 3区医学

Laryngoscope Pub Date : 2025-03-19 DOI: 10.1002/lary.32097

Om B Tripathi, Aman M Patel, Hassaam S Choudhry, David W Wassef, Paul T Cowan, Richard Chan Woo Park, Andrey Filimonov

引用次数: 0

Contrast Agent Uptake in Endolymphatic Sac and Duct: Inverse Relation to Endolymphatic Hydrops. 内淋巴囊和导管内造影剂摄取：与内淋巴水肿呈反比关系。

IF 2.2 3区医学

Laryngoscope Pub Date : 2025-03-19 DOI: 10.1002/lary.32127

Johannes Gerb, Emilie Kierig, Valerie Kirsch, Sandra Becker-Bense, Rainer Boegle, Thomas Brandt, Marianne Dieterich

{"title":"Contrast Agent Uptake in Endolymphatic Sac and Duct: Inverse Relation to Endolymphatic Hydrops.","authors":"Johannes Gerb, Emilie Kierig, Valerie Kirsch, Sandra Becker-Bense, Rainer Boegle, Thomas Brandt, Marianne Dieterich","doi":"10.1002/lary.32127","DOIUrl":"https://doi.org/10.1002/lary.32127","url":null,"abstract":"Objectives: Ménière's disease (MD) and vestibular migraine (VM) can be associated with endolymphatic hydrops (ELH). The differential role of the endolymphatic sac and duct (ES/ED) system for the development of ELH is poorly understood.Methods: On 251 delayed, contrast-enhanced inner ear MRI (iMRI) datasets from neurotological patients and healthy control participants, we evaluated (1) the visibility of the ES/ED system using a novel semi-quantitative scale, and (2) the dimensions of ELH, calculated using volumetric local thresholding (VOLT). Afterwards, statistical analysis of ES/ED radiologic visibility in relation to the grade of ELH, the degree of clinical symptoms, and audiometric findings was performed.Results: Patients were divided into an MD cohort (n = 68, 34 females, mean age 54.5 ± 14.8 years) and a VM cohort (n = 67, 42 females, 45.9 ± 15.5 years). The remaining datasets did not fulfill diagnostic criteria for definite diagnoses (n = 64, 27 females, mean age 51.3 ± 16.6) or were from healthy controls (HC; n = 52, 27 females, 49.0 ± 18.1 years). MD patients showed the lowest ES/ED-visibility scores on the affected side (ANOVA F(172,2): 20.60, p < 0.001), while the ES/ED-visibility on the non-affected side in MD patients was still significantly lower than in VM and HC (ANOVA F(172,2): 6.80, p 1.44 × 10-3). The ES/ED-visibility score and ELH volume (determined by VOLT, in mm3) correlated inversely (Spearman's rho: -0.32, Fisher's z -0.34, p < 0.001).Conclusion: ES/ED radiologic visibility in iMRI is inversely associated with ELH volumes. Patients with MD show substantially decreased ES/ED visibility on the affected ear and (less pronounced) on the unaffected ear, while VM and HC exhibit normal ES/ED visibility.Level of evidence: 3: ","PeriodicalId":49921,"journal":{"name":"Laryngoscope","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143659480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Defining the Appropriate Length of Antimicrobial Therapy for Skull Base Osteomyelitis. 确定颅底骨髓炎抗菌治疗的适当时间。

IF 2.2 3区医学

Laryngoscope Pub Date : 2025-03-19 DOI: 10.1002/lary.32113

Monica Trent, Kathleen M Kelly, Donald Tan, Jonathan Korpon, Jacob B Hunter, Hamid R Djalilian, Edward C Kuan, Ashleigh A Halderman

{"title":"Defining the Appropriate Length of Antimicrobial Therapy for Skull Base Osteomyelitis.","authors":"Monica Trent, Kathleen M Kelly, Donald Tan, Jonathan Korpon, Jacob B Hunter, Hamid R Djalilian, Edward C Kuan, Ashleigh A Halderman","doi":"10.1002/lary.32113","DOIUrl":"https://doi.org/10.1002/lary.32113","url":null,"abstract":"Objectives: Skull base osteomyelitis (SBO) is a rare infection comprising either the lateral (LSBO), central (CSBO), or both lateral and central (BSBO) skull base. Due to its rarity, the optimal length of antimicrobial therapy (AMT) has not been well defined. Therefore, the purpose of this study was to identify factors that may influence outcomes of SBO and formulate clearer recommendations on AMT duration.Methods: A multi-institutional retrospective cohort study of SBO patients was conducted. Patient demographics, medical comorbidities, presenting symptoms, laboratory results, radiographic imaging, surgical treatment, culture results, length of follow-up, and type, length, and number of AMT courses were collected.Results: Sixty-five patients were included. The average age was 66.5 years, and the average length of symptoms (LOS) prior to diagnosis was 3.74 months. The most common pathogen was Pseudomonas aeruginosa (n = 23) followed by coagulase-negative Staphylococcus species (n = 15). The average length of IV AMT was 6.8 weeks, and the average total length of AMT (TLA) was 15.7 weeks. Positive fungal cultures were associated with longer TLA (22.6 vs. 13.7 weeks, p = 0.02) and a greater number of distinct courses of AMT (4.1 vs. 2.7, p = 0.01).Conclusion: In this series, the average length of IV AMT was 6.8 weeks. The average TLA was 15.7 weeks, indicating that a minimum of 6 weeks of IV AMT followed by a prolonged course of oral AMT is necessary to treat most cases of SBO. Fungal involvement significantly impacts the duration of AMT. Clinical guidelines are needed to better define the management of this complex disease.Level of evidence: 4: ","PeriodicalId":49921,"journal":{"name":"Laryngoscope","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143659487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Sheep Head Versus the Pig Head as a Training Model for Sialendoscopy. 羊头与猪头作为鼻内窥镜的训练模型。

IF 2.2 3区医学

Laryngoscope Pub Date : 2025-03-19 DOI: 10.1002/lary.32126

Urs Borner, Samuel Tschopp, Michael Stewart, Olcay Cem Bulut, Frederic Faure, Gunther Pabst, Robert Irvine, Hila Klein, Shirish Ghan, Claudio Cernea, Zahoor Ahmad, David Eisele, Sandro de Paiva Leite, Marco Caversaccio, Lukas Anschuetz, Jean Michel Lopez, Francois Marchal, Siu-Kwan Ng, Olivier Abboud, Francis Marchal

{"title":"The Sheep Head Versus the Pig Head as a Training Model for Sialendoscopy.","authors":"Urs Borner, Samuel Tschopp, Michael Stewart, Olcay Cem Bulut, Frederic Faure, Gunther Pabst, Robert Irvine, Hila Klein, Shirish Ghan, Claudio Cernea, Zahoor Ahmad, David Eisele, Sandro de Paiva Leite, Marco Caversaccio, Lukas Anschuetz, Jean Michel Lopez, Francois Marchal, Siu-Kwan Ng, Olivier Abboud, Francis Marchal","doi":"10.1002/lary.32126","DOIUrl":"https://doi.org/10.1002/lary.32126","url":null,"abstract":"Objective: Sialendoscopy is a minimally invasive technique for treating inflammatory salivary gland diseases, requiring hands-on training due to its steep learning curve. While pig heads have been the standard training model for over two decades, sheep heads have recently emerged as an alternative. This study evaluates the efficiency of sheep heads for sialendoscopy training in newcomers.Methods: Participants of the 32nd International Sialendoscopy Hands-on Course (Geneva, 2023) performed sialendoscopies on fresh pig and sheep heads. Self-assessment questionnaires were completed pre- and post-training, with procedures rated on a Likert scale. Tutors evaluated participants using standardized assessments and recorded procedural times.Results: Among 52 participants from 27 countries, significant improvement in diagnostic sialendoscopy comfort was reported for both models post-training. Female participants demonstrated higher success rates than male participants in diagnostic (2.8 vs. 2.5, p = 0.03) and therapeutic (2.9 vs. 2.4, p = 0.03) procedures. More participants successfully cannulated the parotid duct on sheep heads, while submandibular gland performance was comparable across models. Self-assessments favored sheep for parotid (63%) and pigs for submandibular (79%). Overall, 53% preferred the pig model, while 47% preferred the sheep.Conclusion: Both models are effective for training, with sheep heads offering advantages for parotid duct procedures. Despite the pig model's broader applications, logistical, cultural, and ethical constraints make sheep heads a viable alternative for sialendoscopy training.Level of evidence: N/A.","PeriodicalId":49921,"journal":{"name":"Laryngoscope","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143659497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0