Mean platelet volume-to-lymphocyte ratio predicts poor functional outcome of acute ischemic stroke patients

Background & Objective: The mean platelet volume-to-lymphocyte ratio (MPVLR) is a novel and easily available marker of poor short-term prognosis in myocardial infarction patients. The present study was to investigate the association between MPVLR and clinical outcome of patients with acute ischemic stroke. Methods: A total of 494 acute ischemic stroke patients were included in this study and received 3-months follow-up. Blood samples for MPVLR were obtained at admission and at 7 days after acute ischemic stroke. Poor functional outcome was defined as a modified Rankin Scale (mRS) score of 3-6 at 3 months after stroke. Results: Compared with good prognosis group, MPVLR level at admission and at 7 days in poor prognosis group was significantly higher, the difference between these two groups was statistically significant (P < 0.001). In multivariate logistic regression analysis, both MPVLR as a continuous (OR 1.13; 95%CI, 1.064-1.190, P=0.001) and categorical variable (OR 3.05; 95%CI, 1.85-5.05, P<0.001) were independently associated with poor outcome at 3 months. ROC analysis revealed the predictive value of MPVLR was better than that of platelet-to lymphocyte ratio (PLR). The nomogram was used for predicting 3-months unfavourable outcome after an acute ischemic stroke. Conclusions: MPVLR at admission and at 7 days after stroke were found to be independently associated with poor functional outcome. MPVLR may serve as an activity marker for poor prognosis in patients with acute ischemic stroke.