Neurology Asia最新文献

Impacts of serum biomarkers regarding glucose, lipid and protein on progression and survival of amyotrophic lateral sclerosis: A Chinese cohort study 葡萄糖、脂质和蛋白等血清生物标志物对肌萎缩性侧索硬化症进展和生存的影响：一项中国队列研究

4区医学

Neurology Asia Pub Date : 2024-06-01 DOI: 10.54029/2024esc

Nan Hu, Lei Zhang, Dongchao Shen, Xunzhe Yang, Liying Cui, Mingsheng Liu

{"title":"Impacts of serum biomarkers regarding glucose, lipid and protein on progression and survival of amyotrophic lateral sclerosis: A Chinese cohort study","authors":"Nan Hu, Lei Zhang, Dongchao Shen, Xunzhe Yang, Liying Cui, Mingsheng Liu","doi":"10.54029/2024esc","DOIUrl":"https://doi.org/10.54029/2024esc","url":null,"abstract":"Objective: To explore the impacts of nutritional biomarkers regarding glucose, protein and lipid on amyotrophic lateral sclerosis (ALS) progression and survival in a cohort of Chinese ALS patients. Methods: A total of 191 ALS patients were included in our analysis. Pearson correlation was employed to analyze the relationships between baseline serological and clinical variables. Uni- and multivariate analysis were performed to analyze the influence of nutritional biomarkers on the progression and survival of ALS. A p-value of less than 0.05 was considered to be statistically significant. Results: Hyperglycemia (around 1/6) and hyperlipidemia (1/5-1/3) were common among ALS patients while protein deficiency was not predominant. Serum total cholesterol (TC) (p=0.026) and low-density lipoprotein cholesterol (LDL-C) (p=0.044) was negatively related to baseline ALS functional rating scale-revised (ALSFRS-R) score, while serum PA was positively associated with baseline ALSFRS-R score (p=0.018). Serum levels of TC (p=0.041), apoB (p<0.001), lipoprotein a [Lp (a)] (p=0.002) and free fatty acids (FFA) (p=0.049) were negatively associated with baseline forced vital capacity percentage (FVC%). None of studied biomarkers showed significant relationship with ALS progression or survival time, except for serum level of Lp(a) had a weakly positive correlation to ALS progression rate after backward selection (p=0.048). Conclusion: Serum biomarkers of glucose, lipid or protein might only have a weak relationship with autonomous function and respiratory function status, but have no significant impact on the progression or overall survival of ALS. More studies were needed to provide guidance of nutritional management and diet recommendation for ALS patients.","PeriodicalId":49757,"journal":{"name":"Neurology Asia","volume":"29 2","pages":"385-396"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://doi.org/10.54029/2024esc","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147922878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

A novel aptamer agent showed antidepressant function via binding 5-hydroxytryptamine receptor to block re-uptake of 5-HT 一种新型适配体通过与5-羟色胺受体结合，阻断5-羟色胺再摄取，具有抗抑郁作用

4区医学

Neurology Asia Pub Date : 2024-03-01 DOI: 10.54029/2024pse

Zhiding Shao, Renrui Han, Ying Hua, Jianfeng Hu, Xia Ren, Fan Su, Tang Xiaolei

{"title":"A novel aptamer agent showed antidepressant function via binding 5-hydroxytryptamine receptor to block re-uptake of 5-HT","authors":"Zhiding Shao, Renrui Han, Ying Hua, Jianfeng Hu, Xia Ren, Fan Su, Tang Xiaolei","doi":"10.54029/2024pse","DOIUrl":"https://doi.org/10.54029/2024pse","url":null,"abstract":"Background & Objectives: Systematic evolution of ligands by exponential enrichment (SELEX) technology was widely used to screen the aptamers that bind the target protein safely and efficiently. Our study aimed to screen aptamers for anti-depression via binding to the 5-HTR to block 5-HT re- uptake. Methods: The prokaryotic expression plasmid was constructed and the recombinant 5-HT1AR (mice) was expressed and purified. The ssDNA aptamer that bound 5-HT1AR specifically was screened by SELEX (Enzyme-linked Oligonucleotide assay), and the binding sites and relative binding strength of ssDNA were detected. At the same time, ssDNA aptamer inhibitory protein uptake and against depression was verified in cellular level and mouse depression model. Results: The recombinant 5-HT1AR protein was purified successfully. After 12 rounds of positive screening and 5 rounds of negative screening, four aptamers with high affinity and specificity were obtained and the same epitope was bounded by four aptamers using ELONA (Enzyme-linked Oligonucleotide assay). The uptake of 5-HT was influenced by aptamer 18 in vitro, and the improvement of depression state in mice after intravenous injection of aptamer 18 was proved by tail suspension experiment in mice. Conclusions: Aptamer is expected to be a new type of antidepressant, which can be used in the treatment of depression.","PeriodicalId":49757,"journal":{"name":"Neurology Asia","volume":"29 1","pages":"237-247"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"http://dx.doi.org/10.54029/2024pse","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147914487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The association between atherogenic index of plasma and stroke in Chinese middle-aged and elderly population: a national cross-sectional study 中国中老年人群血浆致动脉粥样硬化指数与脑卒中的关系：一项全国性横断面研究

IF 0.2 4区医学

Neurology Asia Pub Date : 2023-12-01 DOI: 10.54029/2023ayw

Feifei Xu, Xi Zhong

{"title":"The association between atherogenic index of plasma and stroke in Chinese middle-aged and elderly population: a national cross-sectional study","authors":"Feifei Xu, Xi Zhong","doi":"10.54029/2023ayw","DOIUrl":"https://doi.org/10.54029/2023ayw","url":null,"abstract":"Objective: To investigate the association between atherogenic index of plasma (AIP) and stroke. Methods: The 2015 China Health and Retirement Longitudinal Study (CHARLS) survey was used in this study. Logistic regression was adopted to examine the relationship between AIP, calculated as log (TG/HDL), and stroke. Subgroup analysis was used to further explore the associated factors. Restricted cubic spline (RCS) regression was adopted to estimate the non-linear association. Receiver operator characteristic (ROC) analysis was utilized to calculate the cutoff value of AIP. Results: In this study, 13,027 participants aged 45 years above were enrolled. The odds ratios in the fully adjusted logistic model across the quartiles of AIP were 1.00 (reference), 1.09 (95% CI 0.69–1.72), 1.62 (95% CI 1.06–2.49), 1.07 (1.08–2.58), respectively. Non-linear association between AIP and stroke was not found using RCS regression (p for non-linearity > 0.05). The subgroup analyses showed that the association between AIP and stroke varied in different gender, alcohol and cigarette consumption, but the interaction effects were insignificant (all p > 0.05). The cutoff value of AIP was 0.82, and the area under the curve (AUC) was 0.57. Conclusion: Elevated AIP is significantly associated with the increased risk of stroke in the middle- aged and elderly Chinese, indicating that AIP may be a predictive factor for stroke among the Chinese middle-aged and elderly.","PeriodicalId":49757,"journal":{"name":"Neurology Asia","volume":"5 49","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139194023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical exome sequencing reveals an important role for clinical diagnosis of intellectual disability with definition of seven novel variants 临床外显子组测序发现七种新型变异，对智力残疾的临床诊断具有重要作用

IF 0.2 4区医学

Neurology Asia Pub Date : 2023-12-01 DOI: 10.54029/2023rfz

S. Yalçıntepe, Isik Gorker, Leyla Bozatlı, Hazal Sezginer Guler, Drenushe Zhuri, S. Demir, E. Atlı, E. Atlı, D. Eker, H. Gurkan

{"title":"Clinical exome sequencing reveals an important role for clinical diagnosis of intellectual disability with definition of seven novel variants","authors":"S. Yalçıntepe, Isik Gorker, Leyla Bozatlı, Hazal Sezginer Guler, Drenushe Zhuri, S. Demir, E. Atlı, E. Atlı, D. Eker, H. Gurkan","doi":"10.54029/2023rfz","DOIUrl":"https://doi.org/10.54029/2023rfz","url":null,"abstract":"Intellectual disability can be defined as a significantly below-average general mental function, accompanied by environmental adaptation and behavioural deterioration. Patient files of 87 children with intellectual disability were evaluated in this study. After clinical exclusion criterias, clinical exome sequencing was performed for 25 of 87 intellectual disability cases with a massively parallel targeted sequencing method. Seventeen variants in the genes MBOAT7, KDM5C, TUBB3, MAN1B1, GFAP, CACNA1A, BCOR, LMNA, LBR, ALS2, ENPP1, UBE3A, TRAPPC9, HSPG2, AFF2, NLGN4, and SOX10 were identified in 14 of 25 patients (56%). Seven of the 17 variants (41.1%) were novel in the genes KDM5C, BCOR, UBE3A, TRAPPC9, AFF2, NLGN4, and SOX10. Seven cases (7/25, 28%) had a definite diagnosis of intellectual disability with their pathogenic variants. The high rate of variant detection (56%) in the current study shows that multiple gene analysis plays an essential role in diagnosing the uncertain etiology of intellectual disability. This study also presents seven novel variants, which are first reported.","PeriodicalId":49757,"journal":{"name":"Neurology Asia","volume":"264 22-25","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139194839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanical thrombectomy for acute left middle cerebral artery occlusion in a patient with mirror- image dextrocardia 机械取栓术治疗一名镜像右心室缺血患者的急性左侧大脑中动脉闭塞症

IF 0.2 4区医学

Neurology Asia Pub Date : 2023-12-01 DOI: 10.54029/2023fmr

Xianmin Wang, Chao Jiang, Danni Chen, Xiaobo Li

引用次数: 0

Evaluation of inpatients neurology consultations in the department of gynecology, obstetrics, and reproductive medicine of a tertiary hospital in Turkey 对土耳其一家三甲医院妇产科和生殖医学科神经科住院病人就诊情况的评估

IF 0.2 4区医学

Neurology Asia Pub Date : 2023-12-01 DOI: 10.54029/2023xzu

D. Ağırcan, Murat Cekic, H. Uyanıkoğlu, Tülin Gesoğlu Demir, Ozlem Ethemoglu

{"title":"Evaluation of inpatients neurology consultations in the department of gynecology, obstetrics, and reproductive medicine of a tertiary hospital in Turkey","authors":"D. Ağırcan, Murat Cekic, H. Uyanıkoğlu, Tülin Gesoğlu Demir, Ozlem Ethemoglu","doi":"10.54029/2023xzu","DOIUrl":"https://doi.org/10.54029/2023xzu","url":null,"abstract":"Background & Objective: It is important to be aware of hormonal changes in neurological disease in neurology training. We aimed to investigate the most common disorders which resulted in the clinicians from the Department of Gynecology, Obstetrics, and Reproductive Medicine (GORM) to ask for neurology consultation from the Department of Neurology. Methods: All the neurology consultations requested from the Department of GORM between 2015 and 2023 at Harran University Hospital, Sanliurfa, Turkey, were retrospectively evaluated with regard to demographic characteristics, the reason for referral, neurologic diagnoses, and treatment, imaging features. SPSS statistical software version 22 (IBM Inc. NC, USA) was used to perform all statistical analyses. Results: There were 333 patients with a mean age of 32.5 years (range 17-68) seeking consultations; 287 had obstetric problems, and 46 had gynecological issues. In the obstetric group, pre-eclampsia and Posterior Reversible Encephalopathy Syndrome (PRES) were the most frequent final neurological diagnoses, while headache and acute cerebrovascular disease were the most common frequent problems in the gynecological group. The number of consultations rose from 23 in 2015 to 66 in 2022. The predicted rate of final diagnosis of GORM residents was 58%. The neurologist’s contribution has substantial influence on the management of 208 (62%) patients. Conclusion: Neurologists have a significant contribution to the management of GORM inpatients. In neurological training, importance should be given to the effect of hormonal changes on neurological diseases in neurology training.","PeriodicalId":49757,"journal":{"name":"Neurology Asia","volume":"12 2","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139189381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Youtube as a source of information about stroke rehabilitation during the COVID-19 pandemic Youtube 作为 COVID-19 大流行期间中风康复信息的来源

IF 0.2 4区医学

Neurology Asia Pub Date : 2023-12-01 DOI: 10.54029/2023kif

E. Özduran, V. Hancı

{"title":"Youtube as a source of information about stroke rehabilitation during the COVID-19 pandemic","authors":"E. Özduran, V. Hancı","doi":"10.54029/2023kif","DOIUrl":"https://doi.org/10.54029/2023kif","url":null,"abstract":"Objective: Although stroke rehabilitation (SR) is part of post-stroke recovery, patients have limited knowledge on this subject. This study aims to analyze YouTube videos about SR in terms of the information value and quality. Methods: On YouTube.com; the word “SR” was searched in September 6th, 2021. The listed first 100 videos were classified according to count of like, dislike, source of upload, origin of country and contents of SR. Quality, reliability and accuracy of the videos were determined with Global Quality Score (GQS), Journal of American Medical Association (JAMA) benchmark criteria and Modified DISCERN questionnaire, respectively. Results: According to the results of the study, 59 low quality, 28 medium quality, and 13 high-quality videos were determined. Eighty one percent of the videos contained insufficient data. Academic and physician-sourced videos comprised the majority (84.7%) of the high-quality group. A statistically significant result was found between the video sources and the number of views, likes, dislikes, comments, and video duration (p<0.05). A weak positive correlation was found between video durations and GQS (r=0.671), JAMA benchmark criteria (r=0.665), modified DISCERN (r=0.701) scores (p<0.001). Conclusion: Our results showed that most of the YouTube videos on SR have poor quality and insufficient data. High-quality videos have a longer duration and are uploaded by academic and physician video sources. YouTube can be considered an alternative resource besides tele rehabilitation for patients who need SR and whose health care was interrupted during the COVID pandemic. It can be said that higher-quality videos created by health professionals will be more useful for patient education in future.","PeriodicalId":49757,"journal":{"name":"Neurology Asia","volume":"50 4","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139192525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of cold compression before botulinum neuro- toxin injection in hemifacial spasm 肉毒杆菌神经毒素注射前冷敷对半面痉挛的影响

IF 0.2 4区医学

Neurology Asia Pub Date : 2023-12-01 DOI: 10.54029/2023nkf

Tasanee Tantirittisak, Peamnapatch Dhanachanvisith

{"title":"Effect of cold compression before botulinum neuro- toxin injection in hemifacial spasm","authors":"Tasanee Tantirittisak, Peamnapatch Dhanachanvisith","doi":"10.54029/2023nkf","DOIUrl":"https://doi.org/10.54029/2023nkf","url":null,"abstract":"Objectives: To compare the effect of using cold compression before injecting botulinum toxin (BTX) versus not using cold compression, on pain and bleeding at the injection site, efficacy and the quality of life of patients with hemifacial spasm (HFS). Methods: A prospective, randomized, case crossover design was employed. One hundred fifty-nine (159) patients who were diagnosed as having primary HFS with BTX treatment in the botulinum toxin clinic were randomized during the period from May 2017 to November 2017. Patients were divided into two groups – with cold compression and without cold compression before BTX injection and then evaluated for the severity and frequency of HSF using the Jankovic Rating Scale and quality of life questionnaire. Immediate complications after injection such as pain and bleeding were also assessed. Results: Cold compression before BTX injection significantly decreased the severity and frequency of HFS (p<0.001). Pain in cases where cold compression was used before BTX injection was significantly lower than in those cases not receiving cold compression (p<0.001). Satisfaction scores and bleeding were significantly different (p<0.001). Quality of life was significantly improved after treatment with BTX (p<0.001). Conclusion: Cold compression before BTX injection can improve the efficacy of treatment by reducing severity and frequency. This study confirms previous studies that using cold compression before BTX injection results in a good outcome in relation to satisfaction and bleeding. No significant complications were found. Additionally, BTX injection can also improve quality of life in hemifacial spasm patients.","PeriodicalId":49757,"journal":{"name":"Neurology Asia","volume":"14 7","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139188946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serum YKL-40 (chitinase 3-like protein 1) levels in migraine patients during an attack 偏头痛患者发作时的血清 YKL-40（几丁质酶 3 样蛋白 1）水平

IF 0.2 4区医学

Neurology Asia Pub Date : 2023-12-01 DOI: 10.54029/2023rxc

Bahriye Horasanli, Zeynep Caliskan Sak, Aysun Ozsahin, Keziban Ucar Karabulut

{"title":"Serum YKL-40 (chitinase 3-like protein 1) levels in migraine patients during an attack","authors":"Bahriye Horasanli, Zeynep Caliskan Sak, Aysun Ozsahin, Keziban Ucar Karabulut","doi":"10.54029/2023rxc","DOIUrl":"https://doi.org/10.54029/2023rxc","url":null,"abstract":"Objectives: The aim of this study was to investigate YKL-40 in migraine patients during migraine attacks. Methods: In this prospective study, 30 migraine patients with aura (MWA) and 30 migraine patients without aura (MWOA) who presented to the Neurological Outpatient Department of Konya City Hospital during a migraine episode as well as 28 healthy controls were included. According to the manufacturer’s recommendations, serum YKL-40 levels were determined using an ELISA kit (FineTest). Statistical analysis of the data was performed with the IBM SPSS version 20.0 program. Results: The mean gender and age were similar between groups (p>0.05). The serum YKL-40 level was 3575 ± 604.975 pg/ml in the MWA group, 3339 ± 492.689 pg/ml in the MWOA group and 3190 ± 544.018 pg/ml in the control group. YKL-40 levels were significantly higher in MWA than in the control group (p=0.028). YKL-40 levels were similar in the MWA and MWOA groups (p=0.302). No significant difference was found between the group with MWOA and the control group (p=0.915). Conclusion: Although YKL-40 levels are increased in patients with migraine with aura during an attack, comprehensive studies with a larger sample are needed to clarify the relationship between YKL-40 and migraine.","PeriodicalId":49757,"journal":{"name":"Neurology Asia","volume":"63 2","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139188159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cyclic vomiting syndrome plus accompanying Ross syndrome: More than a peripheral autonomic dysfunction 周期性呕吐综合征并伴有罗斯综合征：不仅仅是外周自主神经功能紊乱

IF 0.2 4区医学

Neurology Asia Pub Date : 2023-12-01 DOI: 10.54029/2023hra

Gizem Gürsoy, K. Tutkavul, Şirin Yaşar

引用次数: 0