Molecular Aspects of Medicine最新文献_第5页

Optogenetic tools and their applications for therapeutic intervention in end-stage inherited retinal diseases 光遗传学工具及其在终末期遗传性视网膜疾病治疗干预中的应用

IF 10.3 2区医学

Molecular Aspects of Medicine Pub Date : 2025-10-01 Epub Date: 2025-08-28 DOI: 10.1016/j.mam.2025.101388

Elizaveta Podoliak , Gabriela Guzman , Volker Busskamp

{"title":"Optogenetic tools and their applications for therapeutic intervention in end-stage inherited retinal diseases","authors":"Elizaveta Podoliak , Gabriela Guzman , Volker Busskamp","doi":"10.1016/j.mam.2025.101388","DOIUrl":"10.1016/j.mam.2025.101388","url":null,"abstract":"<div><div>Retinal degenerative diseases pose significant therapeutic challenges; however, optogenetic vision restoration offers a promising strategy that is independent of mutations and disease progression. Optogenetic tools consisting of photosensitive membrane proteins can be ectopically expressed in retinal cells, effectively converting them into artificial photoreceptors. This review outlines the development and application of optogenetic tools to restore light sensitivity in degenerated retinas. A thorough understanding of retinal cell morphology, pathological remodeling, and functional loss is critical to identifying optimal cellular targets to maximize retinal signal restoration and achieve challenging visual outcomes. Precise delivery and expression of tailored optogenetic tools in specific retinal cell types is critical for clinical success. While recent efforts have focused on achieving vision restoration at ambient light levels, other considerations such as dynamic light adaptation, inner retinal signal processing, and improved visual resolution have emerged as critical factors. Technologies such as optogenetic stimulation goggles integrated with artificial intelligence have the potential to improve visual quality in treated patients. This review also summarizes the preclinical fundamentals and highlights the first clinical successes, underscoring that optogenetic vision restoration is on its way to becoming an effective therapy for restoring meaningful vision to people affected by blindness.</div></div>","PeriodicalId":49798,"journal":{"name":"Molecular Aspects of Medicine","volume":"105 ","pages":"Article 101388"},"PeriodicalIF":10.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144907976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Liver aging: underlying mechanisms and therapeutic strategies 肝衰老：潜在机制和治疗策略

IF 10.3 2区医学

Molecular Aspects of Medicine Pub Date : 2025-10-01 Epub Date: 2025-08-30 DOI: 10.1016/j.mam.2025.101397

Ling Zhong , Liu Wang , Jibran Nehal Syed , Jielin Yang , Yuwei Zhang

{"title":"Liver aging: underlying mechanisms and therapeutic strategies","authors":"Ling Zhong , Liu Wang , Jibran Nehal Syed , Jielin Yang , Yuwei Zhang","doi":"10.1016/j.mam.2025.101397","DOIUrl":"10.1016/j.mam.2025.101397","url":null,"abstract":"<div><div>The accelerating pace of global aging underscores the urgent need to address age-related physiological decline and its associated pathologies. The liver, a central organ for metabolic and immune regulation, undergoes structural and functional deterioration with advanced age, positioning liver aging as a critical concern in geriatric medicine. Due to the liver's cellular heterogeneity and complex physiology, our understanding of its aging mechanisms remains fragmented, lacking an integrated framework to consolidate factors such as oxidative stress, inflammaging, metabolic reprogramming, genomic instability, and epigenetic dysregulation. This review systematically summarizes the physiological processes and molecular mechanisms of liver aging, explores its contributions to disease progression, and discusses current intervention strategies, including dietary and exercise regimens, pharmacological therapies, and gene-editing technologies. By synthesizing existing evidence, this review provides a theoretical framework to advance the understanding of the pathophysiological mechanisms underlying liver aging and inform the development of innovative anti-aging interventions.</div></div>","PeriodicalId":49798,"journal":{"name":"Molecular Aspects of Medicine","volume":"105 ","pages":"Article 101397"},"PeriodicalIF":10.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144916860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evolution of the incidence of male fertility disorders over the last decades 近几十年来男性生育障碍发病率的演变

IF 10.3 2区医学

Molecular Aspects of Medicine Pub Date : 2025-10-01 Epub Date: 2025-08-28 DOI: 10.1016/j.mam.2025.101398

Francesco Pallotti , Alessandra Buonacquisto , Gaia Cicolani , Anna Chiara Conflitti , Francesco Lombardo , Donatella Paoli

引用次数: 0

Cardiovascular impact of emerging and Re-emerging Viruses: Pathophysiological mechanisms, diagnosis, and management with a pediatric focus 新出现的和再出现的病毒对心血管的影响：病理生理机制、诊断和管理，以儿科为重点

IF 8.7 2区医学

Molecular Aspects of Medicine Pub Date : 2025-08-01 Epub Date: 2025-05-26 DOI: 10.1016/j.mam.2025.101371

Li Li , Xu Shi , Ruiming Wang , Yuxi Fan , Zhihan Xu , Habibollah Mirzaei , Wuran Wei

{"title":"Cardiovascular impact of emerging and Re-emerging Viruses: Pathophysiological mechanisms, diagnosis, and management with a pediatric focus","authors":"Li Li , Xu Shi , Ruiming Wang , Yuxi Fan , Zhihan Xu , Habibollah Mirzaei , Wuran Wei","doi":"10.1016/j.mam.2025.101371","DOIUrl":"10.1016/j.mam.2025.101371","url":null,"abstract":"<div><div>Emerging and re-emerging viruses are currently known as a major public health issue. These viruses can cause various human complications such as cardiovascular diseases (CVDs), both in adults and pediatric populations. Although various CVDs have been previously reported for emerging and re-emerging viruses, the mechanisms underlying these complications remain relatively unknown. Children and infants, while commonly developing less severe symptoms, may experience notable cardiovascular manifestations during infections caused by emerging and re-emerging viral infections, which can result in both acute and long-term complications. The present review aims to discuss various cardiovascular complications linked to emerging and re-emerging viral pathogens (including severe acute respiratory syndrome <em>coronavirus 2</em> (<em>SARS</em>-<em>CoV</em>-<em>2</em>), dengue virus (DENV), Zika virus (ZIKV), and chikungunya virus (CHIKV)) such as arrhythmias, myocarditis, vascular disorders, and thromboembolic conditions, particularly among the pediatric population. This review also addresses the potential mechanisms by which <em>SARS</em>-<em>CoV</em>-<em>2</em>, DENV, ZIKV, and CHIKV may impact the cardiovascular system and their clinical implications. Moreover, it discusses the diagnostic challenges for viral-caused cardiovascular disorders in children, owing to their common subtle or atypical manifestations. Finally, it addresses the present therapeutic specifically used for pediatric cases.</div></div>","PeriodicalId":49798,"journal":{"name":"Molecular Aspects of Medicine","volume":"104 ","pages":"Article 101371"},"PeriodicalIF":8.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144139220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protein and RNA chaperones 蛋白质和RNA伴侣

IF 8.7 2区医学

Molecular Aspects of Medicine Pub Date : 2025-08-01 Epub Date: 2025-07-14 DOI: 10.1016/j.mam.2025.101384

Bikash R. Sahoo, James CA. Bardwell

引用次数: 0

Ischemia - Reperfusion injury: A roadmap to precision therapies 缺血-再灌注损伤：精确治疗的路线图

IF 8.7 2区医学

Molecular Aspects of Medicine Pub Date : 2025-08-01 Epub Date: 2025-07-08 DOI: 10.1016/j.mam.2025.101382

Wei Li , Yan Liao , Jie Chen , Weichao Kang , Xintao Wang , Xiaozhu Zhai , Ying Xue , Wangzheqi Zhang , Yiyang Xia , Derong Cui

{"title":"Ischemia - Reperfusion injury: A roadmap to precision therapies","authors":"Wei Li , Yan Liao , Jie Chen , Weichao Kang , Xintao Wang , Xiaozhu Zhai , Ying Xue , Wangzheqi Zhang , Yiyang Xia , Derong Cui","doi":"10.1016/j.mam.2025.101382","DOIUrl":"10.1016/j.mam.2025.101382","url":null,"abstract":"<div><div>Ischemia-reperfusion (I/R) injury is prevalent in the medical field and significantly limits the therapeutic outcomes of various ischemic diseases, adversely affecting patient prognosis. The pathogenesis of I/R injury is highly complex, involving intricate interactions among oxidative stress, inflammatory responses, mitochondrial dysfunction, and multiple cell death pathways. Once the mitochondrial respiratory chain is impaired, it triggers oxidative stress responses, leading to the excessive production of reactive oxygen species (ROS). Excessive ROS not only directly damage cells but also activate inflammatory responses and initiate multiple cell death signalling pathways, such as necroptosis, pyroptosis, and ferroptosis, thereby exacerbating tissue damage. Moreover, the clinical manifestations of I/R injury vary significantly across different organs, such as the heart, brain, kidneys, liver, and lungs, and are further influenced by patients' underlying conditions, posing challenges for clinical diagnosis and treatment. Therefore, constructing a comprehensive assessment system based on individual patient characteristics (such as genetic polymorphisms and comorbidities) to accurately predict the risk of I/R injury is particularly important. Currently, there are diverse strategies for the prevention and treatment of I/R injury, but translating basic research into clinical application remains challenging. Developing personalized treatment plans tailored to different cell types holds promise for overcoming existing therapeutic bottlenecks, significantly improving patient outcomes, and providing new directions for addressing the challenges of I/R injury.</div></div>","PeriodicalId":49798,"journal":{"name":"Molecular Aspects of Medicine","volume":"104 ","pages":"Article 101382"},"PeriodicalIF":8.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144572362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Respiratory emerging viruses and drug resistance in lung cancer: challenges and new perspectives in treatment 呼吸道新发病毒和肺癌的耐药：治疗的挑战和新观点

IF 8.7 2区医学

Molecular Aspects of Medicine Pub Date : 2025-08-01 Epub Date: 2025-07-15 DOI: 10.1016/j.mam.2025.101383

Qiang Wu , Wen Li , Hongli Liu , Yinyin Xue , Kaili Huang , Hossein Pourghadamyari , Zhenkun Liu

{"title":"Respiratory emerging viruses and drug resistance in lung cancer: challenges and new perspectives in treatment","authors":"Qiang Wu , Wen Li , Hongli Liu , Yinyin Xue , Kaili Huang , Hossein Pourghadamyari , Zhenkun Liu","doi":"10.1016/j.mam.2025.101383","DOIUrl":"10.1016/j.mam.2025.101383","url":null,"abstract":"<div><div>Emerging viral pathogens, particularly those targeting the respiratory system such as SARS-CoV-2 and influenza virus, pose significant challenges for patients with lung cancer. These patients show increased susceptibility to serious infections caused by these viruses as a result of immunosuppression from various therapies such as immunotherapy, chemotherapy, and targeted agents. Respiratory viral infections can induce tumor progression and drug resistance through affecting the tumor microenvironment (TME), modulating immune checkpoints, or interfering with therapeutic efficacy. The present review discusses the reciprocal interactions between these viral pathogens and lung cancer, underscoring mechanisms by which SARS-CoV-2 and influenza viruses affect the lung cancer TME promoting tumor progression, immune evasion, and ultimately, resistance to anti-cancer therapies such as tyrosine kinase inhibitors (TKIs) and immune checkpoint inhibitors (ICIs). Sections discussed in this study include: (i) increased susceptibility to viral infections, (ii) virus-induced modulation of the tumor microenvironment, and (iii) mechanisms of therapy resistance. This review also addresses emerging strategies, such as oncolytic virotherapy, as potential candidates for lung cancer treatment. It aims to provide new perspectives on therapeutic optimization for patients with lung cancer in the context of SARS-CoV-2 and influenza viruses, by reviewing evidence from virology, oncology, and immunology.</div></div>","PeriodicalId":49798,"journal":{"name":"Molecular Aspects of Medicine","volume":"104 ","pages":"Article 101383"},"PeriodicalIF":8.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144632758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Type 2 Diabetes Mellitus and bladder cancer: A narrative review on associated signaling pathways 2型糖尿病和膀胱癌：相关信号通路的叙述综述

IF 8.7 2区医学

Molecular Aspects of Medicine Pub Date : 2025-08-01 Epub Date: 2025-06-20 DOI: 10.1016/j.mam.2025.101381

Lívia da Cunha Agostini, Glenda Nicioli da Silva

{"title":"Type 2 Diabetes Mellitus and bladder cancer: A narrative review on associated signaling pathways","authors":"Lívia da Cunha Agostini, Glenda Nicioli da Silva","doi":"10.1016/j.mam.2025.101381","DOIUrl":"10.1016/j.mam.2025.101381","url":null,"abstract":"<div><div>Bladder cancer is one of the most common cancers globally. The risk factors for urothelial bladder cancer can be broadly divided into genetic predispositions and external environmental exposures. Type 2 Diabetes Mellitus (T2DM) is a chronic, non-communicable metabolic disorder, and the interaction between genetic, behavioral, and environmental factors plays a significant role in its development. The management of T2DM includes lifestyle modifications and medication. Several studies suggest that T2DM is associated with an increased risk of bladder cancer. This review highlights the key signaling mechanisms involved in this association and explores the impact of T2DM medications on bladder cancer. In conclusion, the literature suggests that metabolic abnormalities associated with T2DM —such as hyperglycemia, insulin resistance and elevated levels of insulin, insulin-like growth factor 1 (IGF-1), inflammatory cytokines, iNOS/eNOS activity, hypoxia, dyslipidemia, matrix metalloproteinase (MMPs), leptin, vimentin, N-cadherin, fibronectin, advanced glycation end products (AGEs), endoplasmic reticulum stress (ERS), and <em>Arntl2</em> gene expression; in addition to reduced E-cadherin, adiponectin, autophagy, and <em>IGF-1</em> and <em>Usp2</em> gene expression—significantly influence signaling pathways essential for bladder tumor development. Additionally, the choice of hypoglycemic treatment should be carefully considered, taking into account potential effects on carcinogenesis.</div></div>","PeriodicalId":49798,"journal":{"name":"Molecular Aspects of Medicine","volume":"104 ","pages":"Article 101381"},"PeriodicalIF":8.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144322188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Invasive fungal infections: An expanding and evolving threat 侵袭性真菌感染：一种不断扩大和演变的威胁。

IF 10.3 2区医学

Molecular Aspects of Medicine Pub Date : 2025-08-01 Epub Date: 2025-04-29 DOI: 10.1016/j.mam.2025.101363

Matteo Bassetti , Antonio Vena

引用次数: 0

The role of free fatty acid receptors activation in pancreatic disorders 游离脂肪酸受体激活在胰腺疾病中的作用

IF 8.7 2区医学

Molecular Aspects of Medicine Pub Date : 2025-08-01 Epub Date: 2025-07-12 DOI: 10.1016/j.mam.2025.101386

Julia Lis, Jakub Fichna, Aleksandra Tarasiuk-Zawadzka

{"title":"The role of free fatty acid receptors activation in pancreatic disorders","authors":"Julia Lis, Jakub Fichna, Aleksandra Tarasiuk-Zawadzka","doi":"10.1016/j.mam.2025.101386","DOIUrl":"10.1016/j.mam.2025.101386","url":null,"abstract":"<div><div>Free fatty acid receptors (FFARs), a subset of G protein-coupled receptors, play a pivotal role in metabolic and immune homeostasis by modulating signaling pathways in response to free fatty acids. The four main FFARs (FFAR1, FFAR2, FFAR3, and FFAR4) are especially significant in pancreatic function, regulating insulin secretion, inflammation, and glucose metabolism. These receptors are involved in key pancreatic disorders, including acute pancreatitis (AP), pancreatic cancer (PC), type 1 diabetes (T1D), and type 2 diabetes (T2D).</div><div>FFAR1, FFAR3, and FFAR4 exhibit protective effects against AP due to their anti-inflammatory properties. In PC, FFAR1 inhibits tumor cell motility, while FFAR2 downregulation may contribute to tumor progression. FFAR3 plays a role in limiting tumor proliferation, whereas FFAR4 has a dual effect, promoting metastasis while also triggering tumor cell apoptosis. In T1D, FFAR2 and FFAR4 help regulate glycemia without directly stimulating insulin secretion. In T2D, all four FFARs contribute to glycemic control and may protect pancreatic β-cells.</div><div>Despite their therapeutic potential, the precise mechanisms underlying FFAR function in pancreatic disorders remain incompletely understood. Ongoing research aims to clarify these pathways, identify optimal ligands, and assess the safety and efficacy of FFAR-targeted therapies. This growing body of evidence underscores the importance of FFARs as potential targets for innovative treatments in pancreatic diseases.</div></div>","PeriodicalId":49798,"journal":{"name":"Molecular Aspects of Medicine","volume":"104 ","pages":"Article 101386"},"PeriodicalIF":8.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144605148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0