Subfatin levels and thiol balance in patients with stroke

IF 0.2 4区医学 Q4 CLINICAL NEUROLOGY

Neurology Asia Pub Date : 2023-06-01 DOI:10.54029/2023aus

H. Demir, E. S. Seyhanli, Tülin Gesoğlu Demir, I. Koyuncu

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引用次数: 0

Abstract

Background & Objective: Acute ischemic stroke leads to the increased production of free radicals and reactive oxygen species in the tissue and plasma via various mechanisms. We aimed to investigate thiol balance and subfatin impairment in patients with minor ischemic stroke (MIS) compared with stroke-free controls. Methods: A total of 70 participants (35 patients and 35 healthy controls) were enrolled in this study. The investigation includes serum subfatin levels, native thiol, total thiol, native thiol-to-total thiol ratio, disulfide, the disulfide-to-native thiol ratio, and the disulfide-to-total thiol ratio. The blood samples were collected at the time of admission to the emergency department. Results: A total of 35 patients with MIS and 35 healthy controls were enrolled in this study. Mean ages of patients and control subjects are 64.5±10.6 and 64.3±5.9, respectively. 20 (57.1%) of both groups were male. The two groups were similar in terms of age (p > 0.912) and did not differ in subfatin levels (p = 0.247). Native thiol, total thiol, and the native thiol-to-total thiol ratio were significantly lower in the patients than in the controls (p < 0.001), whereas disulfide, the disulfide-to-native thiol ratio, and the disulfide-to-total thiol ratio were significantly higher in the controls. Conclusion: Thiol balance is impaired in patients with ischemic stroke, but it was uncertain about subfatin. Additional research required for subfatin in acute ischemic stroke.

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脑卒中患者的亚脂蛋白水平和硫醇平衡

背景与目的：急性缺血性脑卒中通过多种机制导致组织和血浆中自由基和活性氧的产生增加。我们旨在研究轻度缺血性卒中（MIS）患者与无卒中对照组的硫醇平衡和亚锡损伤。方法：共有70名参与者（35名患者和35名健康对照）参加本研究。研究包括血清亚锡水平、天然硫醇、总硫醇、天然硫醇与总硫醇之比、二硫化物、二硫化物与天然硫醇之比以及二硫化物与总硫醇的比。血样是在急诊科入院时采集的。结果：共有35名MIS患者和35名健康对照参加了本研究。患者和对照组的平均年龄分别为64.5±10.6和64.3±5.9。两组均为男性20例（57.1%）。两组患者的年龄相似（p>0.05），亚锡水平无差异（p=0.247）。患者的天然硫醇、总硫醇和天然硫醇与总硫醇之比显著低于对照组（p<0.001），而对照组的二硫化物、二硫化物与天然硫醇之比和二硫化物与总硫醇比率显著高于对照组。结论：缺血性脑卒中患者的巯基平衡受损，但亚锡尚不确定。亚锡在急性缺血性脑卒中中的作用还需要进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurology Asia CLINICAL NEUROLOGY-

CiteScore

0.30

自引率

0.00%

发文量

审稿时长

>0 weeks

期刊介绍： Neurology Asia (ISSN 1823-6138), previously known as Neurological Journal of South East Asia (ISSN 1394-780X), is the official journal of the ASEAN Neurological Association (ASNA), Asian & Oceanian Association of Neurology (AOAN), and the Asian & Oceanian Child Neurology Association. The primary purpose is to publish the results of study and research in neurology, with emphasis to neurological diseases occurring primarily in Asia, aspects of the diseases peculiar to Asia, and practices of neurology in Asia (Asian neurology).