Neurology Asia最新文献_第10页

Not a usual sight: A rare case of pineal gland tumor associated with Down syndrome presenting with absence of ophthalmologic signs: A case report 不寻常的景象:一例罕见的松果体肿瘤与唐氏综合征相关，表现为没有眼科症状:1例报告

IF 0.2 4区医学

Neurology Asia Pub Date : 2023-06-01 DOI: 10.54029/2023ufj

A. ZenyrosFaith, Sabellano MD Mph, T. MarkTimothy, Steven G Cinco MD, Villaraza MD Fpna, Dr Zfa Sabellano, Neurology Asia

引用次数: 0

MOGAD following anti-NMDAR encephalitis: A case report 抗NMDAR脑炎并发MOGAD一例报告

IF 0.2 4区医学

Neurology Asia Pub Date : 2023-06-01 DOI: 10.54029/2023nap

Tian Nie, Wan Wei

引用次数: 0

Endoscopic third ventriculostomy versus ventriculoperitoneal shunt in pediatric patients with post-infective hydrocephalus: A meta-analysis of randomized controlled trials 小儿感染后脑积水患者的内镜第三脑室造口术与脑室-腹膜分流术:随机对照试验的荟萃分析

IF 0.2 4区医学

Neurology Asia Pub Date : 2023-06-01 DOI: 10.54029/2023dhw

Fenjie Lin, Xun Zhang, Ying-hua Rao, Shuchang Zheng, B. Liang, Ming-jun Qin

{"title":"Endoscopic third ventriculostomy versus ventriculoperitoneal shunt in pediatric patients with post-infective hydrocephalus: A meta-analysis of randomized controlled trials","authors":"Fenjie Lin, Xun Zhang, Ying-hua Rao, Shuchang Zheng, B. Liang, Ming-jun Qin","doi":"10.54029/2023dhw","DOIUrl":"https://doi.org/10.54029/2023dhw","url":null,"abstract":"Background: Although studies on the safety and efficacy of endoscopic third ventriculostomy (ETV) and ventriculoperitoneal shunt (VPS) have been conducted, the safety and efficacy for treating post- infective hydrocephalus (PIH) in pediatric patients have not been investigated using meta-analysis and thus remain controversial. Therefore, we conducted a meta-analysis to assess the safety and efficacy of ETV and VPS for PIH treatment and determine whether ETV is more appropriate than VPS for treating PIH in PP.\u0000Methods: We searched Pubmed, Embase, Web of Science, and the Cochrane Library databases up to January 2022. The quality of studies was assessed using the Cochrane Collaboration’s tool for assessing the risk of bias in randomized trials. A fixed-effect model was used for pooling analysis, and heterogeneity was assessed using I2.\u0000Results: Three randomized controlled trials involving 200 patients out of a total 254 identified studies were included. No significant differences were found between ETV and VPS in postoperative success rate (risk ratio RR: 0.89; 95% confidence interval CI: 0.72–1.10; p = 0.27), postoperative infection rate (RR: 0.68; 95% CI: 0.21–2.22; p = 0.52), postoperative blockage rate (RR: 0.90; 95% CI: 0.40–2.00; p = 0.80), complication rates (RR: 1.29; 95% CI: 0.45–3.71; p = 0.63), or mortality (RR: 1.31; 95% CI: 0.47–3.65; p = 0.60). However, patients who underwent VPS showed lower postoperative cerebrospinal fluid leakage than those who underwent ETV (RR: 9.00; 95% CI: 1.18–68.45; p = 0.03).\u0000Conclusions: VPS may be more beneficial for the treatment of PIH in pediatric patients.","PeriodicalId":49757,"journal":{"name":"Neurology Asia","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41479030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spectrum of MECP2 mutations in Iranian Azeri Turkish Rett syndrome patients 伊朗阿塞拜疆土耳其Rett综合征患者MECP2突变谱

IF 0.2 4区医学

Neurology Asia Pub Date : 2023-06-01 DOI: 10.54029/2023xvm

Saba Ahmadpour Nazm, Z. Jahanafrooz, M. Bonyadi, Noushin Masoudi, Z. Nouri, M. Barzegar

{"title":"Spectrum of MECP2 mutations in Iranian Azeri Turkish Rett syndrome patients","authors":"Saba Ahmadpour Nazm, Z. Jahanafrooz, M. Bonyadi, Noushin Masoudi, Z. Nouri, M. Barzegar","doi":"10.54029/2023xvm","DOIUrl":"https://doi.org/10.54029/2023xvm","url":null,"abstract":"Rett syndrome is an X-linked dominant neurodevelopmental disorder that occurs mostly in females. De novo mutations in the MECP2 gene have an important role in the appearance of the features of this syndrome. We planned to study spectrum of MECP2 mutations in Rett syndrome patients and their clinical symptoms. A cohort of 29 patients referred by neurologists from Iranian Azeri Turks was screened. Then direct sequencing was utilized to characterize the spectrum of mutations in the MECP2 gene in Rett syndrome patients. A total of 10 different mutations on MECP2 gene were detected in 22 patients. We identified 2 (9%) frameshift, 10 (45.64%) nonsense, 8 (36.4%) missense mutations, and 2(9%) large deletions. In this cohort, one of the detected deletions was novel, namely 1023-1096del74nt. Random X chromosome inactivation in females’ cells and different MECP2 mutations can cause a phenotypic variability between patients. This is the first report regarding the spectrum of MECP2 mutation and phenotypic spectrum in Iranian Azeri Turks with Rett syndrome. Our finding confirms a high mutation frequency (75.8%) of MECP2 gene in Iranian Rett syndrome patients.","PeriodicalId":49757,"journal":{"name":"Neurology Asia","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41710241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Subfatin levels and thiol balance in patients with stroke 脑卒中患者的亚脂蛋白水平和硫醇平衡

IF 0.2 4区医学

Neurology Asia Pub Date : 2023-06-01 DOI: 10.54029/2023aus

H. Demir, E. S. Seyhanli, Tülin Gesoğlu Demir, I. Koyuncu

{"title":"Subfatin levels and thiol balance in patients with stroke","authors":"H. Demir, E. S. Seyhanli, Tülin Gesoğlu Demir, I. Koyuncu","doi":"10.54029/2023aus","DOIUrl":"https://doi.org/10.54029/2023aus","url":null,"abstract":"Background & Objective: Acute ischemic stroke leads to the increased production of free radicals and reactive oxygen species in the tissue and plasma via various mechanisms. We aimed to investigate thiol balance and subfatin impairment in patients with minor ischemic stroke (MIS) compared with stroke-free controls.\u0000Methods: A total of 70 participants (35 patients and 35 healthy controls) were enrolled in this study. The investigation includes serum subfatin levels, native thiol, total thiol, native thiol-to-total thiol ratio, disulfide, the disulfide-to-native thiol ratio, and the disulfide-to-total thiol ratio. The blood samples were collected at the time of admission to the emergency department.\u0000Results: A total of 35 patients with MIS and 35 healthy controls were enrolled in this study. Mean ages of patients and control subjects are 64.5±10.6 and 64.3±5.9, respectively. 20 (57.1%) of both groups were male. The two groups were similar in terms of age (p > 0.912) and did not differ in subfatin levels (p = 0.247). Native thiol, total thiol, and the native thiol-to-total thiol ratio were significantly lower in the patients than in the controls (p < 0.001), whereas disulfide, the disulfide-to-native thiol ratio, and the disulfide-to-total thiol ratio were significantly higher in the controls.\u0000Conclusion: Thiol balance is impaired in patients with ischemic stroke, but it was uncertain about subfatin. Additional research required for subfatin in acute ischemic stroke.","PeriodicalId":49757,"journal":{"name":"Neurology Asia","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48917653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gene Xpert MTB/RIF assay in patients with clinical suspicion of tuberculous meningitis 临床怀疑结核性脑膜炎患者的基因Xpert MTB/RIF检测

IF 0.2 4区医学

Neurology Asia Pub Date : 2023-06-01 DOI: 10.54029/2023ktz

Mukesh Rathod, A. Qavi, V. Mittal, Ajai Kumar Singh, Pradeep Kumar Maurya, Ashutosh Kumar Singh, A. Thacker, D. Kulshreshtha

{"title":"Gene Xpert MTB/RIF assay in patients with clinical suspicion of tuberculous meningitis","authors":"Mukesh Rathod, A. Qavi, V. Mittal, Ajai Kumar Singh, Pradeep Kumar Maurya, Ashutosh Kumar Singh, A. Thacker, D. Kulshreshtha","doi":"10.54029/2023ktz","DOIUrl":"https://doi.org/10.54029/2023ktz","url":null,"abstract":"Early diagnosis and treatment of tubercular meningitis (TBM) is one of the best predictors of survival. The smear testing of the cerebrospinal fluid (CSF) has a low sensitivity and cultures, though having higher sensitivity, take a long time in TBM diagnosis. The present study was done to evaluate the proportion of positive Gene Xpert test, a rapid nucleic acid amplification test, in clinically suspected patients with TBM. The results of Gene Xpert tests were then compared with the culture results. One hundred and fifty prospective patients with a clinical suspicion of TBM were classified as probable or possible TBM and underwent CSF examination for culture and Gene Xpert assay. Out of 124 patients available for statistical evaluation, 52 were in the probable and 72 in possible TBM group. The proportion of patients with Gene Xpert positivity were significantly more in probable compared to possible TBM (63.15% vs 36.85%, p<0.001). Twenty-eight patients had a positive culture result. The sensitivity of Gene Xpert relative to culture testing was 68.42%, specificity of 97.61%, a positive predictive value of 92.85% and a negative predictive value of 87.23%. Gene Xpert testing provided a rapid diagnosis in patients suspected with TBM. The high sensitivity and specificity of this test relative to culture testing is a strong indication that it should be included as one of the gold standard tests in patients with suspected TBM.","PeriodicalId":49757,"journal":{"name":"Neurology Asia","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47498277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Autopsy evidence of central and peripheral demyelination in a case of Guillain-Barré syndrome/ Bickerstaff brainstem encephalitis overlap syndrome 格林-巴勒综合征/比克斯塔夫脑干脑炎重叠综合征1例中枢性和外周性脱髓鞘的尸检证据

IF 0.2 4区医学

Neurology Asia Pub Date : 2023-06-01 DOI: 10.54029/2023wtv

A. Cabungcal, Ma Luisa Gwenn Pabellano‐Tiongson

{"title":"Autopsy evidence of central and peripheral demyelination in a case of Guillain-Barré syndrome/ Bickerstaff brainstem encephalitis overlap syndrome","authors":"A. Cabungcal, Ma Luisa Gwenn Pabellano‐Tiongson","doi":"10.54029/2023wtv","DOIUrl":"https://doi.org/10.54029/2023wtv","url":null,"abstract":"We report a case of a 59-year-old male who had acute, severe, rapidly progressive ascending weakness, which progressed to difficulty of breathing in a span of twelve hours. Neurophysiologic studies showed acute denervation compatible with acute motor axonal neuropathy. He was started on intravenous immunoglobulin therapy on the first day of hospitalization and completed five days of treatment but still developed decrease in sensorium and bilateral ophthalmoplegia. Imaging studies of the brain and cervical spinal cord showed findings that are non-contributory to the clinical presentation, leading to the consideration of Bickerstaff’s brainstem encephalitis. Pulse therapy with high dose methylprednisolone for five days was given however, despite maximal treatment, he expired on the 12th day of illness. Post-mortem immunohistochemical studies of the pons and sural nerve showed areas of inflammation and demyelination in both areas, suggesting combined central and peripheral demyelination in a single patient. Literature review shows that our patient presents with atypical clinical and diagnostic features, different from Bickerstaff’s brainstem encephalitis and combined central and peripheral demyelination, suggesting another disease entity presenting as acute fulminant neuropathy.","PeriodicalId":49757,"journal":{"name":"Neurology Asia","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43008619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of the relationship between COVID -19 and Guillain Barre syndrome: a single center pandemic experience 评估COVID -19与格林-巴利综合征之间的关系:单中心大流行经验

IF 0.2 4区医学

Neurology Asia Pub Date : 2023-06-01 DOI: 10.54029/2023fth

Z. Bahtiyarca, Ö. Karaahmet, M. Panpallı Ateş, Ece Ünlü Akyüz

{"title":"Assessment of the relationship between COVID -19 and Guillain Barre syndrome: a single center pandemic experience","authors":"Z. Bahtiyarca, Ö. Karaahmet, M. Panpallı Ateş, Ece Ünlü Akyüz","doi":"10.54029/2023fth","DOIUrl":"https://doi.org/10.54029/2023fth","url":null,"abstract":"Background & Objective: This study aimed to determine the relationship between COVID-19 infection/ vaccination and Guillain-Barré syndrome (GBS) and to compare clinical characteristics and functional outcomes between COVID-19-related and non-COVID-19 GBS patients.\u0000Method: The medical files of the patients who sought treatment with the diagnosis of GBS between March 2020 and July 2022 were retrospectively analyzed. The patients were divided into groups as COVID-19-related GBS (C-GBS) and non-COVID-19 GBS (NC-GBS). Demographic and clinical characteristics, neurological examination findings, treatment protocols, and outcomes, including functional status, ambulation level, independence in daily living activities, and anxiety-depression levels of the patients with GBS, were recorded.\u0000Results: A total of 25 patients were included in the study. GBS was found to be associated with COVID-19 in 9 (36%) patients. Among them, 5 (20%) patients developed GBS after COVID-19 infection and 4 (16%) after the COVID-19 vaccine. The latency between COVID-19 infection and the onset of GBS ranged from 7 to 60 days, and the latency between vaccination and the onset of GBS ranged from 3 to 60 days. The clinical presentation and features, disease severity, and electrodiagnostic patterns of C-GBS patients were similar to NC-GBS patients. Also, there was no significant difference between patients with C-GBS and NC-GBS regarding functional status, ambulation level, functional independence in daily activities, and anxiety-depression levels.\u0000Conclusion: GBS is not uncommon in COVID-19. In this study, 20% of GBS cases admitted to our hospital during the pandemic seem to be associated with COVID-19 infection and 16% with COVID-19 vaccination. However, clinical features and functional outcomes of C-GBS and NC-GBS cases are similar.","PeriodicalId":49757,"journal":{"name":"Neurology Asia","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41736541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

De novo STXBP1 mutation in a child with hypotonia, intellectual disability, tremor and without epilepsy 1例张力低下、智力残疾、震颤且无癫痫的儿童新生STXBP1突变

IF 0.2 4区医学

Neurology Asia Pub Date : 2023-06-01 DOI: 10.54029/2023mru

S. Yimenicioglu, Ayca Kocaaga

引用次数: 0

The effects of treadmill training on postural control and balance in children with spastic diplegic cerebral palsy: A cross-over controlled study 平板训练对痉挛性双瘫患儿体位控制和平衡的影响：一项交叉对照研究

IF 0.2 4区医学

Neurology Asia Pub Date : 2023-06-01 DOI: 10.54029/2023wye

Cemil Ozal, S. Aksoy, M. Kerem Gunel

{"title":"The effects of treadmill training on postural control and balance in children with spastic diplegic cerebral palsy: A cross-over controlled study","authors":"Cemil Ozal, S. Aksoy, M. Kerem Gunel","doi":"10.54029/2023wye","DOIUrl":"https://doi.org/10.54029/2023wye","url":null,"abstract":"Background & Objective: Treadmill training (TT) is used for several targets as in walking speed and endurance in rehabilitation programs of children with cerebral palsy (CP). However, its effects on postural stability have not been fully explored. The aim of this study was to investigate the effects of unsupported TT on postural control (PC) parameters and balance in children with spastic diplegic CP.\u0000Methods: Twelve children with CP, level I-II according to Gross-Motor-Function-Classification- System (GMFCS) were included. Participants were divided into two groups using randomized-sampling method. The study was designed as a cross-over study. In the first phase, the first group underwent routine physiotherapy-rehabilitation program (PTR) 3 sessions/week, 45 minutes per session, for 12 weeks. In the second group, 20 minutes of TT starting with 0.5 km/h speed, was added to the same PTR (n=6). At the end of 12 week, 4-week-long wash-out period was given. After this 4 weeks period, both groups crossed-over for another 12 weeks at the second phase of therapy. All tests was applied at baseline and at end of the first and second phases. PC was evaluated with Balance-Master computerized posturography (Neurocom Inc.) which consisted of tests of modified-clinical-sensory- balance-interaction (MCSBT), weight-shifting-in-standing (WSST), limits-of-stability (LoST) and rhythmic-weight-shifting (RWST).\u0000Results: The two groups were similar in age, body composition, GMFCS Levels and spasticity levels before the treatment and after the wash-period (p>0,05). After TT, there were significant improvements in PC parameters, MCSBT: composite-balance-score (p=0.02), center of gravity alignment (p=0.02); WSST: symmetry (p=0.03); LoST: backward weight-shifting (p=0,02), end point reaching (p=0.02-0.04), maximum-orientation (p=0.02-0.04); RWST: direction- control (p=0.02-0.04), on-axis-velocity (p=0.02-0.04).\u0000Conclusion: Including TT in PTR treatment program can enhance PC and balance in children with CP.","PeriodicalId":49757,"journal":{"name":"Neurology Asia","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48869145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0