偏头痛患者发作时的血清 YKL-40（几丁质酶 3 样蛋白 1）水平

IF 0.2 4区医学 Q4 CLINICAL NEUROLOGY

Neurology Asia Pub Date : 2023-12-01 DOI:10.54029/2023rxc

Bahriye Horasanli, Zeynep Caliskan Sak, Aysun Ozsahin, Keziban Ucar Karabulut

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引用次数: 0

摘要

研究目的本研究旨在调查偏头痛发作时偏头痛患者体内的 YKL-40。方法：在这项前瞻性研究中，30 名有先兆的偏头痛患者（MWA）和 30 名无先兆的偏头痛患者（MWA）接受了检测：在这项前瞻性研究中，纳入了在偏头痛发作期间到科尼亚市医院神经科门诊就诊的30名有先兆偏头痛患者（MWA）和30名无先兆偏头痛患者（MWOA）以及28名健康对照者。根据生产商的建议，使用 ELISA 试剂盒（FineTest）测定血清 YKL-40 水平。使用 IBM SPSS 20.0 版程序对数据进行统计分析。结果各组的平均性别和年龄相似（P>0.05）。MWA 组的血清 YKL-40 水平为 3575 ± 604.975 pg/ml，MWOA 组为 3339 ± 492.689 pg/ml，对照组为 3190 ± 544.018 pg/ml。MWA 组的 YKL-40 水平明显高于对照组（P=0.028）。MWA 组和 MWOA 组的 YKL-40 水平相似（p=0.302）。MWOA组与对照组之间无明显差异（p=0.915）。结论虽然有先兆的偏头痛患者在发作时YKL-40水平会升高，但仍需进行更多样本的综合研究，以明确YKL-40与偏头痛之间的关系。

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Serum YKL-40 (chitinase 3-like protein 1) levels in migraine patients during an attack

Objectives: The aim of this study was to investigate YKL-40 in migraine patients during migraine attacks. Methods: In this prospective study, 30 migraine patients with aura (MWA) and 30 migraine patients without aura (MWOA) who presented to the Neurological Outpatient Department of Konya City Hospital during a migraine episode as well as 28 healthy controls were included. According to the manufacturer’s recommendations, serum YKL-40 levels were determined using an ELISA kit (FineTest). Statistical analysis of the data was performed with the IBM SPSS version 20.0 program. Results: The mean gender and age were similar between groups (p>0.05). The serum YKL-40 level was 3575 ± 604.975 pg/ml in the MWA group, 3339 ± 492.689 pg/ml in the MWOA group and 3190 ± 544.018 pg/ml in the control group. YKL-40 levels were significantly higher in MWA than in the control group (p=0.028). YKL-40 levels were similar in the MWA and MWOA groups (p=0.302). No significant difference was found between the group with MWOA and the control group (p=0.915). Conclusion: Although YKL-40 levels are increased in patients with migraine with aura during an attack, comprehensive studies with a larger sample are needed to clarify the relationship between YKL-40 and migraine.

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来源期刊

Neurology Asia CLINICAL NEUROLOGY-

CiteScore

0.30

自引率

0.00%

发文量

审稿时长

>0 weeks

期刊介绍： Neurology Asia (ISSN 1823-6138), previously known as Neurological Journal of South East Asia (ISSN 1394-780X), is the official journal of the ASEAN Neurological Association (ASNA), Asian & Oceanian Association of Neurology (AOAN), and the Asian & Oceanian Child Neurology Association. The primary purpose is to publish the results of study and research in neurology, with emphasis to neurological diseases occurring primarily in Asia, aspects of the diseases peculiar to Asia, and practices of neurology in Asia (Asian neurology).