Neurology Asia最新文献_第3页

Assessment of atrial electromechanical delay and echocardiographic parameters in patients with multiple sclerosis 评估多发性硬化症患者的心房机电延迟和超声心动图参数

IF 0.2 4区医学

Neurology Asia Pub Date : 2023-12-01 DOI: 10.54029/2023yjr

Derya Özdoğru, F. Salkın, Elif Banu Söker, O. Uysal

{"title":"Assessment of atrial electromechanical delay and echocardiographic parameters in patients with multiple sclerosis","authors":"Derya Özdoğru, F. Salkın, Elif Banu Söker, O. Uysal","doi":"10.54029/2023yjr","DOIUrl":"https://doi.org/10.54029/2023yjr","url":null,"abstract":"Objective: Data on cardiovascular dysfunction is limited in the previous literature on patients with multiple sclerosis. In this study, we aimed to elucidate the cardiovascular parameters in multiple sclerosis patients by comparing the systolic-diastolic functions and atrial electro-mechanical delay compared to the control group. Method: A total of 37 patients with a diagnosis of relapsing-remitting multiple sclerosis and had Expanded Disability Status Scale (EDSS) scores between 0 – 3, and 20 individuals in the control group were included in the study. Seventeen of the MS patients (n=17) were taking immunomodulatory drugs and the other 20 did not receive any immunomodulatory agents. Patients with a diagnosis or clinical suspicion of cardiac dysfunction and using cardiotoxic medications were excluded. The measurement of systolic and diastolic function parameters was performed via M – Mode 2D transthoracic echocardiography, and Atrial electro-mechanical delay (AEMD) measurements were performed with tissue Doppler. Results: E’ MV lateral and MV E/A values were determined to be higher in MS patients, who did not use immunomodulatory drugs, compared to the control group (p<0.001, p=0.010 respectively). E/E’ MV lateral and MV AVmax values were determined to be significantly higher in the patient group using immunomodulators compared to the other two groups (p=0.009, p=0.012 respectively). PAs, PAI, left and right intraatrial EMG values were determined to be prolonged in MS patients using and not using drugs compared to the control group, but these values were not determined to be statistically significant. Conclusion: We found that left ventricular diastolic function was impaired in MS patients compared to the control group, and right-left intra- and interatrial AEMD were similar. Based on these results, we recommend echocardiographic assessment for early detection of left ventricular diastolic dysfunction in MS patients.","PeriodicalId":49757,"journal":{"name":"Neurology Asia","volume":"45 2","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139194122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cumulative seizure occurrence and the predictors of seizure in low- and high-grade gliomas 低级别和高级别胶质瘤的累积发作发生率和发作预测因素

IF 0.2 4区医学

Neurology Asia Pub Date : 2023-12-01 DOI: 10.54029/2023swz

Christine Audrey, Kheng Seang Lim, Chet-Ying Chan, Thinisha Sathis Kumar, Rui Jia Hou, Si-Lei Fong, Vairavan Narayanan, Wan Muhammad Afnan Wan Anuar, Chong-Tin Tan

{"title":"Cumulative seizure occurrence and the predictors of seizure in low- and high-grade gliomas","authors":"Christine Audrey, Kheng Seang Lim, Chet-Ying Chan, Thinisha Sathis Kumar, Rui Jia Hou, Si-Lei Fong, Vairavan Narayanan, Wan Muhammad Afnan Wan Anuar, Chong-Tin Tan","doi":"10.54029/2023swz","DOIUrl":"https://doi.org/10.54029/2023swz","url":null,"abstract":"Objective: We aimed to determine the cumulative seizure occurrence, 1-year, and 5-years of preoperative seizures in gliomas, and an update on the predictors. Methods: This was a retrospective analysis of 239 patients with histopathologically confirmed gliomas in University Malaya Medical Centre, Malaysia, between 2008-2020. Kaplan-Meier curves were used to determine the cumulative incidence of seizures. Logistic regression was performed to determine the predictors of preoperative seizures. Results: A total of 80/239 patients (33.5%) had preoperative seizures. They were more commonly seen in those with younger age of presentation (40.0% in those <40 years old vs. 26.9% in ≥40 years old, p<0.05) and low-grade tumors (42.2% vs. 28.8% in high-grade tumors). Those with cortical involvement, especially the frontal lobe, or without focal deficit, headache, nausea, or vomiting were more likely to have seizures preoperatively. Logistic regression identified three significant predictors for preoperative seizure: absence of focal deficits at presentation (OR 6.090, 95% CI 3.110-11.925, p<0.001), cortical location (OR 3.834, 95% CI 1.363-10.786, p<0.05) and absence of headache at presentation (OR 2.487, 95% CI 1.139-5.431, p<0.05). The cumulative incidence of seizure was 29% at one year and 32% at 5-year for gliomas. Specifically, the seizure incidence was higher in low-grade gliomas (39% at 1-year) and certain tumor types such as ganglioglioma (50%), oligodendroglioma (48%), and astrocytoma (45%). Conclusion: The cumulative incidence of preoperative seizures in low-grade gliomas and certain tumor types is high. The predictors included cortical involvement and absence of focal neurological deficit or headache at presentation.","PeriodicalId":49757,"journal":{"name":"Neurology Asia","volume":"15 5","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139188430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intensive care unit admission prediction tool for ischemic stroke patients receiving intravenous thrombolysis: A retrospective cohort study 接受静脉溶栓治疗的缺血性脑卒中患者入住重症监护病房的预测工具：回顾性队列研究

IF 0.2 4区医学

Neurology Asia Pub Date : 2023-12-01 DOI: 10.54029/2023nyd

Chinarong Tiyadechachai, Veerapong Vattanavanit

{"title":"Intensive care unit admission prediction tool for ischemic stroke patients receiving intravenous thrombolysis: A retrospective cohort study","authors":"Chinarong Tiyadechachai, Veerapong Vattanavanit","doi":"10.54029/2023nyd","DOIUrl":"https://doi.org/10.54029/2023nyd","url":null,"abstract":"Background: Some evidence suggests that given the limited healthcare resources, the majority of low- risk stroke patients may not require critical care monitoring. This study aimed to establish a predictive score for identifying post-intravenous thrombolysis (IVT) acute ischemic stroke patients who should be monitored in the intensive care unit (ICU). Methods: This was a retrospective cohort study of patients with acute ischemic stroke who underwent IVT at Songklanagarind Hospital, Thailand between January 2010 and December 2019. Baseline characteristics and clinical outcomes were recorded. Systolic blood pressure (SBP) was collected using the first recorded in the emergency department (ED) as well as the National Institutes of Health Stroke Scale (NIHSS). Results: Of the 171 patients with stroke, 73 (42.7%) needed ICU care. The median age was 67 years old. The median SBP and NIHSS were 160 mm Hg and 10, respectively. The predicting stroke ICU (PSU) score was developed, with the following points assigned: NIHSS score (1 point if > 9), SBP (1 point if > 170 mmHg), and infarct size greater than 1 lobe (2 points if present). The PSU score achieved an area under the ROC curve of 0.759 (95% confidence interval [CI] = 0.688–0.830). A PSU score ≥ 1 predicted the need for ICU care with a sensitivity of 91.78%. Conclusions: The PSU score, which is based on the NIHSS score, systolic blood pressure, and infarct size, predicts the need for ICU care after IVT in patients with stroke.","PeriodicalId":49757,"journal":{"name":"Neurology Asia","volume":"11 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139189573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pharmacogenomics knowledge within Neurology: A brief survey amongst physicians 神经内科药物基因组学知识：对医生的简要调查

IF 0.2 4区医学

Neurology Asia Pub Date : 2023-12-01 DOI: 10.54029/2023xfs

K. Narasimhalu, Joel Soo, Jia Yi Shen, Pei Shieen Wong

引用次数: 0

Depression as comorbidity in Sundanese epilepsy patients 巽他癫痫患者的抑郁症并发症

IF 0.2 4区医学

Neurology Asia Pub Date : 2023-12-01 DOI: 10.54029/2023xmy

Fedrick Tandiawan, Suryani Gunadharma, U. Gamayani, Anam Ong, Ahmad Rizal Ganiem, Sobaryati, Shelly Iskandar

{"title":"Depression as comorbidity in Sundanese epilepsy patients","authors":"Fedrick Tandiawan, Suryani Gunadharma, U. Gamayani, Anam Ong, Ahmad Rizal Ganiem, Sobaryati, Shelly Iskandar","doi":"10.54029/2023xmy","DOIUrl":"https://doi.org/10.54029/2023xmy","url":null,"abstract":"Background: Depressive disorder is a common psychiatric comorbidity in patients with epilepsy (PWE). This health condition is prevalent among the Sundanese who have a calm and polite character, with a tendency to hide their feelings, which is associated with an increased risk of depression. Methods: This cross-sectional study aimed to determine the prevalence of major depressive disorder (MDD) and the associated factors among Sundanese PWE. The study was carried out in the neurology outpatient clinic at Hasan Sadikin General Hospital Bandung, consisting of the Sunda ethnic group as the majority of patients. Self-stigma degree was measured using the Indonesian version of Internalized Stigma of Epilepsy (ISEP) questionnaire, while depression symptom was screened through the Indonesian version of Neurological Disorders Depression Inventory for Epilepsy (NDDI-E). Subsequently, patients who had depression symptoms were referred to a psychiatrist to confirm whether their conditions matched the criteria of MDD according to the Diagnostic and Statistical Manual of Mental Disorder-5. Results: The prevalence of depressive symptoms in Sundanese epilepsy patients was found to be 18.4%, and MDD was 6.8% among 103 patients included in this study. Many PWE with MDD were not married, had uncontrolled seizures, used polytherapy anti-seizure medication, and exhibited a higher degree of self-stigma. Conclusion: In this study, the prevalence of MDD was found to be 6.8% among a cohort of Sundanese PWE. A significant relationship was also observed between MDD and several factors, including single status, uncontrolled seizure, polytherapy, and a higher degree of self-stigma.","PeriodicalId":49757,"journal":{"name":"Neurology Asia","volume":"50 4","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139191884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Factors that impact health-related quality of life in 168 myasthenia gravis in West China: Disease severity, social support, and coping style 影响中国西部 168 例重症肌无力患者健康相关生活质量的因素：疾病严重程度、社会支持和应对方式

IF 0.2 4区医学

Neurology Asia Pub Date : 2023-12-01 DOI: 10.54029/2023uyw

X. Miao, Hongxi Chen, Zi-yan Shi

{"title":"Factors that impact health-related quality of life in 168 myasthenia gravis in West China: Disease severity, social support, and coping style","authors":"X. Miao, Hongxi Chen, Zi-yan Shi","doi":"10.54029/2023uyw","DOIUrl":"https://doi.org/10.54029/2023uyw","url":null,"abstract":"Background: Myasthenia gravis (MG) is associated with reduced health-related quality of life (HRQOL). This study aimed to investigate factors that impact HRQOL in MG in a patient population in West China. Methods: A series of questionnaires were completed by 168 patients to assess the relationships between HRQOL and social support and coping style. We also evaluated the contributions of clinical characteristics to HRQOL. One-way analysis of variance (ANOVA), correlation and regression analysis were conducted to identify predictors that negatively impact HRQOL in MG. Results: There were significant differences in HRQOL scores among patients with different ratio of disease cost to income each month (F = 5.831, P = 0.001) and frequency of MG symptoms (F = 9.128, P < 0.001). Spearman’s correlation analysis showed that reduced HRQOL had low correlation with Myasthenia Gravis Composite score (r = 0.461, P < 0.001), confrontation (r = 0.312, P < 0.001) and acceptance- resignation coping style (r = 0.433, P < 0.001). Stepwise regression analysis further revealed that acceptance-resignation coping style (β = 0.380, P < 0.001) and MGC score (β = 0.322, P < 0.001) were the main predictors of HRQOL. Conclusions: Our study revealed the factors that impact HRQOL in MG patients and provided the first demonstration that acceptance-resignation is the main independent predictor of poor HRQOL in MG, other than disease severity.","PeriodicalId":49757,"journal":{"name":"Neurology Asia","volume":"284 ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139195263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mean platelet volume-to-lymphocyte ratio predicts poor functional outcome of acute ischemic stroke patients 平均血小板体积与淋巴细胞比值可预测急性缺血性脑卒中患者的不良功能预后

IF 0.2 4区医学

Neurology Asia Pub Date : 2023-12-01 DOI: 10.54029/2023thw

Anna Ying, Yiqing Jiang, Lingyan Chen

{"title":"Mean platelet volume-to-lymphocyte ratio predicts poor functional outcome of acute ischemic stroke patients","authors":"Anna Ying, Yiqing Jiang, Lingyan Chen","doi":"10.54029/2023thw","DOIUrl":"https://doi.org/10.54029/2023thw","url":null,"abstract":"Background & Objective: The mean platelet volume-to-lymphocyte ratio (MPVLR) is a novel and easily available marker of poor short-term prognosis in myocardial infarction patients. The present study was to investigate the association between MPVLR and clinical outcome of patients with acute ischemic stroke. Methods: A total of 494 acute ischemic stroke patients were included in this study and received 3-months follow-up. Blood samples for MPVLR were obtained at admission and at 7 days after acute ischemic stroke. Poor functional outcome was defined as a modified Rankin Scale (mRS) score of 3-6 at 3 months after stroke. Results: Compared with good prognosis group, MPVLR level at admission and at 7 days in poor prognosis group was significantly higher, the difference between these two groups was statistically significant (P < 0.001). In multivariate logistic regression analysis, both MPVLR as a continuous (OR 1.13; 95%CI, 1.064-1.190, P=0.001) and categorical variable (OR 3.05; 95%CI, 1.85-5.05, P<0.001) were independently associated with poor outcome at 3 months. ROC analysis revealed the predictive value of MPVLR was better than that of platelet-to lymphocyte ratio (PLR). The nomogram was used for predicting 3-months unfavourable outcome after an acute ischemic stroke. Conclusions: MPVLR at admission and at 7 days after stroke were found to be independently associated with poor functional outcome. MPVLR may serve as an activity marker for poor prognosis in patients with acute ischemic stroke.","PeriodicalId":49757,"journal":{"name":"Neurology Asia","volume":"39 7","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139191166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between language function and body composition characteristics in patients with subacute left hemispheric stroke 亚急性左半球脑卒中患者的语言功能与身体成分特征之间的关系

IF 0.2 4区医学

Neurology Asia Pub Date : 2023-12-01 DOI: 10.54029/2023upt

Soo Jeong Han, J. Suh

引用次数: 0

The level of physical activity among ambulant stroke survivors at one year: a cross sectional study in a tertiary center in Malaysia 中风幸存者一年后的体育锻炼水平：马来西亚一家三级中心的横断面研究

IF 0.2 4区医学

Neurology Asia Pub Date : 2023-12-01 DOI: 10.54029/2023exj

Mitchel Brian Jilimin, Mazlina Mazlan

{"title":"The level of physical activity among ambulant stroke survivors at one year: a cross sectional study in a tertiary center in Malaysia","authors":"Mitchel Brian Jilimin, Mazlina Mazlan","doi":"10.54029/2023exj","DOIUrl":"https://doi.org/10.54029/2023exj","url":null,"abstract":"Background & Objective: Despite the importance of physical activity, there is lack of evidence measuring the level of activity performed by the stroke survivors. This study aims to determine the level of physical activity amongst ambulant stroke patients in a tertiary centre in Malaysia and to investigate the factors that may impact their physical activity. Methods: A cross-sectional study was conducted on ambulant stroke participants at one year post stroke. International Physical Activity Questionnaire (IPAQ) was used to measure the level of physical activity, and 6 Minute Walk Test (6MWT) was recorded to assess the participants functional walking distance and endurance. The participants were categorised into low, moderate, or high physical activity levels. Age-matched healthy controls were recruited form community. Factors including presence of depression were tested in relation to physical activity. P-value of <0.05 was considered statically significant in all statistical analyses. Results: There were 45 stroke patients and 30 controls recruited in this study. Participants in the stroke group has significantly lower level of physical activity compared to the control group, especially in the high physical activity level (p<0.001); 55.6% reported having moderate, 31.1% low and 13.3% high physical activity level respectively. No significant factors were found to be associated with the physical activity. Only depression was found to have a weak negative correlation with level of physical activity (p=0.003). Conclusion: Stroke survivors have lower level of physical activity at one year post stroke despite having mild physical impairments. Rehabilitation strategies to promote physical activities should be implemented early to take advantage on the benefits of cardiovascular fitness as secondary prevention of stroke.","PeriodicalId":49757,"journal":{"name":"Neurology Asia","volume":"26 3","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139192401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of headache in children with psychiatric symptoms 对有精神症状的儿童头痛进行评估

IF 0.2 4区医学

Neurology Asia Pub Date : 2023-12-01 DOI: 10.54029/2023mwn

Arzu Yavuz, Burcu Ersöz Alan, Tuna Çek Esen

{"title":"Assessment of headache in children with psychiatric symptoms","authors":"Arzu Yavuz, Burcu Ersöz Alan, Tuna Çek Esen","doi":"10.54029/2023mwn","DOIUrl":"https://doi.org/10.54029/2023mwn","url":null,"abstract":"Background: This study aims to evaluate the relationship between headaches and psychiatric symptoms in a psychiatric clinic. Methods: We compared 102 children aged 8-16 years (31 girls, 30.4%) who presented to the child and adolescent psychiatry clinic (study group) with 100 children aged 8-16 years, (52 girls, 52%) who did not (control group). Headache was evaluated with the Headache-Attributed Restriction, Disability, Social Handicap, and Impaired Participation (HARDSHIP) Questionnaire. Psychiatric symptoms (depression, anxiety, sleep, attention, hyperactivity) were evaluated via standardized scales. Results: The study group had more headaches in the preceding year as well as the day before. Depression, anxiety and sleep problems were positively correlated with headache frequency in the preceding week in the study group, and in the study group, children with migraine had more depression, anxiety, and emotional problems. While the total quality of life (QoL) scores were not significantly different between groups, migraine decreased the QoL in both the study and control groups. Conclusion: This study indicates that headache type and burden should be evaluated in psychiatric clinics as depression and anxiety are associated with headache, especially migraine.","PeriodicalId":49757,"journal":{"name":"Neurology Asia","volume":"52 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139193147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0