Molecular Aspects of Medicine最新文献_第4页

Unveiling multifaceted roles of myeloid innate immune cells in the pathogenesis of psoriasis 揭示髓系先天性免疫细胞在银屑病发病机制中的多方面作用

IF 8.7 2区医学

Molecular Aspects of Medicine Pub Date : 2024-08-26 DOI: 10.1016/j.mam.2024.101306

Sohyeon Park , Jinsun Jang , Hee Joo Kim , YunJae Jung

{"title":"Unveiling multifaceted roles of myeloid innate immune cells in the pathogenesis of psoriasis","authors":"Sohyeon Park , Jinsun Jang , Hee Joo Kim , YunJae Jung","doi":"10.1016/j.mam.2024.101306","DOIUrl":"10.1016/j.mam.2024.101306","url":null,"abstract":"<div><p>Psoriasis is a chronic inflammatory skin disease occurring worldwide. Initially viewed as a keratinocyte disorder, psoriasis is now recognized to involve a complex interplay between genetic predisposition, environmental triggers, and a dysregulated immune system, with a significant role of CD4<sup>+</sup> T cells producing IL-17. Recent genetic studies have identified susceptibility loci that underscore the importance of innate immune responses, particularly the roles of myeloid cells, such as dendritic cells, macrophages, and neutrophils. These cells initiate and sustain inflammation through cytokine production triggered by external stimuli. They influence keratinocyte behavior and interact with adaptive immune cells. Recent techniques have further revealed the heterogeneity of myeloid cells in psoriatic lesions, highlighting the contributions of less-studied subsets, such as eosinophils and mast cells. This review examines the multifaceted roles of myeloid innate immune cells in psoriasis, emphasizing their functional diversity in promoting psoriatic inflammation. It also describes current treatment targeting myeloid innate immune cells and explores potential new therapeutic strategies based on the functional characteristics of these subsets. Future research should focus on the detailed characterization of myeloid subsets and their interactions to develop targeted treatments that address the complex immune landscape of psoriasis.</p></div>","PeriodicalId":49798,"journal":{"name":"Molecular Aspects of Medicine","volume":"99 ","pages":"Article 101306"},"PeriodicalIF":8.7,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0098299724000657/pdfft?md5=a8fe469b309b5f4b85a33cab9291835f&pid=1-s2.0-S0098299724000657-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142077002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hepatitis C virus chronicity and oncogenic potential: Vaccine development progress 丙型肝炎病毒的慢性化和致癌潜力：疫苗开发进展

IF 8.7 2区医学

Molecular Aspects of Medicine Pub Date : 2024-08-20 DOI: 10.1016/j.mam.2024.101305

Yuki Haga , Sydney Coates , Ranjit Ray

{"title":"Hepatitis C virus chronicity and oncogenic potential: Vaccine development progress","authors":"Yuki Haga , Sydney Coates , Ranjit Ray","doi":"10.1016/j.mam.2024.101305","DOIUrl":"10.1016/j.mam.2024.101305","url":null,"abstract":"<div><p>Hepatitis C virus (HCV) infection is a major health problem worldwide. It can cause liver cirrhosis and hepatocellular carcinoma (HCC), making it a cause of morbidity from liver disease. Thus, there is an urgent need for a prophylactic HCV vaccine. Fortunately, modern medicine has transformed the therapy for HCV infection through development of direct-acting antiviral agents (DAAs), achieving high rates of sustained virologic response and giving significant relief from HCC and associated mortality, but unfortunately it fails to eradicate the risk of HCC, especially in HCV-cleared patients with already advanced liver disease. Additionally, DAA-cured patients do not develop sufficient antiviral immunity and are susceptible to reinfection. A comprehensive strategy to control HCV infection must include a vaccine development approach in which the host can develop humoral and cellular immunity to eradicate HCV successfully; however, this remains a challenge as HCV has developed systems to evade immune attacks from its host. This review highlights the current understanding of HCV's effect on liver disease and cancer progression, the nature of immune responses from cell populations interacting with HCV, and the current strategies for vaccine development. The information in this review will advance prophylactic intervention strategies for HCV infection, with the end goal being to prevent chronicity and subsequent liver disease leading to HCC.</p></div>","PeriodicalId":49798,"journal":{"name":"Molecular Aspects of Medicine","volume":"99 ","pages":"Article 101305"},"PeriodicalIF":8.7,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142012166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extracellular vesicles transport RNA between cells: Unraveling their dual role in diagnostics and therapeutics 细胞外囊泡在细胞间运输 RNA：揭示细胞外囊泡在诊断和治疗中的双重作用

IF 8.7 2区医学

Molecular Aspects of Medicine Pub Date : 2024-08-01 DOI: 10.1016/j.mam.2024.101302

Zahra Payandeh , Benyapa Tangruksa , Jane Synnergren , Sepideh Heydarkhan-Hagvall , Joel Z. Nordin , Samir EL. Andaloussi , Jan Borén , John Wiseman , Mohammad Bohlooly-Y , Lennart Lindfors , Hadi Valadi

{"title":"Extracellular vesicles transport RNA between cells: Unraveling their dual role in diagnostics and therapeutics","authors":"Zahra Payandeh , Benyapa Tangruksa , Jane Synnergren , Sepideh Heydarkhan-Hagvall , Joel Z. Nordin , Samir EL. Andaloussi , Jan Borén , John Wiseman , Mohammad Bohlooly-Y , Lennart Lindfors , Hadi Valadi","doi":"10.1016/j.mam.2024.101302","DOIUrl":"10.1016/j.mam.2024.101302","url":null,"abstract":"<div><p>Modern methods of molecular diagnostics and therapy have revolutionized the field of medicine in recent years by providing more precise and effective tools for detecting and treating diseases. This progress includes a growing exploration of the body's secreted vesicles, known as extracellular vesicles (EVs), for both diagnostic and therapeutic purposes. EVs are a heterogeneous population of lipid bilayer vesicles secreted by almost every cell type studied so far. They are detected in body fluids and conditioned culture media from living cells. EVs play a crucial role in communication between cells and organs, both locally and over long distances. They are recognized for their ability to transport endogenous RNA and proteins between cells, including messenger RNA (mRNA), microRNA (miRNA), misfolded neurodegenerative proteins, and several other biomolecules. This review explores the dual utilization of EVs, serving not only for diagnostic purposes but also as a platform for delivering therapeutic molecules to cells and tissues. Through an exploration of their composition, biogenesis, and selective cargo packaging, we elucidate the intricate mechanisms behind RNA transport between cells via EVs, highlighting their potential use for both diagnostic and therapeutic applications. Finally, it addresses challenges and outlines prospective directions for the clinical utilization of EVs.</p></div>","PeriodicalId":49798,"journal":{"name":"Molecular Aspects of Medicine","volume":"99 ","pages":"Article 101302"},"PeriodicalIF":8.7,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S009829972400061X/pdfft?md5=73ba7a20be41091963375739f9ec2675&pid=1-s2.0-S009829972400061X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141873363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diabetes and male fertility disorders 糖尿病与男性生育障碍

IF 8.7 2区医学

Molecular Aspects of Medicine Pub Date : 2024-07-30 DOI: 10.1016/j.mam.2024.101303

Andrea Graziani , Raffaele Scafa , Giuseppe Grande , Alberto Ferlin

{"title":"Diabetes and male fertility disorders","authors":"Andrea Graziani , Raffaele Scafa , Giuseppe Grande , Alberto Ferlin","doi":"10.1016/j.mam.2024.101303","DOIUrl":"10.1016/j.mam.2024.101303","url":null,"abstract":"<div><p>Couple infertility is a common condition, defined as being unable to conceive after 12 months of regular unprotected sexual intercourse. Male Factor Infertility (MFI) is responsible, alone or in combination with female factors, for about half of the overall cases of couple infertility. MFI is gradually increasing in prevalence, with a notable decline in semen parameters over the last decades. The aetiologies behind the finding of decreasing sperm counts are difficult to pinpoint but might be due in part to increasing rates of overweight and obesity in men of childbearing age. Diabetes mellitus (DM) is a common and chronic metabolic disease, whose prevalence is also gradually increasing, rising up to 10% of the population. The International Diabetes Federation estimates that there are currently more than 500 million people living with DM worldwide, the vast majority of whom suffering from type 2 DM (T2DM). There is growing awareness of the relationship between unhealthy lifestyle, in particular unhealthy diet, and MFI. Starting from all these premises, the aim of this narrative review is to describe the current evidence on the link between DM and MFI, both in terms of DM as a cause of/a risk factor for MFI and of MFI as a possible predictive marker for T2DM. Finally, we will discuss the risk of DM as a consequence of the therapy of MFI or assisted reproductive techniques.</p></div>","PeriodicalId":49798,"journal":{"name":"Molecular Aspects of Medicine","volume":"99 ","pages":"Article 101303"},"PeriodicalIF":8.7,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0098299724000621/pdfft?md5=7fc25e028243290f17b294fca4dbb1aa&pid=1-s2.0-S0098299724000621-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141861389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular mechanisms of cancer cachexia. Role of exercise training 癌症恶病质的分子机制。运动训练的作用

IF 8.7 2区医学

Molecular Aspects of Medicine Pub Date : 2024-07-25 DOI: 10.1016/j.mam.2024.101293

Eva Tamayo-Torres , Amanda Garrido , Rafael de Cabo , Julián Carretero , María Carmen Gómez-Cabrera

{"title":"Molecular mechanisms of cancer cachexia. Role of exercise training","authors":"Eva Tamayo-Torres , Amanda Garrido , Rafael de Cabo , Julián Carretero , María Carmen Gómez-Cabrera","doi":"10.1016/j.mam.2024.101293","DOIUrl":"10.1016/j.mam.2024.101293","url":null,"abstract":"<div><p>Cancer-associated cachexia represents a multifactorial syndrome mainly characterized by muscle mass loss, which causes both a decrease in quality of life and anti-cancer therapy failure, among other consequences. The definition and diagnostic criteria of cachexia have changed and improved over time, including three different stages (pre-cachexia, cachexia, and refractory cachexia) and objective diagnostic markers. This metabolic wasting syndrome is characterized by a negative protein balance, and anti-cancer drugs like chemotherapy or immunotherapy exacerbate it through relatively unknown mechanisms. Due to its complexity, cachexia management involves a multidisciplinary strategy including not only nutritional and pharmacological interventions. Physical exercise has been proposed as a strategy to counteract the effects of cachexia on skeletal muscle, as it influences the mechanisms involved in the disease such as protein turnover, inflammation, oxidative stress, and mitochondrial dysfunction. This review will summarize the experimental and clinical evidence of the impact of physical exercise on cancer-associated cachexia.</p></div>","PeriodicalId":49798,"journal":{"name":"Molecular Aspects of Medicine","volume":"99 ","pages":"Article 101293"},"PeriodicalIF":8.7,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0098299724000529/pdfft?md5=043b63cf65d41888f643301387e1613b&pid=1-s2.0-S0098299724000529-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141767891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vaccines for breast cancer prevention: Are we there yet? 预防乳腺癌的疫苗：我们成功了吗？

IF 8.7 2区医学

Molecular Aspects of Medicine Pub Date : 2024-07-10 DOI: 10.1016/j.mam.2024.101292

Shaveta Vinayak , Denise L. Cecil , Mary L. Disis

引用次数: 0

Frailty and biological age. Which best describes our aging and longevity? 虚弱和生理年龄。哪一种最能说明我们的衰老和长寿？

IF 8.7 2区医学

Molecular Aspects of Medicine Pub Date : 2024-07-01 DOI: 10.1016/j.mam.2024.101291

Judith Félix , Irene Martínez de Toda , Estefanía Díaz-Del Cerro , Mónica González-Sánchez , Mónica De la Fuente

引用次数: 0

Nanoformulations for dismantling fungal biofilms: The latest arsenals of antifungal therapy 破坏真菌生物膜的纳米制剂：抗真菌疗法的最新武器。

IF 8.7 2区医学

Molecular Aspects of Medicine Pub Date : 2024-06-29 DOI: 10.1016/j.mam.2024.101290

Payal Gupta , Mukesh Kumar Meher , Shweta Tripathi , Krishna Mohan Poluri

{"title":"Nanoformulations for dismantling fungal biofilms: The latest arsenals of antifungal therapy","authors":"Payal Gupta , Mukesh Kumar Meher , Shweta Tripathi , Krishna Mohan Poluri","doi":"10.1016/j.mam.2024.101290","DOIUrl":"10.1016/j.mam.2024.101290","url":null,"abstract":"<div><p>Globally, fungal infections have evolved as a strenuous challenge for clinicians, particularly in patients with compromised immunity in intensive care units. Fungal co-infection in Covid-19 patients has made the situation more formidable for healthcare practitioners. Surface adhered fungal population known as biofilm often develop at the diseased site to elicit antifungal tolerance and recalcitrant traits. Thus, an innovative strategy is required to impede/eradicate developed biofilm and avoid the formation of new colonies. The development of nanocomposite-based antibiofilm solutions is the most appropriate way to withstand and dismantle biofilm structures. Nanocomposites can be utilized as a drug delivery medium and for fabrication of anti-biofilm surfaces capable to resist fungal colonization. In this context, the present review comprehensively described different forms of nanocomposites and mode of their action against fungal biofilms. Amongst various nanocomposites, efficacy of metal/organic nanoparticles and nanofibers are particularly emphasized to highlight their role in the pursuit of antibiofilm strategies. Further, the inevitable concern of nanotoxicology has also been introduced and discussed with the exigent need of addressing it while developing nano-based therapies. Further, a list of FDA-approved nano-based antifungal formulations for therapeutic usage available to date has been described. Collectively, the review highlights the potential, scope, and future of nanocomposite-based antibiofilm therapeutics to address the fungal biofilm management issue.</p></div>","PeriodicalId":49798,"journal":{"name":"Molecular Aspects of Medicine","volume":"98 ","pages":"Article 101290"},"PeriodicalIF":8.7,"publicationDate":"2024-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141471955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hippo signaling modulation and its biological implications in urological malignancies Hippo 信号调节及其在泌尿系统恶性肿瘤中的生物学意义

IF 10.6 2区医学

Molecular Aspects of Medicine Pub Date : 2024-06-12 DOI: 10.1016/j.mam.2024.101280

Tongyu Tong , Mengjun Huang , Binyuan Yan , Bingbiao Lin , Jiaying Yu , Qiliang Teng , Peng Li , Jun Pang

{"title":"Hippo signaling modulation and its biological implications in urological malignancies","authors":"Tongyu Tong , Mengjun Huang , Binyuan Yan , Bingbiao Lin , Jiaying Yu , Qiliang Teng , Peng Li , Jun Pang","doi":"10.1016/j.mam.2024.101280","DOIUrl":"https://doi.org/10.1016/j.mam.2024.101280","url":null,"abstract":"<div><p>Although cancer diagnosis and treatment have rapidly advanced in recent decades, urological malignancies, which have high morbidity and mortality rates, are among the most difficult diseases to treat. The Hippo signaling is an evolutionarily conserved pathway in organ size control and tissue homeostasis maintenance. Its downstream effectors, Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ), are key modulators of numerous physiological and pathological processes. Recent work clearly indicates that Hippo signaling is frequently altered in human urological malignancies. In this review, we discuss the disparate viewpoints on the upstream regulators of YAP/TAZ and their downstream targets and systematically summarize the biological implications. More importantly, we highlight the molecular mechanisms involved in Hippo-YAP signaling to improve our understanding of its role in every stage of prostate cancer, bladder cancer and kidney cancer progression. A better understanding of the biological outcomes of YAP/TAZ modulation will contribute to the establishment of future therapeutic approaches.</p></div>","PeriodicalId":49798,"journal":{"name":"Molecular Aspects of Medicine","volume":"98 ","pages":"Article 101280"},"PeriodicalIF":10.6,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141314183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The uniqueness of on-demand male contraception 按需男性避孕的独特性。

IF 10.6 2区医学

Molecular Aspects of Medicine Pub Date : 2024-05-27 DOI: 10.1016/j.mam.2024.101281

Natalia del R. Rivera Sanchez , Carla Ritagliati , Gregory S. Kopf , Steve Kretschmer , Jochen Buck , Lonny R. Levin

引用次数: 0