Molecular Aspects of Medicine最新文献_第3页

Ischemia - Reperfusion injury: A roadmap to precision therapies 缺血-再灌注损伤：精确治疗的路线图

IF 8.7 2区医学

Molecular Aspects of Medicine Pub Date : 2025-07-08 DOI: 10.1016/j.mam.2025.101382

Wei Li , Yan Liao , Jie Chen , Weichao Kang , Xintao Wang , Xiaozhu Zhai , Ying Xue , Wangzheqi Zhang , Yiyang Xia , Derong Cui

{"title":"Ischemia - Reperfusion injury: A roadmap to precision therapies","authors":"Wei Li , Yan Liao , Jie Chen , Weichao Kang , Xintao Wang , Xiaozhu Zhai , Ying Xue , Wangzheqi Zhang , Yiyang Xia , Derong Cui","doi":"10.1016/j.mam.2025.101382","DOIUrl":"10.1016/j.mam.2025.101382","url":null,"abstract":"<div><div>Ischemia-reperfusion (I/R) injury is prevalent in the medical field and significantly limits the therapeutic outcomes of various ischemic diseases, adversely affecting patient prognosis. The pathogenesis of I/R injury is highly complex, involving intricate interactions among oxidative stress, inflammatory responses, mitochondrial dysfunction, and multiple cell death pathways. Once the mitochondrial respiratory chain is impaired, it triggers oxidative stress responses, leading to the excessive production of reactive oxygen species (ROS). Excessive ROS not only directly damage cells but also activate inflammatory responses and initiate multiple cell death signalling pathways, such as necroptosis, pyroptosis, and ferroptosis, thereby exacerbating tissue damage. Moreover, the clinical manifestations of I/R injury vary significantly across different organs, such as the heart, brain, kidneys, liver, and lungs, and are further influenced by patients' underlying conditions, posing challenges for clinical diagnosis and treatment. Therefore, constructing a comprehensive assessment system based on individual patient characteristics (such as genetic polymorphisms and comorbidities) to accurately predict the risk of I/R injury is particularly important. Currently, there are diverse strategies for the prevention and treatment of I/R injury, but translating basic research into clinical application remains challenging. Developing personalized treatment plans tailored to different cell types holds promise for overcoming existing therapeutic bottlenecks, significantly improving patient outcomes, and providing new directions for addressing the challenges of I/R injury.</div></div>","PeriodicalId":49798,"journal":{"name":"Molecular Aspects of Medicine","volume":"104 ","pages":"Article 101382"},"PeriodicalIF":8.7,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144572362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Type 2 Diabetes Mellitus and bladder cancer: A narrative review on associated signaling pathways 2型糖尿病和膀胱癌：相关信号通路的叙述综述

IF 8.7 2区医学

Molecular Aspects of Medicine Pub Date : 2025-06-20 DOI: 10.1016/j.mam.2025.101381

Lívia da Cunha Agostini, Glenda Nicioli da Silva

{"title":"Type 2 Diabetes Mellitus and bladder cancer: A narrative review on associated signaling pathways","authors":"Lívia da Cunha Agostini, Glenda Nicioli da Silva","doi":"10.1016/j.mam.2025.101381","DOIUrl":"10.1016/j.mam.2025.101381","url":null,"abstract":"<div><div>Bladder cancer is one of the most common cancers globally. The risk factors for urothelial bladder cancer can be broadly divided into genetic predispositions and external environmental exposures. Type 2 Diabetes Mellitus (T2DM) is a chronic, non-communicable metabolic disorder, and the interaction between genetic, behavioral, and environmental factors plays a significant role in its development. The management of T2DM includes lifestyle modifications and medication. Several studies suggest that T2DM is associated with an increased risk of bladder cancer. This review highlights the key signaling mechanisms involved in this association and explores the impact of T2DM medications on bladder cancer. In conclusion, the literature suggests that metabolic abnormalities associated with T2DM —such as hyperglycemia, insulin resistance and elevated levels of insulin, insulin-like growth factor 1 (IGF-1), inflammatory cytokines, iNOS/eNOS activity, hypoxia, dyslipidemia, matrix metalloproteinase (MMPs), leptin, vimentin, N-cadherin, fibronectin, advanced glycation end products (AGEs), endoplasmic reticulum stress (ERS), and <em>Arntl2</em> gene expression; in addition to reduced E-cadherin, adiponectin, autophagy, and <em>IGF-1</em> and <em>Usp2</em> gene expression—significantly influence signaling pathways essential for bladder tumor development. Additionally, the choice of hypoglycemic treatment should be carefully considered, taking into account potential effects on carcinogenesis.</div></div>","PeriodicalId":49798,"journal":{"name":"Molecular Aspects of Medicine","volume":"104 ","pages":"Article 101381"},"PeriodicalIF":8.7,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144322188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cardiovascular impact of emerging and Re-emerging Viruses: Pathophysiological mechanisms, diagnosis, and management with a pediatric focus 新出现的和再出现的病毒对心血管的影响：病理生理机制、诊断和管理，以儿科为重点

IF 8.7 2区医学

Molecular Aspects of Medicine Pub Date : 2025-05-26 DOI: 10.1016/j.mam.2025.101371

Li Li , Xu Shi , Ruiming Wang , Yuxi Fan , Zhihan Xu , Habibollah Mirzaei , Wuran Wei

{"title":"Cardiovascular impact of emerging and Re-emerging Viruses: Pathophysiological mechanisms, diagnosis, and management with a pediatric focus","authors":"Li Li , Xu Shi , Ruiming Wang , Yuxi Fan , Zhihan Xu , Habibollah Mirzaei , Wuran Wei","doi":"10.1016/j.mam.2025.101371","DOIUrl":"10.1016/j.mam.2025.101371","url":null,"abstract":"<div><div>Emerging and re-emerging viruses are currently known as a major public health issue. These viruses can cause various human complications such as cardiovascular diseases (CVDs), both in adults and pediatric populations. Although various CVDs have been previously reported for emerging and re-emerging viruses, the mechanisms underlying these complications remain relatively unknown. Children and infants, while commonly developing less severe symptoms, may experience notable cardiovascular manifestations during infections caused by emerging and re-emerging viral infections, which can result in both acute and long-term complications. The present review aims to discuss various cardiovascular complications linked to emerging and re-emerging viral pathogens (including severe acute respiratory syndrome <em>coronavirus 2</em> (<em>SARS</em>-<em>CoV</em>-<em>2</em>), dengue virus (DENV), Zika virus (ZIKV), and chikungunya virus (CHIKV)) such as arrhythmias, myocarditis, vascular disorders, and thromboembolic conditions, particularly among the pediatric population. This review also addresses the potential mechanisms by which <em>SARS</em>-<em>CoV</em>-<em>2</em>, DENV, ZIKV, and CHIKV may impact the cardiovascular system and their clinical implications. Moreover, it discusses the diagnostic challenges for viral-caused cardiovascular disorders in children, owing to their common subtle or atypical manifestations. Finally, it addresses the present therapeutic specifically used for pediatric cases.</div></div>","PeriodicalId":49798,"journal":{"name":"Molecular Aspects of Medicine","volume":"104 ","pages":"Article 101371"},"PeriodicalIF":8.7,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144139220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adiponectin: its role in diabetic and pancreatic cancer 脂联素在糖尿病和胰腺癌中的作用

IF 8.7 2区医学

Molecular Aspects of Medicine Pub Date : 2025-05-21 DOI: 10.1016/j.mam.2025.101370

Seema Kumari , Sujatha Peela , Mundla Srilatha , Bala Prabhakar Girish , Ganji Purnachandra Nagaraju

{"title":"Adiponectin: its role in diabetic and pancreatic cancer","authors":"Seema Kumari , Sujatha Peela , Mundla Srilatha , Bala Prabhakar Girish , Ganji Purnachandra Nagaraju","doi":"10.1016/j.mam.2025.101370","DOIUrl":"10.1016/j.mam.2025.101370","url":null,"abstract":"<div><div>Adiponectin (ApN) is an antidiabetic and anti-inflammatory protein synthesized by adipose tissue. It is essential in regulating insulin sensitivity, glucose, and lipid metabolism by controlling AMPK, PPARα, and MAPK signals. It is an anti-inflammatory property that protects pancreatic β-cells. Often, low levels of ApN are linked to obesity, type II diabetes and the development of PDAC. However, changes in lifestyle and the use of certain drugs can improve ApN function and insulin sensitivity. PDAC is a highly aggressive cancer linked to obesity, type II diabetes, and insulin resistance. ApN plays a complex role in PDAC progression and can suppress PDAC development by weakening β-catenin signaling. Decreases in ApN levels are associated with increased PDAC risk in diabetic patients. PDAC and diabetes are interconnected through the development of insulin resistance, islet dysfunction, change in immunological response, inflammation, oxidative stress, and altered hormone secretion. Genetic studies highlight specific genes like HNF4G and PDX1 that influence both conditions and miRNAs such as miR-19a promote tumor progression through the PI3K/AKT pathway. This review discusses the role of ApN in diabetes and PDAC and the interrelation between diabetes and PDAC.</div></div>","PeriodicalId":49798,"journal":{"name":"Molecular Aspects of Medicine","volume":"103 ","pages":"Article 101370"},"PeriodicalIF":8.7,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144099281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Virus-like particles of retroviral origin in protein aggregation and neurodegenerative diseases 蛋白质聚集和神经退行性疾病中源自逆转录病毒的病毒样颗粒

IF 8.7 2区医学

Molecular Aspects of Medicine Pub Date : 2025-05-20 DOI: 10.1016/j.mam.2025.101369

Serena Carra , Balazs Fabian , Hamed Taghavi , Edoardo Milanetti , Valeria Giliberti , Giancarlo Ruocco , Jason Shepherd , Michele Vendruscolo , Monika Fuxreiter

{"title":"Virus-like particles of retroviral origin in protein aggregation and neurodegenerative diseases","authors":"Serena Carra , Balazs Fabian , Hamed Taghavi , Edoardo Milanetti , Valeria Giliberti , Giancarlo Ruocco , Jason Shepherd , Michele Vendruscolo , Monika Fuxreiter","doi":"10.1016/j.mam.2025.101369","DOIUrl":"10.1016/j.mam.2025.101369","url":null,"abstract":"<div><div>A wide range of human diseases are associated with protein misfolding and amyloid aggregates. Recent studies suggest that in certain neurological disorders, including Amyotrophic Lateral Sclerosis (ALS), Frontotemporal Dementia (FTD) and various tauopathies, protein aggregation may be promoted by virus-like particles (VLPs) formed by endogenous retroviruses (ERVs). The molecular mechanisms by which these VLPs contribute to protein aggregation, however, remain enigmatic. Here, we discuss possible molecular mechanisms of ERV-derived VLPs in the formation and spread of protein aggregates. An intriguing possibility is that liquid-like condensates may facilitate the formation of both protein aggregates and ERV-derived VLPs. We also describe how RNA chaperoning, and the encapsulation and trafficking of misfolded proteins, may contribute to protein homeostasis through the elimination of protein aggregates from cells. Based on these insights, we discuss future potential therapeutic opportunities.</div></div>","PeriodicalId":49798,"journal":{"name":"Molecular Aspects of Medicine","volume":"103 ","pages":"Article 101369"},"PeriodicalIF":8.7,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144089163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metabolic reprogramming of drug resistance in pancreatic cancer: mechanisms and effects 胰腺癌耐药的代谢重编程：机制和影响

IF 8.7 2区医学

Molecular Aspects of Medicine Pub Date : 2025-05-20 DOI: 10.1016/j.mam.2025.101368

Jinyi Zhang , Xueqing Kong , Boyan Zhou , Rui Li , Zhaoan Yu , Jinrong Zhu , Qing Xi , Yan Li , Zichao Zhao , Rongxin Zhang

{"title":"Metabolic reprogramming of drug resistance in pancreatic cancer: mechanisms and effects","authors":"Jinyi Zhang , Xueqing Kong , Boyan Zhou , Rui Li , Zhaoan Yu , Jinrong Zhu , Qing Xi , Yan Li , Zichao Zhao , Rongxin Zhang","doi":"10.1016/j.mam.2025.101368","DOIUrl":"10.1016/j.mam.2025.101368","url":null,"abstract":"<div><div>Pancreatic cancer is a highly aggressive gastrointestinal malignancy, often termed the “king of cancers” due to its notoriously high mortality rate. Its clinical characteristics, including late diagnosis, low surgical resectability, high recurrence rates, significant chemoresistance, and poor prognosis have collectively driven the persistent rise in incidence and mortality. Despite ongoing advancements in therapeutic strategies, the management of pancreatic cancer, particularly at advanced stages, remains challenging. Chemotherapy remains the mainstay of current treatment. However, the prevalent problem of chemotherapy resistance poses a significant obstacle to effective treatment. Metabolic reprogramming, characterized by alterations in glucose metabolism, lipid biosynthesis, and amino acid utilization, supports the high energy demands and rapid proliferation of cancer cells. Emerging evidence suggests that these metabolic changes, possibly mediated by epigenetic mechanisms, also contribute to tumorigenesis and metastasis. These findings highlight the critical role of metabolic alterations in pancreatic cancer pathogenesis. This review explores the relationship between metabolic reprogramming and chemotherapy resistance, discussing underlying mechanisms and summarizing preclinical studies and drug development targeting metabolism. The aim is to provide a comprehensive perspective on potential therapeutic strategies for pancreatic cancer.</div></div>","PeriodicalId":49798,"journal":{"name":"Molecular Aspects of Medicine","volume":"103 ","pages":"Article 101368"},"PeriodicalIF":8.7,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144089107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent advances in the diagnosis of fungal zoonoses in India: A comprehensive overview 印度真菌性人畜共患病诊断的最新进展：全面概述

IF 8.7 2区医学

Molecular Aspects of Medicine Pub Date : 2025-05-09 DOI: 10.1016/j.mam.2025.101366

Pradeep J , P. Lavanya , Mashila A , Naveen Kumar C

引用次数: 0

The bone-muscle unit: from mechanical coupling to soluble factors-mediated signaling 骨骼肌单位：从机械偶联到可溶性因子介导的信号传导

IF 8.7 2区医学

Molecular Aspects of Medicine Pub Date : 2025-05-07 DOI: 10.1016/j.mam.2025.101367

Amir Mohammad Malvandi , Laura Gerosa , Giuseppe Banfi , Giovanni Lombardi

引用次数: 0

The thermodynamic hypothesis of protein aggregation 蛋白质聚集的热力学假设

IF 8.7 2区医学

Molecular Aspects of Medicine Pub Date : 2025-05-03 DOI: 10.1016/j.mam.2025.101364

Michele Vendruscolo

引用次数: 0

Autophagy signaling mediated by non-coding RNAs: Impact on breast cancer progression and treatment 非编码rna介导的自噬信号：对乳腺癌进展和治疗的影响

IF 8.7 2区医学

Molecular Aspects of Medicine Pub Date : 2025-04-29 DOI: 10.1016/j.mam.2025.101365

Lei Yan , Zhuo Quan , Tiantian Sun , Jiajun Wang

{"title":"Autophagy signaling mediated by non-coding RNAs: Impact on breast cancer progression and treatment","authors":"Lei Yan , Zhuo Quan , Tiantian Sun , Jiajun Wang","doi":"10.1016/j.mam.2025.101365","DOIUrl":"10.1016/j.mam.2025.101365","url":null,"abstract":"<div><div>Autophagy, a conserved cellular mechanism which detoxifies and degrades intracellular structures or biomolecules, has been identified as an important factor in the progression of human breast cancer and the development of treatment resistance. Non-coding RNAs (ncRNAs), a broad family of RNA, have the ability to influence various processes, including autophagy, due to their diverse downstream targets. ncRNAs play an important role in suppressing or activating autophagy by targeting autophagy-triggering components such as the ULK1 complex, Beclin1, and ATGs. Recent research has uncovered the intricate regulatory networks that govern autophagy dynamics, with ncRNAs emerging as key participants in this network. miRNAs, lncRNAs, and circRNAs are the three subfamilies of ncRNAs that have the most well-known interactions with autophagy, particularly macroautophagy. The high prevalence of breast cancer necessitates research into finding new biological processes that can help in early detection as well as enhance the effectiveness of treatment. The positive/negative link between autophagy and ncRNAs can be exploited as a supplementary therapy to improve sensitivity to treatment in breast cancer. This review investigates the regulatory roles of ncRNAs, particularly microRNAs (miRNAs), in modifying autophagy pathways in human breast cancer progression and treatment. However, future studies and clinical practice are needed to determine the most relevant microRNAs as biomarkers and also to better understand their role in breast cancer progression or treatment through modifying autophagy.</div></div>","PeriodicalId":49798,"journal":{"name":"Molecular Aspects of Medicine","volume":"103 ","pages":"Article 101365"},"PeriodicalIF":8.7,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143881590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0