Mathematical Biosciences and Engineering最新文献

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Unveiling critical ADHD biomarkers in limbic system and cerebellum using a binary hypothesis testing approach. 利用二元假设检验方法揭示边缘系统和小脑中关键的多动症生物标志物。
IF 2.6 4区 工程技术
Mathematical Biosciences and Engineering Pub Date : 2024-04-28 DOI: 10.3934/mbe.2024256
Ying Chen, Lele Wang, Zhixin Li, Yibin Tang, Zhan Huan
{"title":"Unveiling critical ADHD biomarkers in limbic system and cerebellum using a binary hypothesis testing approach.","authors":"Ying Chen, Lele Wang, Zhixin Li, Yibin Tang, Zhan Huan","doi":"10.3934/mbe.2024256","DOIUrl":"https://doi.org/10.3934/mbe.2024256","url":null,"abstract":"<p><p>Attention deficit hyperactivity disorder (ADHD) is a common childhood developmental disorder. In recent years, pattern recognition methods have been increasingly applied to neuroimaging studies of ADHD. However, these methods often suffer from limited accuracy and interpretability, impeding their contribution to the identification of ADHD-related biomarkers. To address these limitations, we applied the amplitude of low-frequency fluctuation (ALFF) results for the limbic system and cerebellar network as input data and conducted a binary hypothesis testing framework for ADHD biomarker detection. Our study on the ADHD-200 dataset at multiple sites resulted in an average classification accuracy of 93%, indicating strong discriminative power of the input brain regions between the ADHD and control groups. Moreover, our approach identified critical brain regions, including the thalamus, hippocampal gyrus, and cerebellum Crus 2, as biomarkers. Overall, this investigation uncovered potential ADHD biomarkers in the limbic system and cerebellar network through the use of ALFF realizing highly credible results, which can provide new insights for ADHD diagnosis and treatment.</p>","PeriodicalId":49870,"journal":{"name":"Mathematical Biosciences and Engineering","volume":"21 4","pages":"5803-5825"},"PeriodicalIF":2.6,"publicationDate":"2024-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141318833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bayesian inverse problem for a fractional diffusion model of cell migration. 细胞迁移分数扩散模型的贝叶斯逆问题。
IF 2.6 4区 工程技术
Mathematical Biosciences and Engineering Pub Date : 2024-04-28 DOI: 10.3934/mbe.2024257
Francisco Julian Ariza-Hernandez, Juan Carlos Najera-Tinoco, Martin Patricio Arciga-Alejandre, Eduardo Castañeda-Saucedo, Jorge Sanchez-Ortiz
{"title":"Bayesian inverse problem for a fractional diffusion model of cell migration.","authors":"Francisco Julian Ariza-Hernandez, Juan Carlos Najera-Tinoco, Martin Patricio Arciga-Alejandre, Eduardo Castañeda-Saucedo, Jorge Sanchez-Ortiz","doi":"10.3934/mbe.2024257","DOIUrl":"https://doi.org/10.3934/mbe.2024257","url":null,"abstract":"<p><p>In the present work, both direct and inverse problems are considered for a Fisher-type fractional diffusion equation, which is proposed to describe the phenomenon of cell migration. For the direct problem, a solution is given via the Fourier method and the Laplace transform. On the other hand, we solved the inverse problem from a Bayesian statistical framework using a set of data that are the result of a cell migration experiment on a wound closure assay. We estimated the parameters of the mathematical model via Markov Chain Monte Carlo methods.</p>","PeriodicalId":49870,"journal":{"name":"Mathematical Biosciences and Engineering","volume":"21 4","pages":"5826-5837"},"PeriodicalIF":2.6,"publicationDate":"2024-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141318765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Research on a vehicle and pedestrian detection algorithm based on improved attention and feature fusion. 基于改进的注意力和特征融合的车辆和行人检测算法研究。
IF 2.6 4区 工程技术
Mathematical Biosciences and Engineering Pub Date : 2024-04-26 DOI: 10.3934/mbe.2024255
Wenjie Liang
{"title":"Research on a vehicle and pedestrian detection algorithm based on improved attention and feature fusion.","authors":"Wenjie Liang","doi":"10.3934/mbe.2024255","DOIUrl":"https://doi.org/10.3934/mbe.2024255","url":null,"abstract":"<p><p>With the widespread integration of deep learning in intelligent transportation and various industrial sectors, target detection technology is gradually becoming one of the key research areas. Accurately detecting road vehicles and pedestrians is of great significance for the development of autonomous driving technology. Road object detection faces problems such as complex backgrounds, significant scale changes, and occlusion. To accurately identify traffic targets in complex environments, this paper proposes a road target detection algorithm based on the enhanced YOLOv5s. This algorithm introduces the weighted enhanced polarization self attention (WEPSA) self-attention mechanism, which uses spatial attention and channel attention to strengthen the important features extracted by the feature extraction network and suppress insignificant background information. In the neck network, we designed a weighted feature fusion network (CBiFPN) to enhance neck feature representation and enrich semantic information. This strategic feature fusion not only boosts the algorithm's adaptability to intricate scenes, but also contributes to its robust performance. Then, the bounding box regression loss function uses EIoU to accelerate model convergence and reduce losses. Finally, a large number of experiments have shown that the improved YOLOv5s algorithm achieves mAP@0.5 scores of 92.8% and 53.5% on the open-source datasets KITTI and Cityscapes. On the self-built dataset, the mAP@0.5 reaches 88.7%, which is 1.7%, 3.8%, and 3.3% higher than YOLOv5s, respectively, ensuring real-time performance while improving detection accuracy. In addition, compared to the latest YOLOv7 and YOLOv8, the improved YOLOv5 shows good overall performance on the open-source datasets.</p>","PeriodicalId":49870,"journal":{"name":"Mathematical Biosciences and Engineering","volume":"21 4","pages":"5782-5802"},"PeriodicalIF":2.6,"publicationDate":"2024-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141318799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The switching and learning behavior of an octopus cell implemented on FPGA. 在 FPGA 上实现章鱼细胞的开关和学习行为。
IF 2.6 4区 工程技术
Mathematical Biosciences and Engineering Pub Date : 2024-04-25 DOI: 10.3934/mbe.2024254
Alexej Tschumak, Frank Feldhoff, Frank Klefenz
{"title":"The switching and learning behavior of an octopus cell implemented on FPGA.","authors":"Alexej Tschumak, Frank Feldhoff, Frank Klefenz","doi":"10.3934/mbe.2024254","DOIUrl":"https://doi.org/10.3934/mbe.2024254","url":null,"abstract":"<p><p>A dendrocentric backpropagation spike timing-dependent plasticity learning rule has been derived based on temporal logic for a single octopus neuron. It receives parallel spike trains and collectively adjusts its synaptic weights in the range [0, 1] during training. After the training phase, it spikes in reaction to event signaling input patterns in sensory streams. The learning and switching behavior of the octopus cell has been implemented in field-programmable gate array (FPGA) hardware. The application in an FPGA is described and the proof of concept for its application in hardware that was obtained by feeding it with spike cochleagrams is given; also, it is verified by performing a comparison with the pre-computed standard software simulation results.</p>","PeriodicalId":49870,"journal":{"name":"Mathematical Biosciences and Engineering","volume":"21 4","pages":"5762-5781"},"PeriodicalIF":2.6,"publicationDate":"2024-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141318831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multi-phase features interaction transformer network for liver tumor segmentation and microvascular invasion assessment in contrast-enhanced CT. 用于对比增强 CT 中肝脏肿瘤分割和微血管侵犯评估的多相位特征交互变压器网络
IF 2.6 4区 工程技术
Mathematical Biosciences and Engineering Pub Date : 2024-04-24 DOI: 10.3934/mbe.2024253
Wencong Zhang, Yuxi Tao, Zhanyao Huang, Yue Li, Yingjia Chen, Tengfei Song, Xiangyuan Ma, Yaqin Zhang
{"title":"Multi-phase features interaction transformer network for liver tumor segmentation and microvascular invasion assessment in contrast-enhanced CT.","authors":"Wencong Zhang, Yuxi Tao, Zhanyao Huang, Yue Li, Yingjia Chen, Tengfei Song, Xiangyuan Ma, Yaqin Zhang","doi":"10.3934/mbe.2024253","DOIUrl":"https://doi.org/10.3934/mbe.2024253","url":null,"abstract":"<p><p>Precise segmentation of liver tumors from computed tomography (CT) scans is a prerequisite step in various clinical applications. Multi-phase CT imaging enhances tumor characterization, thereby assisting radiologists in accurate identification. However, existing automatic liver tumor segmentation models did not fully exploit multi-phase information and lacked the capability to capture global information. In this study, we developed a pioneering multi-phase feature interaction Transformer network (MI-TransSeg) for accurate liver tumor segmentation and a subsequent microvascular invasion (MVI) assessment in contrast-enhanced CT images. In the proposed network, an efficient multi-phase features interaction module was introduced to enable bi-directional feature interaction among multiple phases, thus maximally exploiting the available multi-phase information. To enhance the model's capability to extract global information, a hierarchical transformer-based encoder and decoder architecture was designed. Importantly, we devised a multi-resolution scales feature aggregation strategy (MSFA) to optimize the parameters and performance of the proposed model. Subsequent to segmentation, the liver tumor masks generated by MI-TransSeg were applied to extract radiomic features for the clinical applications of the MVI assessment. With Institutional Review Board (IRB) approval, a clinical multi-phase contrast-enhanced CT abdominal dataset was collected that included 164 patients with liver tumors. The experimental results demonstrated that the proposed MI-TransSeg was superior to various state-of-the-art methods. Additionally, we found that the tumor mask predicted by our method showed promising potential in the assessment of microvascular invasion. In conclusion, MI-TransSeg presents an innovative paradigm for the segmentation of complex liver tumors, thus underscoring the significance of multi-phase CT data exploitation. The proposed MI-TransSeg network has the potential to assist radiologists in diagnosing liver tumors and assessing microvascular invasion.</p>","PeriodicalId":49870,"journal":{"name":"Mathematical Biosciences and Engineering","volume":"21 4","pages":"5735-5761"},"PeriodicalIF":2.6,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141318794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
EMG gesture signal analysis towards diagnosis of upper limb using dual-pathway convolutional neural network. 利用双通路卷积神经网络对 EMG 手势信号进行分析,以诊断上肢疾病。
IF 2.6 4区 工程技术
Mathematical Biosciences and Engineering Pub Date : 2024-04-24 DOI: 10.3934/mbe.2024252
Hafiz Ghulam Murtza Qamar, Muhammad Farrukh Qureshi, Zohaib Mushtaq, Zubariah Zubariah, Muhammad Zia Ur Rehman, Nagwan Abdel Samee, Noha F Mahmoud, Yeong Hyeon Gu, Mohammed A Al-Masni
{"title":"EMG gesture signal analysis towards diagnosis of upper limb using dual-pathway convolutional neural network.","authors":"Hafiz Ghulam Murtza Qamar, Muhammad Farrukh Qureshi, Zohaib Mushtaq, Zubariah Zubariah, Muhammad Zia Ur Rehman, Nagwan Abdel Samee, Noha F Mahmoud, Yeong Hyeon Gu, Mohammed A Al-Masni","doi":"10.3934/mbe.2024252","DOIUrl":"https://doi.org/10.3934/mbe.2024252","url":null,"abstract":"<p><p>This research introduces a novel dual-pathway convolutional neural network (DP-CNN) architecture tailored for robust performance in Log-Mel spectrogram image analysis derived from raw multichannel electromyography signals. The primary objective is to assess the effectiveness of the proposed DP-CNN architecture across three datasets (NinaPro DB1, DB2, and DB3), encompassing both able-bodied and amputee subjects. Performance metrics, including accuracy, precision, recall, and F1-score, are employed for comprehensive evaluation. The DP-CNN demonstrates notable mean accuracies of 94.93 ± 1.71% and 94.00 ± 3.65% on NinaPro DB1 and DB2 for healthy subjects, respectively. Additionally, it achieves a robust mean classification accuracy of 85.36 ± 0.82% on amputee subjects in DB3, affirming its efficacy. Comparative analysis with previous methodologies on the same datasets reveals substantial improvements of 28.33%, 26.92%, and 39.09% over the baseline for DB1, DB2, and DB3, respectively. The DP-CNN's superior performance extends to comparisons with transfer learning models for image classification, reaffirming its efficacy. Across diverse datasets involving both able-bodied and amputee subjects, the DP-CNN exhibits enhanced capabilities, holding promise for advancing myoelectric control.</p>","PeriodicalId":49870,"journal":{"name":"Mathematical Biosciences and Engineering","volume":"21 4","pages":"5712-5734"},"PeriodicalIF":2.6,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141318773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retraction notice to "Kinesin family member 15 can promote the proliferation of glioblastoma" [Mathematical Biosciences and Engineering 19(8) (2022) 8259-8272]. 驱动蛋白家族成员 15 能促进胶质母细胞瘤的增殖》的撤稿通知 [Mathematical Biosciences and Engineering 19(8) (2022) 8259-8272]。
IF 2.6 4区 工程技术
Mathematical Biosciences and Engineering Pub Date : 2024-04-22 DOI: 10.3934/mbe.2024250
Editorial Office Of Mathematical Biosciences And Engineering
{"title":"Retraction notice to \"Kinesin family member 15 can promote the proliferation of glioblastoma\" [<i>Mathematical Biosciences and Engineering</i> 19(8) (2022) 8259-8272].","authors":"Editorial Office Of Mathematical Biosciences And Engineering","doi":"10.3934/mbe.2024250","DOIUrl":"10.3934/mbe.2024250","url":null,"abstract":"","PeriodicalId":49870,"journal":{"name":"Mathematical Biosciences and Engineering","volume":"21 4","pages":"5686"},"PeriodicalIF":2.6,"publicationDate":"2024-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141318801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Stability and Hopf bifurcation of an intraguild prey-predator fishery model with two delays and Michaelis-Menten type predator harvest. 具有两个延迟和 Michaelis-Menten 型捕食者收获的野内猎物-捕食者渔业模型的稳定性和霍普夫分岔。
IF 2.6 4区 工程技术
Mathematical Biosciences and Engineering Pub Date : 2024-04-22 DOI: 10.3934/mbe.2024251
Min Hou, Tonghua Zhang, Sanling Yuan
{"title":"Stability and Hopf bifurcation of an intraguild prey-predator fishery model with two delays and Michaelis-Menten type predator harvest.","authors":"Min Hou, Tonghua Zhang, Sanling Yuan","doi":"10.3934/mbe.2024251","DOIUrl":"https://doi.org/10.3934/mbe.2024251","url":null,"abstract":"<p><p>In this paper, we have proposed and investigated an intraguild predator-prey system incorporating two delays and a harvesting mechanism based on the Michaelis-Menten principle, and it was assumed that the two species compete for a shared resource. Firstly, we examined the properties of the relevant characteristic equations to derive sufficient conditions for the asymptotical stability of equilibria in the delayed model and the existence of Hopf bifurcation. Using the normal form method and the central manifold theorem, we analyzed the stability and direction of periodic solutions arising from Hopf bifurcations. Our theoretical findings were subsequently validated through numerical simulations. Furthermore, we explored the impact of harvesting on the quantity of biological resources and examined the critical values associated with the two delays.</p>","PeriodicalId":49870,"journal":{"name":"Mathematical Biosciences and Engineering","volume":"21 4","pages":"5687-5711"},"PeriodicalIF":2.6,"publicationDate":"2024-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141318804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bifurcation analysis in a modified Leslie-Gower predator-prey model with fear effect and multiple delays. 具有恐惧效应和多重延迟的改良莱斯利-高尔捕食者-猎物模型的分岔分析
IF 2.6 4区 工程技术
Mathematical Biosciences and Engineering Pub Date : 2024-04-19 DOI: 10.3934/mbe.2024249
Shuo Yao, Jingen Yang, Sanling Yuan
{"title":"Bifurcation analysis in a modified Leslie-Gower predator-prey model with fear effect and multiple delays.","authors":"Shuo Yao, Jingen Yang, Sanling Yuan","doi":"10.3934/mbe.2024249","DOIUrl":"https://doi.org/10.3934/mbe.2024249","url":null,"abstract":"<p><p>In this paper, we explored a modified Leslie-Gower predator-prey model incorporating a fear effect and multiple delays. We analyzed the existence and local stability of each potential equilibrium. Furthermore, we investigated the presence of periodic solutions via Hopf bifurcation bifurcated from the positive equilibrium with respect to both delays. By utilizing the normal form theory and the center manifold theorem, we investigated the direction and stability of these periodic solutions. Our theoretical findings were validated through numerical simulations, which demonstrated that the fear delay could trigger a stability shift at the positive equilibrium. Additionally, we observed that an increase in fear intensity or the presence of substitute prey reinforces the stability of the positive equilibrium.</p>","PeriodicalId":49870,"journal":{"name":"Mathematical Biosciences and Engineering","volume":"21 4","pages":"5658-5685"},"PeriodicalIF":2.6,"publicationDate":"2024-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141318766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Population mobility, well-mixed clustering and disease spread: a look at COVID-19 Spread in the United States and preventive policy insights. 人口流动、混合群聚与疾病传播:COVID-19 在美国的传播情况及预防政策启示。
IF 2.6 4区 工程技术
Mathematical Biosciences and Engineering Pub Date : 2024-04-16 DOI: 10.3934/mbe.2024247
David Lyver, Mihai Nica, Corentin Cot, Giacomo Cacciapaglia, Zahra Mohammadi, Edward W Thommes, Monica-Gabriela Cojocaru
{"title":"Population mobility, well-mixed clustering and disease spread: a look at COVID-19 Spread in the United States and preventive policy insights.","authors":"David Lyver, Mihai Nica, Corentin Cot, Giacomo Cacciapaglia, Zahra Mohammadi, Edward W Thommes, Monica-Gabriela Cojocaru","doi":"10.3934/mbe.2024247","DOIUrl":"https://doi.org/10.3934/mbe.2024247","url":null,"abstract":"<p><p>The epidemiology of pandemics is classically viewed using geographical and political borders; however, these artificial divisions can result in a misunderstanding of the current epidemiological state within a given region. To improve upon current methods, we propose a clustering algorithm which is capable of recasting regions into well-mixed clusters such that they have a high level of interconnection while minimizing the external flow of the population towards other clusters. Moreover, we analyze and identify so-called core clusters, clusters that retain their features over time (temporally stable) and independent of the presence or absence of policy measures. In order to demonstrate the capabilities of this algorithm, we use USA county-level cellular mobility data to divide the country into such clusters. Herein, we show a more granular spread of SARS-CoV-2 throughout the first weeks of the pandemic. Moreover, we are able to identify areas (groups of counties) that were experiencing above average levels of transmission within a state, as well as pan-state areas (clusters overlapping more than one state) with very similar disease spread. Therefore, our method enables policymakers to make more informed decisions on the use of public health interventions within their jurisdiction, as well as guide collaboration with surrounding regions to benefit the general population in controlling the spread of communicable diseases.</p>","PeriodicalId":49870,"journal":{"name":"Mathematical Biosciences and Engineering","volume":"21 4","pages":"5604-5633"},"PeriodicalIF":2.6,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141318797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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