Cardiovascular impact of emerging and Re-emerging Viruses: Pathophysiological mechanisms, diagnosis, and management with a pediatric focus

IF 8.7 2区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular Aspects of Medicine Pub Date : 2025-05-26 DOI:10.1016/j.mam.2025.101371

Li Li , Xu Shi , Ruiming Wang , Yuxi Fan , Zhihan Xu , Habibollah Mirzaei , Wuran Wei

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引用次数: 0

Abstract

Emerging and re-emerging viruses are currently known as a major public health issue. These viruses can cause various human complications such as cardiovascular diseases (CVDs), both in adults and pediatric populations. Although various CVDs have been previously reported for emerging and re-emerging viruses, the mechanisms underlying these complications remain relatively unknown. Children and infants, while commonly developing less severe symptoms, may experience notable cardiovascular manifestations during infections caused by emerging and re-emerging viral infections, which can result in both acute and long-term complications. The present review aims to discuss various cardiovascular complications linked to emerging and re-emerging viral pathogens (including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), dengue virus (DENV), Zika virus (ZIKV), and chikungunya virus (CHIKV)) such as arrhythmias, myocarditis, vascular disorders, and thromboembolic conditions, particularly among the pediatric population. This review also addresses the potential mechanisms by which SARS-CoV-2, DENV, ZIKV, and CHIKV may impact the cardiovascular system and their clinical implications. Moreover, it discusses the diagnostic challenges for viral-caused cardiovascular disorders in children, owing to their common subtle or atypical manifestations. Finally, it addresses the present therapeutic specifically used for pediatric cases.

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新出现的和再出现的病毒对心血管的影响：病理生理机制、诊断和管理，以儿科为重点

新出现和再出现的病毒目前被认为是一个重大的公共卫生问题。这些病毒可在成人和儿童人群中引起各种人类并发症，如心血管疾病（cvd）。虽然以前已经报道了新出现和再出现的病毒引起的各种心血管疾病，但这些并发症的机制仍然相对未知。儿童和婴儿虽然通常出现不太严重的症状，但在新发和再发病毒感染引起的感染期间可能出现明显的心血管症状，这可能导致急性和长期并发症。本综述旨在讨论与新出现和再出现的病毒性病原体（包括严重急性呼吸综合征冠状病毒2 （SARS-CoV-2）、登革热病毒（DENV）、寨卡病毒（ZIKV）和基孔肯雅病毒（CHIKV））相关的各种心血管并发症，如心律失常、心肌炎、血管疾病和血栓栓塞性疾病，特别是在儿科人群中。本综述还探讨了SARS-CoV-2、DENV、ZIKV和CHIKV可能影响心血管系统的潜在机制及其临床意义。此外，它讨论了诊断挑战的病毒引起的心血管疾病的儿童，由于他们的共同微妙或非典型的表现。最后，它解决了目前治疗专门用于儿科病例。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Aspects of Medicine 医学-生化与分子生物学

CiteScore

18.20

自引率

0.00%

发文量

审稿时长

55 days

期刊介绍： Molecular Aspects of Medicine is a review journal that serves as an official publication of the International Union of Biochemistry and Molecular Biology. It caters to physicians and biomedical scientists and aims to bridge the gap between these two fields. The journal encourages practicing clinical scientists to contribute by providing extended reviews on the molecular aspects of a specific medical field. These articles are written in a way that appeals to both doctors who may struggle with basic science and basic scientists who may have limited awareness of clinical practice issues. The journal covers a wide range of medical topics to showcase the molecular insights gained from basic science and highlight the challenging problems that medicine presents to the scientific community.